Lifespan changes: From wild type to K-ras;Trp53
24
mouse/rat diet (No. 7017, Harlan)
266.0
-69.07%
Double mutant mice developed much more aggressive lung cancers and higher tumor burden than K-rasLA1/+ mice, leading to shorter lifespans. p53R172H delta g/+ K-rasLA1/+ mice had significantly reduced survival compared with K-rasLA1/+, p53R172H delta g/+ and wild-type littermates. The p53+/- K-rasLA1/+ mice showed a very similar survival curve to published data, and indicated no difference in survival as compared to p53R172H delta g/+ K-rasLA1/+ mice.
Double mutant K-ras(LA1);p53(KO) has a lifespan of 266.0 days, while single mutant K-ras(LA1) has a lifespan of 373.0 days, single mutant p53(KO) has a lifespan of 510.0 days and wild type has a lifespan of 860.0 days.
Almost additive (negative)
Zheng S et al., 2007, A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene. 26(48):6896-904 17486075 Click here to select all mutants from this PubMed ID in the graph
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group