Lifespan changes: From wild type to taf-4;tpk-1

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Genetic mutants with taf-4, tpk-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Diet


  • Lifespan (days)


  • Lifespan comparisons

    Double mutant taf-4(RNAi);tpk-1(qm162) has a lifespan of 21.36 days, while single mutant tpk-1(qm162) has a lifespan of 32.15 days.

  • Citation
    View abstract

    Khan MH et al., 2013, TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Aging (Albany NY). 5(10):741-58 PubMed 24107417 Click here to select all mutants from this PubMed ID in the graph

Search genes: taf-4 tpk-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

TAF (TBP-associated transcription factor) family

Locus: CELE_R119.6

Wormbase description: taf-4 encodes a TAFII (TBP(TATA-binding protein)-associated factor) that is orthologous to human TAF4 (hTAFII130); TAF-4 is predicted to be a component of the TFIID mRNA transcription complex and is generally required for early embryonic mRNA transcription; consistent with this observation, taf-4(RNAi) results in embryonic lethality at the ~100-cell stage with little cell differentiation, similar to the loss of AMA-1/RNA polymerase II activity; TAF-4 is detected in nuclei in the adult germline, oocytes, and embryo, from the 2-cell stage through early morphogenesis.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Thiamin pyrophosphokinase 1

Locus: CELE_ZK637.9

Wormbase description: none available

Orthologs of taf-4;tpk-1 in SynergyAge
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Species Gene
Orthologs of taf-4 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of tpk-1 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group