Lifespan changes: From wild type to K-ras;Trp53

There is no network for this step.
Fullscreen mode
Hide graph

Genetic mutants with K-ras, Trp53 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Diet

    mouse/rat diet (No. 7017, Harlan)

  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    Double mutant mice developed much more aggressive lung cancers and higher tumor burden than K-rasLA1/+ mice, leading to shorter lifespans. p53R172H delta g/+ K-rasLA1/+ mice had significantly reduced survival compared with K-rasLA1/+, p53R172H delta g/+ and wild-type littermates. The p53+/- K-rasLA1/+ mice showed a very similar survival curve to published data, and indicated no difference in survival as compared to p53R172H delta g/+ K-rasLA1/+ mice.

  • Lifespan comparisons

    Double mutant K-ras(LA1);p53(KO) has a lifespan of 266.0 days, while single mutant K-ras(LA1) has a lifespan of 373.0 days, single mutant p53(KO) has a lifespan of 510.0 days and wild type has a lifespan of 860.0 days.

  • Type of interaction
    See methods

    Almost additive (negative)

  • Citation
    View abstract

    Zheng S et al., 2007, A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene. 26(48):6896-904 PubMed 17486075 Click here to select all mutants from this PubMed ID in the graph

Search genes: K-ras Trp53
  • Symbol
  • GenAge

No gene information for K-ras

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

transformation related protein 53

Orthologs of K-ras;Trp53 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of K-ras in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trp53 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group