Lifespan changes: From wild type to Pink1;Snca

There is no network for this step.
Fullscreen mode
Hide graph

Genetic mutants with Pink1, Snca alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Diet

    ad libitum

  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Lifespan comparisons

    Double mutant Pink1(KO);Snca(KO) has a lifespan of 546.0 days, while wild type has a lifespan of 723.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Gispert S et al., 2015, Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression. Hum Mol Genet. 24(4):1061-76 PubMed 25296918 Click here to select all mutants from this PubMed ID in the graph

Search genes: Pink1 Snca
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

PTEN induced putative kinase 1

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

synuclein, alpha

Orthologs of Pink1;Snca in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Pink1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Snca in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: