Lifespan changes: From wild type to sod-1;sod-2 / From sod-1;sod-2 to multiple mutants

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Genetic mutants with sod-1, sod-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    sod-1;sod-2 mutant worms lived significantly longer than wild-type N2 worms 

  • Lifespan comparisons

    Double mutant sod-1(tm783);sod-2(ok1030) has a lifespan of 29.3 days, while single mutant sod-1(tm783) has a lifespan of 17.3 days, single mutant sod-2(ok1030) has a lifespan of 27.2 days and wild type has a lifespan of 17.7 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 PubMed 19197346 Click here to select all mutants from this PubMed ID in the graph

Search genes: sod-1 sod-2
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Cu-Zn]

Locus: CELE_C15F1.7

Wormbase description: sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Mn] 1, mitochondrial

Locus: CELE_F10D11.1

Wormbase description: sod-2 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-2 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-2 in E. coli protects against methyl viologen-induced oxidative stress.

Orthologs of sod-1;sod-2 in SynergyAge
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Species Gene
Orthologs of sod-1 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster Sod1
Mus musculus Sod1
Orthologs of sod-2 in SynergyAge
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Species Gene
Drosophila melanogaster Sod2

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: