[
    {
        "id1": 1,
        "id2": 2,
        "phenotype_comparison": ""
    },
    {
        "id1": 2,
        "id2": 3,
        "phenotype_comparison": "The daf-16( m26) mutation suppresses the daf-2( e1370) life span extension phenotype using the daf-16( m26) ; daf-2( e1370) strain"
    },
    {
        "id1": 5,
        "id2": 6,
        "phenotype_comparison": "The daf-16 mutation suppressed the extended life spans of the daf- 23 mutants"
    },
    {
        "id1": 7,
        "id2": 8,
        "phenotype_comparison": "The daf-16 mutation suppressed the extended life spans of the daf-2( m41) mutants."
    },
    {
        "id1": 9,
        "id2": 10,
        "phenotype_comparison": "The synergistically enhanced life span of daf-2( e1370) ; daf-12( m20) is completely suppressed by daf-16( m26) in a triple mutant. These results indicate that daf-16 acts downstream of daf-2 and daf-I2 with respect to life span"
    },
    {
        "id1": 11,
        "id2": 12,
        "phenotype_comparison": ""
    },
    {
        "id1": 12,
        "id2": 9,
        "phenotype_comparison": "In the daf-2( e1370); daf- 12 ( m20) strain, the daf-12 mutation modifies the Daf-2 phenotype. Doublemutant animals constitutively arrested development as L2d or dauer-like larvae at 25.5. When the animals were raised at 15, then shifted to 25.5, the daf- 12( m20) mutation nearly doubled daf-2( e1370) adult longevity"
    },
    {
        "id1": 12,
        "id2": 13,
        "phenotype_comparison": "The daf-18 mutation partially suppressed the life span extension of daf-2( e1370). The life span of the double mutant is intermediate between those of daf-18 and daf-2( e1370), but closer to that of daf-18"
    },
    {
        "id1": 5,
        "id2": 14,
        "phenotype_comparison": "Extension of life span by daf- 23( m333) is not suppressed by daf-18."
    },
    {
        "id1": 15,
        "id2": 16,
        "phenotype_comparison": ""
    },
    {
        "id1": 16,
        "id2": 17,
        "phenotype_comparison": "daf-16(m27)\u00a0suppressed the life span extension of both\u00a0unc-64(e246)\u00a0and\u00a0unc-31(e928)"
    },
    {
        "id1": 15,
        "id2": 18,
        "phenotype_comparison": ""
    },
    {
        "id1": 18,
        "id2": 19,
        "phenotype_comparison": "daf-16(m27)\u00a0suppressed the life span extension of both\u00a0unc-64(e246)\u00a0and\u00a0unc-31(e928)"
    },
    {
        "id1": 20,
        "id2": 21,
        "phenotype_comparison": ""
    },
    {
        "id1": 20,
        "id2": 22,
        "phenotype_comparison": ""
    },
    {
        "id1": 21,
        "id2": 23,
        "phenotype_comparison": "The life spans of daf-2 unc-64 and daf-2;unc-31 were similar to or shorter than that of the daf-2 single mutant"
    },
    {
        "id1": 22,
        "id2": 23,
        "phenotype_comparison": "The life spans of daf-2 unc-64 and daf-2;unc-31 were similar to or shorter than that of the daf-2 single mutant"
    },
    {
        "id1": 20,
        "id2": 24,
        "phenotype_comparison": ""
    },
    {
        "id1": 24,
        "id2": 25,
        "phenotype_comparison": "The life spans of daf-2 unc-64 and daf-2;unc-31 were similar to or shorter than that of the daf-2 single mutant"
    },
    {
        "id1": 22,
        "id2": 25,
        "phenotype_comparison": "The life spans of daf-2 unc-64 and daf-2;unc-31 were similar to or shorter than that of the daf-2 single mutant"
    },
    {
        "id1": 24,
        "id2": 26,
        "phenotype_comparison": "Both the dauer and life span phenotypes of an\u00a0unc-64; unc-31\u00a0double mutant were stronger than those of either single mutant, suggesting that\u00a0unc-64\u00a0and\u00a0unc-31\u00a0are partially redundant"
    },
    {
        "id1": 27,
        "id2": 28,
        "phenotype_comparison": ""
    },
    {
        "id1": 28,
        "id2": 29,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0markedly reduced but, in most cases, did not completely eliminate lifespan extension. Thus, most of this lifespan extension requires\u00a0daf-16\u00a0activity, but a fraction is\u00a0daf-16\u00a0independent.\u00a0daf-16\u00a0could act downstream of a sensory signal to regulate lifespan, or it could act in a parallel pathway to provide an activity that these animals simply require for their longevity."
    },
    {
        "id1": 27,
        "id2": 30,
        "phenotype_comparison": ""
    },
    {
        "id1": 30,
        "id2": 31,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0markedly reduced but, in most cases, did not completely eliminate lifespan extension. Thus, most of this lifespan extension requires\u00a0daf-16\u00a0activity, but a fraction is\u00a0daf-16\u00a0independent.\u00a0daf-16\u00a0could act downstream of a sensory signal to regulate lifespan, or it could act in a parallel pathway to provide an activity that these animals simply require for their longevity."
    },
    {
        "id1": 27,
        "id2": 32,
        "phenotype_comparison": ""
    },
    {
        "id1": 32,
        "id2": 33,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0markedly reduced but, in most cases, did not completely eliminate lifespan extension. Thus, most of this lifespan extension requires\u00a0daf-16\u00a0activity, but a fraction is\u00a0daf-16\u00a0independent.\u00a0daf-16\u00a0could act downstream of a sensory signal to regulate lifespan, or it could act in a parallel pathway to provide an activity that these animals simply require for their longevity."
    },
    {
        "id1": 27,
        "id2": 34,
        "phenotype_comparison": ""
    },
    {
        "id1": 34,
        "id2": 35,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0markedly reduced but, in most cases, did not completely eliminate lifespan extension. Thus, most of this lifespan extension requires\u00a0daf-16\u00a0activity, but a fraction is\u00a0daf-16\u00a0independent.\u00a0daf-16\u00a0could act downstream of a sensory signal to regulate lifespan, or it could act in a parallel pathway to provide an activity that these animals simply require for their longevity."
    },
    {
        "id1": 27,
        "id2": 36,
        "phenotype_comparison": ""
    },
    {
        "id1": 36,
        "id2": 37,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0markedly reduced but, in most cases, did not completely eliminate lifespan extension. Thus, most of this lifespan extension requires\u00a0daf-16\u00a0activity, but a fraction is\u00a0daf-16\u00a0independent.\u00a0daf-16\u00a0could act downstream of a sensory signal to regulate lifespan, or it could act in a parallel pathway to provide an activity that these animals simply require for their longevity."
    },
    {
        "id1": 27,
        "id2": 38,
        "phenotype_comparison": ""
    },
    {
        "id1": 38,
        "id2": 39,
        "phenotype_comparison": "The double mutants did not live longer than the\u00a0daf-2(e1370)\u00a0single mutant; instead, unexpectedly, their lifespans were slightly shorter than those of\u00a0daf-2(e1370). Thus, we infer that the cilium-structure mutants do not act exclusively in a daf-2-independent pathway. To reconcile these findings, we propose the model that sensory neurons do act in a daf-2-dependent pathway, but that they also affect the animal in another way. Specifically, we suggest that an environmental signal perceived by sensory cilia regulates a DAF-2 ligand."
    },
    {
        "id1": 38,
        "id2": 40,
        "phenotype_comparison": "The double mutants did not live longer than the\u00a0daf-2(e1370)\u00a0single mutant; instead, unexpectedly, their lifespans were slightly shorter than those of\u00a0daf-2(e1370). Thus, we infer that the cilium-structure mutants do not act exclusively in a daf-2-independent pathway. To reconcile these findings, we propose the model that sensory neurons do act in a daf-2-dependent pathway, but that they also affect the animal in another way. Specifically, we suggest that an environmental signal perceived by sensory cilia regulates a DAF-2 ligand."
    },
    {
        "id1": 41,
        "id2": 42,
        "phenotype_comparison": ""
    },
    {
        "id1": 42,
        "id2": 43,
        "phenotype_comparison": "The life span of\u00a0scl-1\u00a0RNAi-treated\u00a0daf-2(e1370), namely\u00a0daf-2; scl-1(RNAi), was reduced by about 80% compared with the non-RNAi-treated\u00a0daf-2(e1370)\u00a0and became similar to that of non-RNAi-treated N2. Therefore, scl-1 is required for the long life span of daf-2(e1370). scl-1\u00a0RNAi treatment reduced the life span of\u00a0age-1(hx546)\u00a0by about 80% (data not shown). Thus,\u00a0scl-1\u00a0is required for the extension of life span of\u00a0daf-2\u00a0and\u00a0age-1\u00a0mutants and may generally function to extend life span of\u00a0C. elegans."
    },
    {
        "id1": 44,
        "id2": 45,
        "phenotype_comparison": ""
    },
    {
        "id1": 44,
        "id2": 46,
        "phenotype_comparison": ""
    },
    {
        "id1": 45,
        "id2": 47,
        "phenotype_comparison": "Whereas the\u00a0pep-2-dependent restricted amino acid availability is insufficient to promote longevity as long as the DAF-2 signaling pathway is intact, the\u00a0pep-2-dependent restricted amino acid availability is capable of amplifying the\u00a0daf-2\u00a0aging phenotype by reducing the generation of oxidized protein species or by further enhancing the degradation of the oxidatively damaged proteins."
    },
    {
        "id1": 46,
        "id2": 47,
        "phenotype_comparison": "Whereas the\u00a0pep-2-dependent restricted amino acid availability is insufficient to promote longevity as long as the DAF-2 signaling pathway is intact, the\u00a0pep-2-dependent restricted amino acid availability is capable of amplifying the\u00a0daf-2\u00a0aging phenotype by reducing the generation of oxidized protein species or by further enhancing the degradation of the oxidatively damaged proteins."
    },
    {
        "id1": 44,
        "id2": 48,
        "phenotype_comparison": ""
    },
    {
        "id1": 48,
        "id2": 49,
        "phenotype_comparison": "Life span extension is suppressed in a\u00a0daf-16(\u2013) background"
    },
    {
        "id1": 45,
        "id2": 49,
        "phenotype_comparison": "Life span extension is suppressed in a\u00a0daf-16(\u2013) background"
    },
    {
        "id1": 44,
        "id2": 50,
        "phenotype_comparison": ""
    },
    {
        "id1": 45,
        "id2": 51,
        "phenotype_comparison": "All aspects of the\u00a0let-363(RNAi_weak) phenotype were strongly enhanced in a\u00a0pep-2(lg601) background\u00a0"
    },
    {
        "id1": 50,
        "id2": 51,
        "phenotype_comparison": "All aspects of the\u00a0let-363(RNAi_weak) phenotype were strongly enhanced in a\u00a0pep-2(lg601) background\u00a0"
    },
    {
        "id1": 52,
        "id2": 53,
        "phenotype_comparison": ""
    },
    {
        "id1": 53,
        "id2": 54,
        "phenotype_comparison": "Any life span extension is suppressed in a\u00a0daf-16(\u2013) background."
    },
    {
        "id1": 52,
        "id2": 55,
        "phenotype_comparison": ""
    },
    {
        "id1": 52,
        "id2": 56,
        "phenotype_comparison": ""
    },
    {
        "id1": 55,
        "id2": 57,
        "phenotype_comparison": "Any life span extension is suppressed in a\u00a0daf-16(\u2013) background."
    },
    {
        "id1": 56,
        "id2": 57,
        "phenotype_comparison": "Any life span extension is suppressed in a\u00a0daf-16(\u2013) background."
    },
    {
        "id1": 52,
        "id2": 58,
        "phenotype_comparison": ""
    },
    {
        "id1": 56,
        "id2": 59,
        "phenotype_comparison": "The strong\u00a0let-363(RNAi) phenotype cannot be enhanced further in a\u00a0pep-2(lg601) mutant background."
    },
    {
        "id1": 58,
        "id2": 59,
        "phenotype_comparison": "The strong\u00a0let-363(RNAi) phenotype cannot be enhanced further in a\u00a0pep-2(lg601) mutant background."
    },
    {
        "id1": 56,
        "id2": 60,
        "phenotype_comparison": "The survival curves at 25 \u00b0C show that\u00a0pep-2(lg601) animals have a slightly reduced adult life span compared with wild type, but the adult life span of\u00a0daf-2(e1370) mutant animals is extended significantly in the\u00a0pep-2(lg601) mutant background."
    },
    {
        "id1": 53,
        "id2": 60,
        "phenotype_comparison": "The survival curves at 25 \u00b0C show that\u00a0pep-2(lg601) animals have a slightly reduced adult life span compared with wild type, but the adult life span of\u00a0daf-2(e1370) mutant animals is extended significantly in the\u00a0pep-2(lg601) mutant background."
    },
    {
        "id1": 60,
        "id2": 61,
        "phenotype_comparison": "The longevity effect of\u00a0pep-2(lg601) was completely suppressed in a\u00a0daf-16;daf-2;pep-2\u00a0triple mutant"
    },
    {
        "id1": 62,
        "id2": 63,
        "phenotype_comparison": ""
    },
    {
        "id1": 62,
        "id2": 64,
        "phenotype_comparison": ""
    },
    {
        "id1": 63,
        "id2": 65,
        "phenotype_comparison": "Lifespan extension by\u00a0jnk-1\u00a0overexpression is completely suppressed by\u00a0daf-16\u00a0RNAi"
    },
    {
        "id1": 64,
        "id2": 65,
        "phenotype_comparison": "Lifespan extension by\u00a0jnk-1\u00a0overexpression is completely suppressed by\u00a0daf-16\u00a0RNAi"
    },
    {
        "id1": 62,
        "id2": 66,
        "phenotype_comparison": ""
    },
    {
        "id1": 66,
        "id2": 67,
        "phenotype_comparison": "The combination significantly extends lifespan beyond\u00a0daf-2(e1370)"
    },
    {
        "id1": 69,
        "id2": 70,
        "phenotype_comparison": "lpIn1\u00a0strain shows a lifespan extension beyond the\u00a0akt-1(ok525);\u00a0akt-2(ok393) double mutant alone"
    },
    {
        "id1": 71,
        "id2": 72,
        "phenotype_comparison": ""
    },
    {
        "id1": 71,
        "id2": 73,
        "phenotype_comparison": ""
    },
    {
        "id1": 72,
        "id2": 74,
        "phenotype_comparison": "\u00a0Lifespan extension of\u00a0tub-1(nr2004)\u00a0is completely suppressed by a mutation in\u00a0daf-16"
    },
    {
        "id1": 73,
        "id2": 74,
        "phenotype_comparison": "\u00a0Lifespan extension of\u00a0tub-1(nr2004)\u00a0is completely suppressed by a mutation in\u00a0daf-16"
    },
    {
        "id1": 71,
        "id2": 75,
        "phenotype_comparison": ""
    },
    {
        "id1": 73,
        "id2": 76,
        "phenotype_comparison": "Mutation in\u00a0tub-1\u00a0does not further extend the long life span of\u00a0daf-2(e1370), indicating that\u00a0tub-1\u00a0may function in the same pathway as\u00a0daf-2."
    },
    {
        "id1": 75,
        "id2": 76,
        "phenotype_comparison": "Mutation in\u00a0tub-1\u00a0does not further extend the long life span of\u00a0daf-2(e1370), indicating that\u00a0tub-1\u00a0may function in the same pathway as\u00a0daf-2."
    },
    {
        "id1": 71,
        "id2": 77,
        "phenotype_comparison": ""
    },
    {
        "id1": 77,
        "id2": 78,
        "phenotype_comparison": "\u00a0Lifespan of\u00a0tub-1\u00a0mutants is not significantly affected by\u00a0rbg-3\u00a0RNAi"
    },
    {
        "id1": 79,
        "id2": 80,
        "phenotype_comparison": ""
    },
    {
        "id1": 80,
        "id2": 81,
        "phenotype_comparison": "Using\u00a0rrf-a 3(pk1426) worms that show increased sensitivity to RNAi when compared with wild type, we observed a slight but significant increase (mean increase aprox 14%) in life span after cku-70(RNAi)"
    },
    {
        "id1": 79,
        "id2": 82,
        "phenotype_comparison": ""
    },
    {
        "id1": 82,
        "id2": 83,
        "phenotype_comparison": "Long-lived\u00a0daf-2\u00a0mutations become even longer lived (mean increase aprox 35%) and short-lived\u00a0daf-16\u00a0mutants slightly shorter lived (mean decrease aprox 11%)"
    },
    {
        "id1": 79,
        "id2": 84,
        "phenotype_comparison": ""
    },
    {
        "id1": 84,
        "id2": 85,
        "phenotype_comparison": "Long-lived\u00a0daf-2\u00a0mutations become even longer lived (mean increase aprox 35%) and short-lived\u00a0daf-16\u00a0mutants slightly shorter lived (mean decrease aprox 11%)"
    },
    {
        "id1": 86,
        "id2": 87,
        "phenotype_comparison": "\u00a0In the double mutant,\u00a0daf-16(m26);daf-2(e1370) no life span difference was detected"
    },
    {
        "id1": 80,
        "id2": 88,
        "phenotype_comparison": "Using\u00a0rrf-a 3(pk1426) worms that show increased sensitivity to RNAi when compared with wild type, we observed a slight but significant increase (mean increase aprox 14%) in life span after cku-70(RNAi)"
    },
    {
        "id1": 79,
        "id2": 89,
        "phenotype_comparison": ""
    },
    {
        "id1": 89,
        "id2": 90,
        "phenotype_comparison": "Long-lived\u00a0daf-2\u00a0mutations become even longer lived (mean increase aprox 35%) and short-lived\u00a0daf-16\u00a0mutants slightly shorter lived (mean decrease aprox 11%)"
    },
    {
        "id1": 91,
        "id2": 92,
        "phenotype_comparison": "We observed a mild but reproducible increase in life span (mean increase aprox 9%) after\u00a0cku-70(RNAi) but no effect from\u00a0cku-80(RNAi)"
    },
    {
        "id1": 91,
        "id2": 93,
        "phenotype_comparison": "We observed a mild but reproducible increase in life span (mean increase aprox 9%) after\u00a0cku-70(RNAi) but no effect from\u00a0cku-80(RNAi)"
    },
    {
        "id1": 94,
        "id2": 95,
        "phenotype_comparison": ""
    },
    {
        "id1": 95,
        "id2": 96,
        "phenotype_comparison": "let-60(gf)\u00a0enhances the\u00a0daf-2longevity (Age) phenotype, while reduction of Ras signaling partially suppresses it"
    },
    {
        "id1": 94,
        "id2": 97,
        "phenotype_comparison": ""
    },
    {
        "id1": 97,
        "id2": 98,
        "phenotype_comparison": "let-60(gf)\u00a0enhances the\u00a0daf-2longevity (Age) phenotype, while reduction of Ras signaling partially suppresses it"
    },
    {
        "id1": 94,
        "id2": 99,
        "phenotype_comparison": ""
    },
    {
        "id1": 99,
        "id2": 100,
        "phenotype_comparison": "let-60(gf)\u00a0enhances the\u00a0daf-2longevity (Age) phenotype, while reduction of Ras signaling partially suppresses it"
    },
    {
        "id1": 94,
        "id2": 101,
        "phenotype_comparison": ""
    },
    {
        "id1": 101,
        "id2": 102,
        "phenotype_comparison": "let-60(gf)\u00a0enhances the\u00a0daf-2longevity (Age) phenotype, while reduction of Ras signaling partially suppresses it"
    },
    {
        "id1": 94,
        "id2": 103,
        "phenotype_comparison": ""
    },
    {
        "id1": 103,
        "id2": 104,
        "phenotype_comparison": "All three Ras pathway mutations partially suppressed the\u00a0daf-2\u00a0Age phenotype"
    },
    {
        "id1": 103,
        "id2": 105,
        "phenotype_comparison": "All three Ras pathway mutations partially suppressed the\u00a0daf-2\u00a0Age phenotype"
    },
    {
        "id1": 103,
        "id2": 106,
        "phenotype_comparison": "All three Ras pathway mutations partially suppressed the\u00a0daf-2\u00a0Age phenotype"
    },
    {
        "id1": 94,
        "id2": 107,
        "phenotype_comparison": ""
    },
    {
        "id1": 107,
        "id2": 108,
        "phenotype_comparison": "All three Ras pathway mutations partially suppressed the\u00a0daf-2\u00a0Age phenotype"
    },
    {
        "id1": 107,
        "id2": 109,
        "phenotype_comparison": "All three Ras pathway mutations partially suppressed the\u00a0daf-2\u00a0Age phenotype"
    },
    {
        "id1": 107,
        "id2": 110,
        "phenotype_comparison": "All three Ras pathway mutations partially suppressed the\u00a0daf-2\u00a0Age phenotype"
    },
    {
        "id1": 111,
        "id2": 112,
        "phenotype_comparison": ""
    },
    {
        "id1": 112,
        "id2": 113,
        "phenotype_comparison": "\u00a0The life-span extension conferred by the\u00a0lin-14(n179)lf\u00a0mutation is abolished with\u00a0daf-16(RNAi)"
    },
    {
        "id1": 111,
        "id2": 114,
        "phenotype_comparison": ""
    },
    {
        "id1": 114,
        "id2": 115,
        "phenotype_comparison": "lin-14(lf);\u00a0daf-2(RNAi) displays a further lengthening of the life-span extension conferred by\u00a0daf-2(RNAi)"
    },
    {
        "id1": 116,
        "id2": 117,
        "phenotype_comparison": ""
    },
    {
        "id1": 116,
        "id2": 118,
        "phenotype_comparison": ""
    },
    {
        "id1": 117,
        "id2": 119,
        "phenotype_comparison": ""
    },
    {
        "id1": 118,
        "id2": 119,
        "phenotype_comparison": ""
    },
    {
        "id1": 120,
        "id2": 121,
        "phenotype_comparison": ""
    },
    {
        "id1": 121,
        "id2": 122,
        "phenotype_comparison": ""
    },
    {
        "id1": 123,
        "id2": 124,
        "phenotype_comparison": ""
    },
    {
        "id1": 123,
        "id2": 125,
        "phenotype_comparison": ""
    },
    {
        "id1": 124,
        "id2": 126,
        "phenotype_comparison": "lin-14(RNAi)\u00a0is unable to extend the life span of\u00a0daf-16(mu86)\u00a0or\u00a0daf-2(e1370)lf mutants as compared with these strains grown on mock RNAi at 15\u00b0C."
    },
    {
        "id1": 125,
        "id2": 126,
        "phenotype_comparison": "lin-14(RNAi)\u00a0is unable to extend the life span of\u00a0daf-16(mu86)\u00a0or\u00a0daf-2(e1370)lf mutants as compared with these strains grown on mock RNAi at 15\u00b0C."
    },
    {
        "id1": 123,
        "id2": 127,
        "phenotype_comparison": ""
    },
    {
        "id1": 357,
        "id2": 358,
        "phenotype_comparison": "the eIF4E/ife-2(ok306) mutation did not extend the lifespan of\u00a0daf-16(RNAi) animals"
    },
    {
        "id1": 124,
        "id2": 128,
        "phenotype_comparison": "lin-14(RNAi)\u00a0is unable to extend the life span of\u00a0daf-16(mu86)\u00a0or\u00a0daf-2(e1370)lf mutants as compared with these strains grown on mock RNAi at 15\u00b0C."
    },
    {
        "id1": 127,
        "id2": 128,
        "phenotype_comparison": "lin-14(RNAi)\u00a0is unable to extend the life span of\u00a0daf-16(mu86)\u00a0or\u00a0daf-2(e1370)lf mutants as compared with these strains grown on mock RNAi at 15\u00b0C."
    },
    {
        "id1": 129,
        "id2": 130,
        "phenotype_comparison": ""
    },
    {
        "id1": 129,
        "id2": 131,
        "phenotype_comparison": ""
    },
    {
        "id1": 130,
        "id2": 132,
        "phenotype_comparison": "A wild-type copy of\u00a0lin-4\u00a0is required for full life-span extension by\u00a0daf-2(RNAi) and is also required for the life-span phenotype conferred by\u00a0daf-16(RNAi)"
    },
    {
        "id1": 131,
        "id2": 132,
        "phenotype_comparison": "A wild-type copy of\u00a0lin-4\u00a0is required for full life-span extension by\u00a0daf-2(RNAi) and is also required for the life-span phenotype conferred by\u00a0daf-16(RNAi)"
    },
    {
        "id1": 129,
        "id2": 133,
        "phenotype_comparison": ""
    },
    {
        "id1": 130,
        "id2": 134,
        "phenotype_comparison": "A wild-type copy of\u00a0lin-4\u00a0is required for full life-span extension by\u00a0daf-2(RNAi) and is also required for the life-span phenotype conferred by\u00a0daf-16(RNAi)"
    },
    {
        "id1": 133,
        "id2": 134,
        "phenotype_comparison": "A wild-type copy of\u00a0lin-4\u00a0is required for full life-span extension by\u00a0daf-2(RNAi) and is also required for the life-span phenotype conferred by\u00a0daf-16(RNAi)"
    },
    {
        "id1": 135,
        "id2": 136,
        "phenotype_comparison": ""
    },
    {
        "id1": 136,
        "id2": 137,
        "phenotype_comparison": "Reduced levels of\u00a0smk-1\u00a0completely suppressed the extended longevity of\u00a0daf-2(e1370)\u00a0mutant animals"
    },
    {
        "id1": 136,
        "id2": 138,
        "phenotype_comparison": ""
    },
    {
        "id1": 139,
        "id2": 140,
        "phenotype_comparison": "Using\u00a0glp-1(e2141)\u00a0mutant animals that lack germline cells at the nonpermissive temperature (25\u00b0C), we found that these long-lived mutant animals required\u00a0smk-1\u00a0for their increased longevity"
    },
    {
        "id1": 139,
        "id2": 141,
        "phenotype_comparison": "Like\u00a0daf-16\u00a0RNAi,\u00a0smk-1\u00a0RNAi reduced the longevity of these worms by 47% of their normal life span, a much greater reduction than was seen with any of the mitochondrial mutants"
    },
    {
        "id1": 135,
        "id2": 142,
        "phenotype_comparison": ""
    },
    {
        "id1": 142,
        "id2": 143,
        "phenotype_comparison": "\u00a0We found that\u00a0smk-1\u00a0RNAi only slightly suppressed the extended life span of animals with compromised complex III activity, i.e., the\u00a0cyc-1\u00a0RNAi-treated animals and\u00a0isp-1(qm150)\u00a0mutant animals"
    },
    {
        "id1": 142,
        "id2": 144,
        "phenotype_comparison": ""
    },
    {
        "id1": 145,
        "id2": 146,
        "phenotype_comparison": ""
    },
    {
        "id1": 146,
        "id2": 147,
        "phenotype_comparison": "\u00a0We found that\u00a0smk-1\u00a0RNAi only slightly suppressed the extended life span of animals with compromised complex III activity, i.e., the\u00a0cyc-1\u00a0RNAi-treated animals and\u00a0isp-1(qm150)\u00a0mutant animals"
    },
    {
        "id1": 146,
        "id2": 148,
        "phenotype_comparison": ""
    },
    {
        "id1": 135,
        "id2": 149,
        "phenotype_comparison": ""
    },
    {
        "id1": 149,
        "id2": 150,
        "phenotype_comparison": "smk-1\u00a0RNAi did not fully suppress the long life span of\u00a0clk-1(qm30)\u00a0mutant animals, defective in mitochondrial ubiquinone synthesis"
    },
    {
        "id1": 149,
        "id2": 151,
        "phenotype_comparison": ""
    },
    {
        "id1": 135,
        "id2": 152,
        "phenotype_comparison": ""
    },
    {
        "id1": 152,
        "id2": 153,
        "phenotype_comparison": "Unlike its effects on wild-type animals, reduced\u00a0smk-1\u00a0activity did not reduce the life span of\u00a0daf-16\u00a0null mutant animals"
    },
    {
        "id1": 152,
        "id2": 154,
        "phenotype_comparison": "We did observe that the life span of\u00a0daf-16(mu86)\u00a0animals could be further shortened by the loss of other life-span regulatory genes such as\u00a0hsf-1"
    },
    {
        "id1": 155,
        "id2": 156,
        "phenotype_comparison": ""
    },
    {
        "id1": 156,
        "id2": 157,
        "phenotype_comparison": "CST knockdown reduced life span to a similar extent in both N2 and DAF-2-deficient\u00a0daf-2(e1368) C. elegans\u00a0as well as in both\u00a0age-1(hx546)\u00a0and N2 nematodes"
    },
    {
        "id1": 158,
        "id2": 159,
        "phenotype_comparison": ""
    },
    {
        "id1": 159,
        "id2": 160,
        "phenotype_comparison": "\u00a0DAF-16 acts downstream of CST-1 in life-span extension."
    },
    {
        "id1": 158,
        "id2": 161,
        "phenotype_comparison": ""
    },
    {
        "id1": 161,
        "id2": 162,
        "phenotype_comparison": "CST knockdown reduced life span to a similar extent in both N2 and DAF-2-deficient\u00a0daf-2(e1368) C. elegans\u00a0as well as in both\u00a0age-1(hx546)\u00a0and N2 nematodes"
    },
    {
        "id1": 163,
        "id2": 164,
        "phenotype_comparison": ""
    },
    {
        "id1": 163,
        "id2": 165,
        "phenotype_comparison": ""
    },
    {
        "id1": 164,
        "id2": 166,
        "phenotype_comparison": "We compared the lifespan of\u00a0daf-2(e1370)\u00a0mutants,\u00a0ifta-2(tm1724)\u00a0mutants and\u00a0daf-2(e1370);ifta-2(tm1724)\u00a0double mutants, and found that lifespans of all three are not statistically different."
    },
    {
        "id1": 165,
        "id2": 166,
        "phenotype_comparison": "We compared the lifespan of\u00a0daf-2(e1370)\u00a0mutants,\u00a0ifta-2(tm1724)\u00a0mutants and\u00a0daf-2(e1370);ifta-2(tm1724)\u00a0double mutants, and found that lifespans of all three are not statistically different."
    },
    {
        "id1": 167,
        "id2": 168,
        "phenotype_comparison": ""
    },
    {
        "id1": 167,
        "id2": 169,
        "phenotype_comparison": ""
    },
    {
        "id1": 168,
        "id2": 170,
        "phenotype_comparison": "\u00a0The\u00a0ifta-2(tm1724);daf-16(mu86)\u00a0double mutants have a significantly reduced lifespan compared with the\u00a0ifta-2(tm1724)\u00a0strain and were similar to the\u00a0daf-16(mu86)\u00a0mutants alone. Thus, the\u00a0ifta-2(tm1724)\u00a0longevity phenotype is dependent on\u00a0daf-16\u00a0function."
    },
    {
        "id1": 169,
        "id2": 170,
        "phenotype_comparison": "\u00a0The\u00a0ifta-2(tm1724);daf-16(mu86)\u00a0double mutants have a significantly reduced lifespan compared with the\u00a0ifta-2(tm1724)\u00a0strain and were similar to the\u00a0daf-16(mu86)\u00a0mutants alone. Thus, the\u00a0ifta-2(tm1724)\u00a0longevity phenotype is dependent on\u00a0daf-16\u00a0function."
    },
    {
        "id1": 167,
        "id2": 171,
        "phenotype_comparison": ""
    },
    {
        "id1": 167,
        "id2": 172,
        "phenotype_comparison": ""
    },
    {
        "id1": 171,
        "id2": 173,
        "phenotype_comparison": "Our analysis indicates that the lifespan of\u00a0osm-5(m184);ifta-2(tm1724)\u00a0double mutants was not significantly different than the original\u00a0ifta-2(tm1724)\u00a0single mutants (Fig. 4E,\u00a0Table 1). However, lifespan in the double mutant is longer than in the single mutant\u00a0osm-5(m184)\u00a0alone, suggesting that\u00a0ifta-2\u00a0is epistatic to\u00a0osm-5.\u00a0"
    },
    {
        "id1": 172,
        "id2": 173,
        "phenotype_comparison": "Our analysis indicates that the lifespan of\u00a0osm-5(m184);ifta-2(tm1724)\u00a0double mutants was not significantly different than the original\u00a0ifta-2(tm1724)\u00a0single mutants (Fig. 4E,\u00a0Table 1). However, lifespan in the double mutant is longer than in the single mutant\u00a0osm-5(m184)\u00a0alone, suggesting that\u00a0ifta-2\u00a0is epistatic to\u00a0osm-5.\u00a0"
    },
    {
        "id1": 174,
        "id2": 175,
        "phenotype_comparison": ""
    },
    {
        "id1": 175,
        "id2": 176,
        "phenotype_comparison": "The life span extension in\u00a0odr-3; gpc-1\u00a0and\u00a0gpc-1; gpa-11XS\u00a0animals showed no signs of synergism, but was similar to that in\u00a0gpc-1\u00a0single mutants. These results suggest that odr-3 and gpa-11 both function in a genetic pathway with gpc-1 and that the extended life span of gpc-1 mutants requires gpa-11."
    },
    {
        "id1": 175,
        "id2": 177,
        "phenotype_comparison": "The life span extension in\u00a0odr-3; gpc-1\u00a0and\u00a0gpc-1; gpa-11XS\u00a0animals showed no signs of synergism, but was similar to that in\u00a0gpc-1\u00a0single mutants. These results suggest that odr-3 and gpa-11 both function in a genetic pathway with gpc-1 and that the exten"
    },
    {
        "id1": 174,
        "id2": 178,
        "phenotype_comparison": ""
    },
    {
        "id1": 178,
        "id2": 179,
        "phenotype_comparison": "The life span of\u00a0gpa-11(pk349);\u00a0gpc-1\u00a0animals was similar to that of\u00a0gpa-11\u00a0single mutants (which is similar to wild type). These results suggest that odr-3 and gpa-11 both function in a genetic pathway with gpc-1 and that the extended life span of gpc-1 mutants requires gpa-11."
    },
    {
        "id1": 174,
        "id2": 180,
        "phenotype_comparison": ""
    },
    {
        "id1": 180,
        "id2": 181,
        "phenotype_comparison": "The life span extension in\u00a0gpa-1; gpc-1\u00a0double mutants was similar to that in either single mutant (\u00a0Fig. 2D;\u00a0Supplementary Table 1), suggesting that\u00a0gpa-1\u00a0also functions in a genetic pathway with\u00a0gpc-1.\u00a0"
    },
    {
        "id1": 175,
        "id2": 181,
        "phenotype_comparison": "The life span extension in\u00a0gpa-1; gpc-1\u00a0double mutants was similar to that in either single mutant (\u00a0Fig. 2D;\u00a0Supplementary Table 1), suggesting that\u00a0gpa-1\u00a0also functions in a genetic pathway with\u00a0gpc-1.\u00a0"
    },
    {
        "id1": 180,
        "id2": 182,
        "phenotype_comparison": "The life span of\u00a0gpa-1; odr-3\u00a0double mutants was similar to that of\u00a0gpa-1\u00a0single mutants. Thus, gpa-1 might function in the same genetic pathway as odr-3 and in an additional pathway, just like gpc-1."
    },
    {
        "id1": 174,
        "id2": 183,
        "phenotype_comparison": ""
    },
    {
        "id1": 1386,
        "id2": 1387,
        "phenotype_comparison": ""
    },
    {
        "id1": 1529,
        "id2": 1530,
        "phenotype_comparison": ""
    },
    {
        "id1": 180,
        "id2": 184,
        "phenotype_comparison": "The life span of\u00a0gpa-1; gpa-11XS\u00a0animals was similar to that of\u00a0gpa-11XS\u00a0animals, but shorter than that of\u00a0gpa-1\u00a0mutants. These results show that life span extension in gpa-1 animals does not depend on gpa-11, but rather that gpa-11 mediates an additional signal that suppresses life span extension in gpa-1 mutants"
    },
    {
        "id1": 183,
        "id2": 184,
        "phenotype_comparison": "The life span of\u00a0gpa-1; gpa-11XS\u00a0animals was similar to that of\u00a0gpa-11XS\u00a0animals, but shorter than that of\u00a0gpa-1\u00a0mutants. These results show that life span extension in gpa-1 animals does not depend on gpa-11, but rather that gpa-11 mediates an additional signal that suppresses life span extension in gpa-1 mutants"
    },
    {
        "id1": 180,
        "id2": 185,
        "phenotype_comparison": "The life span of\u00a0gpa-11;\u00a0gpa-1\u00a0animals did not significantly differ from that of\u00a0gpa-1\u00a0single mutants. These results show that life span extension in gpa-1 animals does not depend on gpa-11, but rather that gpa-11 mediates an additional signal that suppresses life span extension in gpa-1 mutants"
    },
    {
        "id1": 174,
        "id2": 186,
        "phenotype_comparison": ""
    },
    {
        "id1": 183,
        "id2": 187,
        "phenotype_comparison": "Loss-of-function of\u00a0odr-3\u00a0and extra copies of\u00a0gpa-11\u00a0synergistically extended life span, suggesting that, in wild type animals,\u00a0gpa-11\u00a0promotes longevity and\u00a0odr-3\u00a0inhibits longevity."
    },
    {
        "id1": 186,
        "id2": 187,
        "phenotype_comparison": "Loss-of-function of\u00a0odr-3\u00a0and extra copies of\u00a0gpa-11\u00a0synergistically extended life span, suggesting that, in wild type animals,\u00a0gpa-11\u00a0promotes longevity and\u00a0odr-3\u00a0inhibits longevity."
    },
    {
        "id1": 186,
        "id2": 188,
        "phenotype_comparison": "Loss-of-function of\u00a0odr-3\u00a0and extra copies of\u00a0gpa-11\u00a0synergistically extended life span, suggesting that, in wild type animals,\u00a0gpa-11\u00a0promotes longevity and\u00a0odr-3\u00a0inhibits longevity."
    },
    {
        "id1": 178,
        "id2": 189,
        "phenotype_comparison": "gpa-11; odr-3\u00a0mutants had a life span shorter than\u00a0odr-3\u00a0mutants but similar to\u00a0gpa-11\u00a0mutants, suggesting that the extended life span of\u00a0odr-3\u00a0mutants requires the function of\u00a0gpa-11. We favor the idea that odr-3 inhibits longevity by signaling via gpa-11."
    },
    {
        "id1": 186,
        "id2": 189,
        "phenotype_comparison": "gpa-11; odr-3\u00a0mutants had a life span shorter than\u00a0odr-3\u00a0mutants but similar to\u00a0gpa-11\u00a0mutants, suggesting that the extended life span of\u00a0odr-3\u00a0mutants requires the function of\u00a0gpa-11. We favor the idea that odr-3 inhibits longevity by signaling via gpa-11."
    },
    {
        "id1": 190,
        "id2": 191,
        "phenotype_comparison": ""
    },
    {
        "id1": 190,
        "id2": 192,
        "phenotype_comparison": ""
    },
    {
        "id1": 191,
        "id2": 193,
        "phenotype_comparison": "Loss-of-function of\u00a0odr-3\u00a0and extra copies of\u00a0gpa-11\u00a0synergistically extended life span, suggesting that, in wild type animals,\u00a0gpa-11\u00a0promotes longevity and\u00a0odr-3\u00a0inhibits longevity."
    },
    {
        "id1": 192,
        "id2": 193,
        "phenotype_comparison": "Loss-of-function of\u00a0odr-3\u00a0and extra copies of\u00a0gpa-11\u00a0synergistically extended life span, suggesting that, in wild type animals,\u00a0gpa-11\u00a0promotes longevity and\u00a0odr-3\u00a0inhibits longevity."
    },
    {
        "id1": 190,
        "id2": 194,
        "phenotype_comparison": ""
    },
    {
        "id1": 194,
        "id2": 195,
        "phenotype_comparison": "Loss-of-function of\u00a0odr-3\u00a0and extra copies of\u00a0gpa-11\u00a0synergistically extended life span, suggesting that, in wild type animals,\u00a0gpa-11\u00a0promotes longevity and\u00a0odr-3\u00a0inhibits longevity."
    },
    {
        "id1": 192,
        "id2": 195,
        "phenotype_comparison": "Loss-of-function of\u00a0odr-3\u00a0and extra copies of\u00a0gpa-11\u00a0synergistically extended life span, suggesting that, in wild type animals,\u00a0gpa-11\u00a0promotes longevity and\u00a0odr-3\u00a0inhibits longevity."
    },
    {
        "id1": 190,
        "id2": 196,
        "phenotype_comparison": ""
    },
    {
        "id1": 196,
        "id2": 197,
        "phenotype_comparison": "gpa-11; odr-3\u00a0mutants had a life span shorter than\u00a0odr-3\u00a0mutants but similar to\u00a0gpa-11\u00a0mutants, suggesting that the extended life span of\u00a0odr-3\u00a0mutants requires the function of\u00a0gpa-11. We favor the idea that odr-3 inhibits longevity by signaling via gpa-11."
    },
    {
        "id1": 192,
        "id2": 197,
        "phenotype_comparison": "gpa-11; odr-3\u00a0mutants had a life span shorter than\u00a0odr-3\u00a0mutants but similar to\u00a0gpa-11\u00a0mutants, suggesting that the extended life span of\u00a0odr-3\u00a0mutants requires the function of\u00a0gpa-11. We favor the idea that odr-3 inhibits longevity by signaling via gpa-11."
    },
    {
        "id1": 198,
        "id2": 199,
        "phenotype_comparison": ""
    },
    {
        "id1": 198,
        "id2": 175,
        "phenotype_comparison": ""
    },
    {
        "id1": 199,
        "id2": 200,
        "phenotype_comparison": "Life span extension caused by loss-of-function of\u00a0odr-3,\u00a0gpc-1\u00a0or extra copies of\u00a0gpa-11\u00a0completely depends on\u00a0daf-16"
    },
    {
        "id1": 175,
        "id2": 200,
        "phenotype_comparison": "Life span extension caused by loss-of-function of\u00a0odr-3,\u00a0gpc-1\u00a0or extra copies of\u00a0gpa-11\u00a0completely depends on\u00a0daf-16"
    },
    {
        "id1": 198,
        "id2": 186,
        "phenotype_comparison": ""
    },
    {
        "id1": 199,
        "id2": 201,
        "phenotype_comparison": "Life span extension caused by loss-of-function of\u00a0odr-3,\u00a0gpc-1\u00a0or extra copies of\u00a0gpa-11\u00a0completely depends on\u00a0daf-16. daf-16; odr-3 and daf-16; gpa-11XS animals even showed a slightly shorter life span than daf-16 single mutants."
    },
    {
        "id1": 186,
        "id2": 201,
        "phenotype_comparison": "Life span extension caused by loss-of-function of\u00a0odr-3,\u00a0gpc-1\u00a0or extra copies of\u00a0gpa-11\u00a0completely depends on\u00a0daf-16. daf-16; odr-3 and daf-16; gpa-11XS animals even showed a slightly shorter life span than daf-16 single mutants."
    },
    {
        "id1": 198,
        "id2": 183,
        "phenotype_comparison": ""
    },
    {
        "id1": 199,
        "id2": 202,
        "phenotype_comparison": "Life span extension caused by loss-of-function of\u00a0odr-3,\u00a0gpc-1\u00a0or extra copies of\u00a0gpa-11\u00a0completely depends on\u00a0daf-16. daf-16; odr-3 and daf-16; gpa-11XS animals even showed a slightly shorter life span than daf-16 single mutants."
    },
    {
        "id1": 183,
        "id2": 202,
        "phenotype_comparison": "Life span extension caused by loss-of-function of\u00a0odr-3,\u00a0gpc-1\u00a0or extra copies of\u00a0gpa-11\u00a0completely depends on\u00a0daf-16. daf-16; odr-3 and daf-16; gpa-11XS animals even showed a slightly shorter life span than daf-16 single mutants."
    },
    {
        "id1": 198,
        "id2": 180,
        "phenotype_comparison": ""
    },
    {
        "id1": 199,
        "id2": 203,
        "phenotype_comparison": "Life span extension caused by loss-of-function of\u00a0gpa-1\u00a0was only partially dependent on\u00a0daf-16"
    },
    {
        "id1": 180,
        "id2": 203,
        "phenotype_comparison": "Life span extension caused by loss-of-function of\u00a0gpa-1\u00a0was only partially dependent on\u00a0daf-16"
    },
    {
        "id1": 204,
        "id2": 205,
        "phenotype_comparison": ""
    },
    {
        "id1": 205,
        "id2": 206,
        "phenotype_comparison": "\u00a0Loss-of-function of\u00a0gpa-1\u00a0did not extend the life span of\u00a0daf-2\u00a0mutants, suggesting that\u00a0gpa-1\u00a0signals via\u00a0daf-2\u00a0to regulate life span"
    },
    {
        "id1": 204,
        "id2": 207,
        "phenotype_comparison": ""
    },
    {
        "id1": 207,
        "id2": 208,
        "phenotype_comparison": "daf-2; odr-3\u00a0mutants lived longer than either single mutant, suggesting that\u00a0odr-3\u00a0and\u00a0daf-2\u00a0can function in separate pathways.\u00a0"
    },
    {
        "id1": 205,
        "id2": 208,
        "phenotype_comparison": "daf-2; odr-3\u00a0mutants lived longer than either single mutant, suggesting that\u00a0odr-3\u00a0and\u00a0daf-2\u00a0can function in separate pathways.\u00a0"
    },
    {
        "id1": 204,
        "id2": 209,
        "phenotype_comparison": ""
    },
    {
        "id1": 209,
        "id2": 210,
        "phenotype_comparison": "Extra copies of\u00a0gpa-11\u00a0shortened the life span of\u00a0daf-2\u00a0and\u00a0daf-2; odr-3\u00a0mutants, indicating that in\u00a0daf-2\u00a0mutants\u00a0gpa-11\u00a0has an inhibitory function."
    },
    {
        "id1": 205,
        "id2": 210,
        "phenotype_comparison": "Extra copies of\u00a0gpa-11\u00a0shortened the life span of\u00a0daf-2\u00a0and\u00a0daf-2; odr-3\u00a0mutants, indicating that in\u00a0daf-2\u00a0mutants\u00a0gpa-11\u00a0has an inhibitory function."
    },
    {
        "id1": 208,
        "id2": 211,
        "phenotype_comparison": "Extra copies of\u00a0gpa-11\u00a0shortened the life span of\u00a0daf-2\u00a0and\u00a0daf-2; odr-3\u00a0mutants, indicating that in\u00a0daf-2\u00a0mutants\u00a0gpa-11\u00a0has an inhibitory function."
    },
    {
        "id1": 204,
        "id2": 212,
        "phenotype_comparison": ""
    },
    {
        "id1": 212,
        "id2": 213,
        "phenotype_comparison": "gpa-11\u00a0loss-of-function in\u00a0daf-2\u00a0mutants further extended life span. Thus, like\u00a0odr-3,\u00a0gpa-11\u00a0might inhibit longevity independently of\u00a0daf-2.\u00a0"
    },
    {
        "id1": 205,
        "id2": 213,
        "phenotype_comparison": "gpa-11\u00a0loss-of-function in\u00a0daf-2\u00a0mutants further extended life span. Thus, like\u00a0odr-3,\u00a0gpa-11\u00a0might inhibit longevity independently of\u00a0daf-2.\u00a0"
    },
    {
        "id1": 1386,
        "id2": 1388,
        "phenotype_comparison": ""
    },
    {
        "id1": 1529,
        "id2": 1531,
        "phenotype_comparison": ""
    },
    {
        "id1": 208,
        "id2": 214,
        "phenotype_comparison": "The life span of these triple mutants did not significantly differ from that of\u00a0gpa-11; daf-2\u00a0and\u00a0daf-2; odr-3\u00a0mutants, suggesting that, in\u00a0daf-2\u00a0mutants,\u00a0gpa-11\u00a0and\u00a0odr-3\u00a0share the same signaling pathway."
    },
    {
        "id1": 215,
        "id2": 216,
        "phenotype_comparison": ""
    },
    {
        "id1": 215,
        "id2": 217,
        "phenotype_comparison": ""
    },
    {
        "id1": 216,
        "id2": 218,
        "phenotype_comparison": "\u00a0When RLE-1 expression was disrupted in\u00a0daf-16::gfp\u00a0animals by crossing\u00a0rle-1\u00a0mutants into the\u00a0daf-16::gfp\u00a0background, the lifespan of\u00a0daf-16::gfp\u00a0increased an additional 10%. These results indicate that disruption of RLE-1 adds to the overexpression of DAF-16 to further extends C. elegans lifespan."
    },
    {
        "id1": 217,
        "id2": 218,
        "phenotype_comparison": "\u00a0When RLE-1 expression was disrupted in\u00a0daf-16::gfp\u00a0animals by crossing\u00a0rle-1\u00a0mutants into the\u00a0daf-16::gfp\u00a0background, the lifespan of\u00a0daf-16::gfp\u00a0increased an additional 10%. These results indicate that disruption of RLE-1 adds to the overexpression of DAF-16 to further extends C. elegans lifespan."
    },
    {
        "id1": 215,
        "id2": 219,
        "phenotype_comparison": ""
    },
    {
        "id1": 219,
        "id2": 220,
        "phenotype_comparison": "Disruption of DAF-16 expression in\u00a0rle-1\u00a0mutants reduced their longevity, indicating that RLE-1 strictly depends on DAF-16 to regulate\u00a0C. elegans\u00a0lifespan\u00a0"
    },
    {
        "id1": 217,
        "id2": 220,
        "phenotype_comparison": "Disruption of DAF-16 expression in\u00a0rle-1\u00a0mutants reduced their longevity, indicating that RLE-1 strictly depends on DAF-16 to regulate\u00a0C. elegans\u00a0lifespan\u00a0"
    },
    {
        "id1": 215,
        "id2": 221,
        "phenotype_comparison": ""
    },
    {
        "id1": 221,
        "id2": 222,
        "phenotype_comparison": "Removing one copy of the\u00a0daf-16\u00a0gene, in\u00a0rle-1-/-;daf-16+/-\u00a0animals, partially suppressed the\u00a0rle-1-/-\u00a0mutant lifespan extension. However, when compared to N2 (or\u00a0daf-16+/-) animals,\u00a0rle-1-/-;daf-16+/-\u00a0worms still live slightly longer, suggesting that other protein(s) involved in\u00a0C. elegans\u00a0aging may also be regulated by RLE-1. Taken together, our results indicate that RLE-1 regulates\u00a0C. elegans\u00a0aging in a DAF-16-dependent manner."
    },
    {
        "id1": 217,
        "id2": 222,
        "phenotype_comparison": "Removing one copy of the\u00a0daf-16\u00a0gene, in\u00a0rle-1-/-;daf-16+/-\u00a0animals, partially suppressed the\u00a0rle-1-/-\u00a0mutant lifespan extension. However, when compared to N2 (or\u00a0daf-16+/-) animals,\u00a0rle-1-/-;daf-16+/-\u00a0worms still live slightly longer, suggesting that other protein(s) involved in\u00a0C. elegans\u00a0aging may also be regulated by RLE-1. Taken together, our results indicate that RLE-1 regulates\u00a0C. elegans\u00a0aging in a DAF-16-dependent manner."
    },
    {
        "id1": 223,
        "id2": 224,
        "phenotype_comparison": ""
    },
    {
        "id1": 223,
        "id2": 225,
        "phenotype_comparison": ""
    },
    {
        "id1": 224,
        "id2": 226,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 225,
        "id2": 226,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 227,
        "id2": 228,
        "phenotype_comparison": ""
    },
    {
        "id1": 227,
        "id2": 229,
        "phenotype_comparison": ""
    },
    {
        "id1": 228,
        "id2": 230,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 229,
        "id2": 230,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 231,
        "id2": 232,
        "phenotype_comparison": ""
    },
    {
        "id1": 231,
        "id2": 233,
        "phenotype_comparison": ""
    },
    {
        "id1": 232,
        "id2": 234,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 233,
        "id2": 234,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 235,
        "id2": 236,
        "phenotype_comparison": ""
    },
    {
        "id1": 235,
        "id2": 237,
        "phenotype_comparison": ""
    },
    {
        "id1": 236,
        "id2": 238,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 237,
        "id2": 238,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 239,
        "id2": 240,
        "phenotype_comparison": ""
    },
    {
        "id1": 239,
        "id2": 241,
        "phenotype_comparison": ""
    },
    {
        "id1": 240,
        "id2": 242,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 241,
        "id2": 242,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 243,
        "id2": 244,
        "phenotype_comparison": ""
    },
    {
        "id1": 243,
        "id2": 233,
        "phenotype_comparison": ""
    },
    {
        "id1": 244,
        "id2": 245,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 233,
        "id2": 245,
        "phenotype_comparison": "The long lifespan of\u00a0daf-7\u00a0mutants was suppressed by\u00a0daf-3\u00a0mutations"
    },
    {
        "id1": 246,
        "id2": 247,
        "phenotype_comparison": ""
    },
    {
        "id1": 247,
        "id2": 248,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0activity completely suppressed the longevity phenotype of\u00a0daf-7(-)\u00a0mutants or RNAi"
    },
    {
        "id1": 223,
        "id2": 249,
        "phenotype_comparison": ""
    },
    {
        "id1": 249,
        "id2": 248,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0activity completely suppressed the longevity phenotype of\u00a0daf-7(-)\u00a0mutants or RNAi"
    },
    {
        "id1": 225,
        "id2": 248,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0activity completely suppressed the longevity phenotype of\u00a0daf-7(-)\u00a0mutants or RNAi"
    },
    {
        "id1": 250,
        "id2": 251,
        "phenotype_comparison": ""
    },
    {
        "id1": 250,
        "id2": 241,
        "phenotype_comparison": ""
    },
    {
        "id1": 251,
        "id2": 252,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0activity completely suppressed the longevity phenotype of\u00a0daf-7(-)\u00a0mutants or RNAi"
    },
    {
        "id1": 241,
        "id2": 252,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0activity completely suppressed the longevity phenotype of\u00a0daf-7(-)\u00a0mutants or RNAi"
    },
    {
        "id1": 243,
        "id2": 253,
        "phenotype_comparison": ""
    },
    {
        "id1": 253,
        "id2": 254,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0activity completely suppressed the longevity phenotype of\u00a0daf-7(-)\u00a0mutants or RNAi"
    },
    {
        "id1": 233,
        "id2": 254,
        "phenotype_comparison": "Loss of\u00a0daf-16\u00a0activity completely suppressed the longevity phenotype of\u00a0daf-7(-)\u00a0mutants or RNAi"
    },
    {
        "id1": 243,
        "id2": 255,
        "phenotype_comparison": ""
    },
    {
        "id1": 243,
        "id2": 256,
        "phenotype_comparison": ""
    },
    {
        "id1": 255,
        "id2": 257,
        "phenotype_comparison": ""
    },
    {
        "id1": 256,
        "id2": 257,
        "phenotype_comparison": ""
    },
    {
        "id1": 258,
        "id2": 259,
        "phenotype_comparison": ""
    },
    {
        "id1": 258,
        "id2": 260,
        "phenotype_comparison": ""
    },
    {
        "id1": 259,
        "id2": 261,
        "phenotype_comparison": "Loss of\u00a0daf-3\u00a0was not able to suppress the lifespan extension caused by\u00a0daf-2\u00a0mutations or RNAi"
    },
    {
        "id1": 260,
        "id2": 261,
        "phenotype_comparison": "Loss of\u00a0daf-3\u00a0was not able to suppress the lifespan extension caused by\u00a0daf-2\u00a0mutations or RNAi"
    },
    {
        "id1": 250,
        "id2": 240,
        "phenotype_comparison": ""
    },
    {
        "id1": 250,
        "id2": 262,
        "phenotype_comparison": ""
    },
    {
        "id1": 240,
        "id2": 263,
        "phenotype_comparison": "Loss of\u00a0daf-3\u00a0was not able to suppress the lifespan extension caused by\u00a0daf-2\u00a0mutations or RNAi"
    },
    {
        "id1": 262,
        "id2": 263,
        "phenotype_comparison": "Loss of\u00a0daf-3\u00a0was not able to suppress the lifespan extension caused by\u00a0daf-2\u00a0mutations or RNAi"
    },
    {
        "id1": 243,
        "id2": 264,
        "phenotype_comparison": ""
    },
    {
        "id1": 244,
        "id2": 265,
        "phenotype_comparison": ""
    },
    {
        "id1": 264,
        "id2": 265,
        "phenotype_comparison": ""
    },
    {
        "id1": 250,
        "id2": 266,
        "phenotype_comparison": ""
    },
    {
        "id1": 250,
        "id2": 267,
        "phenotype_comparison": ""
    },
    {
        "id1": 266,
        "id2": 268,
        "phenotype_comparison": ""
    },
    {
        "id1": 267,
        "id2": 268,
        "phenotype_comparison": ""
    },
    {
        "id1": 243,
        "id2": 269,
        "phenotype_comparison": ""
    },
    {
        "id1": 243,
        "id2": 270,
        "phenotype_comparison": ""
    },
    {
        "id1": 269,
        "id2": 271,
        "phenotype_comparison": ""
    },
    {
        "id1": 270,
        "id2": 271,
        "phenotype_comparison": ""
    },
    {
        "id1": 272,
        "id2": 273,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 274,
        "id2": 275,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 276,
        "id2": 277,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 278,
        "id2": 279,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 476,
        "id2": 477,
        "phenotype_comparison": "Depletion of rsks-1 or rskn-1 does not suppress the lifespan extension brought about by IFE-2 deficiency"
    },
    {
        "id1": 278,
        "id2": 280,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 274,
        "id2": 281,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 274,
        "id2": 282,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 274,
        "id2": 283,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 272,
        "id2": 284,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 274,
        "id2": 285,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 276,
        "id2": 286,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 272,
        "id2": 287,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 276,
        "id2": 288,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 272,
        "id2": 289,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 278,
        "id2": 290,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 276,
        "id2": 291,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 274,
        "id2": 292,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 276,
        "id2": 293,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 272,
        "id2": 294,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 278,
        "id2": 295,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 274,
        "id2": 296,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 272,
        "id2": 297,
        "phenotype_comparison": "These RNAi treatments reduced RP mRNA levels approximately two- to fivefold and, in each case, increased lifespan significantly."
    },
    {
        "id1": 298,
        "id2": 299,
        "phenotype_comparison": ""
    },
    {
        "id1": 300,
        "id2": 301,
        "phenotype_comparison": ""
    },
    {
        "id1": 302,
        "id2": 303,
        "phenotype_comparison": ""
    },
    {
        "id1": 304,
        "id2": 305,
        "phenotype_comparison": ""
    },
    {
        "id1": 304,
        "id2": 306,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants, but not those of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 298,
        "id2": 307,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants, but not those of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 302,
        "id2": 308,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants, but not those of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 298,
        "id2": 309,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants, but not those of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 300,
        "id2": 310,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants, but not those of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 302,
        "id2": 311,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants, but not those of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 300,
        "id2": 312,
        "phenotype_comparison": ""
    },
    {
        "id1": 298,
        "id2": 313,
        "phenotype_comparison": ""
    },
    {
        "id1": 304,
        "id2": 314,
        "phenotype_comparison": ""
    },
    {
        "id1": 298,
        "id2": 315,
        "phenotype_comparison": ""
    },
    {
        "id1": 300,
        "id2": 316,
        "phenotype_comparison": ""
    },
    {
        "id1": 300,
        "id2": 317,
        "phenotype_comparison": "TOR RNAi does not further extend the lifespan of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 298,
        "id2": 318,
        "phenotype_comparison": "TOR RNAi does not further extend the lifespan of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 304,
        "id2": 319,
        "phenotype_comparison": "TOR RNAi does not further extend the lifespan of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 320,
        "id2": 321,
        "phenotype_comparison": ""
    },
    {
        "id1": 320,
        "id2": 322,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants, but not those of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 320,
        "id2": 323,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants, but not those of\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 324,
        "id2": 325,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 326,
        "id2": 327,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 328,
        "id2": 329,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 330,
        "id2": 331,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 332,
        "id2": 333,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 324,
        "id2": 334,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 332,
        "id2": 335,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 324,
        "id2": 336,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 326,
        "id2": 337,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 326,
        "id2": 338,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 339,
        "id2": 340,
        "phenotype_comparison": ""
    },
    {
        "id1": 341,
        "id2": 342,
        "phenotype_comparison": ""
    },
    {
        "id1": 324,
        "id2": 343,
        "phenotype_comparison": ""
    },
    {
        "id1": 341,
        "id2": 344,
        "phenotype_comparison": ""
    },
    {
        "id1": 339,
        "id2": 345,
        "phenotype_comparison": ""
    },
    {
        "id1": 328,
        "id2": 346,
        "phenotype_comparison": ""
    },
    {
        "id1": 341,
        "id2": 347,
        "phenotype_comparison": ""
    },
    {
        "id1": 339,
        "id2": 348,
        "phenotype_comparison": ""
    },
    {
        "id1": 324,
        "id2": 349,
        "phenotype_comparison": ""
    },
    {
        "id1": 328,
        "id2": 350,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 351,
        "id2": 352,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 341,
        "id2": 353,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 330,
        "id2": 354,
        "phenotype_comparison": "RNAi of RPs and S6K produced effects similar to RNAi of TOR in both tests, extending the lifespan of\u00a0daf-16\u00a0mutants"
    },
    {
        "id1": 355,
        "id2": 356,
        "phenotype_comparison": "the eIF4E/ife-2(ok306) mutation did not extend the lifespan of\u00a0daf-16(RNAi) animals"
    },
    {
        "id1": 359,
        "id2": 360,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 361,
        "id2": 362,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 363,
        "id2": 364,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 365,
        "id2": 366,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 363,
        "id2": 367,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 365,
        "id2": 368,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 365,
        "id2": 369,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 363,
        "id2": 370,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 363,
        "id2": 371,
        "phenotype_comparison": "\u00a0In each case, lifespan was extended. Thus, in C. elegans, SIR-2.1 is not required for the inhibition of translation, apparently by any mechanism, to increase lifespan."
    },
    {
        "id1": 372,
        "id2": 373,
        "phenotype_comparison": "The extended lifespan of\u00a0eat-2(ad1116) animals, which have impaired feeding behavior and represent a genetic model for DR, was\u00a0sir-2.1-independent"
    },
    {
        "id1": 372,
        "id2": 374,
        "phenotype_comparison": "The extended lifespan of\u00a0eat-2(ad1116) animals, which have impaired feeding behavior and represent a genetic model for DR, was\u00a0sir-2.1-independent"
    },
    {
        "id1": 375,
        "id2": 376,
        "phenotype_comparison": "The extended lifespan of\u00a0eat-2(ad1116) animals, which have impaired feeding behavior and represent a genetic model for DR, was\u00a0sir-2.1-independent"
    },
    {
        "id1": 375,
        "id2": 377,
        "phenotype_comparison": "The extended lifespan of\u00a0eat-2(ad1116) animals, which have impaired feeding behavior and represent a genetic model for DR, was\u00a0sir-2.1-independent"
    },
    {
        "id1": 378,
        "id2": 379,
        "phenotype_comparison": "The extended lifespan of\u00a0eat-2(ad1116) animals, which have impaired feeding behavior and represent a genetic model for DR, was\u00a0sir-2.1-independent"
    },
    {
        "id1": 378,
        "id2": 380,
        "phenotype_comparison": "The extended lifespan of\u00a0eat-2(ad1116) animals, which have impaired feeding behavior and represent a genetic model for DR, was\u00a0sir-2.1-independent"
    },
    {
        "id1": 381,
        "id2": 382,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 383,
        "id2": 382,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 384,
        "id2": 385,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 386,
        "id2": 387,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 386,
        "id2": 388,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 381,
        "id2": 389,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 381,
        "id2": 390,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 386,
        "id2": 391,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 386,
        "id2": 392,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 393,
        "id2": 394,
        "phenotype_comparison": "We subjected\u00a0eat-2(ad1116) mutants to RNAi of genes encoding RPS-15, RPS-22, S6K, eIF2b, or eIF4G, and found that their lifespans were further extended"
    },
    {
        "id1": 386,
        "id2": 395,
        "phenotype_comparison": "TOR RNAi did not further extend the lifespan of the\u00a0eat-2(ad1116) mutant\u00a0"
    },
    {
        "id1": 383,
        "id2": 396,
        "phenotype_comparison": "TOR RNAi did not further extend the lifespan of the\u00a0eat-2(ad1116) mutant\u00a0"
    },
    {
        "id1": 397,
        "id2": 398,
        "phenotype_comparison": "TOR RNAi did not further extend the lifespan of the\u00a0eat-2(ad1116) mutant\u00a0"
    },
    {
        "id1": 381,
        "id2": 399,
        "phenotype_comparison": "TOR RNAi did not further extend the lifespan of the\u00a0eat-2(ad1116) mutant\u00a0"
    },
    {
        "id1": 400,
        "id2": 401,
        "phenotype_comparison": "TOR RNAi did not further extend the lifespan of the\u00a0eat-2(ad1116) mutant\u00a0"
    },
    {
        "id1": 393,
        "id2": 402,
        "phenotype_comparison": "TOR RNAi did not further extend the lifespan of the\u00a0eat-2(ad1116) mutant\u00a0"
    },
    {
        "id1": 403,
        "id2": 404,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 357,
        "id2": 405,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 406,
        "id2": 407,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 406,
        "id2": 408,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 357,
        "id2": 408,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 409,
        "id2": 410,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 411,
        "id2": 412,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 411,
        "id2": 413,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 409,
        "id2": 414,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 409,
        "id2": 415,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 416,
        "id2": 417,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 418,
        "id2": 419,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 411,
        "id2": 420,
        "phenotype_comparison": "The lifespans of S6K/rsks-1(sv31) and eIF4E/ife-2(ok306) mutants subjected to TOR RNAi were longer than the lifespans of either the S6K or eIF4E mutant alone"
    },
    {
        "id1": 421,
        "id2": 422,
        "phenotype_comparison": "Treating the respiratory mutant\u00a0isp-1(qm150) with\u00a0rps-15\u00a0or S6K/rsks-1\u00a0RNAi further extended its lifespan"
    },
    {
        "id1": 423,
        "id2": 424,
        "phenotype_comparison": "Treating the respiratory mutant\u00a0isp-1(qm150) with\u00a0rps-15\u00a0or S6K/rsks-1\u00a0RNAi further extended its lifespan"
    },
    {
        "id1": 425,
        "id2": 426,
        "phenotype_comparison": "Treating the respiratory mutant\u00a0isp-1(qm150) with\u00a0rps-15\u00a0or S6K/rsks-1\u00a0RNAi further extended its lifespan"
    },
    {
        "id1": 425,
        "id2": 427,
        "phenotype_comparison": "Treating the respiratory mutant\u00a0isp-1(qm150) with\u00a0rps-15\u00a0or S6K/rsks-1\u00a0RNAi further extended its lifespan"
    },
    {
        "id1": 428,
        "id2": 429,
        "phenotype_comparison": ""
    },
    {
        "id1": 428,
        "id2": 430,
        "phenotype_comparison": ""
    },
    {
        "id1": 429,
        "id2": 431,
        "phenotype_comparison": "Whereas bec-1 RNAi treatment did not significantly affect the life span of N2 animals, it completely suppressed the longevity phenotype of eat-2(ad1113) mutant animals.  These data demonstrate that bec-1 is required for life span extension in eat-2 mutants, suggesting that autophagy may mediate the effect of dietary restriction in C. elegans."
    },
    {
        "id1": 430,
        "id2": 431,
        "phenotype_comparison": "Whereas bec-1 RNAi treatment did not significantly affect the life span of N2 animals, it completely suppressed the longevity phenotype of eat-2(ad1113) mutant animals.  These data demonstrate that bec-1 is required for life span extension in eat-2 mutants, suggesting that autophagy may mediate the effect of dietary restriction in C. elegans."
    },
    {
        "id1": 432,
        "id2": 433,
        "phenotype_comparison": ""
    },
    {
        "id1": 432,
        "id2": 434,
        "phenotype_comparison": ""
    },
    {
        "id1": 433,
        "id2": 435,
        "phenotype_comparison": "Similar to bec-1 RNAi, knockdown of Ce-atg7 by feeding RNAi did not affect the life span of N2 animals. By contrast, the mean life span of eat-2(ad1113) mutants treated with Ce-atg7 RNAi was decreased by 23% and the maximum life span was decreased by 10 days. "
    },
    {
        "id1": 434,
        "id2": 435,
        "phenotype_comparison": "Similar to bec-1 RNAi, knockdown of Ce-atg7 by feeding RNAi did not affect the life span of N2 animals. By contrast, the mean life span of eat-2(ad1113) mutants treated with Ce-atg7 RNAi was decreased by 23% and the maximum life span was decreased by 10 days. "
    },
    {
        "id1": 436,
        "id2": 437,
        "phenotype_comparison": ""
    },
    {
        "id1": 436,
        "id2": 438,
        "phenotype_comparison": ""
    },
    {
        "id1": 437,
        "id2": 439,
        "phenotype_comparison": "The longevity of daf-2 mutants is blocked by daf-16(m26)."
    },
    {
        "id1": 438,
        "id2": 439,
        "phenotype_comparison": "The longevity of daf-2 mutants is blocked by daf-16(m26)."
    },
    {
        "id1": 440,
        "id2": 441,
        "phenotype_comparison": ""
    },
    {
        "id1": 440,
        "id2": 442,
        "phenotype_comparison": ""
    },
    {
        "id1": 441,
        "id2": 443,
        "phenotype_comparison": "Importantly, life span extension by sir-2.1 overexpression (geIn3) was completely suppressed by par-5 RNAi.  This result suggests that sir-2.1 and par-5 function in a pathway together for life span regulation"
    },
    {
        "id1": 442,
        "id2": 443,
        "phenotype_comparison": "Importantly, life span extension by sir-2.1 overexpression (geIn3) was completely suppressed by par-5 RNAi.  This result suggests that sir-2.1 and par-5 function in a pathway together for life span regulation"
    },
    {
        "id1": 440,
        "id2": 444,
        "phenotype_comparison": ""
    },
    {
        "id1": 441,
        "id2": 445,
        "phenotype_comparison": "Surprisingly, in contrast to sir- 2.1 overexpression, life span extension of daf-2(e1370) mutants was unaffected by par-5 RNAi. These results indicate that decreasing the level of 14-3-3 can specifically suppress the lifespan extension by sir-2.1 overexpression but not when life span is extended by a mutation in the IIS receptor daf-2."
    },
    {
        "id1": 444,
        "id2": 445,
        "phenotype_comparison": "Surprisingly, in contrast to sir- 2.1 overexpression, life span extension of daf-2(e1370) mutants was unaffected by par-5 RNAi. These results indicate that decreasing the level of 14-3-3 can specifically suppress the lifespan extension by sir-2.1 overexpression but not when life span is extended by a mutation in the IIS receptor daf-2."
    },
    {
        "id1": 446,
        "id2": 447,
        "phenotype_comparison": ""
    },
    {
        "id1": 446,
        "id2": 448,
        "phenotype_comparison": ""
    },
    {
        "id1": 447,
        "id2": 449,
        "phenotype_comparison": "Similar to SIR-2.1 and DAF-16, overexpression of the 14-3-3 proteins can extend life span."
    },
    {
        "id1": 448,
        "id2": 449,
        "phenotype_comparison": "Similar to SIR-2.1 and DAF-16, overexpression of the 14-3-3 proteins can extend life span."
    },
    {
        "id1": 446,
        "id2": 450,
        "phenotype_comparison": ""
    },
    {
        "id1": 447,
        "id2": 451,
        "phenotype_comparison": "Similar to SIR-2.1 and DAF-16, overexpression of the 14-3-3 proteins can extend life span."
    },
    {
        "id1": 450,
        "id2": 451,
        "phenotype_comparison": "Similar to SIR-2.1 and DAF-16, overexpression of the 14-3-3 proteins can extend life span."
    },
    {
        "id1": 452,
        "id2": 453,
        "phenotype_comparison": ""
    },
    {
        "id1": 452,
        "id2": 454,
        "phenotype_comparison": ""
    },
    {
        "id1": 453,
        "id2": 455,
        "phenotype_comparison": "IFE-2 depletion further extends the lifespan of long-lived daf-2 and age-1 mutants"
    },
    {
        "id1": 454,
        "id2": 455,
        "phenotype_comparison": "IFE-2 depletion further extends the lifespan of long-lived daf-2 and age-1 mutants"
    },
    {
        "id1": 452,
        "id2": 456,
        "phenotype_comparison": ""
    },
    {
        "id1": 453,
        "id2": 457,
        "phenotype_comparison": "IFE-2 depletion further extends the lifespan of long-lived daf-2 and age-1 mutants"
    },
    {
        "id1": 456,
        "id2": 457,
        "phenotype_comparison": "IFE-2 depletion further extends the lifespan of long-lived daf-2 and age-1 mutants"
    },
    {
        "id1": 458,
        "id2": 459,
        "phenotype_comparison": ""
    },
    {
        "id1": 458,
        "id2": 460,
        "phenotype_comparison": ""
    },
    {
        "id1": 459,
        "id2": 461,
        "phenotype_comparison": "Similar to wild-type animals, knockdown of ife-2 extends the lifespan of glp-4 mutants"
    },
    {
        "id1": 460,
        "id2": 461,
        "phenotype_comparison": "Similar to wild-type animals, knockdown of ife-2 extends the lifespan of glp-4 mutants"
    },
    {
        "id1": 452,
        "id2": 462,
        "phenotype_comparison": ""
    },
    {
        "id1": 453,
        "id2": 463,
        "phenotype_comparison": "DAF-16 is not required for lifespan extension by IFE-2 deficiency. This observation indicates that IFE-2 functions downstream or independently of DAF-16 to control ageing"
    },
    {
        "id1": 462,
        "id2": 463,
        "phenotype_comparison": "DAF-16 is not required for lifespan extension by IFE-2 deficiency. This observation indicates that IFE-2 functions downstream or independently of DAF-16 to control ageing"
    },
    {
        "id1": 452,
        "id2": 464,
        "phenotype_comparison": ""
    },
    {
        "id1": 453,
        "id2": 465,
        "phenotype_comparison": "DAF-16 is not required for lifespan extension by IFE-2 deficiency. This observation indicates that IFE-2 functions downstream or independently of DAF-16 to control ageing"
    },
    {
        "id1": 464,
        "id2": 465,
        "phenotype_comparison": "DAF-16 is not required for lifespan extension by IFE-2 deficiency. This observation indicates that IFE-2 functions downstream or independently of DAF-16 to control ageing"
    },
    {
        "id1": 452,
        "id2": 466,
        "phenotype_comparison": ""
    },
    {
        "id1": 453,
        "id2": 467,
        "phenotype_comparison": "Knockdown of ife-2 further extends the lifespan of long-lived clk-1 mutant animals. "
    },
    {
        "id1": 466,
        "id2": 467,
        "phenotype_comparison": "Knockdown of ife-2 further extends the lifespan of long-lived clk-1 mutant animals. "
    },
    {
        "id1": 452,
        "id2": 468,
        "phenotype_comparison": ""
    },
    {
        "id1": 453,
        "id2": 469,
        "phenotype_comparison": "We observed a similar additive effect on lifespan in long-lived, dietary restricted eat-2 (eating, abnormal pharyngeal pumping-2) mutants"
    },
    {
        "id1": 468,
        "id2": 469,
        "phenotype_comparison": "We observed a similar additive effect on lifespan in long-lived, dietary restricted eat-2 (eating, abnormal pharyngeal pumping-2) mutants"
    },
    {
        "id1": 470,
        "id2": 471,
        "phenotype_comparison": "Knockdown of ife-2 further extends the lifespan of long-lived TORdeficient mutants"
    },
    {
        "id1": 458,
        "id2": 472,
        "phenotype_comparison": ""
    },
    {
        "id1": 458,
        "id2": 473,
        "phenotype_comparison": ""
    },
    {
        "id1": 472,
        "id2": 474,
        "phenotype_comparison": "Similarly, knockdown of TOR in animals carrying an ife-2 deletion results in additional lifespan extension"
    },
    {
        "id1": 473,
        "id2": 474,
        "phenotype_comparison": "Similarly, knockdown of TOR in animals carrying an ife-2 deletion results in additional lifespan extension"
    },
    {
        "id1": 452,
        "id2": 475,
        "phenotype_comparison": ""
    },
    {
        "id1": 452,
        "id2": 476,
        "phenotype_comparison": ""
    },
    {
        "id1": 475,
        "id2": 477,
        "phenotype_comparison": "Depletion of rsks-1 or rskn-1 does not suppress the lifespan extension brought about by IFE-2 deficiency"
    },
    {
        "id1": 452,
        "id2": 478,
        "phenotype_comparison": ""
    },
    {
        "id1": 1387,
        "id2": 1389,
        "phenotype_comparison": ""
    },
    {
        "id1": 478,
        "id2": 479,
        "phenotype_comparison": "Depletion of rsks-1 or rskn-1 does not suppress the lifespan extension brought about by IFE-2 deficiency"
    },
    {
        "id1": 476,
        "id2": 479,
        "phenotype_comparison": "Depletion of rsks-1 or rskn-1 does not suppress the lifespan extension brought about by IFE-2 deficiency"
    },
    {
        "id1": 452,
        "id2": 480,
        "phenotype_comparison": ""
    },
    {
        "id1": 480,
        "id2": 481,
        "phenotype_comparison": "RNAi knockdown of the nematode Mnk homologue mnk- 1 (MAP kinase integrating kinase-1) shortened both wild-type and ife- 2 mutant lifespan"
    },
    {
        "id1": 476,
        "id2": 481,
        "phenotype_comparison": "RNAi knockdown of the nematode Mnk homologue mnk- 1 (MAP kinase integrating kinase-1) shortened both wild-type and ife- 2 mutant lifespan"
    },
    {
        "id1": 460,
        "id2": 482,
        "phenotype_comparison": "No effect on lifespan is observed as a result of mnk-1 knockdown in glp-4 mutant animals lacking a germ line, indicating that MNK-1 function in the germ line is required to maintain normal lifespan."
    },
    {
        "id1": 483,
        "id2": 484,
        "phenotype_comparison": ""
    },
    {
        "id1": 484,
        "id2": 485,
        "phenotype_comparison": "smk-1 was required for the extended lifespan of eat-2(ad1116) mutant animals"
    },
    {
        "id1": 486,
        "id2": 487,
        "phenotype_comparison": ""
    },
    {
        "id1": 487,
        "id2": 488,
        "phenotype_comparison": "RNA interference (RNAi) of pha-4 completely suppressed the long lifespan of eat-2(ad1116) mutant animals"
    },
    {
        "id1": 489,
        "id2": 490,
        "phenotype_comparison": ""
    },
    {
        "id1": 490,
        "id2": 491,
        "phenotype_comparison": "We found that pha-4 was not required for the long lifespan of daf-2 mutant animals"
    },
    {
        "id1": 490,
        "id2": 492,
        "phenotype_comparison": "RNAi knockdown of daf-16, but not pha-4, completely suppressed the long lifespan of daf-2(e1368), daf-2(mu150), and daf-2(e1370) mutant animals"
    },
    {
        "id1": 493,
        "id2": 494,
        "phenotype_comparison": ""
    },
    {
        "id1": 494,
        "id2": 495,
        "phenotype_comparison": "Neither RNAi of pha-4 nor the pha-4(zu225);smg- 1(cc546ts) allele shortened the long lifespan of cyc-1-RNAi-treated animals  or isp- 1(qm130) mutant animals any more than reduction of pha-4 in a wild-type background and to a lesser extent than the loss of daf-16 in cyc-1-RNAi-treated animals"
    },
    {
        "id1": 496,
        "id2": 497,
        "phenotype_comparison": "RNAi knockdown of daf-16, but not pha-4, completely suppressed the long lifespan of daf-2(e1368), daf-2(mu150), and daf-2(e1370) mutant animals"
    },
    {
        "id1": 496,
        "id2": 498,
        "phenotype_comparison": "RNAi knockdown of daf-16, but not pha-4, completely suppressed the long lifespan of daf-2(e1368), daf-2(mu150), and daf-2(e1370) mutant animals"
    },
    {
        "id1": 499,
        "id2": 500,
        "phenotype_comparison": ""
    },
    {
        "id1": 500,
        "id2": 501,
        "phenotype_comparison": "RNAi knockdown of daf-16, but not pha-4, completely suppressed the long lifespan of daf-2(e1368), daf-2(mu150), and daf-2(e1370) mutant animals"
    },
    {
        "id1": 500,
        "id2": 502,
        "phenotype_comparison": "RNAi knockdown of daf-16, but not pha-4, completely suppressed the long lifespan of daf-2(e1368), daf-2(mu150), and daf-2(e1370) mutant animals"
    },
    {
        "id1": 503,
        "id2": 504,
        "phenotype_comparison": ""
    },
    {
        "id1": 504,
        "id2": 505,
        "phenotype_comparison": "Neither RNAi of pha-4 nor the pha-4(zu225);smg- 1(cc546ts) allele shortened the long lifespan of cyc-1-RNAi-treated animals  or isp- 1(qm130) mutant animals any more than reduction of pha-4 in a wild-type background and to a lesser extent than the loss of daf-16 in cyc-1-RNAi-treated animals"
    },
    {
        "id1": 506,
        "id2": 507,
        "phenotype_comparison": ""
    },
    {
        "id1": 506,
        "id2": 508,
        "phenotype_comparison": ""
    },
    {
        "id1": 507,
        "id2": 509,
        "phenotype_comparison": "Neither RNAi of pha-4 nor the pha-4(zu225);smg- 1(cc546ts) allele shortened the long lifespan of cyc-1-RNAi-treated animals  or isp- 1(qm130) mutant animals any more than reduction of pha-4 in a wild-type background and to a lesser extent than the loss of daf-16 in cyc-1-RNAi-treated animals"
    },
    {
        "id1": 508,
        "id2": 509,
        "phenotype_comparison": "Neither RNAi of pha-4 nor the pha-4(zu225);smg- 1(cc546ts) allele shortened the long lifespan of cyc-1-RNAi-treated animals  or isp- 1(qm130) mutant animals any more than reduction of pha-4 in a wild-type background and to a lesser extent than the loss of daf-16 in cyc-1-RNAi-treated animals"
    },
    {
        "id1": 510,
        "id2": 511,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 512,
        "phenotype_comparison": ""
    },
    {
        "id1": 511,
        "id2": 513,
        "phenotype_comparison": ""
    },
    {
        "id1": 512,
        "id2": 513,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 514,
        "phenotype_comparison": ""
    },
    {
        "id1": 514,
        "id2": 515,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 515,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 516,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 517,
        "phenotype_comparison": ""
    },
    {
        "id1": 517,
        "id2": 518,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 518,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 519,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 520,
        "phenotype_comparison": ""
    },
    {
        "id1": 520,
        "id2": 521,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 521,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 522,
        "phenotype_comparison": ""
    },
    {
        "id1": 522,
        "id2": 523,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 523,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 524,
        "phenotype_comparison": ""
    },
    {
        "id1": 524,
        "id2": 525,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 525,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 526,
        "phenotype_comparison": ""
    },
    {
        "id1": 526,
        "id2": 527,
        "phenotype_comparison": ""
    },
    {
        "id1": 512,
        "id2": 527,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 528,
        "phenotype_comparison": ""
    },
    {
        "id1": 528,
        "id2": 529,
        "phenotype_comparison": ""
    },
    {
        "id1": 512,
        "id2": 529,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 530,
        "phenotype_comparison": ""
    },
    {
        "id1": 530,
        "id2": 531,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 594,
        "id2": 610,
        "phenotype_comparison": ""
    },
    {
        "id1": 609,
        "id2": 610,
        "phenotype_comparison": ""
    },
    {
        "id1": 1388,
        "id2": 1389,
        "phenotype_comparison": ""
    },
    {
        "id1": 1530,
        "id2": 1532,
        "phenotype_comparison": ""
    },
    {
        "id1": 1602,
        "id2": 1603,
        "phenotype_comparison": ""
    },
    {
        "id1": 512,
        "id2": 531,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 532,
        "phenotype_comparison": ""
    },
    {
        "id1": 532,
        "id2": 533,
        "phenotype_comparison": ""
    },
    {
        "id1": 512,
        "id2": 533,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 534,
        "phenotype_comparison": ""
    },
    {
        "id1": 534,
        "id2": 535,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 535,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 536,
        "phenotype_comparison": ""
    },
    {
        "id1": 512,
        "id2": 537,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 538,
        "phenotype_comparison": ""
    },
    {
        "id1": 538,
        "id2": 539,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 539,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 540,
        "phenotype_comparison": ""
    },
    {
        "id1": 540,
        "id2": 541,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 541,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 542,
        "phenotype_comparison": ""
    },
    {
        "id1": 542,
        "id2": 543,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 543,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 544,
        "phenotype_comparison": ""
    },
    {
        "id1": 544,
        "id2": 545,
        "phenotype_comparison": ""
    },
    {
        "id1": 512,
        "id2": 545,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 546,
        "phenotype_comparison": ""
    },
    {
        "id1": 546,
        "id2": 547,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 547,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 548,
        "phenotype_comparison": ""
    },
    {
        "id1": 548,
        "id2": 549,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 549,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 550,
        "phenotype_comparison": ""
    },
    {
        "id1": 550,
        "id2": 551,
        "phenotype_comparison": ""
    },
    {
        "id1": 512,
        "id2": 551,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 552,
        "phenotype_comparison": ""
    },
    {
        "id1": 552,
        "id2": 553,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 553,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 554,
        "phenotype_comparison": ""
    },
    {
        "id1": 554,
        "id2": 555,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 555,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 556,
        "phenotype_comparison": ""
    },
    {
        "id1": 556,
        "id2": 557,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 557,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 558,
        "phenotype_comparison": ""
    },
    {
        "id1": 558,
        "id2": 559,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 559,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 560,
        "phenotype_comparison": ""
    },
    {
        "id1": 560,
        "id2": 561,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 561,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 562,
        "phenotype_comparison": ""
    },
    {
        "id1": 562,
        "id2": 563,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 512,
        "id2": 563,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 510,
        "id2": 564,
        "phenotype_comparison": ""
    },
    {
        "id1": 511,
        "id2": 565,
        "phenotype_comparison": ""
    },
    {
        "id1": 564,
        "id2": 565,
        "phenotype_comparison": ""
    },
    {
        "id1": 1387,
        "id2": 1390,
        "phenotype_comparison": ""
    },
    {
        "id1": 514,
        "id2": 566,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 566,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 567,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 517,
        "id2": 568,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 568,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 569,
        "phenotype_comparison": ""
    },
    {
        "id1": 520,
        "id2": 570,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 570,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 522,
        "id2": 571,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 571,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 524,
        "id2": 572,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 572,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 526,
        "id2": 573,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 573,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 528,
        "id2": 574,
        "phenotype_comparison": ""
    },
    {
        "id1": 564,
        "id2": 574,
        "phenotype_comparison": ""
    },
    {
        "id1": 530,
        "id2": 575,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 575,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 532,
        "id2": 576,
        "phenotype_comparison": ""
    },
    {
        "id1": 564,
        "id2": 576,
        "phenotype_comparison": ""
    },
    {
        "id1": 534,
        "id2": 577,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 577,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 578,
        "phenotype_comparison": ""
    },
    {
        "id1": 564,
        "id2": 579,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 538,
        "id2": 580,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 580,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 540,
        "id2": 581,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 581,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 542,
        "id2": 582,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 582,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 544,
        "id2": 583,
        "phenotype_comparison": ""
    },
    {
        "id1": 564,
        "id2": 583,
        "phenotype_comparison": ""
    },
    {
        "id1": 546,
        "id2": 584,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 584,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 548,
        "id2": 585,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 585,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 550,
        "id2": 586,
        "phenotype_comparison": ""
    },
    {
        "id1": 564,
        "id2": 586,
        "phenotype_comparison": ""
    },
    {
        "id1": 763,
        "id2": 779,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 552,
        "id2": 587,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 587,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 554,
        "id2": 588,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 588,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 556,
        "id2": 589,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 589,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 558,
        "id2": 590,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 590,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 560,
        "id2": 591,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 591,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 562,
        "id2": 592,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 564,
        "id2": 592,
        "phenotype_comparison": "\u00a0Proteasomal-RNAi treatments elicited a dramatic shortening of lifespan in wild-type animals as well as in long-lived\u00a0daf-2/IIS-receptor mutants, and a\u00a0glp-1(e2141ts)\u00a0mutant, whose lifespan is extended by germ cell loss"
    },
    {
        "id1": 593,
        "id2": 594,
        "phenotype_comparison": ""
    },
    {
        "id1": 593,
        "id2": 595,
        "phenotype_comparison": ""
    },
    {
        "id1": 594,
        "id2": 596,
        "phenotype_comparison": ""
    },
    {
        "id1": 595,
        "id2": 596,
        "phenotype_comparison": ""
    },
    {
        "id1": 593,
        "id2": 597,
        "phenotype_comparison": ""
    },
    {
        "id1": 597,
        "id2": 598,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 595,
        "id2": 598,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 593,
        "id2": 599,
        "phenotype_comparison": ""
    },
    {
        "id1": 599,
        "id2": 600,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 595,
        "id2": 600,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 593,
        "id2": 601,
        "phenotype_comparison": ""
    },
    {
        "id1": 601,
        "id2": 602,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 595,
        "id2": 602,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 593,
        "id2": 603,
        "phenotype_comparison": ""
    },
    {
        "id1": 603,
        "id2": 604,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 595,
        "id2": 604,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 593,
        "id2": 605,
        "phenotype_comparison": ""
    },
    {
        "id1": 605,
        "id2": 606,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 595,
        "id2": 606,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 593,
        "id2": 607,
        "phenotype_comparison": ""
    },
    {
        "id1": 607,
        "id2": 608,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 595,
        "id2": 608,
        "phenotype_comparison": "Inactivating regulatory proteasomal function by RNAi-knockdown of the six predicted worm Cullins, CUL-1 to -6 , had distinct effects on the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants. Some knockdowns suppressed lifespan extension (cul-1, cul-3), some had less significant effects (cul-4), and others had no effect at all (cul-5)"
    },
    {
        "id1": 593,
        "id2": 609,
        "phenotype_comparison": ""
    },
    {
        "id1": 597,
        "id2": 611,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 609,
        "id2": 611,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 599,
        "id2": 612,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 609,
        "id2": 612,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 601,
        "id2": 613,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 609,
        "id2": 613,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 603,
        "id2": 614,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 609,
        "id2": 614,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 605,
        "id2": 615,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 609,
        "id2": 615,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 607,
        "id2": 616,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 609,
        "id2": 616,
        "phenotype_comparison": "Unlike the general proteasomal subunits, RNAi-knockdown of Cullins did not shorten the lifespan of\u00a0glp-1(e2141ts)\u00a0mutants or wild-type worms. In fact, some RNAi treatments further extended the\u00a0glp-1-mutant lifespan. These findings suggest that reducing Cullin function does not generally shorten lifespan, but instead that Cullin complexes might selectively influence the longevity of particular mutants."
    },
    {
        "id1": 617,
        "id2": 618,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 617,
        "id2": 619,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 617,
        "id2": 620,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 617,
        "id2": 621,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 622,
        "id2": 623,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 622,
        "id2": 624,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 622,
        "id2": 625,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 622,
        "id2": 626,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 595,
        "id2": 627,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 595,
        "id2": 628,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 629,
        "id2": 630,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 629,
        "id2": 631,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 629,
        "id2": 632,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 761,
        "id2": 780,
        "phenotype_comparison": ""
    },
    {
        "id1": 629,
        "id2": 633,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 609,
        "id2": 634,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 609,
        "id2": 635,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 636,
        "id2": 637,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 636,
        "id2": 638,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 636,
        "id2": 639,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 636,
        "id2": 640,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 641,
        "id2": 565,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 641,
        "id2": 642,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 641,
        "id2": 643,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0was required for lifespan extension by other means, we asked whether\u00a0cul-1\u00a0RNAi shortened the long lifespan of the germ-line-defective\u00a0glp-1(e2141ts)\u00a0mutants. We found that it did not"
    },
    {
        "id1": 644,
        "id2": 645,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 644,
        "id2": 646,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 644,
        "id2": 647,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 644,
        "id2": 648,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 649,
        "id2": 650,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 649,
        "id2": 651,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 649,
        "id2": 652,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 649,
        "id2": 653,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 654,
        "id2": 655,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 654,
        "id2": 656,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 654,
        "id2": 657,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 654,
        "id2": 658,
        "phenotype_comparison": "In multiple experiments,\u00a0cul-1\u00a0RNAi significantly reduced the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants as well as\u00a0daf-2(e1368)\u00a0and\u00a0daf-2(e1370)\u00a0mutants"
    },
    {
        "id1": 659,
        "id2": 660,
        "phenotype_comparison": "We found that\u00a0cul-1\u00a0RNAi had no effect on the lifespan extension of\u00a0eat-2(ad1116)\u00a0mutants"
    },
    {
        "id1": 659,
        "id2": 661,
        "phenotype_comparison": "We found that\u00a0cul-1\u00a0RNAi had no effect on the lifespan extension of\u00a0eat-2(ad1116)\u00a0mutants"
    },
    {
        "id1": 659,
        "id2": 662,
        "phenotype_comparison": "We found that\u00a0cul-1\u00a0RNAi had no effect on the lifespan extension of\u00a0eat-2(ad1116)\u00a0mutants"
    },
    {
        "id1": 659,
        "id2": 663,
        "phenotype_comparison": "We found that\u00a0cul-1\u00a0RNAi had no effect on the lifespan extension of\u00a0eat-2(ad1116)\u00a0mutants"
    },
    {
        "id1": 664,
        "id2": 665,
        "phenotype_comparison": "We found that\u00a0cul-1\u00a0RNAi had no effect on the lifespan extension of\u00a0eat-2(ad1116)\u00a0mutants"
    },
    {
        "id1": 664,
        "id2": 666,
        "phenotype_comparison": "We found that\u00a0cul-1\u00a0RNAi had no effect on the lifespan extension of\u00a0eat-2(ad1116)\u00a0mutants"
    },
    {
        "id1": 664,
        "id2": 667,
        "phenotype_comparison": "We found that\u00a0cul-1\u00a0RNAi had no effect on the lifespan extension of\u00a0eat-2(ad1116)\u00a0mutants"
    },
    {
        "id1": 664,
        "id2": 668,
        "phenotype_comparison": "We found that\u00a0cul-1\u00a0RNAi had no effect on the lifespan extension of\u00a0eat-2(ad1116)\u00a0mutants"
    },
    {
        "id1": 669,
        "id2": 670,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0RNAi might shorten the lifespan of\u00a0daf-2\u00a0mutants by increasing germ-line proliferation (15), we removed the reproductive system by killing the gonad precursor cells Z1 and Z4 with a laser microbeam.\u00a0cul-1\u00a0RNAi still shortened the lifespan of\u00a0daf-2(e1368)\u00a0mutants (Fig. 2A\u00a0and\u00a0SI Table 3), as well as that of gonad-ablated\u00a0daf-2(mu150)\u00a0mutants"
    },
    {
        "id1": 669,
        "id2": 671,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0RNAi might shorten the lifespan of\u00a0daf-2\u00a0mutants by increasing germ-line proliferation (15), we removed the reproductive system by killing the gonad precursor cells Z1 and Z4 with a laser microbeam.\u00a0cul-1\u00a0RNAi still shortened the lifespan of\u00a0daf-2(e1368)\u00a0mutants (Fig. 2A\u00a0and\u00a0SI Table 3), as well as that of gonad-ablated\u00a0daf-2(mu150)\u00a0mutants"
    },
    {
        "id1": 672,
        "id2": 673,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0RNAi might shorten the lifespan of\u00a0daf-2\u00a0mutants by increasing germ-line proliferation (15), we removed the reproductive system by killing the gonad precursor cells Z1 and Z4 with a laser microbeam.\u00a0cul-1\u00a0RNAi still shortened the lifespan of\u00a0daf-2(e1368)\u00a0mutants (Fig. 2A\u00a0and\u00a0SI Table 3), as well as that of gonad-ablated\u00a0daf-2(mu150)\u00a0mutants"
    },
    {
        "id1": 672,
        "id2": 674,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0RNAi might shorten the lifespan of\u00a0daf-2\u00a0mutants by increasing germ-line proliferation (15), we removed the reproductive system by killing the gonad precursor cells Z1 and Z4 with a laser microbeam.\u00a0cul-1\u00a0RNAi still shortened the lifespan of\u00a0daf-2(e1368)\u00a0mutants (Fig. 2A\u00a0and\u00a0SI Table 3), as well as that of gonad-ablated\u00a0daf-2(mu150)\u00a0mutants"
    },
    {
        "id1": 718,
        "id2": 719,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 675,
        "id2": 676,
        "phenotype_comparison": "To investigate whether\u00a0cul-1\u00a0RNAi might shorten the lifespan of\u00a0daf-2\u00a0mutants by increasing germ-line proliferation (15), we removed the reproductive system by killing the gonad precursor cells Z1 and Z4 with a laser microbeam.\u00a0cul-1\u00a0RNAi still shortened the lifespan of\u00a0daf-2(e1368)\u00a0mutants (Fig. 2A\u00a0and\u00a0SI Table 3), as well as that of gonad-ablated\u00a0daf-2(mu150)\u00a0mutants"
    },
    {
        "id1": 617,
        "id2": 677,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 678,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 679,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 680,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 681,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 682,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 683,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 684,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 685,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 617,
        "id2": 686,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 596,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 627,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 628,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 688,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 689,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 690,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 691,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 692,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 693,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 694,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 687,
        "id2": 695,
        "phenotype_comparison": "We found that RNAi depletion of\u00a0skr-1\u00a0and\u00a0skr-2\u00a0shortened the lifespan of\u00a0daf-2(mu150)\u00a0mutants by up to 44%. Some of the other\u00a0skr\u00a0RNAi clones also shortened the extended lifespan of\u00a0daf-2(mu150)\u00a0mutants, but not to the same extent."
    },
    {
        "id1": 636,
        "id2": 696,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 697,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 698,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 699,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 700,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 701,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 702,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 703,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 704,
        "phenotype_comparison": ""
    },
    {
        "id1": 636,
        "id2": 705,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 706,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 707,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 708,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 709,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 710,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 711,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 712,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 713,
        "phenotype_comparison": ""
    },
    {
        "id1": 641,
        "id2": 714,
        "phenotype_comparison": ""
    },
    {
        "id1": 715,
        "id2": 716,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 715,
        "id2": 717,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 763,
        "id2": 777,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 718,
        "id2": 720,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 721,
        "id2": 722,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 721,
        "id2": 723,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 721,
        "id2": 724,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 721,
        "id2": 725,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 721,
        "id2": 726,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 721,
        "id2": 727,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 728,
        "id2": 729,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 728,
        "id2": 730,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 728,
        "id2": 731,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 728,
        "id2": 732,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 728,
        "id2": 733,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 728,
        "id2": 727,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 734,
        "id2": 735,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 734,
        "id2": 736,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 737,
        "id2": 738,
        "phenotype_comparison": "lin-23(ot1) extended the lifespan of daf-2(e1370) mutants at 25oC. The reason underlying this temperature-dependent lifespan effect is unclear, but the phenomenon is reminiscent of the lifespan extension produced by the daf-2(e1370) mutation in combination with other longevity mutations such as sir-2.1(ok434) (1) and daf-12(m20) (2) . Similar to lin-23, sir-2.1 and daf-12 are longevity-promoting genes in other contexts"
    },
    {
        "id1": 737,
        "id2": 739,
        "phenotype_comparison": "lin-23(ot1) extended the lifespan of daf-2(e1370) mutants at 25oC. The reason underlying this temperature-dependent lifespan effect is unclear, but the phenomenon is reminiscent of the lifespan extension produced by the daf-2(e1370) mutation in combination with other longevity mutations such as sir-2.1(ok434) (1) and daf-12(m20) (2) . Similar to lin-23, sir-2.1 and daf-12 are longevity-promoting genes in other contexts"
    },
    {
        "id1": 737,
        "id2": 740,
        "phenotype_comparison": "lin-23(ot1) extended the lifespan of daf-2(e1370) mutants at 25oC. The reason underlying this temperature-dependent lifespan effect is unclear, but the phenomenon is reminiscent of the lifespan extension produced by the daf-2(e1370) mutation in combination with other longevity mutations such as sir-2.1(ok434) (1) and daf-12(m20) (2) . Similar to lin-23, sir-2.1 and daf-12 are longevity-promoting genes in other contexts"
    },
    {
        "id1": 737,
        "id2": 741,
        "phenotype_comparison": "lin-23(ot1) extended the lifespan of daf-2(e1370) mutants at 25oC. The reason underlying this temperature-dependent lifespan effect is unclear, but the phenomenon is reminiscent of the lifespan extension produced by the daf-2(e1370) mutation in combination with other longevity mutations such as sir-2.1(ok434) (1) and daf-12(m20) (2) . Similar to lin-23, sir-2.1 and daf-12 are longevity-promoting genes in other contexts"
    },
    {
        "id1": 737,
        "id2": 742,
        "phenotype_comparison": "lin-23(ot1) extended the lifespan of daf-2(e1370) mutants at 25oC. The reason underlying this temperature-dependent lifespan effect is unclear, but the phenomenon is reminiscent of the lifespan extension produced by the daf-2(e1370) mutation in combination with other longevity mutations such as sir-2.1(ok434) (1) and daf-12(m20) (2) . Similar to lin-23, sir-2.1 and daf-12 are longevity-promoting genes in other contexts"
    },
    {
        "id1": 761,
        "id2": 778,
        "phenotype_comparison": ""
    },
    {
        "id1": 778,
        "id2": 779,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 1388,
        "id2": 1390,
        "phenotype_comparison": ""
    },
    {
        "id1": 1604,
        "id2": 1605,
        "phenotype_comparison": ""
    },
    {
        "id1": 737,
        "id2": 743,
        "phenotype_comparison": "lin-23(ot1) extended the lifespan of daf-2(e1370) mutants at 25oC. The reason underlying this temperature-dependent lifespan effect is unclear, but the phenomenon is reminiscent of the lifespan extension produced by the daf-2(e1370) mutation in combination with other longevity mutations such as sir-2.1(ok434) (1) and daf-12(m20) (2) . Similar to lin-23, sir-2.1 and daf-12 are longevity-promoting genes in other contexts"
    },
    {
        "id1": 510,
        "id2": 744,
        "phenotype_comparison": ""
    },
    {
        "id1": 510,
        "id2": 745,
        "phenotype_comparison": ""
    },
    {
        "id1": 744,
        "id2": 746,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 745,
        "id2": 746,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 510,
        "id2": 747,
        "phenotype_comparison": ""
    },
    {
        "id1": 747,
        "id2": 748,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 745,
        "id2": 748,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 749,
        "id2": 750,
        "phenotype_comparison": ""
    },
    {
        "id1": 749,
        "id2": 751,
        "phenotype_comparison": ""
    },
    {
        "id1": 750,
        "id2": 752,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 751,
        "id2": 752,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 749,
        "id2": 753,
        "phenotype_comparison": ""
    },
    {
        "id1": 753,
        "id2": 754,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 751,
        "id2": 754,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 755,
        "id2": 756,
        "phenotype_comparison": ""
    },
    {
        "id1": 755,
        "id2": 757,
        "phenotype_comparison": ""
    },
    {
        "id1": 756,
        "id2": 758,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 757,
        "id2": 758,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 755,
        "id2": 759,
        "phenotype_comparison": ""
    },
    {
        "id1": 759,
        "id2": 760,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 757,
        "id2": 760,
        "phenotype_comparison": "We found that\u00a0lin-23(ot1)\u00a0reduced the lifespan extension of\u00a0daf-2\u00a0mutants and also attenuated the lifespan extension induced by\u00a0daf-2\u00a0RNAi. These data showed that\u00a0lin-23\u00a0is required for the extended lifespan of\u00a0daf-2\u00a0mutants for a function that is independent of its developmental role in cell cycle regulation."
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
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        "phenotype_comparison": ""
    },
    {
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        "phenotype_comparison": ""
    },
    {
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        "phenotype_comparison": ""
    },
    {
        "id1": 765,
        "id2": 766,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 766,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 767,
        "id2": 768,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 768,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 769,
        "id2": 770,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 770,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 771,
        "id2": 772,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 772,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 773,
        "id2": 774,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 774,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 775,
        "id2": 776,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 776,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 1391,
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        "phenotype_comparison": ""
    },
    {
        "id1": 1662,
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        "phenotype_comparison": ""
    },
    {
        "id1": 780,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 781,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 782,
        "id2": 783,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 783,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 784,
        "id2": 785,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 785,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 786,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 787,
        "id2": 788,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 788,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 789,
        "id2": 790,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 790,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 791,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
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        "phenotype_comparison": ""
    },
    {
        "id1": 793,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 795,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 797,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 799,
        "id2": 800,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 801,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
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    },
    {
        "id1": 803,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    },
    {
        "id1": 805,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    {
        "id1": 807,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    },
    {
        "id1": 810,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    },
    {
        "id1": 812,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    {
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    },
    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
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    {
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    {
        "id1": 829,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 830,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 831,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 832,
        "id2": 833,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 833,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 835,
        "id2": 836,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 838,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 839,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 840,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 841,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 842,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 843,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 844,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 845,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 846,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 848,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 849,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 850,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 851,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 852,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
        "id2": 853,
        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 1392,
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        "phenotype_comparison": ""
    },
    {
        "id1": 1584,
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        "phenotype_comparison": ""
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Forty-one gene inactivations functioned specifically within the\u00a0daf-2\u00a0pathway to shorten life span, not decreasing the life span of\u00a0daf-2;daf-16\u00a0animals"
    },
    {
        "id1": 763,
        "id2": 878,
        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 879,
        "id2": 880,
        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 881,
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        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 882,
        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 883,
        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 884,
        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 887,
        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 889,
        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 890,
        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
        "id1": 837,
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        "phenotype_comparison": "Six gene inactivations shortened life span in both\u00a0daf-2\u00a0and\u00a0daf-2; daf-16\u00a0strains; these genes regulate life span independently of insulin/IGF1 signaling"
    },
    {
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        "phenotype_comparison": ""
    },
    {
        "id1": 892,
        "id2": 893,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
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    },
    {
        "id1": 894,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
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    },
    {
        "id1": 896,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
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    },
    {
        "id1": 898,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 900,
        "id2": 901,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
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        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
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        "phenotype_comparison": ""
    },
    {
        "id1": 903,
        "id2": 904,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 904,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 905,
        "phenotype_comparison": ""
    },
    {
        "id1": 905,
        "id2": 906,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 906,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 907,
        "phenotype_comparison": ""
    },
    {
        "id1": 907,
        "id2": 908,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 908,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 909,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 910,
        "phenotype_comparison": ""
    },
    {
        "id1": 910,
        "id2": 911,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 911,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 912,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 913,
        "phenotype_comparison": ""
    },
    {
        "id1": 913,
        "id2": 914,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 914,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 915,
        "phenotype_comparison": ""
    },
    {
        "id1": 915,
        "id2": 916,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 916,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 917,
        "phenotype_comparison": ""
    },
    {
        "id1": 917,
        "id2": 918,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 918,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 919,
        "phenotype_comparison": ""
    },
    {
        "id1": 919,
        "id2": 920,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 920,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 1393,
        "id2": 1394,
        "phenotype_comparison": ""
    },
    {
        "id1": 1604,
        "id2": 1613,
        "phenotype_comparison": ""
    },
    {
        "id1": 763,
        "id2": 921,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 922,
        "phenotype_comparison": ""
    },
    {
        "id1": 922,
        "id2": 923,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 923,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 924,
        "phenotype_comparison": ""
    },
    {
        "id1": 924,
        "id2": 925,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 925,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 926,
        "phenotype_comparison": ""
    },
    {
        "id1": 926,
        "id2": 927,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 927,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 928,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 929,
        "phenotype_comparison": ""
    },
    {
        "id1": 929,
        "id2": 930,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 930,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 931,
        "phenotype_comparison": ""
    },
    {
        "id1": 931,
        "id2": 932,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 932,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 933,
        "phenotype_comparison": ""
    },
    {
        "id1": 933,
        "id2": 934,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 934,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 935,
        "phenotype_comparison": ""
    },
    {
        "id1": 935,
        "id2": 936,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 936,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 937,
        "phenotype_comparison": ""
    },
    {
        "id1": 937,
        "id2": 938,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 938,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 939,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 940,
        "phenotype_comparison": ""
    },
    {
        "id1": 940,
        "id2": 941,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 941,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 942,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 943,
        "phenotype_comparison": ""
    },
    {
        "id1": 1392,
        "id2": 1395,
        "phenotype_comparison": ""
    },
    {
        "id1": 943,
        "id2": 944,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 944,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 945,
        "phenotype_comparison": ""
    },
    {
        "id1": 945,
        "id2": 946,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 946,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 947,
        "phenotype_comparison": ""
    },
    {
        "id1": 947,
        "id2": 948,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 948,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 949,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 950,
        "phenotype_comparison": ""
    },
    {
        "id1": 950,
        "id2": 951,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 951,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 952,
        "phenotype_comparison": ""
    },
    {
        "id1": 952,
        "id2": 953,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 953,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 954,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 955,
        "phenotype_comparison": ""
    },
    {
        "id1": 955,
        "id2": 956,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 956,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 957,
        "phenotype_comparison": ""
    },
    {
        "id1": 957,
        "id2": 958,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 958,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 959,
        "phenotype_comparison": ""
    },
    {
        "id1": 959,
        "id2": 960,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 960,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 961,
        "phenotype_comparison": ""
    },
    {
        "id1": 961,
        "id2": 962,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 962,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 963,
        "phenotype_comparison": ""
    },
    {
        "id1": 963,
        "id2": 964,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 964,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 965,
        "phenotype_comparison": ""
    },
    {
        "id1": 1393,
        "id2": 1395,
        "phenotype_comparison": ""
    },
    {
        "id1": 965,
        "id2": 966,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 966,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 967,
        "phenotype_comparison": ""
    },
    {
        "id1": 967,
        "id2": 968,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 968,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 969,
        "phenotype_comparison": ""
    },
    {
        "id1": 969,
        "id2": 970,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 970,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 971,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 972,
        "phenotype_comparison": ""
    },
    {
        "id1": 972,
        "id2": 973,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 973,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 974,
        "phenotype_comparison": ""
    },
    {
        "id1": 974,
        "id2": 975,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 975,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 976,
        "phenotype_comparison": ""
    },
    {
        "id1": 976,
        "id2": 977,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 977,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 978,
        "phenotype_comparison": ""
    },
    {
        "id1": 978,
        "id2": 979,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 979,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 980,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 981,
        "phenotype_comparison": ""
    },
    {
        "id1": 981,
        "id2": 982,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 982,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 983,
        "phenotype_comparison": ""
    },
    {
        "id1": 983,
        "id2": 984,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 984,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 985,
        "phenotype_comparison": ""
    },
    {
        "id1": 985,
        "id2": 986,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 986,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 987,
        "phenotype_comparison": ""
    },
    {
        "id1": 1396,
        "id2": 1397,
        "phenotype_comparison": ""
    },
    {
        "id1": 987,
        "id2": 988,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 988,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 761,
        "id2": 989,
        "phenotype_comparison": ""
    },
    {
        "id1": 989,
        "id2": 990,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 990,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 991,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 992,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 993,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 994,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 995,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 996,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 997,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 998,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 999,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1000,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1001,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 1396,
        "id2": 1398,
        "phenotype_comparison": ""
    },
    {
        "id1": 1613,
        "id2": 1614,
        "phenotype_comparison": ""
    },
    {
        "id1": 837,
        "id2": 1002,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1003,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1004,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1005,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1006,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1007,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1008,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1009,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1010,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1011,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1012,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1013,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1014,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 1396,
        "id2": 1399,
        "phenotype_comparison": ""
    },
    {
        "id1": 1613,
        "id2": 1615,
        "phenotype_comparison": ""
    },
    {
        "id1": 1664,
        "id2": 1673,
        "phenotype_comparison": ""
    },
    {
        "id1": 837,
        "id2": 1015,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1016,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1017,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1018,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1019,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1020,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1021,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1022,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1023,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1024,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1025,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1026,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1027,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1028,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 1396,
        "id2": 1400,
        "phenotype_comparison": ""
    },
    {
        "id1": 1616,
        "id2": 1617,
        "phenotype_comparison": ""
    },
    {
        "id1": 1670,
        "id2": 1673,
        "phenotype_comparison": ""
    },
    {
        "id1": 837,
        "id2": 1029,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1030,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1031,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1032,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1033,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1034,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1035,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1036,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1037,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1038,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1039,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1040,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 1396,
        "id2": 1401,
        "phenotype_comparison": ""
    },
    {
        "id1": 1616,
        "id2": 1618,
        "phenotype_comparison": ""
    },
    {
        "id1": 1674,
        "id2": 1675,
        "phenotype_comparison": ""
    },
    {
        "id1": 837,
        "id2": 1041,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1042,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1043,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1044,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1045,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1046,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1047,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1048,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 837,
        "id2": 1049,
        "phenotype_comparison": "Fifty-seven gene inactivations (corresponding to 55 RNAi clones) more dramatically shortened the life span of\u00a0daf-2\u00a0animals compared with\u00a0daf-2;daf-16, but still shortened the life span of\u00a0daf-2;daf-16\u00a0animals, suggesting that they function in a parallel/converging pathway to insulin/IGF1 signaling"
    },
    {
        "id1": 763,
        "id2": 1050,
        "phenotype_comparison": ""
    },
    {
        "id1": 763,
        "id2": 1051,
        "phenotype_comparison": ""
    },
    {
        "id1": 837,
        "id2": 1052,
        "phenotype_comparison": ""
    },
    {
        "id1": 837,
        "id2": 1053,
        "phenotype_comparison": ""
    },
    {
        "id1": 1054,
        "id2": 1055,
        "phenotype_comparison": ""
    },
    {
        "id1": 1054,
        "id2": 1056,
        "phenotype_comparison": ""
    },
    {
        "id1": 1055,
        "id2": 1057,
        "phenotype_comparison": "The lifespan extension phenotype of the\u00a0asm-3(ok1744)\u00a0mutants was completely suppressed by the null mutation of\u00a0daf-16"
    },
    {
        "id1": 1056,
        "id2": 1057,
        "phenotype_comparison": "The lifespan extension phenotype of the\u00a0asm-3(ok1744)\u00a0mutants was completely suppressed by the null mutation of\u00a0daf-16"
    },
    {
        "id1": 1058,
        "id2": 1059,
        "phenotype_comparison": ""
    },
    {
        "id1": 1058,
        "id2": 1060,
        "phenotype_comparison": ""
    },
    {
        "id1": 1059,
        "id2": 1061,
        "phenotype_comparison": "While partial loss-of-function\u00a0daf-2(e1370)\u00a0mutants had dramatically extended lifespan at 20\u00b0C, the lifespan of\u00a0daf-2 mutants was not further extended by the loss of\u00a0asm-3. Thus, this result suggests that asm-3 and daf-2 function in the same pathway."
    },
    {
        "id1": 1060,
        "id2": 1061,
        "phenotype_comparison": "While partial loss-of-function\u00a0daf-2(e1370)\u00a0mutants had dramatically extended lifespan at 20\u00b0C, the lifespan of\u00a0daf-2 mutants was not further extended by the loss of\u00a0asm-3. Thus, this result suggests that asm-3 and daf-2 function in the same pathway."
    },
    {
        "id1": 1062,
        "id2": 1063,
        "phenotype_comparison": ""
    },
    {
        "id1": 1062,
        "id2": 1064,
        "phenotype_comparison": ""
    },
    {
        "id1": 1063,
        "id2": 1065,
        "phenotype_comparison": "Remarkably,\u00a0asm-3(ok1744);age-1(mg305)\u00a0double mutants had mean lifespan 67% greater than that of\u00a0age-1(mg305)\u00a0single mutants, or 259% greater than that of wild-type animals\u00a0"
    },
    {
        "id1": 1064,
        "id2": 1065,
        "phenotype_comparison": "Remarkably,\u00a0asm-3(ok1744);age-1(mg305)\u00a0double mutants had mean lifespan 67% greater than that of\u00a0age-1(mg305)\u00a0single mutants, or 259% greater than that of wild-type animals\u00a0"
    },
    {
        "id1": 1066,
        "id2": 1067,
        "phenotype_comparison": ""
    },
    {
        "id1": 1066,
        "id2": 1068,
        "phenotype_comparison": ""
    },
    {
        "id1": 1067,
        "id2": 1069,
        "phenotype_comparison": "Loss of\u00a0asm-3\u00a0did not further extend the lifespan in the partial loss-of-function\u00a0pdk-1(sa709)\u00a0mutant background. This result suggests that\u00a0asm-3\u00a0and\u00a0pdk-1\u00a0likely function in the same pathway.\u00a0"
    },
    {
        "id1": 1068,
        "id2": 1069,
        "phenotype_comparison": "Loss of\u00a0asm-3\u00a0did not further extend the lifespan in the partial loss-of-function\u00a0pdk-1(sa709)\u00a0mutant background. This result suggests that\u00a0asm-3\u00a0and\u00a0pdk-1\u00a0likely function in the same pathway.\u00a0"
    },
    {
        "id1": 1070,
        "id2": 1071,
        "phenotype_comparison": ""
    },
    {
        "id1": 1070,
        "id2": 1072,
        "phenotype_comparison": ""
    },
    {
        "id1": 1071,
        "id2": 1073,
        "phenotype_comparison": "The\u00a0asm-3(ok1744)\u00a0mutation shortened the lifespan of the longer lived\u00a0akt-1(mg306)\u00a0mutant animals, but the\u00a0akt-1(mg306)\u00a0mutation did not seem to affect the lifespan extension phenotype of the\u00a0asm-3(ok1744)mutant\u00a0"
    },
    {
        "id1": 1119,
        "id2": 1120,
        "phenotype_comparison": "Examining the lifespan of\u00a0sod-1\u00a0double deletion mutants revealed that deletion of\u00a0sod-3\u00a0did not shorten the lifespan of\u00a0sod-1\u00a0mutant worms"
    },
    {
        "id1": 1072,
        "id2": 1073,
        "phenotype_comparison": "The\u00a0asm-3(ok1744)\u00a0mutation shortened the lifespan of the longer lived\u00a0akt-1(mg306)\u00a0mutant animals, but the\u00a0akt-1(mg306)\u00a0mutation did not seem to affect the lifespan extension phenotype of the\u00a0asm-3(ok1744)mutant\u00a0"
    },
    {
        "id1": 1075,
        "id2": 1076,
        "phenotype_comparison": "Double inactivation of\u00a0asm-3\u00a0and\u00a0asm-1\u00a0further extended lifespan, with the mean lifespan 30% greater than that of the control."
    },
    {
        "id1": 1075,
        "id2": 1077,
        "phenotype_comparison": "Double inactivation of asm-3 and asm-2 further extended lifespan, with the mean lifespan 28% greater than that of the control."
    },
    {
        "id1": 1075,
        "id2": 1078,
        "phenotype_comparison": "daf-16\u00a0RNAi abolished the lifespan extension phenotype caused by\u00a0asm-3(ok1744)\u00a0mutation"
    },
    {
        "id1": 1079,
        "id2": 1080,
        "phenotype_comparison": "The lifespan extension phenotypes produced by inactivation of\u00a0asm-1\u00a0gene was suppressed by a null mutation of\u00a0daf-18,\u00a0daf-18(nr2037)"
    },
    {
        "id1": 1079,
        "id2": 1081,
        "phenotype_comparison": "The lifespan extension phenotypes produced by inactivation of\u00a0asm-2\u00a0gene was suppressed by a null mutation of\u00a0daf-18,\u00a0daf-18(nr2037)"
    },
    {
        "id1": 1079,
        "id2": 1082,
        "phenotype_comparison": "The lifespan extension phenotypes produced by inactivation of\u00a0asm-3\u00a0gene was suppressed by a null mutation of\u00a0daf-18,\u00a0daf-18(nr2037)"
    },
    {
        "id1": 1083,
        "id2": 1084,
        "phenotype_comparison": "While partial loss-of-function aap-1(m889) mutants exhibited longer lifespan phenotype than wild-type animals, silencing of asm-3 in the aap-1(m889) mutants further extended the mean lifespan by 21%. These genetic results indicate that loss of asm-3 cooperates with an aap-1 loss-of-function mutation to extend animal lifespan, suggesting that asm-3 potentiates aap-1 signaling. "
    },
    {
        "id1": 1085,
        "id2": 1086,
        "phenotype_comparison": ""
    },
    {
        "id1": 1085,
        "id2": 1087,
        "phenotype_comparison": ""
    },
    {
        "id1": 1086,
        "id2": 1088,
        "phenotype_comparison": "The daf- 2(e1370); sod-3(sj134) double mutant had a slightly but significantly longer lifespan than that of the daf-2(e1370) mutant."
    },
    {
        "id1": 1087,
        "id2": 1088,
        "phenotype_comparison": "The daf- 2(e1370); sod-3(sj134) double mutant had a slightly but significantly longer lifespan than that of the daf-2(e1370) mutant."
    },
    {
        "id1": 1085,
        "id2": 1089,
        "phenotype_comparison": ""
    },
    {
        "id1": 1089,
        "id2": 1090,
        "phenotype_comparison": "The sod-2(sj173); daf-2(e1370) double mutant showed a marginally but statistically significantly shorter lifespan than that of the daf-2(e1370) mutant counterparts"
    },
    {
        "id1": 1087,
        "id2": 1090,
        "phenotype_comparison": "The sod-2(sj173); daf-2(e1370) double mutant showed a marginally but statistically significantly shorter lifespan than that of the daf-2(e1370) mutant counterparts"
    },
    {
        "id1": 1088,
        "id2": 1091,
        "phenotype_comparison": "The sod-2(sj173); daf-2(e1370); sod-3(sj134) triple mutant lived longer than the daf-2(e1370) mutant, similarly to the daf-2(e1370); sod-3(sj134) double mutant, demonstrating that sod-3 is epistatic to sod-2 in Age."
    },
    {
        "id1": 1085,
        "id2": 1092,
        "phenotype_comparison": ""
    },
    {
        "id1": 1092,
        "id2": 1093,
        "phenotype_comparison": "The sod-4 deletion had little effect on the lifespan under the wild-type background but slightly extended the lifespan under the daf-2(e1370) background"
    },
    {
        "id1": 1087,
        "id2": 1093,
        "phenotype_comparison": "The sod-4 deletion had little effect on the lifespan under the wild-type background but slightly extended the lifespan under the daf-2(e1370) background"
    },
    {
        "id1": 1094,
        "id2": 1095,
        "phenotype_comparison": ""
    },
    {
        "id1": 1094,
        "id2": 1096,
        "phenotype_comparison": ""
    },
    {
        "id1": 1095,
        "id2": 1097,
        "phenotype_comparison": "The short-life-span phenotype of\u00a0rict-1\u00a0mutants requires\u00a0daf-2\u00a0and\u00a0akt-1\u00a0signaling as\u00a0rict-1;akt-1\u00a0double mutants shift to being long-lived, rather than short-lived, and\u00a0rict-1;daf-2\u00a0double mutants show a life span nearly identical to\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 1096,
        "id2": 1097,
        "phenotype_comparison": "The short-life-span phenotype of\u00a0rict-1\u00a0mutants requires\u00a0daf-2\u00a0and\u00a0akt-1\u00a0signaling as\u00a0rict-1;akt-1\u00a0double mutants shift to being long-lived, rather than short-lived, and\u00a0rict-1;daf-2\u00a0double mutants show a life span nearly identical to\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 1094,
        "id2": 1098,
        "phenotype_comparison": ""
    },
    {
        "id1": 1095,
        "id2": 1099,
        "phenotype_comparison": "The short-life-span phenotype of\u00a0rict-1\u00a0mutants requires\u00a0daf-2\u00a0and\u00a0akt-1\u00a0signaling as\u00a0rict-1;akt-1\u00a0double mutants shift to being long-lived, rather than short-lived, and\u00a0rict-1;daf-2\u00a0double mutants show a life span nearly identical to\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 1098,
        "id2": 1099,
        "phenotype_comparison": "The short-life-span phenotype of\u00a0rict-1\u00a0mutants requires\u00a0daf-2\u00a0and\u00a0akt-1\u00a0signaling as\u00a0rict-1;akt-1\u00a0double mutants shift to being long-lived, rather than short-lived, and\u00a0rict-1;daf-2\u00a0double mutants show a life span nearly identical to\u00a0daf-2\u00a0mutants"
    },
    {
        "id1": 1094,
        "id2": 1100,
        "phenotype_comparison": ""
    },
    {
        "id1": 1100,
        "id2": 1101,
        "phenotype_comparison": "rict-1;daf-16\u00a0double mutants demonstrate shorter life span than either single mutant, indicating that\u00a0rict-1\u00a0does not shorten life span only via regulation of the DAF-16/FOXO transcriptional outputs of insulin signaling"
    },
    {
        "id1": 1096,
        "id2": 1101,
        "phenotype_comparison": "rict-1;daf-16\u00a0double mutants demonstrate shorter life span than either single mutant, indicating that\u00a0rict-1\u00a0does not shorten life span only via regulation of the DAF-16/FOXO transcriptional outputs of insulin signaling"
    },
    {
        "id1": 1100,
        "id2": 1102,
        "phenotype_comparison": "rict-1;daf-16\u00a0double mutants demonstrate shorter life span than either single mutant, indicating that\u00a0rict-1\u00a0does not shorten life span only via regulation of the DAF-16/FOXO transcriptional outputs of insulin signaling"
    },
    {
        "id1": 1098,
        "id2": 1102,
        "phenotype_comparison": "rict-1;daf-16\u00a0double mutants demonstrate shorter life span than either single mutant, indicating that\u00a0rict-1\u00a0does not shorten life span only via regulation of the DAF-16/FOXO transcriptional outputs of insulin signaling"
    },
    {
        "id1": 1103,
        "id2": 1104,
        "phenotype_comparison": ""
    },
    {
        "id1": 1103,
        "id2": 1105,
        "phenotype_comparison": ""
    },
    {
        "id1": 1104,
        "id2": 1106,
        "phenotype_comparison": ""
    },
    {
        "id1": 1105,
        "id2": 1106,
        "phenotype_comparison": ""
    },
    {
        "id1": 1103,
        "id2": 1107,
        "phenotype_comparison": ""
    },
    {
        "id1": 1104,
        "id2": 1108,
        "phenotype_comparison": "daf-16 (mu86)animals and\u00a0daf-16 (mu86) hif-1 (ia04)\u00a0double mutants had similarly short lifespans (aprox 15 days). These data suggest that hif-1 loss-of-function mutations extend life span via a mechanism that requires daf-16 and skn-1 function."
    },
    {
        "id1": 1107,
        "id2": 1108,
        "phenotype_comparison": "daf-16 (mu86)animals and\u00a0daf-16 (mu86) hif-1 (ia04)\u00a0double mutants had similarly short lifespans (aprox 15 days). These data suggest that hif-1 loss-of-function mutations extend life span via a mechanism that requires daf-16 and skn-1 function."
    },
    {
        "id1": 1103,
        "id2": 1109,
        "phenotype_comparison": ""
    },
    {
        "id1": 1104,
        "id2": 1110,
        "phenotype_comparison": "The\u00a0hif-1 (ia04)\u00a0deletion mutation did not extend the lifespan of\u00a0skn-1(zu67)\u00a0animals. These data suggest that hif-1 loss-of-function mutations extend life span via a mechanism that requires daf-16 and skn-1 function."
    },
    {
        "id1": 1109,
        "id2": 1110,
        "phenotype_comparison": "The\u00a0hif-1 (ia04)\u00a0deletion mutation did not extend the lifespan of\u00a0skn-1(zu67)\u00a0animals. These data suggest that hif-1 loss-of-function mutations extend life span via a mechanism that requires daf-16 and skn-1 function."
    },
    {
        "id1": 1111,
        "id2": 1112,
        "phenotype_comparison": ""
    },
    {
        "id1": 1111,
        "id2": 1113,
        "phenotype_comparison": ""
    },
    {
        "id1": 1112,
        "id2": 1114,
        "phenotype_comparison": "\u00a0There was not a significant difference between\u00a0daf-2(e1370)\u00a0and\u00a0daf-2(e1370) hif-1(ia04)\u00a0animals."
    },
    {
        "id1": 1113,
        "id2": 1114,
        "phenotype_comparison": "\u00a0There was not a significant difference between\u00a0daf-2(e1370)\u00a0and\u00a0daf-2(e1370) hif-1(ia04)\u00a0animals."
    },
    {
        "id1": 1115,
        "id2": 1116,
        "phenotype_comparison": ""
    },
    {
        "id1": 1115,
        "id2": 1117,
        "phenotype_comparison": ""
    },
    {
        "id1": 1116,
        "id2": 1118,
        "phenotype_comparison": "sod-1;sod-2\u00a0mutant worms lived significantly longer than wild-type N2 worms\u00a0"
    },
    {
        "id1": 1117,
        "id2": 1118,
        "phenotype_comparison": "sod-1;sod-2\u00a0mutant worms lived significantly longer than wild-type N2 worms\u00a0"
    },
    {
        "id1": 1115,
        "id2": 1119,
        "phenotype_comparison": ""
    },
    {
        "id1": 1368,
        "id2": 1385,
        "phenotype_comparison": ""
    },
    {
        "id1": 1117,
        "id2": 1120,
        "phenotype_comparison": "Examining the lifespan of\u00a0sod-1\u00a0double deletion mutants revealed that deletion of\u00a0sod-3\u00a0did not shorten the lifespan of\u00a0sod-1\u00a0mutant worms"
    },
    {
        "id1": 1115,
        "id2": 1121,
        "phenotype_comparison": ""
    },
    {
        "id1": 1121,
        "id2": 1122,
        "phenotype_comparison": "Examining the lifespan of\u00a0sod-1\u00a0double deletion mutants revealed that deletion of\u00a0sod-4\u00a0did not shorten the lifespan of\u00a0sod-1\u00a0mutant worms"
    },
    {
        "id1": 1117,
        "id2": 1122,
        "phenotype_comparison": "Examining the lifespan of\u00a0sod-1\u00a0double deletion mutants revealed that deletion of\u00a0sod-4\u00a0did not shorten the lifespan of\u00a0sod-1\u00a0mutant worms"
    },
    {
        "id1": 1115,
        "id2": 1123,
        "phenotype_comparison": ""
    },
    {
        "id1": 1123,
        "id2": 1124,
        "phenotype_comparison": "Examining the lifespan of\u00a0sod-1\u00a0double deletion mutants revealed that deletion of sod-5\u00a0did not shorten the lifespan of\u00a0sod-1\u00a0mutant worms"
    },
    {
        "id1": 1117,
        "id2": 1124,
        "phenotype_comparison": "Examining the lifespan of\u00a0sod-1\u00a0double deletion mutants revealed that deletion of sod-5\u00a0did not shorten the lifespan of\u00a0sod-1\u00a0mutant worms"
    },
    {
        "id1": 1119,
        "id2": 1125,
        "phenotype_comparison": "Among the\u00a0sod-2\u00a0double deletion mutants, all of the worms maintained the extended lifespan seen in\u00a0sod-2\u00a0single deletion mutants indicating that in no case is the upregulation of another\u00a0sod\u00a0gene entirely responsible for the long life observed in\u00a0sod-2\u00a0mutant worms\u00a0"
    },
    {
        "id1": 1116,
        "id2": 1125,
        "phenotype_comparison": "Among the\u00a0sod-2\u00a0double deletion mutants, all of the worms maintained the extended lifespan seen in\u00a0sod-2\u00a0single deletion mutants indicating that in no case is the upregulation of another\u00a0sod\u00a0gene entirely responsible for the long life observed in\u00a0sod-2\u00a0mutant worms\u00a0"
    },
    {
        "id1": 1121,
        "id2": 1126,
        "phenotype_comparison": "Among the\u00a0sod-2\u00a0double deletion mutants, all of the worms maintained the extended lifespan seen in\u00a0sod-2\u00a0single deletion mutants indicating that in no case is the upregulation of another\u00a0sod\u00a0gene entirely responsible for the long life observed in\u00a0sod-2\u00a0mutant worms\u00a0"
    },
    {
        "id1": 1116,
        "id2": 1126,
        "phenotype_comparison": "Among the\u00a0sod-2\u00a0double deletion mutants, all of the worms maintained the extended lifespan seen in\u00a0sod-2\u00a0single deletion mutants indicating that in no case is the upregulation of another\u00a0sod\u00a0gene entirely responsible for the long life observed in\u00a0sod-2\u00a0mutant worms\u00a0"
    },
    {
        "id1": 1123,
        "id2": 1127,
        "phenotype_comparison": "Among the\u00a0sod-2\u00a0double deletion mutants, all of the worms maintained the extended lifespan seen in\u00a0sod-2\u00a0single deletion mutants indicating that in no case is the upregulation of another\u00a0sod\u00a0gene entirely responsible for the long life observed in\u00a0sod-2\u00a0mutant worms\u00a0"
    },
    {
        "id1": 1116,
        "id2": 1127,
        "phenotype_comparison": "Among the\u00a0sod-2\u00a0double deletion mutants, all of the worms maintained the extended lifespan seen in\u00a0sod-2\u00a0single deletion mutants indicating that in no case is the upregulation of another\u00a0sod\u00a0gene entirely responsible for the long life observed in\u00a0sod-2\u00a0mutant worms\u00a0"
    },
    {
        "id1": 1123,
        "id2": 1128,
        "phenotype_comparison": "\u00a0sod-3;sod-5\u00a0mutant worms had a similar lifespan to wild-type worms"
    },
    {
        "id1": 1119,
        "id2": 1128,
        "phenotype_comparison": "\u00a0sod-3;sod-5\u00a0mutant worms had a similar lifespan to wild-type worms"
    },
    {
        "id1": 1126,
        "id2": 1129,
        "phenotype_comparison": "Both\u00a0sod-2;sod-3;sod-5\u00a0and\u00a0sod-1;sod-2;sod-4\u00a0mutant worms live significantly longer than wild-type"
    },
    {
        "id1": 1128,
        "id2": 1130,
        "phenotype_comparison": "Examination of worm lifespan revealed that\u00a0sod-1;sod-3;sod-5\u00a0mutant worms live as long as wild-type worms"
    },
    {
        "id1": 1128,
        "id2": 1131,
        "phenotype_comparison": "Both\u00a0sod-2;sod-3;sod-5\u00a0and\u00a0sod-1;sod-2;sod-4\u00a0mutant worms live significantly longer than wild-type"
    },
    {
        "id1": 1115,
        "id2": 1132,
        "phenotype_comparison": ""
    },
    {
        "id1": 1116,
        "id2": 1133,
        "phenotype_comparison": "Deletion of\u00a0sod-2\u00a0did not extend the lifespan of\u00a0daf-2\u00a0worms"
    },
    {
        "id1": 1132,
        "id2": 1133,
        "phenotype_comparison": "Deletion of\u00a0sod-2\u00a0did not extend the lifespan of\u00a0daf-2\u00a0worms"
    },
    {
        "id1": 1115,
        "id2": 1134,
        "phenotype_comparison": ""
    },
    {
        "id1": 1116,
        "id2": 1135,
        "phenotype_comparison": "clk-1\u00a0worms showed a marked extension of lifespan when\u00a0sod-2\u00a0was deleted"
    },
    {
        "id1": 1134,
        "id2": 1135,
        "phenotype_comparison": "clk-1\u00a0worms showed a marked extension of lifespan when\u00a0sod-2\u00a0was deleted"
    },
    {
        "id1": 1115,
        "id2": 1136,
        "phenotype_comparison": ""
    },
    {
        "id1": 1116,
        "id2": 1137,
        "phenotype_comparison": "sod-2\u00a0deletion greatly shortened the lifespan of\u00a0isp-1\u00a0worms such that\u00a0isp-1;sod-2\u00a0worms had a shorter lifespan than wild-type N2 worms"
    },
    {
        "id1": 1136,
        "id2": 1137,
        "phenotype_comparison": "sod-2\u00a0deletion greatly shortened the lifespan of\u00a0isp-1\u00a0worms such that\u00a0isp-1;sod-2\u00a0worms had a shorter lifespan than wild-type N2 worms"
    },
    {
        "id1": 1115,
        "id2": 1138,
        "phenotype_comparison": ""
    },
    {
        "id1": 1116,
        "id2": 1139,
        "phenotype_comparison": "\u00a0eat-2;sod-2\u00a0mutant worms showed a small increase in lifespan compared to\u00a0eat-2\u00a0worms\u00a0"
    },
    {
        "id1": 1138,
        "id2": 1139,
        "phenotype_comparison": "\u00a0eat-2;sod-2\u00a0mutant worms showed a small increase in lifespan compared to\u00a0eat-2\u00a0worms\u00a0"
    },
    {
        "id1": 1115,
        "id2": 1140,
        "phenotype_comparison": ""
    },
    {
        "id1": 1116,
        "id2": 1141,
        "phenotype_comparison": "Deletion of\u00a0sod-2\u00a0in\u00a0glp-1\u00a0worms resulted in a modest increase of mean but not maximum lifespan"
    },
    {
        "id1": 1140,
        "id2": 1141,
        "phenotype_comparison": "Deletion of\u00a0sod-2\u00a0in\u00a0glp-1\u00a0worms resulted in a modest increase of mean but not maximum lifespan"
    },
    {
        "id1": 1142,
        "id2": 1143,
        "phenotype_comparison": ""
    },
    {
        "id1": 1142,
        "id2": 1144,
        "phenotype_comparison": ""
    },
    {
        "id1": 1143,
        "id2": 1145,
        "phenotype_comparison": ""
    },
    {
        "id1": 1144,
        "id2": 1145,
        "phenotype_comparison": "Lifespan extension by hif-1 did not require DAF-16. Inhibition of hif-1 by RNAi extended lifespan of N2 and a daf-16 null mutant to similar levels (18% lifespan extension, p<0.0001)."
    },
    {
        "id1": 1142,
        "id2": 1146,
        "phenotype_comparison": ""
    },
    {
        "id1": 1143,
        "id2": 1147,
        "phenotype_comparison": ""
    },
    {
        "id1": 1146,
        "id2": 1147,
        "phenotype_comparison": "hif-1 RNAi further extended the lifespan of a daf-2 mutant."
    },
    {
        "id1": 1148,
        "id2": 1149,
        "phenotype_comparison": "Inhibition of hif-1 by RNAi did not further extend lifespan of a daf-15 heterozygous mutant."
    },
    {
        "id1": 1150,
        "id2": 1151,
        "phenotype_comparison": ""
    },
    {
        "id1": 1150,
        "id2": 1152,
        "phenotype_comparison": ""
    },
    {
        "id1": 1151,
        "id2": 1153,
        "phenotype_comparison": ""
    },
    {
        "id1": 1152,
        "id2": 1153,
        "phenotype_comparison": "hif-1 did not further extend rsks-1 lifespan."
    },
    {
        "id1": 1150,
        "id2": 1154,
        "phenotype_comparison": ""
    },
    {
        "id1": 1154,
        "id2": 1155,
        "phenotype_comparison": ""
    },
    {
        "id1": 1152,
        "id2": 1155,
        "phenotype_comparison": "The lifespan extension by a deletion mutant of rsks-1 was fully suppressed by egl-9. "
    },
    {
        "id1": 1156,
        "id2": 1154,
        "phenotype_comparison": ""
    },
    {
        "id1": 1156,
        "id2": 1157,
        "phenotype_comparison": ""
    },
    {
        "id1": 1154,
        "id2": 1158,
        "phenotype_comparison": ""
    },
    {
        "id1": 1157,
        "id2": 1158,
        "phenotype_comparison": "The egl-9 mutation significantly suppressed the lifespan extension by a strong loss-of-function allele of eat-2. This suggests that EGL-9 is an important regulator of longevity due to a genetic mimic of DR by the eat-2 mutant."
    },
    {
        "id1": 1150,
        "id2": 1159,
        "phenotype_comparison": ""
    },
    {
        "id1": 1150,
        "id2": 1160,
        "phenotype_comparison": ""
    },
    {
        "id1": 1159,
        "id2": 1161,
        "phenotype_comparison": ""
    },
    {
        "id1": 1160,
        "id2": 1161,
        "phenotype_comparison": "pha-4 RNAi slightly reduced lifespan in both N2 and hif-1 backgrounds, but hif-1 extended lifespan of animals treated with control or pha-4 RNAi to a similar level. Thus, lifespan extension by hif-1 does not require PHA-4."
    },
    {
        "id1": 1162,
        "id2": 1163,
        "phenotype_comparison": ""
    },
    {
        "id1": 1162,
        "id2": 1164,
        "phenotype_comparison": ""
    },
    {
        "id1": 1163,
        "id2": 1165,
        "phenotype_comparison": ""
    },
    {
        "id1": 1164,
        "id2": 1165,
        "phenotype_comparison": "The ire-1 mutation fully suppressed lifespan extension by hif-1 both under AL and under DR conditions"
    },
    {
        "id1": 1166,
        "id2": 1167,
        "phenotype_comparison": ""
    },
    {
        "id1": 1166,
        "id2": 1168,
        "phenotype_comparison": ""
    },
    {
        "id1": 1167,
        "id2": 1169,
        "phenotype_comparison": ""
    },
    {
        "id1": 1168,
        "id2": 1169,
        "phenotype_comparison": "Lifespan extension by ifg-1 RNAi is not dependent on ire-1"
    },
    {
        "id1": 1170,
        "id2": 1171,
        "phenotype_comparison": ""
    },
    {
        "id1": 1170,
        "id2": 1160,
        "phenotype_comparison": ""
    },
    {
        "id1": 1171,
        "id2": 1172,
        "phenotype_comparison": ""
    },
    {
        "id1": 1160,
        "id2": 1172,
        "phenotype_comparison": "RNAi knocking-down of xbp-1, an essential transcription factor downstream of IRE-1 for ER stress response, suppressed the lifespan extension by hif-1."
    },
    {
        "id1": 1173,
        "id2": 1174,
        "phenotype_comparison": ""
    },
    {
        "id1": 1173,
        "id2": 1175,
        "phenotype_comparison": ""
    },
    {
        "id1": 1174,
        "id2": 1176,
        "phenotype_comparison": ""
    },
    {
        "id1": 1175,
        "id2": 1176,
        "phenotype_comparison": "The daf-2 rsks-1 double mutant showed a synergistic lifespan extension by 454% compared to the wild-type N2"
    },
    {
        "id1": 1177,
        "id2": 1178,
        "phenotype_comparison": ""
    },
    {
        "id1": 1177,
        "id2": 1179,
        "phenotype_comparison": ""
    },
    {
        "id1": 1178,
        "id2": 1180,
        "phenotype_comparison": ""
    },
    {
        "id1": 1179,
        "id2": 1180,
        "phenotype_comparison": "The daf-2 rsks-1 double mutant showed a synergistic lifespan extension by 454% compared to the wild-type N2"
    },
    {
        "id1": 1176,
        "id2": 1181,
        "phenotype_comparison": "The daf-16 deletion fully suppressed the prolonged longevity phenotype by daf-2 rsks-1 "
    },
    {
        "id1": 1180,
        "id2": 1182,
        "phenotype_comparison": "The daf-16 deletion fully suppressed the prolonged longevity phenotype by daf-2 rsks-1 "
    },
    {
        "id1": 1183,
        "id2": 1178,
        "phenotype_comparison": ""
    },
    {
        "id1": 1183,
        "id2": 1184,
        "phenotype_comparison": ""
    },
    {
        "id1": 1178,
        "id2": 1185,
        "phenotype_comparison": ""
    },
    {
        "id1": 1184,
        "id2": 1185,
        "phenotype_comparison": "The daf-2 rsks-1 double mutant showed a synergistic lifespan extension compared to the wild-type N2"
    },
    {
        "id1": 1186,
        "id2": 1187,
        "phenotype_comparison": ""
    },
    {
        "id1": 1186,
        "id2": 1188,
        "phenotype_comparison": ""
    },
    {
        "id1": 1187,
        "id2": 1189,
        "phenotype_comparison": ""
    },
    {
        "id1": 1188,
        "id2": 1189,
        "phenotype_comparison": "The daf-2 rsks-1 double mutant showed a synergistic lifespan extension compared to the wild-type N2"
    },
    {
        "id1": 1183,
        "id2": 1190,
        "phenotype_comparison": ""
    },
    {
        "id1": 1190,
        "id2": 1191,
        "phenotype_comparison": ""
    },
    {
        "id1": 1178,
        "id2": 1191,
        "phenotype_comparison": ""
    },
    {
        "id1": 1186,
        "id2": 1190,
        "phenotype_comparison": ""
    },
    {
        "id1": 1190,
        "id2": 1192,
        "phenotype_comparison": ""
    },
    {
        "id1": 1187,
        "id2": 1192,
        "phenotype_comparison": ""
    },
    {
        "id1": 1190,
        "id2": 1193,
        "phenotype_comparison": ""
    },
    {
        "id1": 1184,
        "id2": 1193,
        "phenotype_comparison": ""
    },
    {
        "id1": 1190,
        "id2": 1194,
        "phenotype_comparison": ""
    },
    {
        "id1": 1188,
        "id2": 1194,
        "phenotype_comparison": ""
    },
    {
        "id1": 1185,
        "id2": 1195,
        "phenotype_comparison": "aakg-4, which encodes the gamma regulatory subunit of AMPK, showed the strongest suppression of daf-2 rsks-1 upon inhibition"
    },
    {
        "id1": 1189,
        "id2": 1196,
        "phenotype_comparison": "aakg-4, which encodes the gamma regulatory subunit of AMPK, showed the strongest suppression of daf-2 rsks-1 upon inhibition"
    },
    {
        "id1": 1186,
        "id2": 1197,
        "phenotype_comparison": ""
    },
    {
        "id1": 1186,
        "id2": 1198,
        "phenotype_comparison": ""
    },
    {
        "id1": 1197,
        "id2": 1199,
        "phenotype_comparison": ""
    },
    {
        "id1": 1198,
        "id2": 1199,
        "phenotype_comparison": "The daf-2 rsks-1 double mutant showed a synergistic lifespan extension compared to the wild-type N2"
    },
    {
        "id1": 1200,
        "id2": 1178,
        "phenotype_comparison": ""
    },
    {
        "id1": 1200,
        "id2": 1201,
        "phenotype_comparison": ""
    },
    {
        "id1": 1178,
        "id2": 1202,
        "phenotype_comparison": ""
    },
    {
        "id1": 1201,
        "id2": 1202,
        "phenotype_comparison": "The daf-2 rsks-1 double mutant showed a synergistic lifespan extension compared to the wild-type N2"
    },
    {
        "id1": 1186,
        "id2": 1203,
        "phenotype_comparison": ""
    },
    {
        "id1": 1203,
        "id2": 1204,
        "phenotype_comparison": ""
    },
    {
        "id1": 1197,
        "id2": 1204,
        "phenotype_comparison": ""
    },
    {
        "id1": 1200,
        "id2": 1205,
        "phenotype_comparison": ""
    },
    {
        "id1": 1205,
        "id2": 1206,
        "phenotype_comparison": ""
    },
    {
        "id1": 1178,
        "id2": 1206,
        "phenotype_comparison": ""
    },
    {
        "id1": 1203,
        "id2": 1207,
        "phenotype_comparison": ""
    },
    {
        "id1": 1198,
        "id2": 1207,
        "phenotype_comparison": ""
    },
    {
        "id1": 1205,
        "id2": 1208,
        "phenotype_comparison": ""
    },
    {
        "id1": 1201,
        "id2": 1208,
        "phenotype_comparison": ""
    },
    {
        "id1": 1199,
        "id2": 1209,
        "phenotype_comparison": "A deletion in aak-2, which encodes the alpha catalytic subunit of AMPK suppressed the synergistic longevity of daf-2 and rsks-1"
    },
    {
        "id1": 1202,
        "id2": 1210,
        "phenotype_comparison": "A deletion in aak-2, which encodes the alpha catalytic subunit of AMPK suppressed the synergistic longevity of daf-2 and rsks-1"
    },
    {
        "id1": 1186,
        "id2": 1211,
        "phenotype_comparison": ""
    },
    {
        "id1": 1186,
        "id2": 1212,
        "phenotype_comparison": ""
    },
    {
        "id1": 1211,
        "id2": 1213,
        "phenotype_comparison": ""
    },
    {
        "id1": 1212,
        "id2": 1213,
        "phenotype_comparison": "The daf-2 rsks-1 double mutant showed a synergistic lifespan extension compared to the wild-type N2"
    },
    {
        "id1": 1200,
        "id2": 1214,
        "phenotype_comparison": ""
    },
    {
        "id1": 1200,
        "id2": 1215,
        "phenotype_comparison": ""
    },
    {
        "id1": 1214,
        "id2": 1216,
        "phenotype_comparison": ""
    },
    {
        "id1": 1215,
        "id2": 1216,
        "phenotype_comparison": "The daf-2 rsks-1 double mutant showed a synergistic lifespan extension compared to the wild-type N2"
    },
    {
        "id1": 1186,
        "id2": 1217,
        "phenotype_comparison": ""
    },
    {
        "id1": 1217,
        "id2": 1218,
        "phenotype_comparison": ""
    },
    {
        "id1": 1211,
        "id2": 1218,
        "phenotype_comparison": ""
    },
    {
        "id1": 1200,
        "id2": 1219,
        "phenotype_comparison": ""
    },
    {
        "id1": 1219,
        "id2": 1220,
        "phenotype_comparison": ""
    },
    {
        "id1": 1214,
        "id2": 1220,
        "phenotype_comparison": ""
    },
    {
        "id1": 1217,
        "id2": 1221,
        "phenotype_comparison": ""
    },
    {
        "id1": 1212,
        "id2": 1221,
        "phenotype_comparison": ""
    },
    {
        "id1": 1219,
        "id2": 1222,
        "phenotype_comparison": ""
    },
    {
        "id1": 1215,
        "id2": 1222,
        "phenotype_comparison": ""
    },
    {
        "id1": 1213,
        "id2": 1223,
        "phenotype_comparison": " glp-1(gf) suppressed the synergistic lifespan extension by daf-2 rsks-1."
    },
    {
        "id1": 1216,
        "id2": 1224,
        "phenotype_comparison": " glp-1(gf) suppressed the synergistic lifespan extension by daf-2 rsks-1."
    },
    {
        "id1": 1225,
        "id2": 1226,
        "phenotype_comparison": " Inhibition of daf-12 by RNAi decreased the lifespan of daf-2 rsks-1"
    },
    {
        "id1": 1227,
        "id2": 1228,
        "phenotype_comparison": " Inhibition of daf-12 by RNAi decreased the lifespan of daf-2 rsks-1"
    },
    {
        "id1": 1225,
        "id2": 1229,
        "phenotype_comparison": " Inhibition of kri-1 by RNAi decreased the lifespan of daf-2 rsks-1"
    },
    {
        "id1": 1227,
        "id2": 1230,
        "phenotype_comparison": " Inhibition of kri-1 by RNAi decreased the lifespan of daf-2 rsks-1"
    },
    {
        "id1": 1231,
        "id2": 1232,
        "phenotype_comparison": ""
    },
    {
        "id1": 1233,
        "id2": 1234,
        "phenotype_comparison": ""
    },
    {
        "id1": 1235,
        "id2": 1236,
        "phenotype_comparison": ""
    },
    {
        "id1": 1225,
        "id2": 1237,
        "phenotype_comparison": ""
    },
    {
        "id1": 1238,
        "id2": 1239,
        "phenotype_comparison": ""
    },
    {
        "id1": 1227,
        "id2": 1240,
        "phenotype_comparison": ""
    },
    {
        "id1": 1225,
        "id2": 1241,
        "phenotype_comparison": ""
    },
    {
        "id1": 1238,
        "id2": 1242,
        "phenotype_comparison": ""
    },
    {
        "id1": 1227,
        "id2": 1243,
        "phenotype_comparison": ""
    },
    {
        "id1": 1225,
        "id2": 1244,
        "phenotype_comparison": ""
    },
    {
        "id1": 1238,
        "id2": 1245,
        "phenotype_comparison": ""
    },
    {
        "id1": 1227,
        "id2": 1246,
        "phenotype_comparison": ""
    },
    {
        "id1": 1247,
        "id2": 1248,
        "phenotype_comparison": ""
    },
    {
        "id1": 1247,
        "id2": 1249,
        "phenotype_comparison": ""
    },
    {
        "id1": 1248,
        "id2": 1250,
        "phenotype_comparison": ""
    },
    {
        "id1": 1249,
        "id2": 1250,
        "phenotype_comparison": ""
    },
    {
        "id1": 1247,
        "id2": 1251,
        "phenotype_comparison": ""
    },
    {
        "id1": 1251,
        "id2": 1252,
        "phenotype_comparison": ""
    },
    {
        "id1": 1249,
        "id2": 1252,
        "phenotype_comparison": "Knockdown of pptr-1 resulted in a significant reduction in daf-2(e1370) lifespan"
    },
    {
        "id1": 1253,
        "id2": 1254,
        "phenotype_comparison": ""
    },
    {
        "id1": 1253,
        "id2": 1255,
        "phenotype_comparison": ""
    },
    {
        "id1": 1254,
        "id2": 1256,
        "phenotype_comparison": ""
    },
    {
        "id1": 1255,
        "id2": 1256,
        "phenotype_comparison": ""
    },
    {
        "id1": 1253,
        "id2": 1257,
        "phenotype_comparison": ""
    },
    {
        "id1": 1257,
        "id2": 1258,
        "phenotype_comparison": ""
    },
    {
        "id1": 1255,
        "id2": 1258,
        "phenotype_comparison": "Knockdown of pptr-1 resulted in a significant reduction in daf-2(e1370) lifespan"
    },
    {
        "id1": 1259,
        "id2": 1260,
        "phenotype_comparison": ""
    },
    {
        "id1": 1259,
        "id2": 1261,
        "phenotype_comparison": ""
    },
    {
        "id1": 1260,
        "id2": 1262,
        "phenotype_comparison": ""
    },
    {
        "id1": 1261,
        "id2": 1262,
        "phenotype_comparison": "Although the nhr-80(tm1011) allele does not affect the lifespan of wild type animals, it fully suppresses that of glp-1(e2141ts)mutants."
    },
    {
        "id1": 1263,
        "id2": 1264,
        "phenotype_comparison": ""
    },
    {
        "id1": 1263,
        "id2": 1261,
        "phenotype_comparison": ""
    },
    {
        "id1": 1264,
        "id2": 1265,
        "phenotype_comparison": ""
    },
    {
        "id1": 1261,
        "id2": 1265,
        "phenotype_comparison": "Although the nhr-80(tm1011) allele does not affect the lifespan of wild type animals, it fully suppresses that of glp-1(e2141ts)mutants."
    },
    {
        "id1": 1266,
        "id2": 1267,
        "phenotype_comparison": "daf-2(e1370) mutant animals are long-lived due to a reduction-of-function mutation in the insulin receptor and are not affected by nhr-80 RNAi treatment."
    },
    {
        "id1": 1266,
        "id2": 1268,
        "phenotype_comparison": ""
    },
    {
        "id1": 1269,
        "id2": 1270,
        "phenotype_comparison": "daf-2(e1370) mutant animals are long-lived due to a reduction-of-function mutation in the insulin receptor and are not affected by nhr-80 RNAi treatment."
    },
    {
        "id1": 1269,
        "id2": 1271,
        "phenotype_comparison": ""
    },
    {
        "id1": 1272,
        "id2": 1273,
        "phenotype_comparison": ""
    },
    {
        "id1": 1272,
        "id2": 1274,
        "phenotype_comparison": ""
    },
    {
        "id1": 1273,
        "id2": 1275,
        "phenotype_comparison": ""
    },
    {
        "id1": 1274,
        "id2": 1275,
        "phenotype_comparison": "cyc-1 RNAi, which reduces mitochondrial function, extend longevity to a comparable extent in nhr-80(tm1011) mutants and in wild type animals, suggesting that these pathways are not affected by NHR-80."
    },
    {
        "id1": 1263,
        "id2": 1276,
        "phenotype_comparison": ""
    },
    {
        "id1": 1276,
        "id2": 1277,
        "phenotype_comparison": ""
    },
    {
        "id1": 1264,
        "id2": 1277,
        "phenotype_comparison": "cyc-1 RNAi, which reduces mitochondrial function, extend longevity to a comparable extent in nhr-80(tm1011) mutants and in wild type animals, suggesting that these pathways are not affected by NHR-80."
    },
    {
        "id1": 1278,
        "id2": 1262,
        "phenotype_comparison": ""
    },
    {
        "id1": 1278,
        "id2": 1279,
        "phenotype_comparison": "nhr-80 RNAi  suppresses the lifespan of glp-1(e2141ts) mutant animals"
    },
    {
        "id1": 1261,
        "id2": 1280,
        "phenotype_comparison": "nhr-80 RNAi  suppresses the lifespan of glp-1(e2141ts) mutant animals"
    },
    {
        "id1": 1281,
        "id2": 1282,
        "phenotype_comparison": "nhr-80 RNAi decreases lifespan in daf-16(mu86);glp-1(e2141ts)"
    },
    {
        "id1": 1283,
        "id2": 1284,
        "phenotype_comparison": "nhr-80 RNAi decreases lifespan in daf-16(mu86);glp-1(e2141ts)"
    },
    {
        "id1": 1285,
        "id2": 1286,
        "phenotype_comparison": "Deletion of the fat genes independently in glp-1(e2141ts) mutant animals does not affect longevity "
    },
    {
        "id1": 1285,
        "id2": 1287,
        "phenotype_comparison": ""
    },
    {
        "id1": 1285,
        "id2": 1288,
        "phenotype_comparison": "Deletion of the fat genes independently in glp-1(e2141ts) mutant animals does not affect longevity "
    },
    {
        "id1": 1289,
        "id2": 1290,
        "phenotype_comparison": ""
    },
    {
        "id1": 1289,
        "id2": 1291,
        "phenotype_comparison": ""
    },
    {
        "id1": 1289,
        "id2": 1292,
        "phenotype_comparison": ""
    },
    {
        "id1": 1298,
        "id2": 1299,
        "phenotype_comparison": ""
    },
    {
        "id1": 1298,
        "id2": 1300,
        "phenotype_comparison": ""
    },
    {
        "id1": 1299,
        "id2": 1301,
        "phenotype_comparison": ""
    },
    {
        "id1": 1300,
        "id2": 1301,
        "phenotype_comparison": "fat-2 RNAi does not affect the lifespan of glp-1(e2141ts) mutants"
    },
    {
        "id1": 1298,
        "id2": 1302,
        "phenotype_comparison": ""
    },
    {
        "id1": 1299,
        "id2": 1303,
        "phenotype_comparison": ""
    },
    {
        "id1": 1302,
        "id2": 1303,
        "phenotype_comparison": "fat-2 RNAi does not affect the lifespan of glp-1(e2141ts) mutants"
    },
    {
        "id1": 1304,
        "id2": 1305,
        "phenotype_comparison": ""
    },
    {
        "id1": 1304,
        "id2": 1306,
        "phenotype_comparison": ""
    },
    {
        "id1": 1305,
        "id2": 1307,
        "phenotype_comparison": ""
    },
    {
        "id1": 1306,
        "id2": 1307,
        "phenotype_comparison": "The nhr-80 transgene fails to extend the lifespan of wild type animals, but increases the mean lifespan of glp-1(e2141ts) mutant animals by 80%"
    },
    {
        "id1": 1308,
        "id2": 1309,
        "phenotype_comparison": ""
    },
    {
        "id1": 1308,
        "id2": 1310,
        "phenotype_comparison": ""
    },
    {
        "id1": 1309,
        "id2": 1311,
        "phenotype_comparison": ""
    },
    {
        "id1": 1310,
        "id2": 1311,
        "phenotype_comparison": "The nhr-80 transgene fails to extend the lifespan of wild type animals, but increases the mean lifespan of glp-1(e2141ts) mutant animals by 80%"
    },
    {
        "id1": 1283,
        "id2": 1312,
        "phenotype_comparison": "In daf-16(mu86);glp-1(e2141ts) mutant animals, overexpressing nhr-80 increases lifespan by 40%"
    },
    {
        "id1": 1313,
        "id2": 1314,
        "phenotype_comparison": "In daf-16(mu86);glp-1(e2141ts) mutant animals, overexpressing nhr-80 increases lifespan by 40%"
    },
    {
        "id1": 1315,
        "id2": 1316,
        "phenotype_comparison": "nhr-80 overexpression fails to extend the lifespan of glp-1(e2141ts);daf-12(rh61rh411) mutants"
    },
    {
        "id1": 1317,
        "id2": 1318,
        "phenotype_comparison": "nhr-80 overexpression fails to extend the lifespan of glp-1(e2141ts);daf-12(rh61rh411) mutants"
    },
    {
        "id1": 1319,
        "id2": 1320,
        "phenotype_comparison": "nhr-80 overexpression fails to extend the lifespan of glp-1(e2141ts);daf-12(rh61rh411) mutants"
    },
    {
        "id1": 1321,
        "id2": 1322,
        "phenotype_comparison": "nhr-80 overexpression extends the lifespan of glp-1(e2141ts);daf-9(rh50) mutants."
    },
    {
        "id1": 1321,
        "id2": 1323,
        "phenotype_comparison": "nhr-80 overexpression extends the lifespan of glp-1(e2141ts);daf-9(rh50) mutants."
    },
    {
        "id1": 1324,
        "id2": 1325,
        "phenotype_comparison": "nhr-80 overexpression extends the lifespan of glp-1(e2141ts);daf-9(rh50) mutants."
    },
    {
        "id1": 1326,
        "id2": 1327,
        "phenotype_comparison": ""
    },
    {
        "id1": 1327,
        "id2": 1328,
        "phenotype_comparison": " The nhr-80 transgene fully restores the longevity of glp-1(e2141ts);nhr-80(tm1011) mutant animals."
    },
    {
        "id1": 1261,
        "id2": 1329,
        "phenotype_comparison": ""
    },
    {
        "id1": 1329,
        "id2": 1330,
        "phenotype_comparison": " The nhr-80 transgene fully restores the longevity of glp-1(e2141ts);nhr-80(tm1011) mutant animals."
    },
    {
        "id1": 1331,
        "id2": 1332,
        "phenotype_comparison": ""
    },
    {
        "id1": 1331,
        "id2": 1333,
        "phenotype_comparison": ""
    },
    {
        "id1": 1332,
        "id2": 1334,
        "phenotype_comparison": ""
    },
    {
        "id1": 1333,
        "id2": 1334,
        "phenotype_comparison": "tcer-1 RNAi strongly suppressed the extended lifespan of glp-1 mutants"
    },
    {
        "id1": 1331,
        "id2": 1335,
        "phenotype_comparison": ""
    },
    {
        "id1": 1335,
        "id2": 1336,
        "phenotype_comparison": ""
    },
    {
        "id1": 1333,
        "id2": 1336,
        "phenotype_comparison": ""
    },
    {
        "id1": 1337,
        "id2": 1338,
        "phenotype_comparison": ""
    },
    {
        "id1": 1337,
        "id2": 1339,
        "phenotype_comparison": ""
    },
    {
        "id1": 1338,
        "id2": 1340,
        "phenotype_comparison": ""
    },
    {
        "id1": 1339,
        "id2": 1340,
        "phenotype_comparison": "tcer-1 RNAi strongly suppressed the extended lifespan of glp-1 mutants"
    },
    {
        "id1": 1337,
        "id2": 1335,
        "phenotype_comparison": ""
    },
    {
        "id1": 1335,
        "id2": 1341,
        "phenotype_comparison": ""
    },
    {
        "id1": 1339,
        "id2": 1341,
        "phenotype_comparison": ""
    },
    {
        "id1": 1342,
        "id2": 1343,
        "phenotype_comparison": "tcer-1 RNAi strongly suppressed the extended lifespan of glp-1 mutants"
    },
    {
        "id1": 1342,
        "id2": 1344,
        "phenotype_comparison": ""
    },
    {
        "id1": 1345,
        "id2": 1346,
        "phenotype_comparison": ""
    },
    {
        "id1": 1345,
        "id2": 1347,
        "phenotype_comparison": ""
    },
    {
        "id1": 1346,
        "id2": 1348,
        "phenotype_comparison": ""
    },
    {
        "id1": 1347,
        "id2": 1348,
        "phenotype_comparison": "tcer-1 RNAi strongly suppressed the extended lifespan of glp-1 mutants"
    },
    {
        "id1": 1345,
        "id2": 1349,
        "phenotype_comparison": ""
    },
    {
        "id1": 1349,
        "id2": 1350,
        "phenotype_comparison": ""
    },
    {
        "id1": 1347,
        "id2": 1350,
        "phenotype_comparison": ""
    },
    {
        "id1": 1337,
        "id2": 1351,
        "phenotype_comparison": ""
    },
    {
        "id1": 1337,
        "id2": 1352,
        "phenotype_comparison": ""
    },
    {
        "id1": 1351,
        "id2": 1353,
        "phenotype_comparison": ""
    },
    {
        "id1": 1352,
        "id2": 1353,
        "phenotype_comparison": "tcer-1 RNAi strongly suppressed the extended lifespan of glp-1 mutants"
    },
    {
        "id1": 1335,
        "id2": 1354,
        "phenotype_comparison": ""
    },
    {
        "id1": 1352,
        "id2": 1354,
        "phenotype_comparison": ""
    },
    {
        "id1": 1355,
        "id2": 1356,
        "phenotype_comparison": "tcer-1 RNAi strongly suppressed the extended lifespan of glp-1 mutants"
    },
    {
        "id1": 1355,
        "id2": 1336,
        "phenotype_comparison": ""
    },
    {
        "id1": 1357,
        "id2": 1358,
        "phenotype_comparison": "tcer-1 RNAi strongly suppressed the extended lifespan of glp-1 mutants"
    },
    {
        "id1": 1357,
        "id2": 1350,
        "phenotype_comparison": ""
    },
    {
        "id1": 1359,
        "id2": 1356,
        "phenotype_comparison": "tcer-1 RNAi strongly suppressed the extended lifespan of glp-1 mutants"
    },
    {
        "id1": 1359,
        "id2": 1336,
        "phenotype_comparison": ""
    },
    {
        "id1": 1360,
        "id2": 1361,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1360,
        "id2": 1362,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1360,
        "id2": 1363,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1360,
        "id2": 1364,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1365,
        "id2": 1366,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1365,
        "id2": 1367,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1365,
        "id2": 1368,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1365,
        "id2": 1369,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1370,
        "id2": 1371,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1370,
        "id2": 1372,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1370,
        "id2": 1373,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1370,
        "id2": 1374,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1375,
        "id2": 1376,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1375,
        "id2": 1377,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1375,
        "id2": 1378,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1375,
        "id2": 1379,
        "phenotype_comparison": "tcer-1; glp-1 double mutant had a much shorter lifespan than did glp-1 mutants."
    },
    {
        "id1": 1380,
        "id2": 1381,
        "phenotype_comparison": "Two independent lines expressing the TCER-1::GFP fusion protein completely rescued the lifespan of tcer-1; glp-1 mutants"
    },
    {
        "id1": 1380,
        "id2": 1382,
        "phenotype_comparison": "Two independent lines expressing the TCER-1::GFP fusion protein completely rescued the lifespan of tcer-1; glp-1 mutants"
    },
    {
        "id1": 1368,
        "id2": 1383,
        "phenotype_comparison": ""
    },
    {
        "id1": 1368,
        "id2": 1384,
        "phenotype_comparison": ""
    },
    {
        "id1": 1402,
        "id2": 1403,
        "phenotype_comparison": "Overexpressing tcer-1 in daf-2(e1370) mutants extended their long lifespan by another 6\u201312%"
    },
    {
        "id1": 1404,
        "id2": 1405,
        "phenotype_comparison": " tcer-1 overexpression further extended the lifespan of eat-2(ad1116) mutant"
    },
    {
        "id1": 1404,
        "id2": 1406,
        "phenotype_comparison": " tcer-1 overexpression further extended the lifespan of eat-2(ad1116) mutant"
    },
    {
        "id1": 1407,
        "id2": 1408,
        "phenotype_comparison": ""
    },
    {
        "id1": 1408,
        "id2": 1409,
        "phenotype_comparison": "The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16"
    },
    {
        "id1": 1408,
        "id2": 1410,
        "phenotype_comparison": "The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16"
    },
    {
        "id1": 1411,
        "id2": 1412,
        "phenotype_comparison": ""
    },
    {
        "id1": 1412,
        "id2": 1413,
        "phenotype_comparison": "The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16"
    },
    {
        "id1": 1412,
        "id2": 1414,
        "phenotype_comparison": "The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16"
    },
    {
        "id1": 1415,
        "id2": 1416,
        "phenotype_comparison": ""
    },
    {
        "id1": 1416,
        "id2": 1417,
        "phenotype_comparison": "The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16"
    },
    {
        "id1": 1416,
        "id2": 1410,
        "phenotype_comparison": "The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16"
    },
    {
        "id1": 1412,
        "id2": 1418,
        "phenotype_comparison": "kri-1(ok1251) abolished the lifespan extension evoked by tcer-1overexpression"
    },
    {
        "id1": 1412,
        "id2": 1419,
        "phenotype_comparison": "kri-1(ok1251) abolished the lifespan extension evoked by tcer-1overexpression"
    },
    {
        "id1": 1416,
        "id2": 1420,
        "phenotype_comparison": "kri-1(ok1251) abolished the lifespan extension evoked by tcer-1overexpression"
    },
    {
        "id1": 1416,
        "id2": 1421,
        "phenotype_comparison": "kri-1(ok1251) abolished the lifespan extension evoked by tcer-1overexpression"
    },
    {
        "id1": 1422,
        "id2": 1423,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1422,
        "id2": 1424,
        "phenotype_comparison": ""
    },
    {
        "id1": 1425,
        "id2": 1426,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1425,
        "id2": 1427,
        "phenotype_comparison": ""
    },
    {
        "id1": 1428,
        "id2": 1429,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1428,
        "id2": 1430,
        "phenotype_comparison": ""
    },
    {
        "id1": 1431,
        "id2": 1432,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1431,
        "id2": 1433,
        "phenotype_comparison": ""
    },
    {
        "id1": 1434,
        "id2": 1435,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1434,
        "id2": 1436,
        "phenotype_comparison": ""
    },
    {
        "id1": 1437,
        "id2": 1438,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1437,
        "id2": 1439,
        "phenotype_comparison": "The longevity response to caloric restriction caused by the feeding-defective mutant eat-2(ad1116) is daf-16 independent"
    },
    {
        "id1": 1440,
        "id2": 1441,
        "phenotype_comparison": "tcer-1 was not required for eat-2 mutation to extend lifespan"
    },
    {
        "id1": 1442,
        "id2": 1443,
        "phenotype_comparison": "tcer-1 was not required for eat-2 mutation to extend lifespan"
    },
    {
        "id1": 1444,
        "id2": 1445,
        "phenotype_comparison": "tcer-1 was not required for isp-1 mutation to extend lifespan"
    },
    {
        "id1": 1444,
        "id2": 1446,
        "phenotype_comparison": "The longevity response to caloric restriction  to inhibition of mitochondrial respiration caused by isp-1(qm150) is daf-16 independent"
    },
    {
        "id1": 1447,
        "id2": 1448,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1449,
        "id2": 1450,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1451,
        "id2": 1452,
        "phenotype_comparison": ""
    },
    {
        "id1": 1452,
        "id2": 1453,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1454,
        "id2": 1455,
        "phenotype_comparison": "Neither tcer-1(tm1452) nor tcer-1 RNAi suppressed the extended lifespans of the insulin/IGF-1-receptor mutants daf-2(e1370) or daf-2(e1368)"
    },
    {
        "id1": 1531,
        "id2": 1532,
        "phenotype_comparison": "The median overall survival of Bub3+/- and Rae1+/- mice was slightly reduced in comparison with wild-type animals (24 vs. 25 mo, respectively), but these differences were not significant. In contrast, the median survival of Bub3+/-/Rae1+/- mice was significantly reduced to 22 mo, which translates into a 12% decrease in lifespan. The reduced lifespan of Bub3+/-/Rae1+/- mice may be the result of the sum of the lifespan reductions in Bub3+/- and Rae1+/- mice."
    },
    {
        "id1": 1556,
        "id2": 1557,
        "phenotype_comparison": "Homozygous and heterozygous knock out of Ku70, Ku80, or both results in identical premature aging phenotypes without substantially increasing the incidence of cancer."
    },
    {
        "id1": 1580,
        "id2": 1583,
        "phenotype_comparison": "Heterozygosity of Trp53 rescues in part the extremely reduced longevity of Sirt6-deficient (Sirt6-/-) male mice."
    },
    {
        "id1": 1617,
        "id2": 1619,
        "phenotype_comparison": ""
    },
    {
        "id1": 1630,
        "id2": 1637,
        "phenotype_comparison": "The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway"
    },
    {
        "id1": 1622,
        "id2": 1655,
        "phenotype_comparison": " utx-1 RNAi can still further extend life span of the germline lacking glp-1(e2141) mutant"
    },
    {
        "id1": 1675,
        "id2": 1676,
        "phenotype_comparison": ""
    },
    {
        "id1": 1701,
        "id2": 1705,
        "phenotype_comparison": ""
    },
    {
        "id1": 1729,
        "id2": 1730,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1753,
        "id2": 1754,
        "phenotype_comparison": ""
    },
    {
        "id1": 1798,
        "id2": 1799,
        "phenotype_comparison": ""
    },
    {
        "id1": 1828,
        "id2": 1829,
        "phenotype_comparison": ""
    },
    {
        "id1": 1854,
        "id2": 1855,
        "phenotype_comparison": "Eak-7 mutants live longer than wild-type animals, and this phenotype requires daf-16/FoxO, as well as the protein phosphatase 4 regulatory subunit SMK-1 and the heat-shock transcription factor HSF-1"
    },
    {
        "id1": 1873,
        "id2": 1874,
        "phenotype_comparison": ""
    },
    {
        "id1": 1892,
        "id2": 1893,
        "phenotype_comparison": ""
    },
    {
        "id1": 1912,
        "id2": 1914,
        "phenotype_comparison": ""
    },
    {
        "id1": 1930,
        "id2": 1934,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1953,
        "phenotype_comparison": ""
    },
    {
        "id1": 1968,
        "id2": 1969,
        "phenotype_comparison": ""
    },
    {
        "id1": 1985,
        "id2": 1987,
        "phenotype_comparison": ""
    },
    {
        "id1": 2001,
        "id2": 2003,
        "phenotype_comparison": ""
    },
    {
        "id1": 2023,
        "id2": 2024,
        "phenotype_comparison": "elt-3(RNAi) suppresses the longevity phenotype of eat-2(ad1116) mutants, which have a defect in pharyngeal pumping that results in dietary restriction."
    },
    {
        "id1": 2046,
        "id2": 2048,
        "phenotype_comparison": ""
    },
    {
        "id1": 2071,
        "id2": 2069,
        "phenotype_comparison": ""
    },
    {
        "id1": 2098,
        "id2": 2101,
        "phenotype_comparison": ""
    },
    {
        "id1": 2121,
        "id2": 2123,
        "phenotype_comparison": ""
    },
    {
        "id1": 2142,
        "id2": 2144,
        "phenotype_comparison": ""
    },
    {
        "id1": 2144,
        "id2": 2161,
        "phenotype_comparison": "mekk-3 RNAi significantly increased the lifespan of gas-1(fc21), a mutant in the NADH:ubiquinone oxidoreductase 49 kD subunit of Complex I."
    },
    {
        "id1": 2182,
        "id2": 2184,
        "phenotype_comparison": ""
    },
    {
        "id1": 2182,
        "id2": 2200,
        "phenotype_comparison": ""
    },
    {
        "id1": 2220,
        "id2": 2221,
        "phenotype_comparison": ""
    },
    {
        "id1": 2140,
        "id2": 2243,
        "phenotype_comparison": "mekk-3 RNAi had limited effect on the lifespan of RNAi-deficient rde-1(ne219)."
    },
    {
        "id1": 2258,
        "id2": 2260,
        "phenotype_comparison": ""
    },
    {
        "id1": 2284,
        "id2": 2285,
        "phenotype_comparison": ""
    },
    {
        "id1": 2309,
        "id2": 2311,
        "phenotype_comparison": ""
    },
    {
        "id1": 2333,
        "id2": 2335,
        "phenotype_comparison": ""
    },
    {
        "id1": 2361,
        "id2": 2363,
        "phenotype_comparison": ""
    },
    {
        "id1": 2384,
        "id2": 2385,
        "phenotype_comparison": ""
    },
    {
        "id1": 2406,
        "id2": 2408,
        "phenotype_comparison": ""
    },
    {
        "id1": 2437,
        "id2": 2438,
        "phenotype_comparison": ""
    },
    {
        "id1": 2460,
        "id2": 2462,
        "phenotype_comparison": ""
    },
    {
        "id1": 2479,
        "id2": 2480,
        "phenotype_comparison": "The deletion of gcy-33 did not affect N2 worms\u2019 lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609)."
    },
    {
        "id1": 1533,
        "id2": 1534,
        "phenotype_comparison": ""
    },
    {
        "id1": 1618,
        "id2": 1619,
        "phenotype_comparison": "While utx-1 RNAi effectively extended the life span of wild-type N2 strain, such an effect could not be observed in any mutant on IIS pathway; utx-1 RNAi could not further increase the life span of daf-2(e1370) worms and could not at all increase the life span in daf-16(mu86) mutant animals."
    },
    {
        "id1": 1616,
        "id2": 1638,
        "phenotype_comparison": ""
    },
    {
        "id1": 1628,
        "id2": 1656,
        "phenotype_comparison": ""
    },
    {
        "id1": 1675,
        "id2": 1677,
        "phenotype_comparison": ""
    },
    {
        "id1": 1706,
        "id2": 1707,
        "phenotype_comparison": ""
    },
    {
        "id1": 1731,
        "id2": 1732,
        "phenotype_comparison": ""
    },
    {
        "id1": 1753,
        "id2": 1755,
        "phenotype_comparison": ""
    },
    {
        "id1": 1776,
        "id2": 1778,
        "phenotype_comparison": ""
    },
    {
        "id1": 1798,
        "id2": 1800,
        "phenotype_comparison": ""
    },
    {
        "id1": 1828,
        "id2": 1830,
        "phenotype_comparison": ""
    },
    {
        "id1": 1852,
        "id2": 1856,
        "phenotype_comparison": ""
    },
    {
        "id1": 1873,
        "id2": 1875,
        "phenotype_comparison": ""
    },
    {
        "id1": 1892,
        "id2": 1894,
        "phenotype_comparison": ""
    },
    {
        "id1": 1913,
        "id2": 1915,
        "phenotype_comparison": ""
    },
    {
        "id1": 1931,
        "id2": 1935,
        "phenotype_comparison": ""
    },
    {
        "id1": 1952,
        "id2": 1954,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1970,
        "phenotype_comparison": ""
    },
    {
        "id1": 1986,
        "id2": 1987,
        "phenotype_comparison": ""
    },
    {
        "id1": 2002,
        "id2": 2004,
        "phenotype_comparison": ""
    },
    {
        "id1": 2025,
        "id2": 2026,
        "phenotype_comparison": ""
    },
    {
        "id1": 2047,
        "id2": 2049,
        "phenotype_comparison": ""
    },
    {
        "id1": 2071,
        "id2": 2072,
        "phenotype_comparison": ""
    },
    {
        "id1": 2100,
        "id2": 2101,
        "phenotype_comparison": ""
    },
    {
        "id1": 2122,
        "id2": 2123,
        "phenotype_comparison": "The lifespan extension observed on knocking down mekk-3 does not require daf-16."
    },
    {
        "id1": 2143,
        "id2": 2145,
        "phenotype_comparison": ""
    },
    {
        "id1": 2162,
        "id2": 2163,
        "phenotype_comparison": ""
    },
    {
        "id1": 2183,
        "id2": 2185,
        "phenotype_comparison": ""
    },
    {
        "id1": 2200,
        "id2": 2201,
        "phenotype_comparison": ""
    },
    {
        "id1": 2222,
        "id2": 2223,
        "phenotype_comparison": ""
    },
    {
        "id1": 2162,
        "id2": 2240,
        "phenotype_comparison": ""
    },
    {
        "id1": 2259,
        "id2": 2261,
        "phenotype_comparison": ""
    },
    {
        "id1": 2285,
        "id2": 2286,
        "phenotype_comparison": ""
    },
    {
        "id1": 2310,
        "id2": 2311,
        "phenotype_comparison": "RNAi treatment of ddl-1 failed to produce any significant lifespan extension on hsf-1(sy441) mutants, while reducing expression of ddl-1 by RNAi extends lifespan in wild type. This finding suggests that hsf-1 is required for the extended lifespan observed in ddl-1 RNAi treated animals."
    },
    {
        "id1": 2334,
        "id2": 2335,
        "phenotype_comparison": "Inhibition of ddl-1 does not further increase the lifespan of hsb-1(cg116) mutants, while it typically increases N2 lifespan by up to 33%."
    },
    {
        "id1": 2362,
        "id2": 2363,
        "phenotype_comparison": "Over-expression of eIF4H/drr-2 did not have any effect on the lifespan of S6K/rsks-1 RNAi animals. Although S6K is known to act downstream of TOR to regulate translation by modulating the activity of several eIFs, this finding suggests that eIF4H/DRR-2 might be regulated by TOR via an S6K-independent pathway."
    },
    {
        "id1": 2384,
        "id2": 2386,
        "phenotype_comparison": ""
    },
    {
        "id1": 2407,
        "id2": 2409,
        "phenotype_comparison": ""
    },
    {
        "id1": 2461,
        "id2": 2463,
        "phenotype_comparison": ""
    },
    {
        "id1": 2464,
        "id2": 2477,
        "phenotype_comparison": ""
    },
    {
        "id1": 2495,
        "id2": 2496,
        "phenotype_comparison": "Growing the worms on live OP50 at 25\u00b0C shortened the lifespan of all strains. The lifespans of gcy-35, and npr-1(ad609) mutants grown in this environment were similar to N2 controls. "
    },
    {
        "id1": 2520,
        "id2": 2521,
        "phenotype_comparison": ""
    },
    {
        "id1": 2541,
        "id2": 2548,
        "phenotype_comparison": ""
    },
    {
        "id1": 2542,
        "id2": 2558,
        "phenotype_comparison": "The lifespan of daf-2(e1370) mutants was not further extended by npr-1 loss of function, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1 takes place through overlapping mechanisms."
    },
    {
        "id1": 2581,
        "id2": 2582,
        "phenotype_comparison": ""
    },
    {
        "id1": 2569,
        "id2": 2593,
        "phenotype_comparison": ""
    },
    {
        "id1": 2610,
        "id2": 2615,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2646,
        "phenotype_comparison": ""
    },
    {
        "id1": 2670,
        "id2": 2671,
        "phenotype_comparison": ""
    },
    {
        "id1": 2692,
        "id2": 2701,
        "phenotype_comparison": ""
    },
    {
        "id1": 2692,
        "id2": 2732,
        "phenotype_comparison": ""
    },
    {
        "id1": 2764,
        "id2": 2765,
        "phenotype_comparison": ""
    },
    {
        "id1": 2774,
        "id2": 2790,
        "phenotype_comparison": ""
    },
    {
        "id1": 2819,
        "id2": 2820,
        "phenotype_comparison": ""
    },
    {
        "id1": 2840,
        "id2": 2848,
        "phenotype_comparison": ""
    },
    {
        "id1": 2877,
        "id2": 2878,
        "phenotype_comparison": ""
    },
    {
        "id1": 2901,
        "id2": 2902,
        "phenotype_comparison": "Maternal RNAi of atg-3 significantly extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2897,
        "id2": 2917,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2933,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2947,
        "phenotype_comparison": ""
    },
    {
        "id1": 2964,
        "id2": 2967,
        "phenotype_comparison": ""
    },
    {
        "id1": 2993,
        "id2": 2995,
        "phenotype_comparison": ""
    },
    {
        "id1": 3014,
        "id2": 3015,
        "phenotype_comparison": ""
    },
    {
        "id1": 3032,
        "id2": 3036,
        "phenotype_comparison": ""
    },
    {
        "id1": 3058,
        "id2": 3060,
        "phenotype_comparison": ""
    },
    {
        "id1": 3077,
        "id2": 3078,
        "phenotype_comparison": ""
    },
    {
        "id1": 3091,
        "id2": 3092,
        "phenotype_comparison": ""
    },
    {
        "id1": 3108,
        "id2": 3112,
        "phenotype_comparison": ""
    },
    {
        "id1": 3133,
        "id2": 3134,
        "phenotype_comparison": ""
    },
    {
        "id1": 3155,
        "id2": 3156,
        "phenotype_comparison": "Inactivation of pek-1 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3172,
        "id2": 3174,
        "phenotype_comparison": "Inactivation of abu-11 by RNAi did not shorten the lifespan of daf-2 mutants, whereas it did shorten the lifespan of wild type. "
    },
    {
        "id1": 3187,
        "id2": 3191,
        "phenotype_comparison": ""
    },
    {
        "id1": 3057,
        "id2": 3209,
        "phenotype_comparison": ""
    },
    {
        "id1": 3222,
        "id2": 3223,
        "phenotype_comparison": ""
    },
    {
        "id1": 3243,
        "id2": 3244,
        "phenotype_comparison": ""
    },
    {
        "id1": 3267,
        "id2": 3268,
        "phenotype_comparison": ""
    },
    {
        "id1": 3283,
        "id2": 3285,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3299,
        "id2": 3301,
        "phenotype_comparison": ""
    },
    {
        "id1": 3298,
        "id2": 3315,
        "phenotype_comparison": ""
    },
    {
        "id1": 3333,
        "id2": 3335,
        "phenotype_comparison": ""
    },
    {
        "id1": 3361,
        "id2": 3362,
        "phenotype_comparison": "Inactivation of the NF1 gene reduced life spans in females. NF1 mutant strains (NF1 and NF1 ) and their intercross (NF1 p1/p2) showed shorter life spans than the control K33."
    },
    {
        "id1": 1533,
        "id2": 1535,
        "phenotype_comparison": ""
    },
    {
        "id1": 1560,
        "id2": 1561,
        "phenotype_comparison": ""
    },
    {
        "id1": 1584,
        "id2": 1586,
        "phenotype_comparison": ""
    },
    {
        "id1": 1620,
        "id2": 1621,
        "phenotype_comparison": ""
    },
    {
        "id1": 1638,
        "id2": 1639,
        "phenotype_comparison": ""
    },
    {
        "id1": 1656,
        "id2": 1657,
        "phenotype_comparison": ""
    },
    {
        "id1": 1675,
        "id2": 1678,
        "phenotype_comparison": ""
    },
    {
        "id1": 1706,
        "id2": 1708,
        "phenotype_comparison": ""
    },
    {
        "id1": 1731,
        "id2": 1733,
        "phenotype_comparison": ""
    },
    {
        "id1": 1754,
        "id2": 1756,
        "phenotype_comparison": ""
    },
    {
        "id1": 1777,
        "id2": 1779,
        "phenotype_comparison": ""
    },
    {
        "id1": 1798,
        "id2": 1801,
        "phenotype_comparison": ""
    },
    {
        "id1": 1828,
        "id2": 1831,
        "phenotype_comparison": ""
    },
    {
        "id1": 1853,
        "id2": 1857,
        "phenotype_comparison": ""
    },
    {
        "id1": 1874,
        "id2": 1876,
        "phenotype_comparison": ""
    },
    {
        "id1": 1893,
        "id2": 1895,
        "phenotype_comparison": ""
    },
    {
        "id1": 1914,
        "id2": 1915,
        "phenotype_comparison": "The rle-1(tm2447) mutation does not extend lifespan."
    },
    {
        "id1": 1934,
        "id2": 1935,
        "phenotype_comparison": "ftt-2 RNAi do not significantly shorten the life span of daf-16(mgDf50) animals."
    },
    {
        "id1": 1953,
        "id2": 1954,
        "phenotype_comparison": ""
    },
    {
        "id1": 1967,
        "id2": 1971,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1988,
        "phenotype_comparison": ""
    },
    {
        "id1": 2003,
        "id2": 2004,
        "phenotype_comparison": "If a GATA transcription factor functions specifically to extend life span rather than shorten it, then RNAi treatment may suppress the longevity of a long-lived mutant such as daf-2(e1370) without causing nonspecific early lethality of wild-type worms. Of the ten GATA transcription factor genes, we found that RNAi treatment of three (elt-3, egr-1, and egl-27) behave in this way in multiple independent life span experiments"
    },
    {
        "id1": 2025,
        "id2": 2027,
        "phenotype_comparison": ""
    },
    {
        "id1": 2048,
        "id2": 2049,
        "phenotype_comparison": "RNAi reduction of pha-4 suppressed the increased longevity of worms overexpressing wwp-1"
    },
    {
        "id1": 2073,
        "id2": 2074,
        "phenotype_comparison": ""
    },
    {
        "id1": 2046,
        "id2": 2102,
        "phenotype_comparison": ""
    },
    {
        "id1": 2111,
        "id2": 2124,
        "phenotype_comparison": ""
    },
    {
        "id1": 2144,
        "id2": 2145,
        "phenotype_comparison": "mekk-3 RNAi failed to increase the long lifespans of eat-2(ad1116) to the same extent as in WT, suggesting that they may function in the same genetic pathway for lifespan regulation."
    },
    {
        "id1": 2162,
        "id2": 2164,
        "phenotype_comparison": ""
    },
    {
        "id1": 2184,
        "id2": 2185,
        "phenotype_comparison": "mekk-3 RNAi failed to extend the lifespan of nhr-49(ok2165) significantly."
    },
    {
        "id1": 2184,
        "id2": 2201,
        "phenotype_comparison": "mekk-3 RNAi failed to extend lifespan in ahr-1(ia3) to the same extent as in WT worms."
    },
    {
        "id1": 2224,
        "id2": 2225,
        "phenotype_comparison": ""
    },
    {
        "id1": 2164,
        "id2": 2241,
        "phenotype_comparison": "mekk-3 RNAi had limited effect on the lifespan of RNAi-deficient rde-1(ne219)."
    },
    {
        "id1": 2260,
        "id2": 2261,
        "phenotype_comparison": "RNAi knock-down of mekk-3 increased lifespan of daf-2(e1370) shifted to 25 \u00b0C at L3 when IIS completely shuts down."
    },
    {
        "id1": 2284,
        "id2": 2287,
        "phenotype_comparison": ""
    },
    {
        "id1": 2312,
        "id2": 2313,
        "phenotype_comparison": ""
    },
    {
        "id1": 2336,
        "id2": 2337,
        "phenotype_comparison": ""
    },
    {
        "id1": 2364,
        "id2": 2365,
        "phenotype_comparison": ""
    },
    {
        "id1": 2385,
        "id2": 2387,
        "phenotype_comparison": ""
    },
    {
        "id1": 2406,
        "id2": 2410,
        "phenotype_comparison": ""
    },
    {
        "id1": 2429,
        "id2": 2439,
        "phenotype_comparison": ""
    },
    {
        "id1": 2462,
        "id2": 2463,
        "phenotype_comparison": ""
    },
    {
        "id1": 2465,
        "id2": 2481,
        "phenotype_comparison": ""
    },
    {
        "id1": 2497,
        "id2": 2498,
        "phenotype_comparison": ""
    },
    {
        "id1": 2521,
        "id2": 2522,
        "phenotype_comparison": ""
    },
    {
        "id1": 2543,
        "id2": 2549,
        "phenotype_comparison": ""
    },
    {
        "id1": 2537,
        "id2": 2559,
        "phenotype_comparison": "The lifespan of daf-2(e1370) mutants was not further extended by either npr-1 loss of function or the joint loss of function of npr-1/gcy-35, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1/gcy-35 takes place through overlapping mechanisms."
    },
    {
        "id1": 2568,
        "id2": 2583,
        "phenotype_comparison": ""
    },
    {
        "id1": 2610,
        "id2": 2616,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2647,
        "phenotype_comparison": ""
    },
    {
        "id1": 2670,
        "id2": 2672,
        "phenotype_comparison": ""
    },
    {
        "id1": 2702,
        "id2": 2703,
        "phenotype_comparison": ""
    },
    {
        "id1": 2694,
        "id2": 2733,
        "phenotype_comparison": ""
    },
    {
        "id1": 2766,
        "id2": 2767,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2791,
        "phenotype_comparison": ""
    },
    {
        "id1": 2796,
        "id2": 2821,
        "phenotype_comparison": ""
    },
    {
        "id1": 2838,
        "id2": 2849,
        "phenotype_comparison": ""
    },
    {
        "id1": 2879,
        "id2": 2880,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2903,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2918,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2934,
        "phenotype_comparison": ""
    },
    {
        "id1": 2946,
        "id2": 2947,
        "phenotype_comparison": "RNAi suppression of atg-9 after development extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2968,
        "id2": 2969,
        "phenotype_comparison": ""
    },
    {
        "id1": 2994,
        "id2": 2995,
        "phenotype_comparison": ""
    },
    {
        "id1": 3014,
        "id2": 3016,
        "phenotype_comparison": ""
    },
    {
        "id1": 3035,
        "id2": 3036,
        "phenotype_comparison": ""
    },
    {
        "id1": 3059,
        "id2": 3060,
        "phenotype_comparison": ""
    },
    {
        "id1": 3077,
        "id2": 3079,
        "phenotype_comparison": ""
    },
    {
        "id1": 3091,
        "id2": 3093,
        "phenotype_comparison": ""
    },
    {
        "id1": 3111,
        "id2": 3112,
        "phenotype_comparison": "Inactivation of ire-1 by RNAi shortened the lifespan of daf-2 mutants. In both wild-type and daf-2(-) backgrounds, animals subjected to ire-1 RNAi appeared normal and healthy, whereas ire-1(ok799)\u2013null mutants had morphological and behavioral defects. Thus, whereas complete loss of ire-1 compromised the health of the animal, partial loss of ire-1, through RNAi, could shorten lifespan without making the animals appear unhealthy. "
    },
    {
        "id1": 3135,
        "id2": 3136,
        "phenotype_comparison": ""
    },
    {
        "id1": 3157,
        "id2": 3158,
        "phenotype_comparison": ""
    },
    {
        "id1": 3144,
        "id2": 3175,
        "phenotype_comparison": ""
    },
    {
        "id1": 3188,
        "id2": 3192,
        "phenotype_comparison": ""
    },
    {
        "id1": 3209,
        "id2": 3210,
        "phenotype_comparison": ""
    },
    {
        "id1": 3061,
        "id2": 3223,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the eat-2 mutation by an average of less than 20%."
    },
    {
        "id1": 3244,
        "id2": 3242,
        "phenotype_comparison": ""
    },
    {
        "id1": 3267,
        "id2": 3269,
        "phenotype_comparison": ""
    },
    {
        "id1": 3281,
        "id2": 3286,
        "phenotype_comparison": ""
    },
    {
        "id1": 3300,
        "id2": 3301,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3315,
        "id2": 3316,
        "phenotype_comparison": ""
    },
    {
        "id1": 3334,
        "id2": 3335,
        "phenotype_comparison": "mNSC-ablated flies are long-lived and females show reduced fecundity."
    },
    {
        "id1": 3363,
        "id2": 3364,
        "phenotype_comparison": ""
    },
    {
        "id1": 1536,
        "id2": 1537,
        "phenotype_comparison": ""
    },
    {
        "id1": 1561,
        "id2": 1562,
        "phenotype_comparison": ""
    },
    {
        "id1": 1585,
        "id2": 1587,
        "phenotype_comparison": ""
    },
    {
        "id1": 1620,
        "id2": 1622,
        "phenotype_comparison": ""
    },
    {
        "id1": 1618,
        "id2": 1639,
        "phenotype_comparison": "The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway"
    },
    {
        "id1": 1630,
        "id2": 1657,
        "phenotype_comparison": " utx-1 RNAi can still further extend life span of the germline lacking glp-1(e2141) mutant"
    },
    {
        "id1": 1679,
        "id2": 1680,
        "phenotype_comparison": ""
    },
    {
        "id1": 1706,
        "id2": 1709,
        "phenotype_comparison": ""
    },
    {
        "id1": 1732,
        "id2": 1734,
        "phenotype_comparison": ""
    },
    {
        "id1": 1755,
        "id2": 1756,
        "phenotype_comparison": ""
    },
    {
        "id1": 1776,
        "id2": 1780,
        "phenotype_comparison": ""
    },
    {
        "id1": 1798,
        "id2": 1802,
        "phenotype_comparison": ""
    },
    {
        "id1": 1828,
        "id2": 1832,
        "phenotype_comparison": ""
    },
    {
        "id1": 1856,
        "id2": 1857,
        "phenotype_comparison": "Eak-7 mutants live longer than wild-type animals, and this phenotype requires daf-16/FoxO, as well as the protein phosphatase 4 regulatory subunit SMK-1 and the heat-shock transcription factor HSF-1"
    },
    {
        "id1": 1875,
        "id2": 1876,
        "phenotype_comparison": "Lifespan extension in eak-7 null mutants does not require eak-3 activity. "
    },
    {
        "id1": 1894,
        "id2": 1895,
        "phenotype_comparison": "The lifespan extension phenotype of eak-7 mutants is suppressed by RNAi of smk-1."
    },
    {
        "id1": 1916,
        "id2": 1917,
        "phenotype_comparison": ""
    },
    {
        "id1": 1930,
        "id2": 1936,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1955,
        "phenotype_comparison": ""
    },
    {
        "id1": 1970,
        "id2": 1971,
        "phenotype_comparison": ""
    },
    {
        "id1": 1985,
        "id2": 1989,
        "phenotype_comparison": ""
    },
    {
        "id1": 2001,
        "id2": 2005,
        "phenotype_comparison": ""
    },
    {
        "id1": 2026,
        "id2": 2024,
        "phenotype_comparison": ""
    },
    {
        "id1": 2046,
        "id2": 2050,
        "phenotype_comparison": ""
    },
    {
        "id1": 2074,
        "id2": 2075,
        "phenotype_comparison": ""
    },
    {
        "id1": 2047,
        "id2": 2103,
        "phenotype_comparison": ""
    },
    {
        "id1": 2124,
        "id2": 2125,
        "phenotype_comparison": ""
    },
    {
        "id1": 2142,
        "id2": 2146,
        "phenotype_comparison": ""
    },
    {
        "id1": 2163,
        "id2": 2165,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2186,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2202,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2226,
        "phenotype_comparison": ""
    },
    {
        "id1": 2244,
        "id2": 2240,
        "phenotype_comparison": ""
    },
    {
        "id1": 2262,
        "id2": 2263,
        "phenotype_comparison": ""
    },
    {
        "id1": 2287,
        "id2": 2288,
        "phenotype_comparison": ""
    },
    {
        "id1": 2312,
        "id2": 2314,
        "phenotype_comparison": ""
    },
    {
        "id1": 2336,
        "id2": 2338,
        "phenotype_comparison": ""
    },
    {
        "id1": 2364,
        "id2": 2366,
        "phenotype_comparison": ""
    },
    {
        "id1": 2386,
        "id2": 2387,
        "phenotype_comparison": "pha-4 is not required for eIF4H/drr-2 inhibition to extend lifespan, as the RNAi of eIF4H/drr-2 extends lifespan to a similar extent in the pha-4(zu225) mutant background compared to that in wild types."
    },
    {
        "id1": 2406,
        "id2": 2411,
        "phenotype_comparison": ""
    },
    {
        "id1": 2464,
        "id2": 2465,
        "phenotype_comparison": ""
    },
    {
        "id1": 2477,
        "id2": 2481,
        "phenotype_comparison": "The deletion of gcy-33 did not affect N2 worms\u2019 lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609)."
    },
    {
        "id1": 2497,
        "id2": 2499,
        "phenotype_comparison": ""
    },
    {
        "id1": 2523,
        "id2": 2524,
        "phenotype_comparison": ""
    },
    {
        "id1": 2536,
        "id2": 2550,
        "phenotype_comparison": ""
    },
    {
        "id1": 2540,
        "id2": 2560,
        "phenotype_comparison": "The lifespan of daf-2(e1370) mutants was not further extended by either npr-1 loss of function or the joint loss of function of npr-1/gcy-35, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1/gcy-35 takes place through overlapping mechanisms."
    },
    {
        "id1": 2582,
        "id2": 2583,
        "phenotype_comparison": "N2 worms bearing the hif-1(ia4) deletion allele lived significantly longer than N2 controls . By contrast, the deletion of hif-1 shortened the lifespans of npr-1(ad609) mutants to less than that of N2, suggesting that the beneficial effect of HIF-1 on worm lifespan is mediated by NPR-1(215V) activity."
    },
    {
        "id1": 2572,
        "id2": 2594,
        "phenotype_comparison": ""
    },
    {
        "id1": 2610,
        "id2": 2617,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2648,
        "phenotype_comparison": ""
    },
    {
        "id1": 2670,
        "id2": 2673,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2704,
        "phenotype_comparison": ""
    },
    {
        "id1": 2721,
        "id2": 2734,
        "phenotype_comparison": ""
    },
    {
        "id1": 2757,
        "id2": 2768,
        "phenotype_comparison": ""
    },
    {
        "id1": 2774,
        "id2": 2792,
        "phenotype_comparison": ""
    },
    {
        "id1": 2822,
        "id2": 2823,
        "phenotype_comparison": ""
    },
    {
        "id1": 2840,
        "id2": 2850,
        "phenotype_comparison": ""
    },
    {
        "id1": 2877,
        "id2": 2881,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2904,
        "phenotype_comparison": ""
    },
    {
        "id1": 2917,
        "id2": 2918,
        "phenotype_comparison": "Maternal RNAi of atg-9 significantly extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2933,
        "id2": 2934,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2948,
        "phenotype_comparison": ""
    },
    {
        "id1": 2968,
        "id2": 2970,
        "phenotype_comparison": ""
    },
    {
        "id1": 2996,
        "id2": 2997,
        "phenotype_comparison": ""
    },
    {
        "id1": 2996,
        "id2": 3017,
        "phenotype_comparison": ""
    },
    {
        "id1": 3037,
        "id2": 3038,
        "phenotype_comparison": ""
    },
    {
        "id1": 3057,
        "id2": 3061,
        "phenotype_comparison": ""
    },
    {
        "id1": 3078,
        "id2": 3080,
        "phenotype_comparison": ""
    },
    {
        "id1": 3093,
        "id2": 3094,
        "phenotype_comparison": ""
    },
    {
        "id1": 3113,
        "id2": 3114,
        "phenotype_comparison": ""
    },
    {
        "id1": 3135,
        "id2": 3137,
        "phenotype_comparison": ""
    },
    {
        "id1": 3157,
        "id2": 3159,
        "phenotype_comparison": ""
    },
    {
        "id1": 3144,
        "id2": 3176,
        "phenotype_comparison": ""
    },
    {
        "id1": 3191,
        "id2": 3192,
        "phenotype_comparison": "Inactivation of dox-1 had a substantial effect on the lifespan of daf-2 mutants without affecting their apparent health. In four of six trials, dox-1 RNAi shortened the lifespan of daf-2 animals substantially more than it shortened wild-type lifespan. Thus, dox-1 contributes significantly to the longevity of daf-2 mutants."
    },
    {
        "id1": 3090,
        "id2": 3210,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the isp-1 mutation by an average of less than 20%."
    },
    {
        "id1": 3096,
        "id2": 3224,
        "phenotype_comparison": ""
    },
    {
        "id1": 3243,
        "id2": 3241,
        "phenotype_comparison": ""
    },
    {
        "id1": 3268,
        "id2": 3270,
        "phenotype_comparison": ""
    },
    {
        "id1": 3283,
        "id2": 3286,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant."
    },
    {
        "id1": 3298,
        "id2": 3302,
        "phenotype_comparison": ""
    },
    {
        "id1": 3311,
        "id2": 3316,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant."
    },
    {
        "id1": 3336,
        "id2": 3337,
        "phenotype_comparison": ""
    },
    {
        "id1": 3363,
        "id2": 3365,
        "phenotype_comparison": ""
    },
    {
        "id1": 1536,
        "id2": 1538,
        "phenotype_comparison": ""
    },
    {
        "id1": 1563,
        "id2": 1564,
        "phenotype_comparison": ""
    },
    {
        "id1": 1586,
        "id2": 1587,
        "phenotype_comparison": "Late generation mTerc-/- mice with telomere dysfunction have shorter median lifespans relative to those with intact telomeres independent of DNA-PKcs status. When combined with DNA-PKcs deficiency, the telomere deficient mice experience a further dramatic reduction in median lifespan."
    },
    {
        "id1": 1621,
        "id2": 1623,
        "phenotype_comparison": ""
    },
    {
        "id1": 1620,
        "id2": 1640,
        "phenotype_comparison": ""
    },
    {
        "id1": 1658,
        "id2": 1659,
        "phenotype_comparison": ""
    },
    {
        "id1": 1679,
        "id2": 1681,
        "phenotype_comparison": ""
    },
    {
        "id1": 1706,
        "id2": 1710,
        "phenotype_comparison": ""
    },
    {
        "id1": 1733,
        "id2": 1734,
        "phenotype_comparison": ""
    },
    {
        "id1": 1715,
        "id2": 1757,
        "phenotype_comparison": ""
    },
    {
        "id1": 1780,
        "id2": 1781,
        "phenotype_comparison": ""
    },
    {
        "id1": 1798,
        "id2": 1803,
        "phenotype_comparison": ""
    },
    {
        "id1": 1828,
        "id2": 1833,
        "phenotype_comparison": ""
    },
    {
        "id1": 1852,
        "id2": 1858,
        "phenotype_comparison": ""
    },
    {
        "id1": 1870,
        "id2": 1874,
        "phenotype_comparison": ""
    },
    {
        "id1": 1896,
        "id2": 1867,
        "phenotype_comparison": ""
    },
    {
        "id1": 1916,
        "id2": 1918,
        "phenotype_comparison": ""
    },
    {
        "id1": 1936,
        "id2": 1937,
        "phenotype_comparison": ""
    },
    {
        "id1": 1952,
        "id2": 1956,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1972,
        "phenotype_comparison": ""
    },
    {
        "id1": 1988,
        "id2": 1989,
        "phenotype_comparison": ""
    },
    {
        "id1": 2002,
        "id2": 2006,
        "phenotype_comparison": ""
    },
    {
        "id1": 2027,
        "id2": 2024,
        "phenotype_comparison": "elt-3(RNAi) suppresses the longevity phenotype of eat-2(ad1116) mutants, which have a defect in pharyngeal pumping that results in dietary restriction."
    },
    {
        "id1": 2046,
        "id2": 2051,
        "phenotype_comparison": ""
    },
    {
        "id1": 2074,
        "id2": 2076,
        "phenotype_comparison": ""
    },
    {
        "id1": 2102,
        "id2": 2103,
        "phenotype_comparison": "Knockdown of ubc-18 suppressed the extended lifespan of wwp-1 overexpressing animals ."
    },
    {
        "id1": 2113,
        "id2": 2125,
        "phenotype_comparison": "mekk-3 RNAi was also able to extend the lifespans of daf-3(e1390)."
    },
    {
        "id1": 2146,
        "id2": 2147,
        "phenotype_comparison": ""
    },
    {
        "id1": 2164,
        "id2": 2165,
        "phenotype_comparison": "mekk-3 RNAi significantly increased the lifespan of gas-1(fc21), a mutant in the NADH:ubiquinone oxidoreductase 49 kD subunit of Complex I."
    },
    {
        "id1": 2186,
        "id2": 2187,
        "phenotype_comparison": ""
    },
    {
        "id1": 2202,
        "id2": 2203,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2227,
        "phenotype_comparison": ""
    },
    {
        "id1": 2244,
        "id2": 2245,
        "phenotype_comparison": ""
    },
    {
        "id1": 2262,
        "id2": 2264,
        "phenotype_comparison": ""
    },
    {
        "id1": 2289,
        "id2": 2290,
        "phenotype_comparison": ""
    },
    {
        "id1": 2313,
        "id2": 2315,
        "phenotype_comparison": ""
    },
    {
        "id1": 2337,
        "id2": 2339,
        "phenotype_comparison": ""
    },
    {
        "id1": 2365,
        "id2": 2367,
        "phenotype_comparison": ""
    },
    {
        "id1": 2388,
        "id2": 2389,
        "phenotype_comparison": ""
    },
    {
        "id1": 2410,
        "id2": 2412,
        "phenotype_comparison": ""
    },
    {
        "id1": 2432,
        "id2": 2440,
        "phenotype_comparison": ""
    },
    {
        "id1": 2464,
        "id2": 2466,
        "phenotype_comparison": ""
    },
    {
        "id1": 2468,
        "id2": 2482,
        "phenotype_comparison": ""
    },
    {
        "id1": 2498,
        "id2": 2500,
        "phenotype_comparison": ""
    },
    {
        "id1": 2524,
        "id2": 2525,
        "phenotype_comparison": ""
    },
    {
        "id1": 2544,
        "id2": 2550,
        "phenotype_comparison": "daf-16;npr-1(ad609) mutants lived significantly longer than daf-16 mutants, indicating that the beneficial effect of NPR-1(215V) inhibition is not mediated by daf-16 signaling."
    },
    {
        "id1": 2543,
        "id2": 2561,
        "phenotype_comparison": "The lifespan of daf-2(e1370) mutants was not further extended by either npr-1 loss of function or the joint loss of function of npr-1/gcy-35, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1/gcy-35 takes place through overlapping mechanisms."
    },
    {
        "id1": 2618,
        "id2": 2619,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2649,
        "phenotype_comparison": ""
    },
    {
        "id1": 2670,
        "id2": 2674,
        "phenotype_comparison": ""
    },
    {
        "id1": 2692,
        "id2": 2705,
        "phenotype_comparison": ""
    },
    {
        "id1": 2730,
        "id2": 2735,
        "phenotype_comparison": ""
    },
    {
        "id1": 2764,
        "id2": 2769,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2793,
        "phenotype_comparison": ""
    },
    {
        "id1": 2817,
        "id2": 2824,
        "phenotype_comparison": ""
    },
    {
        "id1": 2838,
        "id2": 2851,
        "phenotype_comparison": ""
    },
    {
        "id1": 2879,
        "id2": 2882,
        "phenotype_comparison": ""
    },
    {
        "id1": 2903,
        "id2": 2904,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2919,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2905,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2949,
        "phenotype_comparison": ""
    },
    {
        "id1": 2968,
        "id2": 2971,
        "phenotype_comparison": ""
    },
    {
        "id1": 2996,
        "id2": 2998,
        "phenotype_comparison": ""
    },
    {
        "id1": 2997,
        "id2": 3018,
        "phenotype_comparison": ""
    },
    {
        "id1": 3037,
        "id2": 3039,
        "phenotype_comparison": ""
    },
    {
        "id1": 3058,
        "id2": 3062,
        "phenotype_comparison": ""
    },
    {
        "id1": 3079,
        "id2": 3080,
        "phenotype_comparison": "A putative xbp-1\u2013null mutation, which causes truncation of the XBP-1 protein before its DNA binding domain, shortened the lifespan of daf-2 mutants more than it shortened the lifespan of wild type without affecting the apparent health of the animals."
    },
    {
        "id1": 3092,
        "id2": 3094,
        "phenotype_comparison": ""
    },
    {
        "id1": 3113,
        "id2": 3115,
        "phenotype_comparison": ""
    },
    {
        "id1": 3138,
        "id2": 3139,
        "phenotype_comparison": ""
    },
    {
        "id1": 3158,
        "id2": 3160,
        "phenotype_comparison": ""
    },
    {
        "id1": 3175,
        "id2": 3177,
        "phenotype_comparison": ""
    },
    {
        "id1": 3187,
        "id2": 3193,
        "phenotype_comparison": ""
    },
    {
        "id1": 3209,
        "id2": 3211,
        "phenotype_comparison": ""
    },
    {
        "id1": 3224,
        "id2": 3225,
        "phenotype_comparison": ""
    },
    {
        "id1": 3245,
        "id2": 3246,
        "phenotype_comparison": ""
    },
    {
        "id1": 1916,
        "id2": 1920,
        "phenotype_comparison": ""
    },
    {
        "id1": 1934,
        "id2": 1938,
        "phenotype_comparison": "Reducing 14-3-3 gene expression caused little or no reduction in the life span of sir-2.1(ok434)."
    },
    {
        "id1": 3269,
        "id2": 3270,
        "phenotype_comparison": "Adult-conditioned expression of a dominant negative form of insulin receptor (UAS-InRDN) under the control of the inducible daughterless-GeneSwitch (daGS) driver, results in females having a significantly longer median lifespan than controls. The same effect is however completely cancelled out in a dFoxo background, suggesting that the increase in lifespan by InR knock-down is dependent on the existence of dFoxo. It should be noted that homozygotes dfoxo mutant (delta 94) female flies, which have delayed development time, are smaller in size with significant reductions in both body weight and wing area, are short leaved by ~33%."
    },
    {
        "id1": 3275,
        "id2": 3287,
        "phenotype_comparison": ""
    },
    {
        "id1": 3302,
        "id2": 3303,
        "phenotype_comparison": ""
    },
    {
        "id1": 3298,
        "id2": 3317,
        "phenotype_comparison": ""
    },
    {
        "id1": 3336,
        "id2": 3338,
        "phenotype_comparison": ""
    },
    {
        "id1": 3364,
        "id2": 3366,
        "phenotype_comparison": ""
    },
    {
        "id1": 1539,
        "id2": 1540,
        "phenotype_comparison": ""
    },
    {
        "id1": 1565,
        "id2": 1566,
        "phenotype_comparison": ""
    },
    {
        "id1": 1588,
        "id2": 1589,
        "phenotype_comparison": ""
    },
    {
        "id1": 1622,
        "id2": 1623,
        "phenotype_comparison": "While utx-1 RNAi effectively extended the life span of wild-type N2 strain, such an effect could not be observed in any mutant on IIS pathway; utx-1 RNAi could not further increase the life span of daf-2(e1370) worms and could not at all increase the life span in daf-16(mu86) mutant animals."
    },
    {
        "id1": 1640,
        "id2": 1641,
        "phenotype_comparison": ""
    },
    {
        "id1": 1658,
        "id2": 1660,
        "phenotype_comparison": ""
    },
    {
        "id1": 1679,
        "id2": 1682,
        "phenotype_comparison": ""
    },
    {
        "id1": 1711,
        "id2": 1712,
        "phenotype_comparison": ""
    },
    {
        "id1": 1735,
        "id2": 1736,
        "phenotype_comparison": ""
    },
    {
        "id1": 1715,
        "id2": 1758,
        "phenotype_comparison": ""
    },
    {
        "id1": 1778,
        "id2": 1781,
        "phenotype_comparison": "SKN-1 is inhibited by IIS phosphorylation but is dispensable for dauer development, adulthood dauer-related traits, or lifespan extension by Class 2 daf-2 mutations at 20\u00b0C ."
    },
    {
        "id1": 1798,
        "id2": 1804,
        "phenotype_comparison": ""
    },
    {
        "id1": 1835,
        "id2": 1836,
        "phenotype_comparison": ""
    },
    {
        "id1": 1852,
        "id2": 1859,
        "phenotype_comparison": ""
    },
    {
        "id1": 1870,
        "id2": 1877,
        "phenotype_comparison": ""
    },
    {
        "id1": 1896,
        "id2": 1897,
        "phenotype_comparison": ""
    },
    {
        "id1": 1917,
        "id2": 1919,
        "phenotype_comparison": ""
    },
    {
        "id1": 1932,
        "id2": 1937,
        "phenotype_comparison": "Reducing 14-3-3 gene expression caused little or no reduction in the life span of sir-2.1(ok434)."
    },
    {
        "id1": 1955,
        "id2": 1956,
        "phenotype_comparison": ""
    },
    {
        "id1": 1967,
        "id2": 1973,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1990,
        "phenotype_comparison": ""
    },
    {
        "id1": 2005,
        "id2": 2006,
        "phenotype_comparison": "If a GATA transcription factor functions specifically to extend life span rather than shorten it, then RNAi treatment may suppress the longevity of a long-lived mutant such as daf-2(e1370) without causing nonspecific early lethality of wild-type worms. Of the ten GATA transcription factor genes, we found that RNAi treatment of three (elt-3, egr-1, and egl-27) behave in this way in multiple independent life span experiments"
    },
    {
        "id1": 2007,
        "id2": 2028,
        "phenotype_comparison": ""
    },
    {
        "id1": 2050,
        "id2": 2052,
        "phenotype_comparison": ""
    },
    {
        "id1": 2077,
        "id2": 2078,
        "phenotype_comparison": ""
    },
    {
        "id1": 2104,
        "id2": 2050,
        "phenotype_comparison": ""
    },
    {
        "id1": 2126,
        "id2": 2127,
        "phenotype_comparison": ""
    },
    {
        "id1": 2144,
        "id2": 2147,
        "phenotype_comparison": "mekk-3 RNAi failed to increase the long lifespans of eat-2(ad1113) to the same extent as in WT, suggesting that they may function in the same genetic pathway for lifespan regulation."
    },
    {
        "id1": 2162,
        "id2": 2166,
        "phenotype_comparison": ""
    },
    {
        "id1": 2180,
        "id2": 2187,
        "phenotype_comparison": "In nhr-8(ok186), knocking down mekk-3 did not result in increased lifespan. In fact, mekk-3 RNAi decreased the lifespan of nhr-8(ok186)."
    },
    {
        "id1": 2180,
        "id2": 2203,
        "phenotype_comparison": "In ABC transporter (P-glycoproteins) mutants such as pgp-3(ok3091) or pgp-3(pk18), mekk-3 RNAi did not extend lifespan to the same extent as in WT."
    },
    {
        "id1": 2226,
        "id2": 2228,
        "phenotype_comparison": ""
    },
    {
        "id1": 2245,
        "id2": 2241,
        "phenotype_comparison": "mekk-3 RNAi had limited effect on the lifespan of RNAi-deficient rde-1(ne219)."
    },
    {
        "id1": 2263,
        "id2": 2265,
        "phenotype_comparison": ""
    },
    {
        "id1": 2290,
        "id2": 2291,
        "phenotype_comparison": ""
    },
    {
        "id1": 2314,
        "id2": 2315,
        "phenotype_comparison": "RNAi treatment of ddl-2 failed to produce any significant lifespan extension on hsf-1(sy441) mutants, while reducing expression of ddl-2 by RNAi extends lifespan in wild type. This finding suggests that hsf-1 is required for the extended lifespan observed in ddl-2 RNAi treated animals."
    },
    {
        "id1": 2338,
        "id2": 2339,
        "phenotype_comparison": "The lifespan of hsb-1(cg116); ddl-2(ok3235) double mutants is not statistically different from hsb-1(cg116) single mutants."
    },
    {
        "id1": 2366,
        "id2": 2367,
        "phenotype_comparison": "Over-expression of eIF4H/drr-2 did not have any effect on the lifespan of S6K/rsks-1 RNAi animals. Although S6K is known to act downstream of TOR to regulate translation by modulating the activity of several eIFs, this finding suggests that eIF4H/DRR-2 might be regulated by TOR via an S6K-independent pathway."
    },
    {
        "id1": 2388,
        "id2": 2390,
        "phenotype_comparison": ""
    },
    {
        "id1": 2411,
        "id2": 2412,
        "phenotype_comparison": "The daf-18(e1375) mutation suppresses the lifespan extension of daf-2(e1370) mutant."
    },
    {
        "id1": 2465,
        "id2": 2467,
        "phenotype_comparison": ""
    },
    {
        "id1": 2469,
        "id2": 2483,
        "phenotype_comparison": ""
    },
    {
        "id1": 2499,
        "id2": 2500,
        "phenotype_comparison": "Growing the worms on live OP50 at 25\u00b0C shortened the lifespan of all strains. The lifespans of gcy-35, and npr-1(ad609) mutants grown in this environment were similar to N2 controls. "
    },
    {
        "id1": 2526,
        "id2": 2527,
        "phenotype_comparison": ""
    },
    {
        "id1": 2539,
        "id2": 2551,
        "phenotype_comparison": ""
    },
    {
        "id1": 2427,
        "id2": 2562,
        "phenotype_comparison": ""
    },
    {
        "id1": 2563,
        "id2": 2584,
        "phenotype_comparison": ""
    },
    {
        "id1": 2575,
        "id2": 2595,
        "phenotype_comparison": ""
    },
    {
        "id1": 2618,
        "id2": 2620,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2650,
        "phenotype_comparison": ""
    },
    {
        "id1": 2665,
        "id2": 2675,
        "phenotype_comparison": ""
    },
    {
        "id1": 2706,
        "id2": 2707,
        "phenotype_comparison": ""
    },
    {
        "id1": 2736,
        "id2": 2737,
        "phenotype_comparison": ""
    },
    {
        "id1": 2757,
        "id2": 2769,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2794,
        "phenotype_comparison": ""
    },
    {
        "id1": 2817,
        "id2": 2825,
        "phenotype_comparison": ""
    },
    {
        "id1": 2840,
        "id2": 2852,
        "phenotype_comparison": ""
    },
    {
        "id1": 2879,
        "id2": 2883,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2905,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2920,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2935,
        "phenotype_comparison": ""
    },
    {
        "id1": 2948,
        "id2": 2949,
        "phenotype_comparison": ""
    },
    {
        "id1": 2972,
        "id2": 2973,
        "phenotype_comparison": ""
    },
    {
        "id1": 2997,
        "id2": 2999,
        "phenotype_comparison": ""
    },
    {
        "id1": 3017,
        "id2": 3018,
        "phenotype_comparison": ""
    },
    {
        "id1": 3038,
        "id2": 3040,
        "phenotype_comparison": ""
    },
    {
        "id1": 3061,
        "id2": 3062,
        "phenotype_comparison": "Inactivation of ire-1 by a deletion mutation shortened the lifespan of daf-2 mutants. ire-1(ok799)\u2013null mutants had morphological and behavioral defects."
    },
    {
        "id1": 3077,
        "id2": 3061,
        "phenotype_comparison": ""
    },
    {
        "id1": 3093,
        "id2": 3095,
        "phenotype_comparison": ""
    },
    {
        "id1": 3114,
        "id2": 3116,
        "phenotype_comparison": ""
    },
    {
        "id1": 3138,
        "id2": 3140,
        "phenotype_comparison": ""
    },
    {
        "id1": 3159,
        "id2": 3160,
        "phenotype_comparison": "Inactivation of pek-1 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3176,
        "id2": 3177,
        "phenotype_comparison": "Inactivation of abu-11 by RNAi did not shorten the lifespan of daf-2 mutants, whereas it did shorten the lifespan of wild type. "
    },
    {
        "id1": 3188,
        "id2": 3194,
        "phenotype_comparison": ""
    },
    {
        "id1": 3090,
        "id2": 3211,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the isp-1 mutation by an average of less than 20%."
    },
    {
        "id1": 3099,
        "id2": 3225,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the eat-2 mutation by an average of less than 20%."
    },
    {
        "id1": 3247,
        "id2": 3248,
        "phenotype_comparison": ""
    },
    {
        "id1": 3271,
        "id2": 3272,
        "phenotype_comparison": ""
    },
    {
        "id1": 3275,
        "id2": 3288,
        "phenotype_comparison": ""
    },
    {
        "id1": 1952,
        "id2": 1958,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1974,
        "phenotype_comparison": ""
    },
    {
        "id1": 1990,
        "id2": 1991,
        "phenotype_comparison": "If a GATA transcription factor functions specifically to extend life span rather than shorten it, then RNAi treatment may suppress the longevity of a long-lived mutant such as daf-2(e1370) without causing nonspecific early lethality of wild-type worms. Of the ten GATA transcription factor genes, we found that RNAi treatment of three (elt-3, egr-1, and egl-27) behave in this way in multiple independent life span experiments"
    },
    {
        "id1": 3300,
        "id2": 3303,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3310,
        "id2": 3318,
        "phenotype_comparison": ""
    },
    {
        "id1": 3337,
        "id2": 3339,
        "phenotype_comparison": ""
    },
    {
        "id1": 3365,
        "id2": 3366,
        "phenotype_comparison": "The NF1 P1 mutant strain had a 60%-73% reduction in life span, and the NF1 P2 mutant strain had a 24%-40% reduction in life span, relative to the isogenic K33 control strain. The NF1 P1/P2 intercross heterozygotes had a life span similar to the NF1 P2 flies."
    },
    {
        "id1": 1539,
        "id2": 1541,
        "phenotype_comparison": ""
    },
    {
        "id1": 1567,
        "id2": 1568,
        "phenotype_comparison": ""
    },
    {
        "id1": 1588,
        "id2": 1590,
        "phenotype_comparison": ""
    },
    {
        "id1": 1616,
        "id2": 1624,
        "phenotype_comparison": ""
    },
    {
        "id1": 1622,
        "id2": 1641,
        "phenotype_comparison": "The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway"
    },
    {
        "id1": 1659,
        "id2": 1661,
        "phenotype_comparison": ""
    },
    {
        "id1": 1679,
        "id2": 1683,
        "phenotype_comparison": ""
    },
    {
        "id1": 1711,
        "id2": 1713,
        "phenotype_comparison": ""
    },
    {
        "id1": 1735,
        "id2": 1737,
        "phenotype_comparison": ""
    },
    {
        "id1": 1757,
        "id2": 1759,
        "phenotype_comparison": ""
    },
    {
        "id1": 1782,
        "id2": 1783,
        "phenotype_comparison": ""
    },
    {
        "id1": 1805,
        "id2": 1806,
        "phenotype_comparison": ""
    },
    {
        "id1": 1835,
        "id2": 1837,
        "phenotype_comparison": ""
    },
    {
        "id1": 1858,
        "id2": 1860,
        "phenotype_comparison": ""
    },
    {
        "id1": 1874,
        "id2": 1878,
        "phenotype_comparison": ""
    },
    {
        "id1": 1867,
        "id2": 1898,
        "phenotype_comparison": ""
    },
    {
        "id1": 1918,
        "id2": 1919,
        "phenotype_comparison": "daf-2(m577); aak-2(ok524) double mutants have lifespans that are indistinguishable from those of aak-2(ok524) single mutants"
    },
    {
        "id1": 1936,
        "id2": 1938,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1957,
        "phenotype_comparison": ""
    },
    {
        "id1": 1972,
        "id2": 1973,
        "phenotype_comparison": "If a GATA transcription factor functions specifically to extend life span rather than shorten it, then RNAi treatment may suppress the longevity of a long-lived mutant such as daf-2(e1370) without causing nonspecific early lethality of wild-type worms. Of the ten GATA transcription factor genes, we found that RNAi treatment of three (elt-3, egr-1, and egl-27) behave in this way in multiple independent life span experiments"
    },
    {
        "id1": 1985,
        "id2": 1991,
        "phenotype_comparison": ""
    },
    {
        "id1": 2007,
        "id2": 2008,
        "phenotype_comparison": ""
    },
    {
        "id1": 2007,
        "id2": 2029,
        "phenotype_comparison": ""
    },
    {
        "id1": 2051,
        "id2": 2052,
        "phenotype_comparison": "RNAi reduction of pha-4 suppressed the increased longevity of worms overexpressing wwp-1"
    },
    {
        "id1": 2079,
        "id2": 2080,
        "phenotype_comparison": ""
    },
    {
        "id1": 2104,
        "id2": 2105,
        "phenotype_comparison": ""
    },
    {
        "id1": 2126,
        "id2": 2128,
        "phenotype_comparison": ""
    },
    {
        "id1": 2138,
        "id2": 2148,
        "phenotype_comparison": ""
    },
    {
        "id1": 2166,
        "id2": 2167,
        "phenotype_comparison": ""
    },
    {
        "id1": 2182,
        "id2": 2188,
        "phenotype_comparison": ""
    },
    {
        "id1": 2182,
        "id2": 2204,
        "phenotype_comparison": ""
    },
    {
        "id1": 2227,
        "id2": 2228,
        "phenotype_comparison": "The long lifespan of eat-2(ad1116) is significantly suppressed by nhr-49 RNAi. The nhr-49 RNAi had no effect on WT worms."
    },
    {
        "id1": 2229,
        "id2": 2242,
        "phenotype_comparison": ""
    },
    {
        "id1": 2264,
        "id2": 2265,
        "phenotype_comparison": "RNAi knock-down of mekk-3 increased lifespan of daf-2(e1370) shifted to 25 \u00b0C at L3 when IIS completely shuts down."
    },
    {
        "id1": 2289,
        "id2": 2292,
        "phenotype_comparison": ""
    },
    {
        "id1": 2316,
        "id2": 2317,
        "phenotype_comparison": ""
    },
    {
        "id1": 2340,
        "id2": 2341,
        "phenotype_comparison": ""
    },
    {
        "id1": 2368,
        "id2": 2369,
        "phenotype_comparison": ""
    },
    {
        "id1": 2389,
        "id2": 2391,
        "phenotype_comparison": ""
    },
    {
        "id1": 2413,
        "id2": 2414,
        "phenotype_comparison": ""
    },
    {
        "id1": 2435,
        "id2": 2441,
        "phenotype_comparison": ""
    },
    {
        "id1": 2466,
        "id2": 2467,
        "phenotype_comparison": ""
    },
    {
        "id1": 2482,
        "id2": 2483,
        "phenotype_comparison": "The deletion of gcy-33 did not affect N2 worms\u2019 lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609)."
    },
    {
        "id1": 2501,
        "id2": 2502,
        "phenotype_comparison": ""
    },
    {
        "id1": 2527,
        "id2": 2528,
        "phenotype_comparison": ""
    },
    {
        "id1": 2546,
        "id2": 2551,
        "phenotype_comparison": "daf-16;npr-1(ad609) mutants lived significantly longer than daf-16 mutants, indicating that the beneficial effect of NPR-1(215V) inhibition is not mediated by daf-16 signaling."
    },
    {
        "id1": 2562,
        "id2": 2563,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2597,
        "phenotype_comparison": ""
    },
    {
        "id1": 2618,
        "id2": 2621,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2651,
        "phenotype_comparison": ""
    },
    {
        "id1": 2665,
        "id2": 2676,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2708,
        "phenotype_comparison": ""
    },
    {
        "id1": 2712,
        "id2": 2738,
        "phenotype_comparison": ""
    },
    {
        "id1": 2770,
        "id2": 2771,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2795,
        "phenotype_comparison": ""
    },
    {
        "id1": 2826,
        "id2": 2827,
        "phenotype_comparison": ""
    },
    {
        "id1": 2838,
        "id2": 2853,
        "phenotype_comparison": ""
    },
    {
        "id1": 2884,
        "id2": 2885,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2906,
        "phenotype_comparison": ""
    },
    {
        "id1": 2919,
        "id2": 2920,
        "phenotype_comparison": ""
    },
    {
        "id1": 2905,
        "id2": 2935,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2950,
        "phenotype_comparison": ""
    },
    {
        "id1": 2972,
        "id2": 2974,
        "phenotype_comparison": ""
    },
    {
        "id1": 2998,
        "id2": 2999,
        "phenotype_comparison": ""
    },
    {
        "id1": 3019,
        "id2": 3020,
        "phenotype_comparison": ""
    },
    {
        "id1": 3039,
        "id2": 3040,
        "phenotype_comparison": ""
    },
    {
        "id1": 3063,
        "id2": 3064,
        "phenotype_comparison": ""
    },
    {
        "id1": 3078,
        "id2": 3081,
        "phenotype_comparison": ""
    },
    {
        "id1": 3092,
        "id2": 3095,
        "phenotype_comparison": ""
    },
    {
        "id1": 3115,
        "id2": 3116,
        "phenotype_comparison": ""
    },
    {
        "id1": 3138,
        "id2": 3141,
        "phenotype_comparison": ""
    },
    {
        "id1": 3157,
        "id2": 3161,
        "phenotype_comparison": ""
    },
    {
        "id1": 3144,
        "id2": 3125,
        "phenotype_comparison": ""
    },
    {
        "id1": 3193,
        "id2": 3194,
        "phenotype_comparison": ""
    },
    {
        "id1": 3077,
        "id2": 3212,
        "phenotype_comparison": ""
    },
    {
        "id1": 3107,
        "id2": 3226,
        "phenotype_comparison": ""
    },
    {
        "id1": 3249,
        "id2": 3250,
        "phenotype_comparison": ""
    },
    {
        "id1": 3271,
        "id2": 3273,
        "phenotype_comparison": ""
    },
    {
        "id1": 3287,
        "id2": 3289,
        "phenotype_comparison": ""
    },
    {
        "id1": 3298,
        "id2": 3304,
        "phenotype_comparison": ""
    },
    {
        "id1": 3317,
        "id2": 3318,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3338,
        "id2": 3339,
        "phenotype_comparison": "The chico homozygotes lived significantly longer than all other genotypes. In addition, the partially fertile chico 1 heterozygotes lived as long as the sterile flies that were heterozygous for both ovo D1 and chico 1 and lived significantly longer than the sterile ovo D1 heterozygotes."
    },
    {
        "id1": 1542,
        "id2": 1543,
        "phenotype_comparison": ""
    },
    {
        "id1": 1567,
        "id2": 1569,
        "phenotype_comparison": ""
    },
    {
        "id1": 1589,
        "id2": 1591,
        "phenotype_comparison": ""
    },
    {
        "id1": 1624,
        "id2": 1625,
        "phenotype_comparison": ""
    },
    {
        "id1": 1616,
        "id2": 1642,
        "phenotype_comparison": ""
    },
    {
        "id1": 1660,
        "id2": 1661,
        "phenotype_comparison": "utx-1 RNAi extended lifespan in N2 worm, but not in rrf-1(ok589)."
    },
    {
        "id1": 1684,
        "id2": 1685,
        "phenotype_comparison": ""
    },
    {
        "id1": 1712,
        "id2": 1714,
        "phenotype_comparison": ""
    },
    {
        "id1": 1736,
        "id2": 1738,
        "phenotype_comparison": ""
    },
    {
        "id1": 1758,
        "id2": 1759,
        "phenotype_comparison": ""
    },
    {
        "id1": 1782,
        "id2": 1784,
        "phenotype_comparison": ""
    },
    {
        "id1": 1805,
        "id2": 1807,
        "phenotype_comparison": ""
    },
    {
        "id1": 1835,
        "id2": 1838,
        "phenotype_comparison": ""
    },
    {
        "id1": 1859,
        "id2": 1860,
        "phenotype_comparison": ""
    },
    {
        "id1": 1877,
        "id2": 1878,
        "phenotype_comparison": "Lifespan extension in eak-7 null mutants does not require eak-3 activity. "
    },
    {
        "id1": 1897,
        "id2": 1898,
        "phenotype_comparison": "Lifespan extension in eak-7 null mutants does not require sdf-9."
    },
    {
        "id1": 2007,
        "id2": 2009,
        "phenotype_comparison": ""
    },
    {
        "id1": 2028,
        "id2": 2030,
        "phenotype_comparison": ""
    },
    {
        "id1": 2046,
        "id2": 2053,
        "phenotype_comparison": ""
    },
    {
        "id1": 2081,
        "id2": 2082,
        "phenotype_comparison": ""
    },
    {
        "id1": 2050,
        "id2": 2106,
        "phenotype_comparison": ""
    },
    {
        "id1": 2127,
        "id2": 2129,
        "phenotype_comparison": ""
    },
    {
        "id1": 2148,
        "id2": 2149,
        "phenotype_comparison": ""
    },
    {
        "id1": 2164,
        "id2": 2167,
        "phenotype_comparison": "mekk-3 RNAi did not significantly increase the lifespan of clk-1(qm30), a mutant in the highly conserved demethoxyubiquinone (DMQ) hydroxylase gene that is necessary for the biosynthesis of ubiquinone."
    },
    {
        "id1": 2188,
        "id2": 2189,
        "phenotype_comparison": ""
    },
    {
        "id1": 2204,
        "id2": 2205,
        "phenotype_comparison": ""
    },
    {
        "id1": 2229,
        "id2": 2230,
        "phenotype_comparison": ""
    },
    {
        "id1": 2229,
        "id2": 2246,
        "phenotype_comparison": ""
    },
    {
        "id1": 2266,
        "id2": 2267,
        "phenotype_comparison": ""
    },
    {
        "id1": 2292,
        "id2": 2293,
        "phenotype_comparison": ""
    },
    {
        "id1": 2316,
        "id2": 2318,
        "phenotype_comparison": ""
    },
    {
        "id1": 2340,
        "id2": 2342,
        "phenotype_comparison": ""
    },
    {
        "id1": 2368,
        "id2": 2370,
        "phenotype_comparison": ""
    },
    {
        "id1": 2390,
        "id2": 2391,
        "phenotype_comparison": "Inhibition of eIF4H/drr-2 consistently extends the lifespan of wild-type animals and animals over-expressing sams-1 (EQ2). Taken together, these results strongly imply that eIF4H/drr-2 may act downstream of both rab-10 and sams-1 and its activity might be essential for RAB-10 and SAMS-1 to mediate the longevity effects of DR. "
    },
    {
        "id1": 2414,
        "id2": 2415,
        "phenotype_comparison": ""
    },
    {
        "id1": 2468,
        "id2": 2469,
        "phenotype_comparison": ""
    },
    {
        "id1": 2471,
        "id2": 2484,
        "phenotype_comparison": ""
    },
    {
        "id1": 2501,
        "id2": 2503,
        "phenotype_comparison": ""
    },
    {
        "id1": 2529,
        "id2": 2530,
        "phenotype_comparison": ""
    },
    {
        "id1": 2542,
        "id2": 2552,
        "phenotype_comparison": ""
    },
    {
        "id1": 2564,
        "id2": 2565,
        "phenotype_comparison": ""
    },
    {
        "id1": 2566,
        "id2": 2585,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2598,
        "phenotype_comparison": ""
    },
    {
        "id1": 2618,
        "id2": 2622,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2652,
        "phenotype_comparison": ""
    },
    {
        "id1": 2677,
        "id2": 2678,
        "phenotype_comparison": ""
    },
    {
        "id1": 2709,
        "id2": 2710,
        "phenotype_comparison": ""
    },
    {
        "id1": 2739,
        "id2": 2740,
        "phenotype_comparison": ""
    },
    {
        "id1": 2757,
        "id2": 2772,
        "phenotype_comparison": ""
    },
    {
        "id1": 2796,
        "id2": 2797,
        "phenotype_comparison": ""
    },
    {
        "id1": 2822,
        "id2": 2828,
        "phenotype_comparison": ""
    },
    {
        "id1": 2838,
        "id2": 2854,
        "phenotype_comparison": ""
    },
    {
        "id1": 2879,
        "id2": 2886,
        "phenotype_comparison": ""
    },
    {
        "id1": 2905,
        "id2": 2906,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2921,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2936,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2951,
        "phenotype_comparison": ""
    },
    {
        "id1": 2972,
        "id2": 2975,
        "phenotype_comparison": ""
    },
    {
        "id1": 2996,
        "id2": 3000,
        "phenotype_comparison": ""
    },
    {
        "id1": 3019,
        "id2": 3021,
        "phenotype_comparison": ""
    },
    {
        "id1": 3037,
        "id2": 3041,
        "phenotype_comparison": ""
    },
    {
        "id1": 3063,
        "id2": 3065,
        "phenotype_comparison": ""
    },
    {
        "id1": 3061,
        "id2": 3081,
        "phenotype_comparison": "Inactivation of ire-1 by a deletion mutation shortened the lifespan of daf-2 mutants. ire-1(ok799)\u2013null mutants had morphological and behavioral defects."
    },
    {
        "id1": 3096,
        "id2": 3058,
        "phenotype_comparison": ""
    },
    {
        "id1": 3113,
        "id2": 3117,
        "phenotype_comparison": ""
    },
    {
        "id1": 3141,
        "id2": 3142,
        "phenotype_comparison": ""
    },
    {
        "id1": 3161,
        "id2": 3162,
        "phenotype_comparison": ""
    },
    {
        "id1": 3125,
        "id2": 3178,
        "phenotype_comparison": ""
    },
    {
        "id1": 3077,
        "id2": 3188,
        "phenotype_comparison": ""
    },
    {
        "id1": 3212,
        "id2": 3213,
        "phenotype_comparison": ""
    },
    {
        "id1": 3226,
        "id2": 3227,
        "phenotype_comparison": ""
    },
    {
        "id1": 3251,
        "id2": 3252,
        "phenotype_comparison": ""
    },
    {
        "id1": 3272,
        "id2": 3274,
        "phenotype_comparison": ""
    },
    {
        "id1": 3288,
        "id2": 3289,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant."
    },
    {
        "id1": 3304,
        "id2": 3305,
        "phenotype_comparison": ""
    },
    {
        "id1": 3313,
        "id2": 3319,
        "phenotype_comparison": ""
    },
    {
        "id1": 3340,
        "id2": 3342,
        "phenotype_comparison": ""
    },
    {
        "id1": 1542,
        "id2": 1544,
        "phenotype_comparison": ""
    },
    {
        "id1": 1568,
        "id2": 1570,
        "phenotype_comparison": ""
    },
    {
        "id1": 1590,
        "id2": 1591,
        "phenotype_comparison": "Skn-1 mutations significantly reduced the lifespan of the Class 1 daf-2 mutant e1368."
    },
    {
        "id1": 1618,
        "id2": 1625,
        "phenotype_comparison": "While utx-1 RNAi effectively extended the life span of wild-type N2 strain, such an effect could not be observed in any mutant on IIS pathway; utx-1 RNAi could not further increase the life span of daf-2(e1370) worms and could not at all increase the life span in daf-16(mu86) mutant animals."
    },
    {
        "id1": 1642,
        "id2": 1643,
        "phenotype_comparison": ""
    },
    {
        "id1": 1658,
        "id2": 1662,
        "phenotype_comparison": ""
    },
    {
        "id1": 1684,
        "id2": 1686,
        "phenotype_comparison": ""
    },
    {
        "id1": 1713,
        "id2": 1714,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1737,
        "id2": 1738,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1760,
        "id2": 1761,
        "phenotype_comparison": ""
    },
    {
        "id1": 1783,
        "id2": 1785,
        "phenotype_comparison": ""
    },
    {
        "id1": 1805,
        "id2": 1808,
        "phenotype_comparison": ""
    },
    {
        "id1": 1835,
        "id2": 1839,
        "phenotype_comparison": ""
    },
    {
        "id1": 1852,
        "id2": 1861,
        "phenotype_comparison": ""
    },
    {
        "id1": 1879,
        "id2": 1880,
        "phenotype_comparison": ""
    },
    {
        "id1": 1899,
        "id2": 1900,
        "phenotype_comparison": ""
    },
    {
        "id1": 1920,
        "id2": 1921,
        "phenotype_comparison": ""
    },
    {
        "id1": 1936,
        "id2": 1939,
        "phenotype_comparison": ""
    },
    {
        "id1": 1957,
        "id2": 1958,
        "phenotype_comparison": "If a GATA transcription factor functions specifically to extend life span rather than shorten it, then RNAi treatment may suppress the longevity of a long-lived mutant such as daf-2(e1370) without causing nonspecific early lethality of wild-type worms. Of the ten GATA transcription factor genes, we found that RNAi treatment of three (elt-3, egr-1, and egl-27) behave in this way in multiple independent life span experiments"
    },
    {
        "id1": 1967,
        "id2": 1975,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1992,
        "phenotype_comparison": ""
    },
    {
        "id1": 2008,
        "id2": 2010,
        "phenotype_comparison": ""
    },
    {
        "id1": 2029,
        "id2": 2030,
        "phenotype_comparison": ""
    },
    {
        "id1": 2046,
        "id2": 2054,
        "phenotype_comparison": ""
    },
    {
        "id1": 2082,
        "id2": 2083,
        "phenotype_comparison": ""
    },
    {
        "id1": 2105,
        "id2": 2106,
        "phenotype_comparison": "Knockdown of ubc-18 suppressed the extended lifespan of wwp-1 overexpressing animals ."
    },
    {
        "id1": 2128,
        "id2": 2129,
        "phenotype_comparison": "mekk-3 RNAi was also able to extend the lifespans of daf-3(e1390)."
    },
    {
        "id1": 2140,
        "id2": 2149,
        "phenotype_comparison": "mekk-3 RNAi failed to increase the long lifespans of eat-2(ad1113) to the same extent as in WT, suggesting that they may function in the same genetic pathway for lifespan regulation."
    },
    {
        "id1": 2168,
        "id2": 2169,
        "phenotype_comparison": ""
    },
    {
        "id1": 2184,
        "id2": 2189,
        "phenotype_comparison": "In nhr-8(ok186), knocking down mekk-3 did not result in increased lifespan. In fact, mekk-3 RNAi decreased the lifespan of nhr-8(ok186)."
    },
    {
        "id1": 2184,
        "id2": 2205,
        "phenotype_comparison": "In ABC transporter (P-glycoproteins) mutants such as pgp-3(ok3091) or pgp-3(pk18), mekk-3 RNAi did not extend lifespan to the same extent as in WT."
    },
    {
        "id1": 2229,
        "id2": 2231,
        "phenotype_comparison": ""
    },
    {
        "id1": 2246,
        "id2": 2243,
        "phenotype_comparison": "mekk-3 RNAi had limited effect on the lifespan of RNAi-deficient rde-1(ne219)."
    },
    {
        "id1": 2266,
        "id2": 2268,
        "phenotype_comparison": ""
    },
    {
        "id1": 2294,
        "id2": 2295,
        "phenotype_comparison": ""
    },
    {
        "id1": 2317,
        "id2": 2319,
        "phenotype_comparison": ""
    },
    {
        "id1": 2341,
        "id2": 2343,
        "phenotype_comparison": ""
    },
    {
        "id1": 2369,
        "id2": 2371,
        "phenotype_comparison": ""
    },
    {
        "id1": 2392,
        "id2": 2393,
        "phenotype_comparison": ""
    },
    {
        "id1": 2438,
        "id2": 2442,
        "phenotype_comparison": ""
    },
    {
        "id1": 2468,
        "id2": 2470,
        "phenotype_comparison": ""
    },
    {
        "id1": 2472,
        "id2": 2485,
        "phenotype_comparison": ""
    },
    {
        "id1": 2502,
        "id2": 2504,
        "phenotype_comparison": ""
    },
    {
        "id1": 2531,
        "id2": 2532,
        "phenotype_comparison": ""
    },
    {
        "id1": 2548,
        "id2": 2552,
        "phenotype_comparison": "daf-16;npr-1(ad609) mutants lived significantly longer than daf-16 mutants, indicating that the beneficial effect of NPR-1(215V) inhibition is not mediated by daf-16 signaling."
    },
    {
        "id1": 2565,
        "id2": 2566,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2599,
        "phenotype_comparison": ""
    },
    {
        "id1": 2623,
        "id2": 2624,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2653,
        "phenotype_comparison": ""
    },
    {
        "id1": 2677,
        "id2": 2679,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2711,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2741,
        "phenotype_comparison": ""
    },
    {
        "id1": 2753,
        "id2": 2773,
        "phenotype_comparison": ""
    },
    {
        "id1": 2798,
        "id2": 2799,
        "phenotype_comparison": ""
    },
    {
        "id1": 2800,
        "id2": 2829,
        "phenotype_comparison": ""
    },
    {
        "id1": 2855,
        "id2": 2856,
        "phenotype_comparison": ""
    },
    {
        "id1": 2884,
        "id2": 2887,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2907,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2922,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2937,
        "phenotype_comparison": ""
    },
    {
        "id1": 2950,
        "id2": 2951,
        "phenotype_comparison": ""
    },
    {
        "id1": 2976,
        "id2": 2977,
        "phenotype_comparison": ""
    },
    {
        "id1": 2997,
        "id2": 3001,
        "phenotype_comparison": ""
    },
    {
        "id1": 3020,
        "id2": 3022,
        "phenotype_comparison": ""
    },
    {
        "id1": 3038,
        "id2": 3042,
        "phenotype_comparison": ""
    },
    {
        "id1": 3064,
        "id2": 3066,
        "phenotype_comparison": ""
    },
    {
        "id1": 3077,
        "id2": 3082,
        "phenotype_comparison": ""
    },
    {
        "id1": 3096,
        "id2": 3097,
        "phenotype_comparison": ""
    },
    {
        "id1": 3114,
        "id2": 3118,
        "phenotype_comparison": ""
    },
    {
        "id1": 3141,
        "id2": 3143,
        "phenotype_comparison": ""
    },
    {
        "id1": 3159,
        "id2": 3162,
        "phenotype_comparison": "Inactivation of pek-1 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3176,
        "id2": 3178,
        "phenotype_comparison": "Inactivation of abu-11 by RNAi did not shorten the lifespan of daf-2 mutants, whereas it did shorten the lifespan of wild type. "
    },
    {
        "id1": 3077,
        "id2": 3195,
        "phenotype_comparison": ""
    },
    {
        "id1": 3061,
        "id2": 3213,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the isp-1 mutation by an average of less than 20%."
    },
    {
        "id1": 3111,
        "id2": 3227,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the eat-2 mutation by an average of less than 20%."
    },
    {
        "id1": 3251,
        "id2": 3253,
        "phenotype_comparison": ""
    },
    {
        "id1": 3273,
        "id2": 3274,
        "phenotype_comparison": "Adult-conditioned expression of a catalytically inactive, dominant negative form of PI3 kinase (UAS-Dp110DN) under the control of the inducible daughterless-GeneSwitch (daGS) driver, results in females having a significantly longer median lifespan than controls. The same effect is however completely cancelled out in a dFoxo background, suggesting that the increase in lifespan by InR knock-down is dependent on the existence of dFoxo. It should be noted that homozygotes dfoxo mutant (delta 94) female flies, which have delayed development time, are smaller in size with significant reductions in both body weight and wing area, are short leaved by ~33%."
    },
    {
        "id1": 3275,
        "id2": 3290,
        "phenotype_comparison": ""
    },
    {
        "id1": 3300,
        "id2": 3305,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3317,
        "id2": 3319,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan."
    },
    {
        "id1": 3341,
        "id2": 3342,
        "phenotype_comparison": ""
    },
    {
        "id1": 3359,
        "id2": 3369,
        "phenotype_comparison": ""
    },
    {
        "id1": 1543,
        "id2": 1545,
        "phenotype_comparison": ""
    },
    {
        "id1": 1569,
        "id2": 1570,
        "phenotype_comparison": "The double mutant obtained by crossing heterozygous APC(MIN) and Ku80 homozygous -/- mutants has decreased lifespan compared to WT and single mutants"
    },
    {
        "id1": 1588,
        "id2": 1592,
        "phenotype_comparison": ""
    },
    {
        "id1": 1620,
        "id2": 1626,
        "phenotype_comparison": ""
    },
    {
        "id1": 1618,
        "id2": 1643,
        "phenotype_comparison": "The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway"
    },
    {
        "id1": 1662,
        "id2": 1663,
        "phenotype_comparison": ""
    },
    {
        "id1": 1684,
        "id2": 1687,
        "phenotype_comparison": ""
    },
    {
        "id1": 1715,
        "id2": 1716,
        "phenotype_comparison": ""
    },
    {
        "id1": 1739,
        "id2": 1740,
        "phenotype_comparison": ""
    },
    {
        "id1": 1760,
        "id2": 1762,
        "phenotype_comparison": ""
    },
    {
        "id1": 1784,
        "id2": 1785,
        "phenotype_comparison": "Skn-1 was required at 15\u00b0C, 20\u00b0C, or 25\u00b0C for lifespan extension from daf-2 RNA interference (RNAi)."
    },
    {
        "id1": 1805,
        "id2": 1809,
        "phenotype_comparison": ""
    },
    {
        "id1": 1835,
        "id2": 1840,
        "phenotype_comparison": ""
    },
    {
        "id1": 1858,
        "id2": 1862,
        "phenotype_comparison": ""
    },
    {
        "id1": 1879,
        "id2": 1881,
        "phenotype_comparison": ""
    },
    {
        "id1": 1899,
        "id2": 1901,
        "phenotype_comparison": ""
    },
    {
        "id1": 1918,
        "id2": 1921,
        "phenotype_comparison": "Double mutants of aak-2(ok524) and stronger daf-2 reduction-of-function alleles have shortened lifespans compared with daf-2 single mutants, although they live longer than aak-2(ok524) single mutants. Therefore, aak-2-independent as well as aak-2-dependent mechanisms are required to produce the exceptionally long lifespans of daf-2 mutants."
    },
    {
        "id1": 1930,
        "id2": 1940,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1959,
        "phenotype_comparison": ""
    },
    {
        "id1": 1974,
        "id2": 1975,
        "phenotype_comparison": ""
    },
    {
        "id1": 1985,
        "id2": 1993,
        "phenotype_comparison": ""
    },
    {
        "id1": 2009,
        "id2": 2010,
        "phenotype_comparison": "If a GATA transcription factor functions specifically to extend life span rather than shorten it, then RNAi treatment may suppress the longevity of a long-lived mutant such as daf-2(e1370) without causing nonspecific early lethality of wild-type worms. Of the ten GATA transcription factor genes, we found that RNAi treatment of three (elt-3, egr-1, and egl-27) behave in this way in multiple independent life span experiments"
    },
    {
        "id1": 2007,
        "id2": 2031,
        "phenotype_comparison": ""
    },
    {
        "id1": 2053,
        "id2": 2055,
        "phenotype_comparison": ""
    },
    {
        "id1": 2082,
        "id2": 2084,
        "phenotype_comparison": ""
    },
    {
        "id1": 2107,
        "id2": 2108,
        "phenotype_comparison": ""
    },
    {
        "id1": 2126,
        "id2": 2130,
        "phenotype_comparison": ""
    },
    {
        "id1": 2150,
        "id2": 2151,
        "phenotype_comparison": ""
    },
    {
        "id1": 2168,
        "id2": 2170,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2190,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2206,
        "phenotype_comparison": ""
    },
    {
        "id1": 2230,
        "id2": 2232,
        "phenotype_comparison": ""
    },
    {
        "id1": 2247,
        "id2": 2248,
        "phenotype_comparison": ""
    },
    {
        "id1": 2267,
        "id2": 2269,
        "phenotype_comparison": ""
    },
    {
        "id1": 2294,
        "id2": 2296,
        "phenotype_comparison": ""
    },
    {
        "id1": 2318,
        "id2": 2319,
        "phenotype_comparison": "RNAi treatment of ddl-2 failed to produce any significant lifespan extension on hsf-1(sy441) mutants, while reducing expression of ddl-2 by RNAi extends lifespan in wild type. This finding suggests that hsf-1 is required for the extended lifespan observed in ddl-2 RNAi treated animals."
    },
    {
        "id1": 2342,
        "id2": 2343,
        "phenotype_comparison": "The lifespan of hsb-1(cg116); ddl-2(ok3235) double mutants is not statistically different from hsb-1(cg116) single mutants."
    },
    {
        "id1": 2370,
        "id2": 2371,
        "phenotype_comparison": "Inhibition of rab-10 by RNAi does not extend the lifespan of EQ19 (drr-2 over-expression) significantly, while inhibition of rab-10 xtends the lifespan of wild-type animals, suggesting a common mechanism that mediates the lifespan effects of eIF4H/drr-2 and rab-10."
    },
    {
        "id1": 2392,
        "id2": 2394,
        "phenotype_comparison": ""
    },
    {
        "id1": 2416,
        "id2": 2417,
        "phenotype_comparison": ""
    },
    {
        "id1": 2443,
        "id2": 2444,
        "phenotype_comparison": ""
    },
    {
        "id1": 2469,
        "id2": 2467,
        "phenotype_comparison": ""
    },
    {
        "id1": 2484,
        "id2": 2485,
        "phenotype_comparison": "The deletion of gcy-33 did not affect N2 worms\u2019 lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609)."
    },
    {
        "id1": 2503,
        "id2": 2504,
        "phenotype_comparison": "gcy-35 mutants had shorter lifespans than N2 controls on dead OP50 at 25\u00b0C. When gcy-35;npr-1(ad609) worms were grown at 25\u00b0C on dead OP50, their lifespan was similar to N2 animals."
    },
    {
        "id1": 2533,
        "id2": 2534,
        "phenotype_comparison": ""
    },
    {
        "id1": 2567,
        "id2": 2568,
        "phenotype_comparison": ""
    },
    {
        "id1": 2569,
        "id2": 2586,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2600,
        "phenotype_comparison": ""
    },
    {
        "id1": 2623,
        "id2": 2625,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2654,
        "phenotype_comparison": ""
    },
    {
        "id1": 2680,
        "id2": 2681,
        "phenotype_comparison": ""
    },
    {
        "id1": 2712,
        "id2": 2713,
        "phenotype_comparison": ""
    },
    {
        "id1": 2742,
        "id2": 2743,
        "phenotype_comparison": ""
    },
    {
        "id1": 2774,
        "id2": 2775,
        "phenotype_comparison": ""
    },
    {
        "id1": 2800,
        "id2": 2801,
        "phenotype_comparison": ""
    },
    {
        "id1": 2822,
        "id2": 2830,
        "phenotype_comparison": ""
    },
    {
        "id1": 2857,
        "id2": 2858,
        "phenotype_comparison": ""
    },
    {
        "id1": 2888,
        "id2": 2889,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2908,
        "phenotype_comparison": ""
    },
    {
        "id1": 2921,
        "id2": 2922,
        "phenotype_comparison": "Maternal RNAi of lgg-3 significantly extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2936,
        "id2": 2937,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2952,
        "phenotype_comparison": ""
    },
    {
        "id1": 2976,
        "id2": 2978,
        "phenotype_comparison": ""
    },
    {
        "id1": 3000,
        "id2": 3002,
        "phenotype_comparison": ""
    },
    {
        "id1": 3021,
        "id2": 3022,
        "phenotype_comparison": ""
    },
    {
        "id1": 3041,
        "id2": 3042,
        "phenotype_comparison": ""
    },
    {
        "id1": 3065,
        "id2": 3066,
        "phenotype_comparison": "Inactivation of ire-1 by a deletion mutation shortened the lifespan of daf-2 mutants. ire-1(ok799)\u2013null mutants had morphological and behavioral defects."
    },
    {
        "id1": 3082,
        "id2": 3083,
        "phenotype_comparison": ""
    },
    {
        "id1": 3058,
        "id2": 3098,
        "phenotype_comparison": ""
    },
    {
        "id1": 3117,
        "id2": 3118,
        "phenotype_comparison": "Inactivation of ire-1 by RNAi shortened the lifespan of daf-2 mutants. In both wild-type and daf-2(-) backgrounds, animals subjected to ire-1 RNAi appeared normal and healthy, whereas ire-1(ok799)\u2013null mutants had morphological and behavioral defects. Thus, whereas complete loss of ire-1 compromised the health of the animal, partial loss of ire-1, through RNAi, could shorten lifespan without making the animals appear unhealthy. "
    },
    {
        "id1": 3144,
        "id2": 3145,
        "phenotype_comparison": ""
    },
    {
        "id1": 3163,
        "id2": 3164,
        "phenotype_comparison": ""
    },
    {
        "id1": 3179,
        "id2": 3180,
        "phenotype_comparison": ""
    },
    {
        "id1": 3188,
        "id2": 3196,
        "phenotype_comparison": ""
    },
    {
        "id1": 3096,
        "id2": 3214,
        "phenotype_comparison": ""
    },
    {
        "id1": 3228,
        "id2": 3230,
        "phenotype_comparison": ""
    },
    {
        "id1": 3252,
        "id2": 3254,
        "phenotype_comparison": ""
    },
    {
        "id1": 3275,
        "id2": 3276,
        "phenotype_comparison": ""
    },
    {
        "id1": 3290,
        "id2": 3291,
        "phenotype_comparison": ""
    },
    {
        "id1": 3298,
        "id2": 3306,
        "phenotype_comparison": ""
    },
    {
        "id1": 3315,
        "id2": 3320,
        "phenotype_comparison": ""
    },
    {
        "id1": 3343,
        "id2": 3345,
        "phenotype_comparison": ""
    },
    {
        "id1": 3361,
        "id2": 3370,
        "phenotype_comparison": ""
    },
    {
        "id1": 1544,
        "id2": 1545,
        "phenotype_comparison": "Median survival for Mgat5+/- male mice is similar to that of wild-type C57BL6 mice. In contrast, median survival for Pten+/- males was 417, in particular due early cancer development (mainly lymphomas). The survival of Pten+/- is slightly ameliorated in males by the Mgat5+/- mutation."
    },
    {
        "id1": 1567,
        "id2": 1571,
        "phenotype_comparison": ""
    },
    {
        "id1": 1589,
        "id2": 1593,
        "phenotype_comparison": ""
    },
    {
        "id1": 1626,
        "id2": 1627,
        "phenotype_comparison": ""
    },
    {
        "id1": 1620,
        "id2": 1644,
        "phenotype_comparison": ""
    },
    {
        "id1": 1660,
        "id2": 1663,
        "phenotype_comparison": "utx-1 RNAi extended lifespan in N2 worm, but not in rrf-1(ok589)."
    },
    {
        "id1": 1684,
        "id2": 1688,
        "phenotype_comparison": ""
    },
    {
        "id1": 1715,
        "id2": 1717,
        "phenotype_comparison": ""
    },
    {
        "id1": 1739,
        "id2": 1741,
        "phenotype_comparison": ""
    },
    {
        "id1": 1761,
        "id2": 1763,
        "phenotype_comparison": ""
    },
    {
        "id1": 1782,
        "id2": 1786,
        "phenotype_comparison": ""
    },
    {
        "id1": 1805,
        "id2": 1810,
        "phenotype_comparison": ""
    },
    {
        "id1": 1835,
        "id2": 1841,
        "phenotype_comparison": ""
    },
    {
        "id1": 1861,
        "id2": 1862,
        "phenotype_comparison": "Eak-7 null mutation enhances the lifespan extension observed in akt-2 null mutants."
    },
    {
        "id1": 1880,
        "id2": 1882,
        "phenotype_comparison": ""
    },
    {
        "id1": 1900,
        "id2": 1902,
        "phenotype_comparison": ""
    },
    {
        "id1": 1916,
        "id2": 1922,
        "phenotype_comparison": ""
    },
    {
        "id1": 1940,
        "id2": 1941,
        "phenotype_comparison": ""
    },
    {
        "id1": 1952,
        "id2": 1960,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1976,
        "phenotype_comparison": ""
    },
    {
        "id1": 1992,
        "id2": 1993,
        "phenotype_comparison": ""
    },
    {
        "id1": 2007,
        "id2": 2011,
        "phenotype_comparison": ""
    },
    {
        "id1": 2028,
        "id2": 2032,
        "phenotype_comparison": ""
    },
    {
        "id1": 2054,
        "id2": 2055,
        "phenotype_comparison": "RNAi reduction of pha-4 suppressed the increased longevity of worms overexpressing wwp-1"
    },
    {
        "id1": 2077,
        "id2": 2085,
        "phenotype_comparison": ""
    },
    {
        "id1": 2107,
        "id2": 2109,
        "phenotype_comparison": ""
    },
    {
        "id1": 2130,
        "id2": 2131,
        "phenotype_comparison": ""
    },
    {
        "id1": 2150,
        "id2": 2152,
        "phenotype_comparison": ""
    },
    {
        "id1": 2169,
        "id2": 2171,
        "phenotype_comparison": ""
    },
    {
        "id1": 2190,
        "id2": 2191,
        "phenotype_comparison": ""
    },
    {
        "id1": 2206,
        "id2": 2207,
        "phenotype_comparison": ""
    },
    {
        "id1": 2231,
        "id2": 2232,
        "phenotype_comparison": "The long lifespan of eat-2(ad1116) is significantly suppressed by nhr-49 RNAi. The nhr-49 RNAi had no effect on WT worms."
    },
    {
        "id1": 2247,
        "id2": 2249,
        "phenotype_comparison": ""
    },
    {
        "id1": 2268,
        "id2": 2269,
        "phenotype_comparison": "RNAi knock-down of mekk-3 increased lifespan of daf-2(e1368), a weaker allele"
    },
    {
        "id1": 2295,
        "id2": 2297,
        "phenotype_comparison": ""
    },
    {
        "id1": 2320,
        "id2": 2321,
        "phenotype_comparison": ""
    },
    {
        "id1": 2344,
        "id2": 2345,
        "phenotype_comparison": ""
    },
    {
        "id1": 2372,
        "id2": 2373,
        "phenotype_comparison": ""
    },
    {
        "id1": 2393,
        "id2": 2395,
        "phenotype_comparison": ""
    },
    {
        "id1": 2414,
        "id2": 2418,
        "phenotype_comparison": ""
    },
    {
        "id1": 2444,
        "id2": 2445,
        "phenotype_comparison": ""
    },
    {
        "id1": 2470,
        "id2": 2467,
        "phenotype_comparison": ""
    },
    {
        "id1": 2505,
        "id2": 2506,
        "phenotype_comparison": ""
    },
    {
        "id1": 2535,
        "id2": 2536,
        "phenotype_comparison": ""
    },
    {
        "id1": 2550,
        "id2": 2545,
        "phenotype_comparison": ""
    },
    {
        "id1": 2568,
        "id2": 2569,
        "phenotype_comparison": ""
    },
    {
        "id1": 2573,
        "id2": 2568,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2601,
        "phenotype_comparison": ""
    },
    {
        "id1": 2626,
        "id2": 2627,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2655,
        "phenotype_comparison": ""
    },
    {
        "id1": 2680,
        "id2": 2682,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2714,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2744,
        "phenotype_comparison": ""
    },
    {
        "id1": 2766,
        "id2": 2776,
        "phenotype_comparison": ""
    },
    {
        "id1": 2802,
        "id2": 2803,
        "phenotype_comparison": ""
    },
    {
        "id1": 2817,
        "id2": 2831,
        "phenotype_comparison": ""
    },
    {
        "id1": 2859,
        "id2": 2860,
        "phenotype_comparison": ""
    },
    {
        "id1": 2877,
        "id2": 2890,
        "phenotype_comparison": ""
    },
    {
        "id1": 2907,
        "id2": 2908,
        "phenotype_comparison": "Maternal RNAi of atg-5 significantly extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2897,
        "id2": 2923,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2938,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2953,
        "phenotype_comparison": ""
    },
    {
        "id1": 2976,
        "id2": 2979,
        "phenotype_comparison": ""
    },
    {
        "id1": 3003,
        "id2": 3004,
        "phenotype_comparison": ""
    },
    {
        "id1": 3023,
        "id2": 3024,
        "phenotype_comparison": ""
    },
    {
        "id1": 3043,
        "id2": 3044,
        "phenotype_comparison": ""
    },
    {
        "id1": 3067,
        "id2": 3068,
        "phenotype_comparison": ""
    },
    {
        "id1": 3079,
        "id2": 3083,
        "phenotype_comparison": "A putative xbp-1\u2013null mutation, which causes truncation of the XBP-1 protein before its DNA binding domain, shortened the lifespan of daf-2 mutants more than it shortened the lifespan of wild type without affecting the apparent health of the animals."
    },
    {
        "id1": 3097,
        "id2": 3098,
        "phenotype_comparison": ""
    },
    {
        "id1": 3119,
        "id2": 3120,
        "phenotype_comparison": ""
    },
    {
        "id1": 3144,
        "id2": 3146,
        "phenotype_comparison": ""
    },
    {
        "id1": 3163,
        "id2": 3165,
        "phenotype_comparison": ""
    },
    {
        "id1": 3179,
        "id2": 3181,
        "phenotype_comparison": ""
    },
    {
        "id1": 3195,
        "id2": 3196,
        "phenotype_comparison": "Inactivation of dox-1 had a substantial effect on the lifespan of daf-2 mutants without affecting their apparent health. In four of six trials, dox-1 RNAi shortened the lifespan of daf-2 animals substantially more than it shortened wild-type lifespan. Thus, dox-1 contributes significantly to the longevity of daf-2 mutants."
    },
    {
        "id1": 3214,
        "id2": 3215,
        "phenotype_comparison": ""
    },
    {
        "id1": 3229,
        "id2": 3230,
        "phenotype_comparison": "Flies with both a dSir2 mutation and rpd3 (def24) mutation were not long-lived, whereas their counterparts, flies mutant for only rpd3(def24), remained long-livedr2 and Rpd3, therefore, seem to be in the calorie-reduction life-span-extending pathway in flies. "
    },
    {
        "id1": 3253,
        "id2": 3254,
        "phenotype_comparison": "The TrxT- mutant (w Df(1)J5) had very similar lifespans to the control and the double mutant had only a slightly shorter lifespan than the single TrxT mutant."
    },
    {
        "id1": 3275,
        "id2": 3277,
        "phenotype_comparison": ""
    },
    {
        "id1": 1622,
        "id2": 1645,
        "phenotype_comparison": "The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway"
    },
    {
        "id1": 1664,
        "id2": 1665,
        "phenotype_comparison": ""
    },
    {
        "id1": 1689,
        "id2": 1691,
        "phenotype_comparison": ""
    },
    {
        "id1": 1717,
        "id2": 1718,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1741,
        "id2": 1742,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1764,
        "id2": 1765,
        "phenotype_comparison": ""
    },
    {
        "id1": 3288,
        "id2": 3291,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan."
    },
    {
        "id1": 3299,
        "id2": 3307,
        "phenotype_comparison": ""
    },
    {
        "id1": 3317,
        "id2": 3320,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and an increase in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3344,
        "id2": 3345,
        "phenotype_comparison": "Cohousing with w helpers conferred lifespan extension for the various Sod alleles and heteroallelic combinations."
    },
    {
        "id1": 3369,
        "id2": 3370,
        "phenotype_comparison": "Two rutabaga mutants (rut 1), had significantly shortened life spans, and the rut and NF1 double mutant (rut;NF1 P2 ) did not further shorten the life span, implicating cAMP in mediating longevity. "
    },
    {
        "id1": 1542,
        "id2": 1546,
        "phenotype_comparison": ""
    },
    {
        "id1": 1568,
        "id2": 1572,
        "phenotype_comparison": ""
    },
    {
        "id1": 1592,
        "id2": 1593,
        "phenotype_comparison": "Skn-1 mutations significantly reduced the lifespan of the Class 1 daf-2 mutant e1368."
    },
    {
        "id1": 1622,
        "id2": 1627,
        "phenotype_comparison": "While utx-1 RNAi effectively extended the life span of wild-type N2 strain, such an effect could not be observed in any mutant on IIS pathway; utx-1 RNAi could not further increase the life span of daf-2(e1370) worms and could not at all increase the life span in daf-16(mu86) mutant animals."
    },
    {
        "id1": 1644,
        "id2": 1645,
        "phenotype_comparison": ""
    },
    {
        "id1": 1658,
        "id2": 1664,
        "phenotype_comparison": ""
    },
    {
        "id1": 1689,
        "id2": 1690,
        "phenotype_comparison": ""
    },
    {
        "id1": 1716,
        "id2": 1718,
        "phenotype_comparison": ""
    },
    {
        "id1": 1740,
        "id2": 1742,
        "phenotype_comparison": ""
    },
    {
        "id1": 1762,
        "id2": 1763,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1786,
        "id2": 1787,
        "phenotype_comparison": ""
    },
    {
        "id1": 1811,
        "id2": 1812,
        "phenotype_comparison": ""
    },
    {
        "id1": 1835,
        "id2": 1842,
        "phenotype_comparison": ""
    },
    {
        "id1": 1852,
        "id2": 1863,
        "phenotype_comparison": ""
    },
    {
        "id1": 1881,
        "id2": 1882,
        "phenotype_comparison": "Eak-7 null mutation enhances the lifespan extension observed in akt-2 null mutants."
    },
    {
        "id1": 1901,
        "id2": 1902,
        "phenotype_comparison": "Lifespan extension in eak-7 null mutants does not require sdf-9."
    },
    {
        "id1": 1922,
        "id2": 1923,
        "phenotype_comparison": ""
    },
    {
        "id1": 1932,
        "id2": 1941,
        "phenotype_comparison": "Reducing 14-3-3 gene expression in a daf-2 mutant, which displays an increased life span, did not shorten life span"
    },
    {
        "id1": 1959,
        "id2": 1960,
        "phenotype_comparison": ""
    },
    {
        "id1": 1967,
        "id2": 1977,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1994,
        "phenotype_comparison": ""
    },
    {
        "id1": 2008,
        "id2": 2012,
        "phenotype_comparison": ""
    },
    {
        "id1": 2031,
        "id2": 2032,
        "phenotype_comparison": ""
    },
    {
        "id1": 2056,
        "id2": 2057,
        "phenotype_comparison": ""
    },
    {
        "id1": 2086,
        "id2": 2087,
        "phenotype_comparison": ""
    },
    {
        "id1": 2108,
        "id2": 2110,
        "phenotype_comparison": ""
    },
    {
        "id1": 2128,
        "id2": 2131,
        "phenotype_comparison": "mekk-3 RNAi was also able to extend the lifespans of daf-5(e1386)."
    },
    {
        "id1": 2151,
        "id2": 2153,
        "phenotype_comparison": ""
    },
    {
        "id1": 2170,
        "id2": 2171,
        "phenotype_comparison": "mekk-3 RNAi did not significantly increase the lifespan of clk-1(qm30), a mutant in the highly conserved demethoxyubiquinone (DMQ) hydroxylase gene that is necessary for the biosynthesis of ubiquinone."
    },
    {
        "id1": 2180,
        "id2": 2191,
        "phenotype_comparison": "mekk-3 RNAi decreased the lifespan of aha-1(ok1396)."
    },
    {
        "id1": 2180,
        "id2": 2207,
        "phenotype_comparison": "In ABC transporter (P-glycoproteins) mutants such as pgp-3(ok3091) or pgp-3(pk18), mekk-3 RNAi did not extend lifespan to the same extent as in WT."
    },
    {
        "id1": 2233,
        "id2": 2230,
        "phenotype_comparison": ""
    },
    {
        "id1": 2248,
        "id2": 2250,
        "phenotype_comparison": ""
    },
    {
        "id1": 2107,
        "id2": 2270,
        "phenotype_comparison": ""
    },
    {
        "id1": 2296,
        "id2": 2297,
        "phenotype_comparison": "sgk-1(gf) increased mean and median lifespan, compared with wild-type siblings. This lifespan extension was suppressed by a null mutation in daf-16/FoxO."
    },
    {
        "id1": 2320,
        "id2": 2322,
        "phenotype_comparison": ""
    },
    {
        "id1": 2344,
        "id2": 2346,
        "phenotype_comparison": ""
    },
    {
        "id1": 2372,
        "id2": 2374,
        "phenotype_comparison": ""
    },
    {
        "id1": 2394,
        "id2": 2395,
        "phenotype_comparison": "Inhibition of eIF4H/drr-2 consistently extends the lifespan of wild-type animals and animals over-expressing sams-1 (EQ2). Taken together, these results strongly imply that eIF4H/drr-2 may act downstream of both rab-10 and sams-1 and its activity might be essential for RAB-10 and SAMS-1 to mediate the longevity effects of DR. "
    },
    {
        "id1": 2446,
        "id2": 2447,
        "phenotype_comparison": ""
    },
    {
        "id1": 2471,
        "id2": 2472,
        "phenotype_comparison": ""
    },
    {
        "id1": 2459,
        "id2": 2486,
        "phenotype_comparison": ""
    },
    {
        "id1": 2505,
        "id2": 2507,
        "phenotype_comparison": ""
    },
    {
        "id1": 2536,
        "id2": 2537,
        "phenotype_comparison": ""
    },
    {
        "id1": 2570,
        "id2": 2571,
        "phenotype_comparison": ""
    },
    {
        "id1": 2573,
        "id2": 2587,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2602,
        "phenotype_comparison": ""
    },
    {
        "id1": 2628,
        "id2": 2629,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2656,
        "phenotype_comparison": ""
    },
    {
        "id1": 2680,
        "id2": 2683,
        "phenotype_comparison": ""
    },
    {
        "id1": 2715,
        "id2": 2716,
        "phenotype_comparison": ""
    },
    {
        "id1": 2725,
        "id2": 2745,
        "phenotype_comparison": ""
    },
    {
        "id1": 2753,
        "id2": 2777,
        "phenotype_comparison": ""
    },
    {
        "id1": 2800,
        "id2": 2804,
        "phenotype_comparison": ""
    },
    {
        "id1": 2822,
        "id2": 2832,
        "phenotype_comparison": ""
    },
    {
        "id1": 2861,
        "id2": 2862,
        "phenotype_comparison": ""
    },
    {
        "id1": 2879,
        "id2": 2891,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2909,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2924,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2939,
        "phenotype_comparison": ""
    },
    {
        "id1": 2952,
        "id2": 2953,
        "phenotype_comparison": ""
    },
    {
        "id1": 2980,
        "id2": 2981,
        "phenotype_comparison": ""
    },
    {
        "id1": 3005,
        "id2": 3006,
        "phenotype_comparison": ""
    },
    {
        "id1": 3023,
        "id2": 3025,
        "phenotype_comparison": ""
    },
    {
        "id1": 3043,
        "id2": 3045,
        "phenotype_comparison": ""
    },
    {
        "id1": 3067,
        "id2": 3069,
        "phenotype_comparison": ""
    },
    {
        "id1": 3082,
        "id2": 3084,
        "phenotype_comparison": ""
    },
    {
        "id1": 3096,
        "id2": 3099,
        "phenotype_comparison": ""
    },
    {
        "id1": 3119,
        "id2": 3121,
        "phenotype_comparison": ""
    },
    {
        "id1": 3145,
        "id2": 3147,
        "phenotype_comparison": ""
    },
    {
        "id1": 3164,
        "id2": 3166,
        "phenotype_comparison": ""
    },
    {
        "id1": 3180,
        "id2": 3182,
        "phenotype_comparison": ""
    },
    {
        "id1": 3197,
        "id2": 3198,
        "phenotype_comparison": ""
    },
    {
        "id1": 3099,
        "id2": 3215,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the isp-1 mutation by an average of less than 20%."
    },
    {
        "id1": 3231,
        "id2": 3232,
        "phenotype_comparison": ""
    },
    {
        "id1": 3255,
        "id2": 3256,
        "phenotype_comparison": ""
    },
    {
        "id1": 3276,
        "id2": 3278,
        "phenotype_comparison": ""
    },
    {
        "id1": 3275,
        "id2": 3292,
        "phenotype_comparison": ""
    },
    {
        "id1": 3306,
        "id2": 3307,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3321,
        "id2": 3323,
        "phenotype_comparison": ""
    },
    {
        "id1": 3346,
        "id2": 3347,
        "phenotype_comparison": ""
    },
    {
        "id1": 3363,
        "id2": 3371,
        "phenotype_comparison": ""
    },
    {
        "id1": 1543,
        "id2": 1547,
        "phenotype_comparison": ""
    },
    {
        "id1": 1571,
        "id2": 1572,
        "phenotype_comparison": "The double mutant obtained by crossing heterozygous APC(MIN) and Ku80 heterozygous +/- mutants has decreased lifespan compared to WT and single mutants"
    },
    {
        "id1": 1588,
        "id2": 1594,
        "phenotype_comparison": ""
    },
    {
        "id1": 1628,
        "id2": 1629,
        "phenotype_comparison": ""
    },
    {
        "id1": 1783,
        "id2": 1787,
        "phenotype_comparison": "Lifespan extension is extremely robust when daf-2 RNAi is performed in the Class 1 mutant daf-2(e1368), which lacks adulthood dauer traits but predisposes to dauer entry."
    },
    {
        "id1": 1811,
        "id2": 1813,
        "phenotype_comparison": ""
    },
    {
        "id1": 1835,
        "id2": 1843,
        "phenotype_comparison": ""
    },
    {
        "id1": 1858,
        "id2": 1864,
        "phenotype_comparison": ""
    },
    {
        "id1": 1879,
        "id2": 1883,
        "phenotype_comparison": ""
    },
    {
        "id1": 1873,
        "id2": 1903,
        "phenotype_comparison": ""
    },
    {
        "id1": 1918,
        "id2": 1923,
        "phenotype_comparison": "Double mutants of aak-2(ok524) and stronger daf-2 reduction-of-function alleles have shortened lifespans compared with daf-2 single mutants, although they live longer than aak-2(ok524) single mutants. Therefore, aak-2-independent as well as aak-2-dependent mechanisms are required to produce the exceptionally long lifespans of daf-2 mutants."
    },
    {
        "id1": 1940,
        "id2": 1942,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1961,
        "phenotype_comparison": ""
    },
    {
        "id1": 1976,
        "id2": 1977,
        "phenotype_comparison": ""
    },
    {
        "id1": 1985,
        "id2": 1995,
        "phenotype_comparison": ""
    },
    {
        "id1": 2011,
        "id2": 2012,
        "phenotype_comparison": "If a GATA transcription factor functions specifically to extend life span rather than shorten it, then RNAi treatment may suppress the longevity of a long-lived mutant such as daf-2(e1370) without causing nonspecific early lethality of wild-type worms. Of the ten GATA transcription factor genes, we found that RNAi treatment of three (elt-3, egr-1, and egl-27) behave in this way in multiple independent life span experiments"
    },
    {
        "id1": 2033,
        "id2": 2034,
        "phenotype_comparison": ""
    },
    {
        "id1": 2056,
        "id2": 2058,
        "phenotype_comparison": ""
    },
    {
        "id1": 2081,
        "id2": 2088,
        "phenotype_comparison": ""
    },
    {
        "id1": 2109,
        "id2": 2110,
        "phenotype_comparison": "When daf-2(e1370) worms were grown on mekk-3 RNAi at 20 \u00b0C, a dramatic increase in lifespan was observed over control RNAi-grown worms, suggesting that MEKK-3 may work in a parallel pathway."
    },
    {
        "id1": 2126,
        "id2": 2132,
        "phenotype_comparison": ""
    },
    {
        "id1": 2152,
        "id2": 2153,
        "phenotype_comparison": "mekk-3 RNAi failed to increase the long lifespans of eat-2(ad465) to the same extent as in WT, suggesting that they may function in the same genetic pathway for lifespan regulation."
    },
    {
        "id1": 2162,
        "id2": 2172,
        "phenotype_comparison": ""
    },
    {
        "id1": 2182,
        "id2": 2192,
        "phenotype_comparison": ""
    },
    {
        "id1": 2182,
        "id2": 2208,
        "phenotype_comparison": ""
    },
    {
        "id1": 2233,
        "id2": 2234,
        "phenotype_comparison": ""
    },
    {
        "id1": 2249,
        "id2": 2250,
        "phenotype_comparison": "The mekk-3 RNAi was not able to increase lifespan in nhr-49(nr2041) to the same extent as in wild type."
    },
    {
        "id1": 2270,
        "id2": 2271,
        "phenotype_comparison": ""
    },
    {
        "id1": 2298,
        "id2": 2299,
        "phenotype_comparison": ""
    },
    {
        "id1": 2321,
        "id2": 2323,
        "phenotype_comparison": ""
    },
    {
        "id1": 2345,
        "id2": 2347,
        "phenotype_comparison": ""
    },
    {
        "id1": 2373,
        "id2": 2375,
        "phenotype_comparison": ""
    },
    {
        "id1": 2396,
        "id2": 2397,
        "phenotype_comparison": ""
    },
    {
        "id1": 2419,
        "id2": 2421,
        "phenotype_comparison": ""
    },
    {
        "id1": 2447,
        "id2": 2448,
        "phenotype_comparison": ""
    },
    {
        "id1": 2471,
        "id2": 2473,
        "phenotype_comparison": ""
    },
    {
        "id1": 2506,
        "id2": 2504,
        "phenotype_comparison": ""
    },
    {
        "id1": 2538,
        "id2": 2539,
        "phenotype_comparison": ""
    },
    {
        "id1": 2551,
        "id2": 2547,
        "phenotype_comparison": ""
    },
    {
        "id1": 2571,
        "id2": 2572,
        "phenotype_comparison": ""
    },
    {
        "id1": 2568,
        "id2": 2588,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2603,
        "phenotype_comparison": ""
    },
    {
        "id1": 2630,
        "id2": 2631,
        "phenotype_comparison": ""
    },
    {
        "id1": 2657,
        "id2": 2658,
        "phenotype_comparison": ""
    },
    {
        "id1": 2680,
        "id2": 2684,
        "phenotype_comparison": ""
    },
    {
        "id1": 2717,
        "id2": 2718,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2746,
        "phenotype_comparison": ""
    },
    {
        "id1": 2753,
        "id2": 2778,
        "phenotype_comparison": ""
    },
    {
        "id1": 2800,
        "id2": 2805,
        "phenotype_comparison": ""
    },
    {
        "id1": 2814,
        "id2": 2833,
        "phenotype_comparison": ""
    },
    {
        "id1": 2863,
        "id2": 2864,
        "phenotype_comparison": ""
    },
    {
        "id1": 2877,
        "id2": 2892,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2910,
        "phenotype_comparison": ""
    },
    {
        "id1": 2923,
        "id2": 2924,
        "phenotype_comparison": "Maternal RNAi of atg-16.2 significantly extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2938,
        "id2": 2939,
        "phenotype_comparison": "RNAi suppression of bec-1 after development extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2927,
        "id2": 2954,
        "phenotype_comparison": ""
    },
    {
        "id1": 2980,
        "id2": 2982,
        "phenotype_comparison": ""
    },
    {
        "id1": 3005,
        "id2": 3007,
        "phenotype_comparison": ""
    },
    {
        "id1": 3024,
        "id2": 3026,
        "phenotype_comparison": ""
    },
    {
        "id1": 3044,
        "id2": 3046,
        "phenotype_comparison": ""
    },
    {
        "id1": 3068,
        "id2": 3070,
        "phenotype_comparison": ""
    },
    {
        "id1": 3061,
        "id2": 3084,
        "phenotype_comparison": "Inactivation of ire-1 by a deletion mutation shortened the lifespan of daf-2 mutants. ire-1(ok799)\u2013null mutants had morphological and behavioral defects."
    },
    {
        "id1": 3058,
        "id2": 3100,
        "phenotype_comparison": ""
    },
    {
        "id1": 3122,
        "id2": 3123,
        "phenotype_comparison": ""
    },
    {
        "id1": 3146,
        "id2": 3147,
        "phenotype_comparison": "Inactivation of atf-6 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3165,
        "id2": 3166,
        "phenotype_comparison": "Inactivation of pek-1 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3181,
        "id2": 3182,
        "phenotype_comparison": ""
    },
    {
        "id1": 3197,
        "id2": 3199,
        "phenotype_comparison": ""
    },
    {
        "id1": 3113,
        "id2": 3216,
        "phenotype_comparison": ""
    },
    {
        "id1": 3232,
        "id2": 3233,
        "phenotype_comparison": ""
    },
    {
        "id1": 3255,
        "id2": 3257,
        "phenotype_comparison": ""
    },
    {
        "id1": 3277,
        "id2": 3278,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3292,
        "id2": 3293,
        "phenotype_comparison": ""
    },
    {
        "id1": 3302,
        "id2": 3308,
        "phenotype_comparison": ""
    },
    {
        "id1": 3322,
        "id2": 3323,
        "phenotype_comparison": "The extension of lifespan by puc heterozygosity requires functional Hep. hep 1 hemizygous males exhibit lifespan comparable to wild-type flies. Reduction of the puc gene-dose only marginally extends lifespan in these flies. Compared to puc mutants in a wild-type background, hep 1 reduces lifespan."
    },
    {
        "id1": 3348,
        "id2": 3349,
        "phenotype_comparison": ""
    },
    {
        "id1": 3365,
        "id2": 3372,
        "phenotype_comparison": ""
    },
    {
        "id1": 1546,
        "id2": 1547,
        "phenotype_comparison": "Median survival for Mgat5-/- male mice is reduced to 520, compared with >650 days for wild-type C57BL6 mice. Median survival for Pten+/- males is reduced even more to 417, in particular due early cancer development (mainly lymphomas). The survival of Pten+/- is slightly ameliorated in males by the Mgat5-/- mutation."
    },
    {
        "id1": 1573,
        "id2": 1575,
        "phenotype_comparison": ""
    },
    {
        "id1": 1589,
        "id2": 1595,
        "phenotype_comparison": ""
    },
    {
        "id1": 1628,
        "id2": 1630,
        "phenotype_comparison": ""
    },
    {
        "id1": 1616,
        "id2": 1646,
        "phenotype_comparison": ""
    },
    {
        "id1": 1660,
        "id2": 1665,
        "phenotype_comparison": "utx-1 RNAi extended lifespan in N2 worm, but not in rrf-1(ok589)."
    },
    {
        "id1": 1692,
        "id2": 1693,
        "phenotype_comparison": ""
    },
    {
        "id1": 1719,
        "id2": 1720,
        "phenotype_comparison": ""
    },
    {
        "id1": 1739,
        "id2": 1743,
        "phenotype_comparison": ""
    },
    {
        "id1": 1764,
        "id2": 1766,
        "phenotype_comparison": ""
    },
    {
        "id1": 1814,
        "id2": 1815,
        "phenotype_comparison": ""
    },
    {
        "id1": 1844,
        "id2": 1845,
        "phenotype_comparison": ""
    },
    {
        "id1": 1863,
        "id2": 1864,
        "phenotype_comparison": "sgk-1 activity is required for lifespan extension in eak-7 null mutants. "
    },
    {
        "id1": 1880,
        "id2": 1884,
        "phenotype_comparison": ""
    },
    {
        "id1": 1874,
        "id2": 1904,
        "phenotype_comparison": ""
    },
    {
        "id1": 1916,
        "id2": 1924,
        "phenotype_comparison": ""
    },
    {
        "id1": 1934,
        "id2": 1942,
        "phenotype_comparison": "Reducing 14-3-3 gene expression in a daf-2 mutant, which displays an increased life span, did not shorten life span"
    },
    {
        "id1": 1952,
        "id2": 1962,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1978,
        "phenotype_comparison": ""
    },
    {
        "id1": 1994,
        "id2": 1995,
        "phenotype_comparison": ""
    },
    {
        "id1": 2013,
        "id2": 2014,
        "phenotype_comparison": ""
    },
    {
        "id1": 2033,
        "id2": 2035,
        "phenotype_comparison": ""
    },
    {
        "id1": 2057,
        "id2": 2059,
        "phenotype_comparison": ""
    },
    {
        "id1": 2088,
        "id2": 2089,
        "phenotype_comparison": ""
    },
    {
        "id1": 2111,
        "id2": 2112,
        "phenotype_comparison": ""
    },
    {
        "id1": 2132,
        "id2": 2133,
        "phenotype_comparison": ""
    },
    {
        "id1": 2138,
        "id2": 2154,
        "phenotype_comparison": ""
    },
    {
        "id1": 2172,
        "id2": 2173,
        "phenotype_comparison": ""
    },
    {
        "id1": 2192,
        "id2": 2193,
        "phenotype_comparison": ""
    },
    {
        "id1": 2208,
        "id2": 2209,
        "phenotype_comparison": ""
    },
    {
        "id1": 2230,
        "id2": 2235,
        "phenotype_comparison": ""
    },
    {
        "id1": 2244,
        "id2": 2251,
        "phenotype_comparison": ""
    },
    {
        "id1": 2109,
        "id2": 2271,
        "phenotype_comparison": "RNAi knock-down of mekk-3 increased lifespan of daf-2(e1368), a weaker allele"
    },
    {
        "id1": 2298,
        "id2": 2300,
        "phenotype_comparison": ""
    },
    {
        "id1": 2322,
        "id2": 2323,
        "phenotype_comparison": "hsf-1 is required for the lifespan extension caused by hsb-1 mutations, as hsb-1(cg116); hsf-1(RNAi) animals\u2019 lifespans are as short as hsf-1(RNAi) animals."
    },
    {
        "id1": 2346,
        "id2": 2347,
        "phenotype_comparison": "Inhibition of both ddl-1 and ddl-2 by RNAi does not lead to a larger lifespan extension compared to animals treated with ddl-1 or ddl-2 RNAi alone, suggesting that ddl-1 and ddl-2may have common effectors and act in the same genetic pathway."
    },
    {
        "id1": 2374,
        "id2": 2375,
        "phenotype_comparison": "Inhibition of rab-10 by RNAi does not extend the lifespan of EQ19 (drr-2 over-expression) significantly, while inhibition of rab-10 xtends the lifespan of wild-type animals, suggesting a common mechanism that mediates the lifespan effects of eIF4H/drr-2 and rab-10."
    },
    {
        "id1": 2396,
        "id2": 2398,
        "phenotype_comparison": ""
    },
    {
        "id1": 2420,
        "id2": 2422,
        "phenotype_comparison": ""
    },
    {
        "id1": 2449,
        "id2": 2450,
        "phenotype_comparison": ""
    },
    {
        "id1": 2472,
        "id2": 2463,
        "phenotype_comparison": ""
    },
    {
        "id1": 2463,
        "id2": 2487,
        "phenotype_comparison": ""
    },
    {
        "id1": 2507,
        "id2": 2504,
        "phenotype_comparison": "gcy-35 mutants had shorter lifespans than N2 controls on dead OP50 at 25\u00b0C. When gcy-35;npr-1(ad609) worms were grown at 25\u00b0C on dead OP50, their lifespan was similar to N2 animals."
    },
    {
        "id1": 2539,
        "id2": 2540,
        "phenotype_comparison": ""
    },
    {
        "id1": 2573,
        "id2": 2574,
        "phenotype_comparison": ""
    },
    {
        "id1": 2587,
        "id2": 2588,
        "phenotype_comparison": "egl-9 loss of function significantly increased the lifespan of N2 worms, but significantly shortened the lifespan of npr-1(ad609) animals, indicating that the function of egl-9 in lifespan is regulated by npr-1."
    },
    {
        "id1": 2596,
        "id2": 2604,
        "phenotype_comparison": ""
    },
    {
        "id1": 2630,
        "id2": 2632,
        "phenotype_comparison": ""
    },
    {
        "id1": 2657,
        "id2": 2659,
        "phenotype_comparison": ""
    },
    {
        "id1": 2685,
        "id2": 2686,
        "phenotype_comparison": ""
    },
    {
        "id1": 2715,
        "id2": 2719,
        "phenotype_comparison": ""
    },
    {
        "id1": 2736,
        "id2": 2747,
        "phenotype_comparison": ""
    },
    {
        "id1": 2753,
        "id2": 2779,
        "phenotype_comparison": ""
    },
    {
        "id1": 2800,
        "id2": 2806,
        "phenotype_comparison": ""
    },
    {
        "id1": 2826,
        "id2": 2834,
        "phenotype_comparison": ""
    },
    {
        "id1": 2865,
        "id2": 2866,
        "phenotype_comparison": ""
    },
    {
        "id1": 2879,
        "id2": 2893,
        "phenotype_comparison": ""
    },
    {
        "id1": 2909,
        "id2": 2910,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2925,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2940,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2955,
        "phenotype_comparison": ""
    },
    {
        "id1": 2980,
        "id2": 2983,
        "phenotype_comparison": ""
    },
    {
        "id1": 3006,
        "id2": 3008,
        "phenotype_comparison": ""
    },
    {
        "id1": 3025,
        "id2": 3026,
        "phenotype_comparison": ""
    },
    {
        "id1": 3045,
        "id2": 3046,
        "phenotype_comparison": ""
    },
    {
        "id1": 3069,
        "id2": 3070,
        "phenotype_comparison": "A putative xbp-1\u2013null mutation, which causes truncation of the XBP-1 protein before its DNA binding domain, shortened the lifespan of daf-2 mutants more than it shortened the lifespan of wild type without affecting the apparent health of the animals."
    },
    {
        "id1": 3067,
        "id2": 3085,
        "phenotype_comparison": ""
    },
    {
        "id1": 3099,
        "id2": 3100,
        "phenotype_comparison": "Inactivation of ire-1 by RNAi shortened the lifespan of daf-2 mutants. In both wild-type and daf-2(-) backgrounds, animals subjected to ire-1 RNAi appeared normal and healthy, whereas ire-1(ok799)\u2013null mutants had morphological and behavioral defects. Thus, whereas complete loss of ire-1 compromised the health of the animal, partial loss of ire-1, through RNAi, could shorten lifespan without making the animals appear unhealthy. "
    },
    {
        "id1": 3122,
        "id2": 3124,
        "phenotype_comparison": ""
    },
    {
        "id1": 3148,
        "id2": 3058,
        "phenotype_comparison": ""
    },
    {
        "id1": 3167,
        "id2": 3168,
        "phenotype_comparison": ""
    },
    {
        "id1": 3179,
        "id2": 3183,
        "phenotype_comparison": ""
    },
    {
        "id1": 3198,
        "id2": 3200,
        "phenotype_comparison": ""
    },
    {
        "id1": 3216,
        "id2": 3215,
        "phenotype_comparison": ""
    },
    {
        "id1": 3234,
        "id2": 3235,
        "phenotype_comparison": ""
    },
    {
        "id1": 3256,
        "id2": 3258,
        "phenotype_comparison": ""
    },
    {
        "id1": 3275,
        "id2": 3279,
        "phenotype_comparison": ""
    },
    {
        "id1": 3288,
        "id2": 3293,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3306,
        "id2": 3308,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Cat single mutant."
    },
    {
        "id1": 3324,
        "id2": 3325,
        "phenotype_comparison": ""
    },
    {
        "id1": 3350,
        "id2": 3351,
        "phenotype_comparison": ""
    },
    {
        "id1": 3371,
        "id2": 3372,
        "phenotype_comparison": "Two rutabaga mutants (rut 1), had significantly shortened life spans, and the rut and NF1 double mutant (rut;NF1 P2 ) did not further shorten the life span, implicating cAMP in mediating longevity."
    },
    {
        "id1": 1548,
        "id2": 1549,
        "phenotype_comparison": ""
    },
    {
        "id1": 1574,
        "id2": 1575,
        "phenotype_comparison": "Double homozygous p18/p53 mutant lives much less than the single homozygous mutant p18, with a slight recovery in lifespan compared to the p53 single homozygous mutant"
    },
    {
        "id1": 1594,
        "id2": 1595,
        "phenotype_comparison": "Skn-1 mutations significantly reduced the lifespan of the Class 1 daf-2 mutant e1368."
    },
    {
        "id1": 1629,
        "id2": 1631,
        "phenotype_comparison": ""
    },
    {
        "id1": 1646,
        "id2": 1647,
        "phenotype_comparison": ""
    },
    {
        "id1": 1658,
        "id2": 1666,
        "phenotype_comparison": ""
    },
    {
        "id1": 1692,
        "id2": 1694,
        "phenotype_comparison": ""
    },
    {
        "id1": 1719,
        "id2": 1721,
        "phenotype_comparison": ""
    },
    {
        "id1": 1740,
        "id2": 1744,
        "phenotype_comparison": ""
    },
    {
        "id1": 1765,
        "id2": 1767,
        "phenotype_comparison": ""
    },
    {
        "id1": 1788,
        "id2": 1789,
        "phenotype_comparison": ""
    },
    {
        "id1": 1814,
        "id2": 1816,
        "phenotype_comparison": ""
    },
    {
        "id1": 1844,
        "id2": 1846,
        "phenotype_comparison": ""
    },
    {
        "id1": 1859,
        "id2": 1865,
        "phenotype_comparison": ""
    },
    {
        "id1": 1883,
        "id2": 1884,
        "phenotype_comparison": "sgk-1 activity is required for lifespan extension in eak-7 null mutants. "
    },
    {
        "id1": 1903,
        "id2": 1904,
        "phenotype_comparison": "Lifespan extension in eak-7 null mutants does not require eak-6 activity. "
    },
    {
        "id1": 1924,
        "id2": 1925,
        "phenotype_comparison": ""
    },
    {
        "id1": 1940,
        "id2": 1943,
        "phenotype_comparison": ""
    },
    {
        "id1": 1961,
        "id2": 1962,
        "phenotype_comparison": ""
    },
    {
        "id1": 1967,
        "id2": 1979,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1996,
        "phenotype_comparison": ""
    },
    {
        "id1": 2013,
        "id2": 2015,
        "phenotype_comparison": ""
    },
    {
        "id1": 2034,
        "id2": 2036,
        "phenotype_comparison": ""
    },
    {
        "id1": 2058,
        "id2": 2059,
        "phenotype_comparison": "RNAi reduction of daf-16 did not suppress the increased longevity of worms overexpressing wwp-1."
    },
    {
        "id1": 2064,
        "id2": 2090,
        "phenotype_comparison": ""
    },
    {
        "id1": 2111,
        "id2": 2113,
        "phenotype_comparison": ""
    },
    {
        "id1": 2128,
        "id2": 2133,
        "phenotype_comparison": "mekk-3 RNAi was also able to extend the lifespans of daf-5(e1386)."
    },
    {
        "id1": 2154,
        "id2": 2155,
        "phenotype_comparison": ""
    },
    {
        "id1": 2164,
        "id2": 2173,
        "phenotype_comparison": "When null mutant skn-1(zu169) was grown on mekk-3 RNAi, lifespan was significantly extended, but not to the same extent as WT control. Thus, mekk-3 knock-down-mediated DR partially depends on skn-1 for extended longevity."
    },
    {
        "id1": 2184,
        "id2": 2193,
        "phenotype_comparison": "mekk-3 RNAi decreased the lifespan of aha-1(ok1396)."
    },
    {
        "id1": 2184,
        "id2": 2209,
        "phenotype_comparison": "In ABC transporter (P-glycoproteins) mutants such as pgp-3(ok3091) or pgp-3(pk18), mekk-3 RNAi did not extend lifespan to the same extent as in WT."
    },
    {
        "id1": 2234,
        "id2": 2235,
        "phenotype_comparison": "Although nhr-8 plays a crucial role in mekk-3 knock-down-mediated DR, it appears that eat-2(ad1116) does not require nhr-8 for its increased longevity. The long lifespan on eat-2(ad1116) remains unaffected on nhr-8 RNAi."
    },
    {
        "id1": 2244,
        "id2": 2252,
        "phenotype_comparison": ""
    },
    {
        "id1": 2272,
        "id2": 2273,
        "phenotype_comparison": ""
    },
    {
        "id1": 2299,
        "id2": 2301,
        "phenotype_comparison": ""
    },
    {
        "id1": 2324,
        "id2": 2325,
        "phenotype_comparison": ""
    },
    {
        "id1": 2348,
        "id2": 2349,
        "phenotype_comparison": ""
    },
    {
        "id1": 2368,
        "id2": 2376,
        "phenotype_comparison": ""
    },
    {
        "id1": 2397,
        "id2": 2399,
        "phenotype_comparison": ""
    },
    {
        "id1": 2450,
        "id2": 2451,
        "phenotype_comparison": ""
    },
    {
        "id1": 2473,
        "id2": 2463,
        "phenotype_comparison": ""
    },
    {
        "id1": 2508,
        "id2": 2509,
        "phenotype_comparison": ""
    },
    {
        "id1": 2541,
        "id2": 2542,
        "phenotype_comparison": ""
    },
    {
        "id1": 2552,
        "id2": 2549,
        "phenotype_comparison": ""
    },
    {
        "id1": 2574,
        "id2": 2575,
        "phenotype_comparison": ""
    },
    {
        "id1": 2564,
        "id2": 2571,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2605,
        "phenotype_comparison": ""
    },
    {
        "id1": 2630,
        "id2": 2633,
        "phenotype_comparison": ""
    },
    {
        "id1": 2657,
        "id2": 2660,
        "phenotype_comparison": ""
    },
    {
        "id1": 2685,
        "id2": 2687,
        "phenotype_comparison": ""
    },
    {
        "id1": 2717,
        "id2": 2720,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2748,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2781,
        "phenotype_comparison": ""
    },
    {
        "id1": 2800,
        "id2": 2807,
        "phenotype_comparison": ""
    },
    {
        "id1": 2817,
        "id2": 2835,
        "phenotype_comparison": ""
    },
    {
        "id1": 2867,
        "id2": 2868,
        "phenotype_comparison": ""
    },
    {
        "id1": 2877,
        "id2": 2894,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2911,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2926,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2941,
        "phenotype_comparison": ""
    },
    {
        "id1": 2954,
        "id2": 2955,
        "phenotype_comparison": ""
    },
    {
        "id1": 2984,
        "id2": 2985,
        "phenotype_comparison": ""
    },
    {
        "id1": 3007,
        "id2": 3008,
        "phenotype_comparison": "nhr-62(tm1818) significantly suppressed the lifespan of eat-2(ad465) animals. Importantly, the nhr-62(tm1818) mutant had little or no effect on wild-type (N2), suggesting that nhr-62 does not suppress eat-2 longevity through general sickness "
    },
    {
        "id1": 3027,
        "id2": 3028,
        "phenotype_comparison": ""
    },
    {
        "id1": 3047,
        "id2": 3048,
        "phenotype_comparison": ""
    },
    {
        "id1": 3068,
        "id2": 3071,
        "phenotype_comparison": ""
    },
    {
        "id1": 3085,
        "id2": 3086,
        "phenotype_comparison": ""
    },
    {
        "id1": 3101,
        "id2": 3102,
        "phenotype_comparison": ""
    },
    {
        "id1": 3125,
        "id2": 3126,
        "phenotype_comparison": ""
    },
    {
        "id1": 3148,
        "id2": 3149,
        "phenotype_comparison": ""
    },
    {
        "id1": 3148,
        "id2": 3169,
        "phenotype_comparison": ""
    },
    {
        "id1": 3180,
        "id2": 3184,
        "phenotype_comparison": ""
    },
    {
        "id1": 3199,
        "id2": 3200,
        "phenotype_comparison": "Inactivation of dox-1 had a substantial effect on the lifespan of daf-2 mutants without affecting their apparent health. In four of six trials, dox-1 RNAi shortened the lifespan of daf-2 animals substantially more than it shortened wild-type lifespan. Thus, dox-1 contributes significantly to the longevity of daf-2 mutants."
    },
    {
        "id1": 3117,
        "id2": 3215,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the isp-1 mutation by an average of less than 20%."
    },
    {
        "id1": 3234,
        "id2": 3236,
        "phenotype_comparison": ""
    },
    {
        "id1": 3257,
        "id2": 3258,
        "phenotype_comparison": "The dhd- mutant (w Df(1)J5) had very similar lifespans to the control and the double mutant had only a slightly shorter lifespan than the single dhd- mutant."
    },
    {
        "id1": 3279,
        "id2": 3280,
        "phenotype_comparison": ""
    },
    {
        "id1": 3275,
        "id2": 3294,
        "phenotype_comparison": ""
    },
    {
        "id1": 3304,
        "id2": 3309,
        "phenotype_comparison": ""
    },
    {
        "id1": 3324,
        "id2": 3326,
        "phenotype_comparison": ""
    },
    {
        "id1": 3352,
        "id2": 3353,
        "phenotype_comparison": ""
    },
    {
        "id1": 1548,
        "id2": 1550,
        "phenotype_comparison": ""
    },
    {
        "id1": 1576,
        "id2": 1577,
        "phenotype_comparison": ""
    },
    {
        "id1": 1588,
        "id2": 1596,
        "phenotype_comparison": ""
    },
    {
        "id1": 1630,
        "id2": 1631,
        "phenotype_comparison": "While utx-1 RNAi effectively extended the life span of wild-type N2 strain, such an effect could not be observed in any mutant on IIS pathway; utx-1 RNAi could not further increase the life span of daf-2(e1370) worms and could not at all increase the life span in daf-16(mu86) mutant animals."
    },
    {
        "id1": 1620,
        "id2": 1648,
        "phenotype_comparison": ""
    },
    {
        "id1": 1659,
        "id2": 1667,
        "phenotype_comparison": ""
    },
    {
        "id1": 1692,
        "id2": 1695,
        "phenotype_comparison": ""
    },
    {
        "id1": 1720,
        "id2": 1722,
        "phenotype_comparison": ""
    },
    {
        "id1": 1743,
        "id2": 1744,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1766,
        "id2": 1767,
        "phenotype_comparison": "SKN-1 is inhibited by IIS phosphorylation but is dispensable for dauer development, adulthood dauer-related traits, or lifespan extension by Class 2 daf-2 mutations at 20\u00b0C ."
    },
    {
        "id1": 1790,
        "id2": 1791,
        "phenotype_comparison": ""
    },
    {
        "id1": 1814,
        "id2": 1817,
        "phenotype_comparison": ""
    },
    {
        "id1": 1845,
        "id2": 1847,
        "phenotype_comparison": ""
    },
    {
        "id1": 1863,
        "id2": 1865,
        "phenotype_comparison": "Sgk-1 activity is required for lifespan extension in akt-1 null mutants."
    },
    {
        "id1": 1879,
        "id2": 1885,
        "phenotype_comparison": ""
    },
    {
        "id1": 1905,
        "id2": 1906,
        "phenotype_comparison": ""
    },
    {
        "id1": 1918,
        "id2": 1925,
        "phenotype_comparison": "daf-16(mu86); aak-2(ok524) double mutants have 15% shorter lifespans than either single mutant. Therefore, aak-2 is able to influence lifespan in a daf-16-independent manner."
    },
    {
        "id1": 1944,
        "id2": 1946,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1963,
        "phenotype_comparison": ""
    },
    {
        "id1": 1978,
        "id2": 1979,
        "phenotype_comparison": ""
    },
    {
        "id1": 1985,
        "id2": 1964,
        "phenotype_comparison": ""
    },
    {
        "id1": 2014,
        "id2": 2016,
        "phenotype_comparison": ""
    },
    {
        "id1": 2035,
        "id2": 2036,
        "phenotype_comparison": ""
    },
    {
        "id1": 2060,
        "id2": 2053,
        "phenotype_comparison": ""
    },
    {
        "id1": 2068,
        "id2": 2091,
        "phenotype_comparison": ""
    },
    {
        "id1": 2112,
        "id2": 2114,
        "phenotype_comparison": ""
    },
    {
        "id1": 2140,
        "id2": 2155,
        "phenotype_comparison": "mekk-3 RNAi failed to increase the long lifespans of eat-2(ad465) to the same extent as in WT, suggesting that they may function in the same genetic pathway for lifespan regulation."
    },
    {
        "id1": 2174,
        "id2": 2175,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2194,
        "phenotype_comparison": ""
    },
    {
        "id1": 2210,
        "id2": 2211,
        "phenotype_comparison": ""
    },
    {
        "id1": 2236,
        "id2": 2237,
        "phenotype_comparison": ""
    },
    {
        "id1": 2251,
        "id2": 2253,
        "phenotype_comparison": ""
    },
    {
        "id1": 2274,
        "id2": 2275,
        "phenotype_comparison": ""
    },
    {
        "id1": 2300,
        "id2": 2301,
        "phenotype_comparison": "sgk-1(gf) did not extend the lifespan of akt-1(null) animals."
    },
    {
        "id1": 2324,
        "id2": 2326,
        "phenotype_comparison": ""
    },
    {
        "id1": 2348,
        "id2": 2350,
        "phenotype_comparison": ""
    },
    {
        "id1": 2369,
        "id2": 2377,
        "phenotype_comparison": ""
    },
    {
        "id1": 2398,
        "id2": 2399,
        "phenotype_comparison": "Inhibition of eIF4H/drr-2 consistently extends the lifespan of wild-type animals and animals over-expressing rab-10 (EQ28). Taken together, these results strongly imply that eIF4H/drr-2 may act downstream of both rab-10 and sams-1 and its activity might be essential for RAB-10 and SAMS-1 to mediate the longevity effects of DR. "
    },
    {
        "id1": 2423,
        "id2": 2425,
        "phenotype_comparison": ""
    },
    {
        "id1": 2446,
        "id2": 2452,
        "phenotype_comparison": ""
    },
    {
        "id1": 2474,
        "id2": 2475,
        "phenotype_comparison": ""
    },
    {
        "id1": 2467,
        "id2": 2488,
        "phenotype_comparison": ""
    },
    {
        "id1": 2508,
        "id2": 2503,
        "phenotype_comparison": ""
    },
    {
        "id1": 2542,
        "id2": 2543,
        "phenotype_comparison": ""
    },
    {
        "id1": 2535,
        "id2": 2553,
        "phenotype_comparison": ""
    },
    {
        "id1": 2427,
        "id2": 2576,
        "phenotype_comparison": ""
    },
    {
        "id1": 2564,
        "id2": 2589,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2606,
        "phenotype_comparison": ""
    },
    {
        "id1": 2634,
        "id2": 2635,
        "phenotype_comparison": ""
    },
    {
        "id1": 2657,
        "id2": 2661,
        "phenotype_comparison": ""
    },
    {
        "id1": 2688,
        "id2": 2689,
        "phenotype_comparison": ""
    },
    {
        "id1": 2721,
        "id2": 2722,
        "phenotype_comparison": ""
    },
    {
        "id1": 2749,
        "id2": 2750,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2782,
        "phenotype_comparison": ""
    },
    {
        "id1": 2808,
        "id2": 2809,
        "phenotype_comparison": ""
    },
    {
        "id1": 2836,
        "id2": 2837,
        "phenotype_comparison": ""
    },
    {
        "id1": 2867,
        "id2": 2869,
        "phenotype_comparison": ""
    },
    {
        "id1": 2879,
        "id2": 2895,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2912,
        "phenotype_comparison": ""
    },
    {
        "id1": 2925,
        "id2": 2926,
        "phenotype_comparison": ""
    },
    {
        "id1": 2940,
        "id2": 2941,
        "phenotype_comparison": ""
    },
    {
        "id1": 2956,
        "id2": 2957,
        "phenotype_comparison": ""
    },
    {
        "id1": 2984,
        "id2": 2986,
        "phenotype_comparison": ""
    },
    {
        "id1": 3006,
        "id2": 3009,
        "phenotype_comparison": ""
    },
    {
        "id1": 3027,
        "id2": 3029,
        "phenotype_comparison": ""
    },
    {
        "id1": 3047,
        "id2": 3049,
        "phenotype_comparison": ""
    },
    {
        "id1": 3069,
        "id2": 3071,
        "phenotype_comparison": "A putative xbp-1\u2013null mutation, which causes truncation of the XBP-1 protein before its DNA binding domain, shortened the lifespan of daf-2 mutants more than it shortened the lifespan of wild type without affecting the apparent health of the animals."
    },
    {
        "id1": 3069,
        "id2": 3086,
        "phenotype_comparison": "A putative xbp-1\u2013null mutation, which causes truncation of the XBP-1 protein before its DNA binding domain, shortened the lifespan of daf-2 mutants more than it shortened the lifespan of wild type without affecting the apparent health of the animals."
    },
    {
        "id1": 3101,
        "id2": 3103,
        "phenotype_comparison": ""
    },
    {
        "id1": 3125,
        "id2": 3127,
        "phenotype_comparison": ""
    },
    {
        "id1": 3058,
        "id2": 3150,
        "phenotype_comparison": ""
    },
    {
        "id1": 3058,
        "id2": 3170,
        "phenotype_comparison": ""
    },
    {
        "id1": 2212,
        "id2": 2213,
        "phenotype_comparison": "The lifespan extension observed on knocking down mekk-3 does not require hsf-1."
    },
    {
        "id1": 2990,
        "id2": 2991,
        "phenotype_comparison": ""
    },
    {
        "id1": 2993,
        "id2": 3012,
        "phenotype_comparison": ""
    },
    {
        "id1": 3032,
        "id2": 3034,
        "phenotype_comparison": ""
    },
    {
        "id1": 3055,
        "id2": 3056,
        "phenotype_comparison": ""
    },
    {
        "id1": 3183,
        "id2": 3184,
        "phenotype_comparison": "Inactivation of dox-1 had a substantial effect on the lifespan of daf-2 mutants without affecting their apparent health. In four of six trials, dox-1 RNAi shortened the lifespan of daf-2 animals substantially more than it shortened wild-type lifespan. Thus, dox-1 contributes significantly to the longevity of daf-2 mutants."
    },
    {
        "id1": 3201,
        "id2": 3202,
        "phenotype_comparison": ""
    },
    {
        "id1": 3107,
        "id2": 3217,
        "phenotype_comparison": ""
    },
    {
        "id1": 3235,
        "id2": 3237,
        "phenotype_comparison": ""
    },
    {
        "id1": 3259,
        "id2": 3260,
        "phenotype_comparison": ""
    },
    {
        "id1": 3277,
        "id2": 3280,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Cat single mutant and a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3287,
        "id2": 3295,
        "phenotype_comparison": ""
    },
    {
        "id1": 3306,
        "id2": 3309,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant and an increase in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3325,
        "id2": 3327,
        "phenotype_comparison": ""
    },
    {
        "id1": 3354,
        "id2": 3355,
        "phenotype_comparison": ""
    },
    {
        "id1": 1549,
        "id2": 1551,
        "phenotype_comparison": ""
    },
    {
        "id1": 1574,
        "id2": 1577,
        "phenotype_comparison": "Double p27/p53 mutant lives much less compared to the single mutant p27, as well as compared to the p53 single mutant"
    },
    {
        "id1": 1596,
        "id2": 1597,
        "phenotype_comparison": ""
    },
    {
        "id1": 1616,
        "id2": 1632,
        "phenotype_comparison": ""
    },
    {
        "id1": 1648,
        "id2": 1649,
        "phenotype_comparison": ""
    },
    {
        "id1": 1666,
        "id2": 1667,
        "phenotype_comparison": "utx-1 RNAi extended lifespan in N2 worm, but not in rrf-1(ok589)."
    },
    {
        "id1": 1692,
        "id2": 1696,
        "phenotype_comparison": ""
    },
    {
        "id1": 1721,
        "id2": 1722,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1745,
        "id2": 1746,
        "phenotype_comparison": ""
    },
    {
        "id1": 1768,
        "id2": 1769,
        "phenotype_comparison": ""
    },
    {
        "id1": 1790,
        "id2": 1792,
        "phenotype_comparison": ""
    },
    {
        "id1": 1818,
        "id2": 1819,
        "phenotype_comparison": ""
    },
    {
        "id1": 1846,
        "id2": 1847,
        "phenotype_comparison": "The double mutation of fat-5 and cyp-35A2  had survival significantly extended when compared to wild-type nematodes or the short-lived fat-5(tm420) and cyp-35A2(gk317) mutants."
    },
    {
        "id1": 1866,
        "id2": 1867,
        "phenotype_comparison": ""
    },
    {
        "id1": 1885,
        "id2": 1886,
        "phenotype_comparison": ""
    },
    {
        "id1": 1905,
        "id2": 1907,
        "phenotype_comparison": ""
    },
    {
        "id1": 1926,
        "id2": 1927,
        "phenotype_comparison": ""
    },
    {
        "id1": 1945,
        "id2": 1946,
        "phenotype_comparison": ""
    },
    {
        "id1": 1952,
        "id2": 1964,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1980,
        "phenotype_comparison": ""
    },
    {
        "id1": 1996,
        "id2": 1964,
        "phenotype_comparison": ""
    },
    {
        "id1": 2015,
        "id2": 2016,
        "phenotype_comparison": "elt-3(vp1) suppresses the longevity phenotype of both daf-2(e1370) and daf-2(RNAi) animals"
    },
    {
        "id1": 2033,
        "id2": 2037,
        "phenotype_comparison": ""
    },
    {
        "id1": 2060,
        "id2": 2061,
        "phenotype_comparison": ""
    },
    {
        "id1": 2068,
        "id2": 2072,
        "phenotype_comparison": ""
    },
    {
        "id1": 2113,
        "id2": 2114,
        "phenotype_comparison": "When daf-2(e1370) worms were grown on mekk-3 RNAi at 20 \u00b0C, a dramatic increase in lifespan was observed over control RNAi-grown worms, suggesting that MEKK-3 may work in a parallel pathway."
    },
    {
        "id1": 2134,
        "id2": 2135,
        "phenotype_comparison": ""
    },
    {
        "id1": 2142,
        "id2": 2156,
        "phenotype_comparison": ""
    },
    {
        "id1": 2174,
        "id2": 2176,
        "phenotype_comparison": ""
    },
    {
        "id1": 2194,
        "id2": 2195,
        "phenotype_comparison": ""
    },
    {
        "id1": 2210,
        "id2": 2212,
        "phenotype_comparison": ""
    },
    {
        "id1": 2236,
        "id2": 2238,
        "phenotype_comparison": ""
    },
    {
        "id1": 2252,
        "id2": 2253,
        "phenotype_comparison": "The mekk-3 RNAi was not able to increase lifespan in nhr-49(nr2041) to the same extent as in wild type."
    },
    {
        "id1": 2276,
        "id2": 2277,
        "phenotype_comparison": ""
    },
    {
        "id1": 2302,
        "id2": 2303,
        "phenotype_comparison": ""
    },
    {
        "id1": 2325,
        "id2": 2327,
        "phenotype_comparison": ""
    },
    {
        "id1": 2349,
        "id2": 2351,
        "phenotype_comparison": ""
    },
    {
        "id1": 2376,
        "id2": 2377,
        "phenotype_comparison": "Inhibition of sams-1 by RNAi does not extend the lifespan of EQ19 (drr-2 over-expression) significantly, while inhibition of sams-1 extends the lifespan of wild-type animals, suggesting a common mechanism that mediates the lifespan effects of eIF4H/drr-2 and sams-1. "
    },
    {
        "id1": 2400,
        "id2": 2401,
        "phenotype_comparison": ""
    },
    {
        "id1": 2424,
        "id2": 2426,
        "phenotype_comparison": ""
    },
    {
        "id1": 2452,
        "id2": 2453,
        "phenotype_comparison": ""
    },
    {
        "id1": 2474,
        "id2": 2476,
        "phenotype_comparison": ""
    },
    {
        "id1": 2489,
        "id2": 2490,
        "phenotype_comparison": ""
    },
    {
        "id1": 2509,
        "id2": 2510,
        "phenotype_comparison": ""
    },
    {
        "id1": 2553,
        "id2": 2554,
        "phenotype_comparison": ""
    },
    {
        "id1": 2562,
        "id2": 2577,
        "phenotype_comparison": ""
    },
    {
        "id1": 2571,
        "id2": 2590,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2607,
        "phenotype_comparison": ""
    },
    {
        "id1": 2636,
        "id2": 2637,
        "phenotype_comparison": ""
    },
    {
        "id1": 2657,
        "id2": 2662,
        "phenotype_comparison": ""
    },
    {
        "id1": 2690,
        "id2": 2691,
        "phenotype_comparison": ""
    },
    {
        "id1": 2717,
        "id2": 2723,
        "phenotype_comparison": ""
    },
    {
        "id1": 2751,
        "id2": 2752,
        "phenotype_comparison": ""
    },
    {
        "id1": 2753,
        "id2": 2783,
        "phenotype_comparison": ""
    },
    {
        "id1": 2800,
        "id2": 2810,
        "phenotype_comparison": ""
    },
    {
        "id1": 2838,
        "id2": 2839,
        "phenotype_comparison": ""
    },
    {
        "id1": 2863,
        "id2": 2870,
        "phenotype_comparison": ""
    },
    {
        "id1": 2877,
        "id2": 2896,
        "phenotype_comparison": ""
    },
    {
        "id1": 2911,
        "id2": 2912,
        "phenotype_comparison": "Maternal RNAi of atg-7 significantly extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2927,
        "id2": 2928,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2942,
        "phenotype_comparison": ""
    },
    {
        "id1": 2956,
        "id2": 2958,
        "phenotype_comparison": ""
    },
    {
        "id1": 2984,
        "id2": 2987,
        "phenotype_comparison": ""
    },
    {
        "id1": 3007,
        "id2": 3009,
        "phenotype_comparison": "nhr-62(tm1818) significantly suppressed the lifespan of eat-2(ad465) animals. Importantly, the nhr-62(tm1818) mutant had little or no effect on wild-type (N2), suggesting that nhr-62 does not suppress eat-2 longevity through general sickness "
    },
    {
        "id1": 3028,
        "id2": 3030,
        "phenotype_comparison": ""
    },
    {
        "id1": 3048,
        "id2": 3050,
        "phenotype_comparison": ""
    },
    {
        "id1": 3072,
        "id2": 3073,
        "phenotype_comparison": ""
    },
    {
        "id1": 3057,
        "id2": 3087,
        "phenotype_comparison": ""
    },
    {
        "id1": 3104,
        "id2": 3105,
        "phenotype_comparison": ""
    },
    {
        "id1": 3113,
        "id2": 3128,
        "phenotype_comparison": ""
    },
    {
        "id1": 3149,
        "id2": 3150,
        "phenotype_comparison": "Inactivation of atf-6 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3169,
        "id2": 3170,
        "phenotype_comparison": "Inactivation of pek-1 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3179,
        "id2": 3185,
        "phenotype_comparison": ""
    },
    {
        "id1": 3201,
        "id2": 3203,
        "phenotype_comparison": ""
    },
    {
        "id1": 3217,
        "id2": 3218,
        "phenotype_comparison": ""
    },
    {
        "id1": 3236,
        "id2": 3237,
        "phenotype_comparison": "The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway."
    },
    {
        "id1": 3259,
        "id2": 3261,
        "phenotype_comparison": ""
    },
    {
        "id1": 3275,
        "id2": 3281,
        "phenotype_comparison": ""
    },
    {
        "id1": 3294,
        "id2": 3295,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan."
    },
    {
        "id1": 3298,
        "id2": 3310,
        "phenotype_comparison": ""
    },
    {
        "id1": 3326,
        "id2": 3327,
        "phenotype_comparison": "mNSC-ablated flies are long-lived and females show reduced fecundity."
    },
    {
        "id1": 3354,
        "id2": 3356,
        "phenotype_comparison": ""
    },
    {
        "id1": 1550,
        "id2": 1551,
        "phenotype_comparison": "Median survival for Mgat5+/- female mice is slightly reduced to 600 compared to that of >650 in wild-type C57BL6 mice. In contrast, median survival for Pten+/- females is only 289, in particular due early cancer development (mainly lymphomas). The survival of Pten+/- is slightly ameliorated in females by the Mgat5+/- mutation."
    },
    {
        "id1": 1578,
        "id2": 1579,
        "phenotype_comparison": ""
    },
    {
        "id1": 1590,
        "id2": 1597,
        "phenotype_comparison": ""
    },
    {
        "id1": 1632,
        "id2": 1633,
        "phenotype_comparison": ""
    },
    {
        "id1": 1616,
        "id2": 1650,
        "phenotype_comparison": ""
    },
    {
        "id1": 1662,
        "id2": 1668,
        "phenotype_comparison": ""
    },
    {
        "id1": 1697,
        "id2": 1693,
        "phenotype_comparison": ""
    },
    {
        "id1": 1723,
        "id2": 1724,
        "phenotype_comparison": ""
    },
    {
        "id1": 1745,
        "id2": 1747,
        "phenotype_comparison": ""
    },
    {
        "id1": 1768,
        "id2": 1770,
        "phenotype_comparison": ""
    },
    {
        "id1": 1791,
        "id2": 1793,
        "phenotype_comparison": ""
    },
    {
        "id1": 1818,
        "id2": 1820,
        "phenotype_comparison": ""
    },
    {
        "id1": 1848,
        "id2": 1849,
        "phenotype_comparison": ""
    },
    {
        "id1": 1866,
        "id2": 1868,
        "phenotype_comparison": ""
    },
    {
        "id1": 1883,
        "id2": 1886,
        "phenotype_comparison": "Sgk-1 activity is required for lifespan extension in akt-1 null mutants."
    },
    {
        "id1": 1906,
        "id2": 1908,
        "phenotype_comparison": ""
    },
    {
        "id1": 1926,
        "id2": 1928,
        "phenotype_comparison": ""
    },
    {
        "id1": 1930,
        "id2": 1947,
        "phenotype_comparison": ""
    },
    {
        "id1": 1963,
        "id2": 1964,
        "phenotype_comparison": ""
    },
    {
        "id1": 1967,
        "id2": 1981,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1997,
        "phenotype_comparison": ""
    },
    {
        "id1": 2017,
        "id2": 2018,
        "phenotype_comparison": ""
    },
    {
        "id1": 2034,
        "id2": 2038,
        "phenotype_comparison": ""
    },
    {
        "id1": 2053,
        "id2": 2062,
        "phenotype_comparison": ""
    },
    {
        "id1": 2071,
        "id2": 2092,
        "phenotype_comparison": ""
    },
    {
        "id1": 2115,
        "id2": 2116,
        "phenotype_comparison": ""
    },
    {
        "id1": 2156,
        "id2": 2157,
        "phenotype_comparison": ""
    },
    {
        "id1": 2175,
        "id2": 2177,
        "phenotype_comparison": ""
    },
    {
        "id1": 2180,
        "id2": 2195,
        "phenotype_comparison": "mekk-3 RNAi failed to extend lifespan in ahr-1(ju145) to the same extent as in WT worms."
    },
    {
        "id1": 2211,
        "id2": 2213,
        "phenotype_comparison": ""
    },
    {
        "id1": 2237,
        "id2": 2239,
        "phenotype_comparison": ""
    },
    {
        "id1": 2247,
        "id2": 2254,
        "phenotype_comparison": ""
    },
    {
        "id1": 2276,
        "id2": 2278,
        "phenotype_comparison": ""
    },
    {
        "id1": 2302,
        "id2": 2304,
        "phenotype_comparison": ""
    },
    {
        "id1": 2326,
        "id2": 2327,
        "phenotype_comparison": "hsf-1 is required for the lifespan extension caused by hsb-1 mutations, as hsb-1(cg116); hsf-1(RNAi) animals\u2019 lifespans are as short as hsf-1(RNAi) animals."
    },
    {
        "id1": 2350,
        "id2": 2351,
        "phenotype_comparison": "Inhibition of TOR signaling by knocking down both TOR/let-363 and Raptor/daf-15(a binding partner of TOR that is necessary for TOR activity) or TOR/let-363 alone in the EQ19 (i.e. the eIF4H/drr-2 over-expressing line) background failed to extend lifespan. This finding strongly implies that a common mechanism mediates the lifespan effects of TOR and eIF4H/drr-2, and that eIF4H/drr-2 might function genetically downstream of TOR to influence lifespan."
    },
    {
        "id1": 2372,
        "id2": 2378,
        "phenotype_comparison": ""
    },
    {
        "id1": 2400,
        "id2": 2402,
        "phenotype_comparison": ""
    },
    {
        "id1": 2427,
        "id2": 2428,
        "phenotype_comparison": ""
    },
    {
        "id1": 2443,
        "id2": 2454,
        "phenotype_comparison": ""
    },
    {
        "id1": 2475,
        "id2": 2459,
        "phenotype_comparison": ""
    },
    {
        "id1": 2489,
        "id2": 2491,
        "phenotype_comparison": ""
    },
    {
        "id1": 2503,
        "id2": 2510,
        "phenotype_comparison": "gcy-35 mutants had shorter lifespans than N2 controls on dead OP50 at 25\u00b0C. When gcy-35;npr-1(ad609) worms were grown at 25\u00b0C on dead OP50, their lifespan was similar to N2 animals."
    },
    {
        "id1": 2535,
        "id2": 2544,
        "phenotype_comparison": ""
    },
    {
        "id1": 2536,
        "id2": 2554,
        "phenotype_comparison": "The lifespan of daf-2(e1370) mutants was not further extended by npr-1 loss of function, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1 takes place through overlapping mechanisms."
    },
    {
        "id1": 2576,
        "id2": 2577,
        "phenotype_comparison": "N2 worms bearing the hif-1(ia4) deletion allele lived significantly longer than N2 controls . By contrast, the deletion of hif-1 shortened the lifespans of npr-1(ad609) mutants to less than that of N2, suggesting that the beneficial effect of HIF-1 on worm lifespan is mediated by NPR-1(215V) activity."
    },
    {
        "id1": 2589,
        "id2": 2590,
        "phenotype_comparison": "egl-9 loss of function significantly increased the lifespan of N2 worms, but significantly shortened the lifespan of npr-1(ad609) animals, indicating that the function of egl-9 in lifespan is regulated by npr-1."
    },
    {
        "id1": 2596,
        "id2": 2608,
        "phenotype_comparison": ""
    },
    {
        "id1": 2636,
        "id2": 2638,
        "phenotype_comparison": ""
    },
    {
        "id1": 2657,
        "id2": 2663,
        "phenotype_comparison": ""
    },
    {
        "id1": 2692,
        "id2": 2693,
        "phenotype_comparison": ""
    },
    {
        "id1": 2694,
        "id2": 2724,
        "phenotype_comparison": ""
    },
    {
        "id1": 2753,
        "id2": 2754,
        "phenotype_comparison": ""
    },
    {
        "id1": 2774,
        "id2": 2784,
        "phenotype_comparison": ""
    },
    {
        "id1": 2800,
        "id2": 2811,
        "phenotype_comparison": ""
    },
    {
        "id1": 2840,
        "id2": 2841,
        "phenotype_comparison": ""
    },
    {
        "id1": 2863,
        "id2": 2871,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2898,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2913,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2929,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2943,
        "phenotype_comparison": ""
    },
    {
        "id1": 2956,
        "id2": 2959,
        "phenotype_comparison": ""
    },
    {
        "id1": 2988,
        "id2": 2989,
        "phenotype_comparison": ""
    },
    {
        "id1": 3006,
        "id2": 3010,
        "phenotype_comparison": ""
    },
    {
        "id1": 3029,
        "id2": 3030,
        "phenotype_comparison": ""
    },
    {
        "id1": 3049,
        "id2": 3050,
        "phenotype_comparison": ""
    },
    {
        "id1": 3072,
        "id2": 3074,
        "phenotype_comparison": ""
    },
    {
        "id1": 3057,
        "id2": 3088,
        "phenotype_comparison": ""
    },
    {
        "id1": 3104,
        "id2": 3106,
        "phenotype_comparison": ""
    },
    {
        "id1": 3128,
        "id2": 3129,
        "phenotype_comparison": ""
    },
    {
        "id1": 3148,
        "id2": 3151,
        "phenotype_comparison": ""
    },
    {
        "id1": 3151,
        "id2": 3171,
        "phenotype_comparison": ""
    },
    {
        "id1": 3180,
        "id2": 3186,
        "phenotype_comparison": ""
    },
    {
        "id1": 3202,
        "id2": 3204,
        "phenotype_comparison": ""
    },
    {
        "id1": 3111,
        "id2": 3218,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the isp-1 mutation by an average of less than 20%."
    },
    {
        "id1": 3234,
        "id2": 3238,
        "phenotype_comparison": ""
    },
    {
        "id1": 3260,
        "id2": 3262,
        "phenotype_comparison": ""
    },
    {
        "id1": 3281,
        "id2": 3282,
        "phenotype_comparison": ""
    },
    {
        "id1": 3290,
        "id2": 3296,
        "phenotype_comparison": ""
    },
    {
        "id1": 3298,
        "id2": 3311,
        "phenotype_comparison": ""
    },
    {
        "id1": 3328,
        "id2": 3329,
        "phenotype_comparison": ""
    },
    {
        "id1": 3355,
        "id2": 3357,
        "phenotype_comparison": ""
    },
    {
        "id1": 1548,
        "id2": 1552,
        "phenotype_comparison": ""
    },
    {
        "id1": 1578,
        "id2": 1580,
        "phenotype_comparison": ""
    },
    {
        "id1": 1596,
        "id2": 1598,
        "phenotype_comparison": ""
    },
    {
        "id1": 1618,
        "id2": 1633,
        "phenotype_comparison": "The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway"
    },
    {
        "id1": 1650,
        "id2": 1651,
        "phenotype_comparison": ""
    },
    {
        "id1": 1666,
        "id2": 1668,
        "phenotype_comparison": "utx-1 RNAi extended lifespan in N2 worm, but not in rrf-1(ok589)."
    },
    {
        "id1": 1697,
        "id2": 1698,
        "phenotype_comparison": ""
    },
    {
        "id1": 1723,
        "id2": 1725,
        "phenotype_comparison": ""
    },
    {
        "id1": 1746,
        "id2": 1748,
        "phenotype_comparison": ""
    },
    {
        "id1": 1769,
        "id2": 1771,
        "phenotype_comparison": ""
    },
    {
        "id1": 1792,
        "id2": 1793,
        "phenotype_comparison": "Skn-1 was required at 15\u00b0C, 20\u00b0C, or 25\u00b0C for lifespan extension from daf-2 RNA interference (RNAi)."
    },
    {
        "id1": 1818,
        "id2": 1821,
        "phenotype_comparison": ""
    },
    {
        "id1": 1848,
        "id2": 1850,
        "phenotype_comparison": ""
    },
    {
        "id1": 1867,
        "id2": 1869,
        "phenotype_comparison": ""
    },
    {
        "id1": 1885,
        "id2": 1887,
        "phenotype_comparison": ""
    },
    {
        "id1": 1907,
        "id2": 1908,
        "phenotype_comparison": "Lifespan extension in eak-7 null mutants does not require eak-6 activity. "
    },
    {
        "id1": 1927,
        "id2": 1929,
        "phenotype_comparison": ""
    },
    {
        "id1": 1947,
        "id2": 1948,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1965,
        "phenotype_comparison": ""
    },
    {
        "id1": 1980,
        "id2": 1981,
        "phenotype_comparison": ""
    },
    {
        "id1": 1985,
        "id2": 1998,
        "phenotype_comparison": ""
    },
    {
        "id1": 2017,
        "id2": 2019,
        "phenotype_comparison": ""
    },
    {
        "id1": 2037,
        "id2": 2038,
        "phenotype_comparison": ""
    },
    {
        "id1": 2061,
        "id2": 2062,
        "phenotype_comparison": "RNAi reduction of daf-16 did not suppress the increased longevity of worms overexpressing wwp-1."
    },
    {
        "id1": 2093,
        "id2": 2094,
        "phenotype_comparison": ""
    },
    {
        "id1": 2115,
        "id2": 2117,
        "phenotype_comparison": ""
    },
    {
        "id1": 2136,
        "id2": 2137,
        "phenotype_comparison": ""
    },
    {
        "id1": 2144,
        "id2": 2157,
        "phenotype_comparison": "mekk-3 RNAi failed to increase the lifespan of mev-1(kn1) significantly. These experiments show that mekk-3 knock-down that programmes a metabolic shift towards beta-oxidation requires normal Complex II activity to support lifespan extension."
    },
    {
        "id1": 2176,
        "id2": 2177,
        "phenotype_comparison": "When null mutant skn-1(zu169) was grown on mekk-3 RNAi, lifespan was significantly extended, but not to the same extent as WT control. Thus, mekk-3 knock-down-mediated DR partially depends on skn-1 for extended longevity."
    },
    {
        "id1": 2182,
        "id2": 2196,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2931,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2945,
        "phenotype_comparison": ""
    },
    {
        "id1": 2238,
        "id2": 2239,
        "phenotype_comparison": "Although nhr-8 plays a crucial role in mekk-3 knock-down-mediated DR, it appears that eat-2(ad1116) does not require nhr-8 for its increased longevity. The long lifespan on eat-2(ad1116) remains unaffected on nhr-8 RNAi."
    },
    {
        "id1": 2254,
        "id2": 2255,
        "phenotype_comparison": ""
    },
    {
        "id1": 2277,
        "id2": 2279,
        "phenotype_comparison": ""
    },
    {
        "id1": 2303,
        "id2": 2305,
        "phenotype_comparison": ""
    },
    {
        "id1": 2328,
        "id2": 2329,
        "phenotype_comparison": ""
    },
    {
        "id1": 2352,
        "id2": 2353,
        "phenotype_comparison": ""
    },
    {
        "id1": 2373,
        "id2": 2379,
        "phenotype_comparison": ""
    },
    {
        "id1": 2401,
        "id2": 2403,
        "phenotype_comparison": ""
    },
    {
        "id1": 2428,
        "id2": 2429,
        "phenotype_comparison": ""
    },
    {
        "id1": 2454,
        "id2": 2455,
        "phenotype_comparison": ""
    },
    {
        "id1": 2476,
        "id2": 2459,
        "phenotype_comparison": ""
    },
    {
        "id1": 2490,
        "id2": 2492,
        "phenotype_comparison": ""
    },
    {
        "id1": 2511,
        "id2": 2512,
        "phenotype_comparison": ""
    },
    {
        "id1": 2537,
        "id2": 2545,
        "phenotype_comparison": ""
    },
    {
        "id1": 2538,
        "id2": 2555,
        "phenotype_comparison": ""
    },
    {
        "id1": 2578,
        "id2": 2565,
        "phenotype_comparison": ""
    },
    {
        "id1": 2567,
        "id2": 2574,
        "phenotype_comparison": ""
    },
    {
        "id1": 2596,
        "id2": 2609,
        "phenotype_comparison": ""
    },
    {
        "id1": 2636,
        "id2": 2639,
        "phenotype_comparison": ""
    },
    {
        "id1": 2657,
        "id2": 2664,
        "phenotype_comparison": ""
    },
    {
        "id1": 2694,
        "id2": 2695,
        "phenotype_comparison": ""
    },
    {
        "id1": 2725,
        "id2": 2726,
        "phenotype_comparison": ""
    },
    {
        "id1": 2755,
        "id2": 2756,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2785,
        "phenotype_comparison": ""
    },
    {
        "id1": 2796,
        "id2": 2812,
        "phenotype_comparison": ""
    },
    {
        "id1": 2842,
        "id2": 2843,
        "phenotype_comparison": ""
    },
    {
        "id1": 2867,
        "id2": 2872,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2899,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2914,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2930,
        "phenotype_comparison": ""
    },
    {
        "id1": 2942,
        "id2": 2943,
        "phenotype_comparison": ""
    },
    {
        "id1": 2960,
        "id2": 2961,
        "phenotype_comparison": ""
    },
    {
        "id1": 2988,
        "id2": 2990,
        "phenotype_comparison": ""
    },
    {
        "id1": 3007,
        "id2": 3010,
        "phenotype_comparison": "nhr-62(tm1818) significantly suppressed the lifespan of eat-2(ad465) animals. Importantly, the nhr-62(tm1818) mutant had little or no effect on wild-type (N2), suggesting that nhr-62 does not suppress eat-2 longevity through general sickness "
    },
    {
        "id1": 3031,
        "id2": 3032,
        "phenotype_comparison": ""
    },
    {
        "id1": 3051,
        "id2": 3052,
        "phenotype_comparison": ""
    },
    {
        "id1": 3073,
        "id2": 3060,
        "phenotype_comparison": ""
    },
    {
        "id1": 3087,
        "id2": 3089,
        "phenotype_comparison": ""
    },
    {
        "id1": 3107,
        "id2": 3108,
        "phenotype_comparison": ""
    },
    {
        "id1": 3115,
        "id2": 3129,
        "phenotype_comparison": ""
    },
    {
        "id1": 3151,
        "id2": 3152,
        "phenotype_comparison": ""
    },
    {
        "id1": 3169,
        "id2": 3171,
        "phenotype_comparison": "Inactivation of pek-1 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3185,
        "id2": 3186,
        "phenotype_comparison": ""
    },
    {
        "id1": 3203,
        "id2": 3204,
        "phenotype_comparison": "Inactivation of dox-1 had a substantial effect on the lifespan of daf-2 mutants without affecting their apparent health. In four of six trials, dox-1 RNAi shortened the lifespan of daf-2 animals substantially more than it shortened wild-type lifespan. Thus, dox-1 contributes significantly to the longevity of daf-2 mutants."
    },
    {
        "id1": 3067,
        "id2": 3219,
        "phenotype_comparison": ""
    },
    {
        "id1": 3238,
        "id2": 3239,
        "phenotype_comparison": ""
    },
    {
        "id1": 3261,
        "id2": 3262,
        "phenotype_comparison": "Overexpression of a dominant negative form of the Drosophila insulin receptor (UAS-InRDN) under the control of the ubiquitous and constitutive daughterless-GAL4 driver (daGAL) results in females having a significantly longer median lifespan than controls. The same effect is however strongly attenuated in a dFoxo background and negative control of InR si very weak, suggesting that the increase in lifespan by InR knock-down is dependent on the existence of dFoxo. It should be noted that homozygotes dfoxo mutant (delta 94) female flies, which have delayed development time, are smaller in size with significant reductions in both body weight and wing area, are short leaved by ~33%."
    },
    {
        "id1": 3277,
        "id2": 3282,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3A1 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3294,
        "id2": 3296,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan."
    },
    {
        "id1": 3310,
        "id2": 3312,
        "phenotype_comparison": ""
    },
    {
        "id1": 3328,
        "id2": 3330,
        "phenotype_comparison": ""
    },
    {
        "id1": 3356,
        "id2": 3357,
        "phenotype_comparison": "The increase in lifespan of sun mutants was observed in sun EM67 in w/yw 67c23."
    },
    {
        "id1": 1549,
        "id2": 1553,
        "phenotype_comparison": ""
    },
    {
        "id1": 1579,
        "id2": 1581,
        "phenotype_comparison": ""
    },
    {
        "id1": 1592,
        "id2": 1598,
        "phenotype_comparison": "Skn-1(zu129) suppressed the increased longevity of the Class 2 daf-2 allele e1370."
    },
    {
        "id1": 1620,
        "id2": 1634,
        "phenotype_comparison": ""
    },
    {
        "id1": 1616,
        "id2": 1652,
        "phenotype_comparison": ""
    },
    {
        "id1": 1664,
        "id2": 1669,
        "phenotype_comparison": ""
    },
    {
        "id1": 1697,
        "id2": 1699,
        "phenotype_comparison": ""
    },
    {
        "id1": 1724,
        "id2": 1726,
        "phenotype_comparison": ""
    },
    {
        "id1": 1747,
        "id2": 1748,
        "phenotype_comparison": "SKN-1 is inhibited by IIS phosphorylation but is dispensable for dauer development, adulthood dauer-related traits, or lifespan extension by Class 2 daf-2 mutations at 20\u00b0C ."
    },
    {
        "id1": 1770,
        "id2": 1771,
        "phenotype_comparison": "Skn-1 was required at 15\u00b0C, 20\u00b0C, or 25\u00b0C for lifespan extension from daf-2 RNA interference (RNAi)."
    },
    {
        "id1": 1790,
        "id2": 1794,
        "phenotype_comparison": ""
    },
    {
        "id1": 1818,
        "id2": 1822,
        "phenotype_comparison": ""
    },
    {
        "id1": 1849,
        "id2": 1851,
        "phenotype_comparison": ""
    },
    {
        "id1": 1868,
        "id2": 1869,
        "phenotype_comparison": "Eak-7 null mutation enhances lifespan extension of glp-1(e2141) mutants."
    },
    {
        "id1": 1881,
        "id2": 1887,
        "phenotype_comparison": "Akt-1;akt-2 double mutants are extremely long-lived compared to single mutants. "
    },
    {
        "id1": 1852,
        "id2": 1909,
        "phenotype_comparison": ""
    },
    {
        "id1": 1928,
        "id2": 1929,
        "phenotype_comparison": "par-4(it47ts) partially suppresses the lifespan extension and dauer-constitutive phenotypes of daf-2(e1368) mutants. "
    },
    {
        "id1": 1932,
        "id2": 1948,
        "phenotype_comparison": "Reduction of 14-3-3 levels in animals with extra copies of sir-2.1 fully suppressed the life-span extension observed in this strain"
    },
    {
        "id1": 1952,
        "id2": 1966,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1982,
        "phenotype_comparison": ""
    },
    {
        "id1": 1997,
        "id2": 1998,
        "phenotype_comparison": ""
    },
    {
        "id1": 2018,
        "id2": 2020,
        "phenotype_comparison": ""
    },
    {
        "id1": 2039,
        "id2": 2040,
        "phenotype_comparison": ""
    },
    {
        "id1": 2063,
        "id2": 2064,
        "phenotype_comparison": ""
    },
    {
        "id1": 2093,
        "id2": 2095,
        "phenotype_comparison": ""
    },
    {
        "id1": 2116,
        "id2": 2118,
        "phenotype_comparison": ""
    },
    {
        "id1": 2138,
        "id2": 2139,
        "phenotype_comparison": ""
    },
    {
        "id1": 2138,
        "id2": 2158,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2179,
        "phenotype_comparison": ""
    },
    {
        "id1": 2196,
        "id2": 2197,
        "phenotype_comparison": ""
    },
    {
        "id1": 2214,
        "id2": 2215,
        "phenotype_comparison": ""
    },
    {
        "id1": 2142,
        "id2": 2240,
        "phenotype_comparison": ""
    },
    {
        "id1": 2249,
        "id2": 2255,
        "phenotype_comparison": "RNAi of mekk-3 was unable to increase lifespan in daf-22(m130)."
    },
    {
        "id1": 2278,
        "id2": 2279,
        "phenotype_comparison": "When knocking down mekk-3 in glp-1(e2141ts), the lifespan extension was not to the same extent as in wild type."
    },
    {
        "id1": 2304,
        "id2": 2305,
        "phenotype_comparison": "In hcf-1(null) animals, sgk-1(gf) did not further increase lifespan"
    },
    {
        "id1": 2328,
        "id2": 2330,
        "phenotype_comparison": ""
    },
    {
        "id1": 2354,
        "id2": 2355,
        "phenotype_comparison": "Inhibition of TOR signaling by knocking down both TOR/let-363 and Raptor/daf-15(a binding partner of TOR that is necessary for TOR activity) or TOR/let-363 alone in the EQ19 (i.e. the eIF4H/drr-2 over-expressing line) background failed to extend lifespan. This finding strongly implies that a common mechanism mediates the lifespan effects of TOR and eIF4H/drr-2, and that eIF4H/drr-2 might function genetically downstream of TOR to influence lifespan."
    },
    {
        "id1": 2960,
        "id2": 2963,
        "phenotype_comparison": ""
    },
    {
        "id1": 2378,
        "id2": 2379,
        "phenotype_comparison": "Inhibition of sams-1 by RNAi does not extend the lifespan of EQ19 (drr-2 over-expression) significantly, while inhibition of sams-1 extends the lifespan of wild-type animals, suggesting a common mechanism that mediates the lifespan effects of eIF4H/drr-2 and sams-1. "
    },
    {
        "id1": 2402,
        "id2": 2403,
        "phenotype_comparison": "Inhibition of eIF4H/drr-2 consistently extends the lifespan of wild-type animals and animals over-expressing rab-10 (EQ28). Taken together, these results strongly imply that eIF4H/drr-2 may act downstream of both rab-10 and sams-1 and its activity might be essential for RAB-10 and SAMS-1 to mediate the longevity effects of DR. "
    },
    {
        "id1": 2430,
        "id2": 2431,
        "phenotype_comparison": ""
    },
    {
        "id1": 2456,
        "id2": 2457,
        "phenotype_comparison": ""
    },
    {
        "id1": 2456,
        "id2": 2477,
        "phenotype_comparison": ""
    },
    {
        "id1": 2491,
        "id2": 2492,
        "phenotype_comparison": "Growing the worms on live OP50 at 25\u00b0C shortened the lifespan of all strains. The lifespans of gcy-35, and npr-1(ad609) mutants grown in this environment were similar to N2 controls. "
    },
    {
        "id1": 2512,
        "id2": 2513,
        "phenotype_comparison": ""
    },
    {
        "id1": 2555,
        "id2": 2556,
        "phenotype_comparison": ""
    },
    {
        "id1": 2578,
        "id2": 2579,
        "phenotype_comparison": ""
    },
    {
        "id1": 2567,
        "id2": 2591,
        "phenotype_comparison": ""
    },
    {
        "id1": 2610,
        "id2": 2611,
        "phenotype_comparison": ""
    },
    {
        "id1": 2636,
        "id2": 2640,
        "phenotype_comparison": ""
    },
    {
        "id1": 2665,
        "id2": 2666,
        "phenotype_comparison": ""
    },
    {
        "id1": 2692,
        "id2": 2696,
        "phenotype_comparison": ""
    },
    {
        "id1": 2688,
        "id2": 2727,
        "phenotype_comparison": ""
    },
    {
        "id1": 2757,
        "id2": 2758,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2786,
        "phenotype_comparison": ""
    },
    {
        "id1": 2798,
        "id2": 2813,
        "phenotype_comparison": ""
    },
    {
        "id1": 2840,
        "id2": 2844,
        "phenotype_comparison": ""
    },
    {
        "id1": 2867,
        "id2": 2873,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2900,
        "phenotype_comparison": ""
    },
    {
        "id1": 2913,
        "id2": 2914,
        "phenotype_comparison": ""
    },
    {
        "id1": 2929,
        "id2": 2930,
        "phenotype_comparison": "RNAi suppression of unc-51 after development extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2927,
        "id2": 2944,
        "phenotype_comparison": ""
    },
    {
        "id1": 2960,
        "id2": 2962,
        "phenotype_comparison": ""
    },
    {
        "id1": 2989,
        "id2": 2991,
        "phenotype_comparison": ""
    },
    {
        "id1": 2992,
        "id2": 3011,
        "phenotype_comparison": ""
    },
    {
        "id1": 3031,
        "id2": 3033,
        "phenotype_comparison": ""
    },
    {
        "id1": 3053,
        "id2": 3054,
        "phenotype_comparison": ""
    },
    {
        "id1": 3074,
        "id2": 3060,
        "phenotype_comparison": "A putative xbp-1\u2013null mutation, which causes truncation of the XBP-1 protein before its DNA binding domain, shortened the lifespan of daf-2 mutants more than it shortened the lifespan of wild type without affecting the apparent health of the animals."
    },
    {
        "id1": 3088,
        "id2": 3089,
        "phenotype_comparison": "A putative xbp-1\u2013null mutation, which causes truncation of the XBP-1 protein before its DNA binding domain, shortened the lifespan of daf-2 mutants more than it shortened the lifespan of wild type without affecting the apparent health of the animals."
    },
    {
        "id1": 3107,
        "id2": 3109,
        "phenotype_comparison": ""
    },
    {
        "id1": 3128,
        "id2": 3130,
        "phenotype_comparison": ""
    },
    {
        "id1": 3149,
        "id2": 3152,
        "phenotype_comparison": "Inactivation of atf-6 did not shorten the lifespan of daf-2 mutants."
    },
    {
        "id1": 3148,
        "id2": 3172,
        "phenotype_comparison": ""
    },
    {
        "id1": 3187,
        "id2": 3188,
        "phenotype_comparison": ""
    },
    {
        "id1": 3205,
        "id2": 3206,
        "phenotype_comparison": ""
    },
    {
        "id1": 3067,
        "id2": 3220,
        "phenotype_comparison": ""
    },
    {
        "id1": 3236,
        "id2": 3239,
        "phenotype_comparison": "The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway."
    },
    {
        "id1": 3263,
        "id2": 3264,
        "phenotype_comparison": ""
    },
    {
        "id1": 3275,
        "id2": 3283,
        "phenotype_comparison": ""
    },
    {
        "id1": 3292,
        "id2": 3297,
        "phenotype_comparison": ""
    },
    {
        "id1": 3311,
        "id2": 3312,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan."
    },
    {
        "id1": 3329,
        "id2": 3331,
        "phenotype_comparison": ""
    },
    {
        "id1": 3356,
        "id2": 3358,
        "phenotype_comparison": "w /yw 67c23 ; +/pW8gDmM-Sal(3 ' ) female progeny were used to examine whether additional copies of the sun gene could by itself affect the lifespan of Drosophila. An increase in lifespan was not observed in other heterozygotes, such as pW8gDmM-Sal(3 ' ) in w/yw 67c23."
    },
    {
        "id1": 1552,
        "id2": 1553,
        "phenotype_comparison": "Median survival for Mgat5-/- female mice is reduced to 522, compared with >650 days for wild-type C57BL6 mice. Median survival for Pten+/- females is reduced even more to 289, in particular due early cancer development (mainly lymphomas). The survival of Pten+/- is slightly ameliorated in males by the Mgat5-/- mutation."
    },
    {
        "id1": 1580,
        "id2": 1581,
        "phenotype_comparison": "Heterozygosity of Trp53 rescues in part the extremely reduced longevity of Sirt6-deficient (Sirt6-/-) female mice."
    },
    {
        "id1": 1596,
        "id2": 1599,
        "phenotype_comparison": ""
    },
    {
        "id1": 1634,
        "id2": 1635,
        "phenotype_comparison": ""
    },
    {
        "id1": 1652,
        "id2": 1653,
        "phenotype_comparison": ""
    },
    {
        "id1": 1666,
        "id2": 1669,
        "phenotype_comparison": "utx-1 RNAi extended lifespan in N2 worm, but not in rrf-1(ok589)."
    },
    {
        "id1": 1697,
        "id2": 1700,
        "phenotype_comparison": ""
    },
    {
        "id1": 1725,
        "id2": 1726,
        "phenotype_comparison": "At 15\u00b0C SKN-1 was completely required for longevity in the Class 2 daf-2 mutants"
    },
    {
        "id1": 1749,
        "id2": 1750,
        "phenotype_comparison": ""
    },
    {
        "id1": 1772,
        "id2": 1773,
        "phenotype_comparison": ""
    },
    {
        "id1": 1794,
        "id2": 1795,
        "phenotype_comparison": ""
    },
    {
        "id1": 1818,
        "id2": 1823,
        "phenotype_comparison": ""
    },
    {
        "id1": 1850,
        "id2": 1851,
        "phenotype_comparison": ""
    },
    {
        "id1": 1870,
        "id2": 1871,
        "phenotype_comparison": ""
    },
    {
        "id1": 1888,
        "id2": 1889,
        "phenotype_comparison": ""
    },
    {
        "id1": 1852,
        "id2": 1910,
        "phenotype_comparison": ""
    },
    {
        "id1": 1930,
        "id2": 1931,
        "phenotype_comparison": ""
    },
    {
        "id1": 1947,
        "id2": 1949,
        "phenotype_comparison": ""
    },
    {
        "id1": 1965,
        "id2": 1966,
        "phenotype_comparison": ""
    },
    {
        "id1": 1967,
        "id2": 1983,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1999,
        "phenotype_comparison": ""
    },
    {
        "id1": 2019,
        "id2": 2020,
        "phenotype_comparison": ""
    },
    {
        "id1": 2040,
        "id2": 2041,
        "phenotype_comparison": ""
    },
    {
        "id1": 2064,
        "id2": 2065,
        "phenotype_comparison": ""
    },
    {
        "id1": 2094,
        "id2": 2096,
        "phenotype_comparison": ""
    },
    {
        "id1": 2117,
        "id2": 2118,
        "phenotype_comparison": "The lifespan extension observed on knocking down mekk-3 does not require daf-16."
    },
    {
        "id1": 2138,
        "id2": 2140,
        "phenotype_comparison": ""
    },
    {
        "id1": 2158,
        "id2": 2159,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2180,
        "phenotype_comparison": ""
    },
    {
        "id1": 2184,
        "id2": 2197,
        "phenotype_comparison": "mekk-3 RNAi failed to extend lifespan in ahr-1(ju145) to the same extent as in WT worms."
    },
    {
        "id1": 2214,
        "id2": 2216,
        "phenotype_comparison": ""
    },
    {
        "id1": 2240,
        "id2": 2241,
        "phenotype_comparison": ""
    },
    {
        "id1": 2244,
        "id2": 2256,
        "phenotype_comparison": ""
    },
    {
        "id1": 2280,
        "id2": 2281,
        "phenotype_comparison": ""
    },
    {
        "id1": 2303,
        "id2": 2306,
        "phenotype_comparison": ""
    },
    {
        "id1": 2329,
        "id2": 2331,
        "phenotype_comparison": ""
    },
    {
        "id1": 2356,
        "id2": 2357,
        "phenotype_comparison": ""
    },
    {
        "id1": 2380,
        "id2": 2381,
        "phenotype_comparison": ""
    },
    {
        "id1": 2400,
        "id2": 2404,
        "phenotype_comparison": ""
    },
    {
        "id1": 2431,
        "id2": 2432,
        "phenotype_comparison": ""
    },
    {
        "id1": 2456,
        "id2": 2458,
        "phenotype_comparison": ""
    },
    {
        "id1": 2457,
        "id2": 2478,
        "phenotype_comparison": ""
    },
    {
        "id1": 2493,
        "id2": 2494,
        "phenotype_comparison": ""
    },
    {
        "id1": 2514,
        "id2": 2515,
        "phenotype_comparison": ""
    },
    {
        "id1": 2538,
        "id2": 2546,
        "phenotype_comparison": ""
    },
    {
        "id1": 2539,
        "id2": 2556,
        "phenotype_comparison": "The lifespan of daf-2(e1370) mutants was not further extended by npr-1 loss of function, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1 takes place through overlapping mechanisms."
    },
    {
        "id1": 2565,
        "id2": 2580,
        "phenotype_comparison": ""
    },
    {
        "id1": 2574,
        "id2": 2592,
        "phenotype_comparison": ""
    },
    {
        "id1": 2610,
        "id2": 2612,
        "phenotype_comparison": ""
    },
    {
        "id1": 2641,
        "id2": 2642,
        "phenotype_comparison": ""
    },
    {
        "id1": 2665,
        "id2": 2667,
        "phenotype_comparison": ""
    },
    {
        "id1": 2692,
        "id2": 2697,
        "phenotype_comparison": ""
    },
    {
        "id1": 2715,
        "id2": 2728,
        "phenotype_comparison": ""
    },
    {
        "id1": 2759,
        "id2": 2760,
        "phenotype_comparison": ""
    },
    {
        "id1": 2780,
        "id2": 2787,
        "phenotype_comparison": ""
    },
    {
        "id1": 2814,
        "id2": 2815,
        "phenotype_comparison": ""
    },
    {
        "id1": 2840,
        "id2": 2845,
        "phenotype_comparison": ""
    },
    {
        "id1": 2861,
        "id2": 2874,
        "phenotype_comparison": ""
    },
    {
        "id1": 2899,
        "id2": 2900,
        "phenotype_comparison": "Maternal RNAi of unc-51 significantly extended lifespan in the daf-2 mutant."
    },
    {
        "id1": 2897,
        "id2": 2915,
        "phenotype_comparison": ""
    },
    {
        "id1": 3072,
        "id2": 3075,
        "phenotype_comparison": ""
    },
    {
        "id1": 3057,
        "id2": 3090,
        "phenotype_comparison": ""
    },
    {
        "id1": 3108,
        "id2": 3110,
        "phenotype_comparison": ""
    },
    {
        "id1": 3117,
        "id2": 3130,
        "phenotype_comparison": "Inactivation of ire-1 by RNAi shortened the lifespan of daf-2 mutants. In both wild-type and daf-2(-) backgrounds, animals subjected to ire-1 RNAi appeared normal and healthy, whereas ire-1(ok799)\u2013null mutants had morphological and behavioral defects. Thus, whereas complete loss of ire-1 compromised the health of the animal, partial loss of ire-1, through RNAi, could shorten lifespan without making the animals appear unhealthy. "
    },
    {
        "id1": 3153,
        "id2": 3154,
        "phenotype_comparison": ""
    },
    {
        "id1": 3058,
        "id2": 3173,
        "phenotype_comparison": ""
    },
    {
        "id1": 3187,
        "id2": 3189,
        "phenotype_comparison": ""
    },
    {
        "id1": 3205,
        "id2": 3207,
        "phenotype_comparison": ""
    },
    {
        "id1": 3219,
        "id2": 3221,
        "phenotype_comparison": ""
    },
    {
        "id1": 3238,
        "id2": 3240,
        "phenotype_comparison": ""
    },
    {
        "id1": 3263,
        "id2": 3265,
        "phenotype_comparison": ""
    },
    {
        "id1": 3276,
        "id2": 3284,
        "phenotype_comparison": ""
    },
    {
        "id1": 3294,
        "id2": 3297,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2B12,Sod1 3B2 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with an increase in lifespan compared to the Cat single mutant."
    },
    {
        "id1": 3298,
        "id2": 3313,
        "phenotype_comparison": ""
    },
    {
        "id1": 3330,
        "id2": 3331,
        "phenotype_comparison": "mNSC-ablated flies are long-lived and females show reduced fecundity."
    },
    {
        "id1": 3359,
        "id2": 3360,
        "phenotype_comparison": ""
    },
    {
        "id1": 1554,
        "id2": 1555,
        "phenotype_comparison": ""
    },
    {
        "id1": 1582,
        "id2": 1579,
        "phenotype_comparison": ""
    },
    {
        "id1": 1594,
        "id2": 1599,
        "phenotype_comparison": ""
    },
    {
        "id1": 1622,
        "id2": 1635,
        "phenotype_comparison": "The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway"
    },
    {
        "id1": 1618,
        "id2": 1653,
        "phenotype_comparison": " utx-1 RNAi can still further extend life span of the germline lacking glp-1(e2141) mutant"
    },
    {
        "id1": 1658,
        "id2": 1670,
        "phenotype_comparison": ""
    },
    {
        "id1": 1701,
        "id2": 1702,
        "phenotype_comparison": ""
    },
    {
        "id1": 1727,
        "id2": 1728,
        "phenotype_comparison": ""
    },
    {
        "id1": 1749,
        "id2": 1751,
        "phenotype_comparison": ""
    },
    {
        "id1": 1772,
        "id2": 1774,
        "phenotype_comparison": ""
    },
    {
        "id1": 1791,
        "id2": 1795,
        "phenotype_comparison": "Lifespan extension is extremely robust when daf-2 RNAi is performed in the Class 1 mutant daf-2(e1368), which lacks adulthood dauer traits but predisposes to dauer entry."
    },
    {
        "id1": 1824,
        "id2": 1825,
        "phenotype_comparison": ""
    },
    {
        "id1": 1852,
        "id2": 1853,
        "phenotype_comparison": ""
    },
    {
        "id1": 1870,
        "id2": 1868,
        "phenotype_comparison": ""
    },
    {
        "id1": 1888,
        "id2": 1890,
        "phenotype_comparison": ""
    },
    {
        "id1": 1909,
        "id2": 1911,
        "phenotype_comparison": ""
    },
    {
        "id1": 1930,
        "id2": 1932,
        "phenotype_comparison": ""
    },
    {
        "id1": 1934,
        "id2": 1949,
        "phenotype_comparison": "Reduction of 14-3-3 levels in animals with extra copies of sir-2.1 fully suppressed the life-span extension observed in this strain"
    },
    {
        "id1": 1951,
        "id2": 1967,
        "phenotype_comparison": ""
    },
    {
        "id1": 1982,
        "id2": 1983,
        "phenotype_comparison": ""
    },
    {
        "id1": 1985,
        "id2": 2000,
        "phenotype_comparison": ""
    },
    {
        "id1": 2021,
        "id2": 2022,
        "phenotype_comparison": ""
    },
    {
        "id1": 2042,
        "id2": 2043,
        "phenotype_comparison": ""
    },
    {
        "id1": 2066,
        "id2": 2067,
        "phenotype_comparison": ""
    },
    {
        "id1": 2095,
        "id2": 2096,
        "phenotype_comparison": ""
    },
    {
        "id1": 2116,
        "id2": 2119,
        "phenotype_comparison": ""
    },
    {
        "id1": 2139,
        "id2": 2141,
        "phenotype_comparison": ""
    },
    {
        "id1": 2140,
        "id2": 2159,
        "phenotype_comparison": "mekk-3 RNAi failed to increase the lifespan of mev-1(kn1) significantly. These experiments show that mekk-3 knock-down that programmes a metabolic shift towards beta-oxidation requires normal Complex II activity to support lifespan extension."
    },
    {
        "id1": 2179,
        "id2": 2181,
        "phenotype_comparison": ""
    },
    {
        "id1": 2178,
        "id2": 2198,
        "phenotype_comparison": ""
    },
    {
        "id1": 2215,
        "id2": 2217,
        "phenotype_comparison": ""
    },
    {
        "id1": 2144,
        "id2": 2241,
        "phenotype_comparison": "mekk-3 RNAi had limited effect on the lifespan of RNAi-deficient rde-1(ne219)."
    },
    {
        "id1": 2256,
        "id2": 2257,
        "phenotype_comparison": ""
    },
    {
        "id1": 2280,
        "id2": 2282,
        "phenotype_comparison": ""
    },
    {
        "id1": 2303,
        "id2": 2307,
        "phenotype_comparison": ""
    },
    {
        "id1": 2330,
        "id2": 2331,
        "phenotype_comparison": "Inhibition of ddl-1 does not further increase the lifespan of hsb-1(cg116) mutants, while it typically increases N2 lifespan by up to 33%."
    },
    {
        "id1": 2358,
        "id2": 2359,
        "phenotype_comparison": "Inhibition of TOR signaling by knocking down both TOR/let-363 and Raptor/daf-15(a binding partner of TOR that is necessary for TOR activity) or TOR/let-363 alone in the EQ19 (i.e. the eIF4H/drr-2 over-expressing line) background failed to extend lifespan. This finding strongly implies that a common mechanism mediates the lifespan effects of TOR and eIF4H/drr-2, and that eIF4H/drr-2 might function genetically downstream of TOR to influence lifespan."
    },
    {
        "id1": 2380,
        "id2": 2382,
        "phenotype_comparison": ""
    },
    {
        "id1": 2404,
        "id2": 2405,
        "phenotype_comparison": ""
    },
    {
        "id1": 2433,
        "id2": 2434,
        "phenotype_comparison": ""
    },
    {
        "id1": 2457,
        "id2": 2459,
        "phenotype_comparison": ""
    },
    {
        "id1": 2477,
        "id2": 2478,
        "phenotype_comparison": "The deletion of gcy-33 did not affect N2 worms\u2019 lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609)."
    },
    {
        "id1": 2493,
        "id2": 2495,
        "phenotype_comparison": ""
    },
    {
        "id1": 2515,
        "id2": 2516,
        "phenotype_comparison": ""
    },
    {
        "id1": 2540,
        "id2": 2547,
        "phenotype_comparison": ""
    },
    {
        "id1": 2541,
        "id2": 2557,
        "phenotype_comparison": ""
    },
    {
        "id1": 2579,
        "id2": 2580,
        "phenotype_comparison": "N2 worms bearing the hif-1(ia4) deletion allele lived significantly longer than N2 controls . By contrast, the deletion of hif-1 shortened the lifespans of npr-1(ad609) mutants to less than that of N2, suggesting that the beneficial effect of HIF-1 on worm lifespan is mediated by NPR-1(215V) activity."
    },
    {
        "id1": 2591,
        "id2": 2592,
        "phenotype_comparison": "egl-9 loss of function significantly increased the lifespan of N2 worms, but significantly shortened the lifespan of npr-1(ad609) animals, indicating that the function of egl-9 in lifespan is regulated by npr-1."
    },
    {
        "id1": 2610,
        "id2": 2613,
        "phenotype_comparison": ""
    },
    {
        "id1": 2641,
        "id2": 2643,
        "phenotype_comparison": ""
    },
    {
        "id1": 2665,
        "id2": 2668,
        "phenotype_comparison": ""
    },
    {
        "id1": 2692,
        "id2": 2698,
        "phenotype_comparison": ""
    },
    {
        "id1": 2717,
        "id2": 2729,
        "phenotype_comparison": ""
    },
    {
        "id1": 2761,
        "id2": 2762,
        "phenotype_comparison": ""
    },
    {
        "id1": 2774,
        "id2": 2788,
        "phenotype_comparison": ""
    },
    {
        "id1": 2814,
        "id2": 2816,
        "phenotype_comparison": ""
    },
    {
        "id1": 2836,
        "id2": 2846,
        "phenotype_comparison": ""
    },
    {
        "id1": 2863,
        "id2": 2875,
        "phenotype_comparison": ""
    },
    {
        "id1": 2897,
        "id2": 2901,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2916,
        "phenotype_comparison": ""
    },
    {
        "id1": 2928,
        "id2": 2932,
        "phenotype_comparison": ""
    },
    {
        "id1": 2944,
        "id2": 2945,
        "phenotype_comparison": ""
    },
    {
        "id1": 2964,
        "id2": 2965,
        "phenotype_comparison": ""
    },
    {
        "id1": 2992,
        "id2": 2993,
        "phenotype_comparison": ""
    },
    {
        "id1": 3011,
        "id2": 3012,
        "phenotype_comparison": ""
    },
    {
        "id1": 3033,
        "id2": 3034,
        "phenotype_comparison": ""
    },
    {
        "id1": 3057,
        "id2": 3058,
        "phenotype_comparison": ""
    },
    {
        "id1": 3073,
        "id2": 3076,
        "phenotype_comparison": ""
    },
    {
        "id1": 3087,
        "id2": 3084,
        "phenotype_comparison": ""
    },
    {
        "id1": 3109,
        "id2": 3110,
        "phenotype_comparison": ""
    },
    {
        "id1": 3131,
        "id2": 3132,
        "phenotype_comparison": ""
    },
    {
        "id1": 3153,
        "id2": 3155,
        "phenotype_comparison": ""
    },
    {
        "id1": 3172,
        "id2": 3173,
        "phenotype_comparison": "Inactivation of abu-11 by RNAi did not shorten the lifespan of daf-2 mutants, whereas it did shorten the lifespan of wild type. "
    },
    {
        "id1": 3188,
        "id2": 3190,
        "phenotype_comparison": ""
    },
    {
        "id1": 3206,
        "id2": 3208,
        "phenotype_comparison": ""
    },
    {
        "id1": 3220,
        "id2": 3221,
        "phenotype_comparison": "Inactivation of ire-1 shortened wild-type lifespan by an average of 22% and ire-1 knockdown shortened the extended lifespan caused by the eat-2 mutation by an average of less than 20%."
    },
    {
        "id1": 3236,
        "id2": 3240,
        "phenotype_comparison": "The transheterozygotes for mas1 and Edem1 showed similar lifespan profiles to those resulting from crossing for different alleles of mas1. These results support the hypothesis that the two genes act to extend longevity through a common genetic pathway."
    },
    {
        "id1": 3264,
        "id2": 3266,
        "phenotype_comparison": ""
    },
    {
        "id1": 1472,
        "id2": 1473,
        "phenotype_comparison": "The Rad54B(-/-) Atm (-/-) double mutant is shorter lived than both single mutants."
    },
    {
        "id1": 1474,
        "id2": 1475,
        "phenotype_comparison": ""
    },
    {
        "id1": 1475,
        "id2": 1476,
        "phenotype_comparison": ""
    },
    {
        "id1": 1478,
        "id2": 1479,
        "phenotype_comparison": ""
    },
    {
        "id1": 3283,
        "id2": 3284,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the first experiment, the transgenic line containing the gene combination Cat 2A2,Sod1 3B2 (insert location-specific) in the (D, long-lived) background resulted in a double mutant with a decrease in lifespan compared to the Sod1 single mutant."
    },
    {
        "id1": 3298,
        "id2": 3299,
        "phenotype_comparison": ""
    },
    {
        "id1": 3313,
        "id2": 3314,
        "phenotype_comparison": ""
    },
    {
        "id1": 3332,
        "id2": 3333,
        "phenotype_comparison": ""
    },
    {
        "id1": 3359,
        "id2": 3361,
        "phenotype_comparison": ""
    },
    {
        "id1": 1554,
        "id2": 1556,
        "phenotype_comparison": ""
    },
    {
        "id1": 1582,
        "id2": 1580,
        "phenotype_comparison": ""
    },
    {
        "id1": 1588,
        "id2": 1600,
        "phenotype_comparison": ""
    },
    {
        "id1": 1628,
        "id2": 1636,
        "phenotype_comparison": ""
    },
    {
        "id1": 1620,
        "id2": 1654,
        "phenotype_comparison": ""
    },
    {
        "id1": 1659,
        "id2": 1671,
        "phenotype_comparison": ""
    },
    {
        "id1": 1701,
        "id2": 1703,
        "phenotype_comparison": ""
    },
    {
        "id1": 1727,
        "id2": 1729,
        "phenotype_comparison": ""
    },
    {
        "id1": 1750,
        "id2": 1752,
        "phenotype_comparison": ""
    },
    {
        "id1": 1773,
        "id2": 1775,
        "phenotype_comparison": ""
    },
    {
        "id1": 1824,
        "id2": 1826,
        "phenotype_comparison": ""
    },
    {
        "id1": 1852,
        "id2": 1854,
        "phenotype_comparison": ""
    },
    {
        "id1": 1871,
        "id2": 1872,
        "phenotype_comparison": ""
    },
    {
        "id1": 1889,
        "id2": 1891,
        "phenotype_comparison": ""
    },
    {
        "id1": 1910,
        "id2": 1911,
        "phenotype_comparison": "The rle-1(tm2447) mutation does not extend lifespan."
    },
    {
        "id1": 1931,
        "id2": 1933,
        "phenotype_comparison": ""
    },
    {
        "id1": 1947,
        "id2": 1950,
        "phenotype_comparison": ""
    },
    {
        "id1": 1951,
        "id2": 1968,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1985,
        "phenotype_comparison": ""
    },
    {
        "id1": 1999,
        "id2": 2000,
        "phenotype_comparison": ""
    },
    {
        "id1": 2021,
        "id2": 2023,
        "phenotype_comparison": ""
    },
    {
        "id1": 2044,
        "id2": 2045,
        "phenotype_comparison": ""
    },
    {
        "id1": 2068,
        "id2": 2069,
        "phenotype_comparison": ""
    },
    {
        "id1": 2097,
        "id2": 2098,
        "phenotype_comparison": ""
    },
    {
        "id1": 2120,
        "id2": 2121,
        "phenotype_comparison": ""
    },
    {
        "id1": 2140,
        "id2": 2141,
        "phenotype_comparison": "mekk-3 RNAi failed to increase the long lifespans of eat-2(ad1116) to the same extent as in WT, suggesting that they may function in the same genetic pathway for lifespan regulation."
    },
    {
        "id1": 2142,
        "id2": 2160,
        "phenotype_comparison": ""
    },
    {
        "id1": 2180,
        "id2": 2181,
        "phenotype_comparison": "mekk-3 RNAi failed to extend the lifespan of nhr-49(ok2165) significantly."
    },
    {
        "id1": 2198,
        "id2": 2199,
        "phenotype_comparison": ""
    },
    {
        "id1": 2216,
        "id2": 2217,
        "phenotype_comparison": "The lifespan extension observed on knocking down mekk-3 does not require hsf-1."
    },
    {
        "id1": 2138,
        "id2": 2242,
        "phenotype_comparison": ""
    },
    {
        "id1": 2252,
        "id2": 2257,
        "phenotype_comparison": "RNAi of mekk-3 was unable to increase lifespan in daf-22(m130)."
    },
    {
        "id1": 2281,
        "id2": 2283,
        "phenotype_comparison": ""
    },
    {
        "id1": 2308,
        "id2": 2309,
        "phenotype_comparison": ""
    },
    {
        "id1": 2332,
        "id2": 2333,
        "phenotype_comparison": ""
    },
    {
        "id1": 2360,
        "id2": 2361,
        "phenotype_comparison": ""
    },
    {
        "id1": 2381,
        "id2": 2383,
        "phenotype_comparison": ""
    },
    {
        "id1": 2402,
        "id2": 2405,
        "phenotype_comparison": "Inhibition of eIF4H/drr-2 consistently extends the lifespan of wild-type animals and animals over-expressing sams-1 (EQ2). Taken together, these results strongly imply that eIF4H/drr-2 may act downstream of both rab-10 and sams-1 and its activity might be essential for RAB-10 and SAMS-1 to mediate the longevity effects of DR. "
    },
    {
        "id1": 2434,
        "id2": 2435,
        "phenotype_comparison": ""
    },
    {
        "id1": 2458,
        "id2": 2459,
        "phenotype_comparison": ""
    },
    {
        "id1": 2460,
        "id2": 2479,
        "phenotype_comparison": ""
    },
    {
        "id1": 2494,
        "id2": 2496,
        "phenotype_comparison": ""
    },
    {
        "id1": 2517,
        "id2": 2518,
        "phenotype_comparison": ""
    },
    {
        "id1": 2557,
        "id2": 2558,
        "phenotype_comparison": ""
    },
    {
        "id1": 2581,
        "id2": 2568,
        "phenotype_comparison": ""
    },
    {
        "id1": 2610,
        "id2": 2614,
        "phenotype_comparison": ""
    },
    {
        "id1": 2644,
        "id2": 2645,
        "phenotype_comparison": ""
    },
    {
        "id1": 2665,
        "id2": 2669,
        "phenotype_comparison": ""
    },
    {
        "id1": 2699,
        "id2": 2700,
        "phenotype_comparison": ""
    },
    {
        "id1": 2730,
        "id2": 2731,
        "phenotype_comparison": ""
    },
    {
        "id1": 2757,
        "id2": 2763,
        "phenotype_comparison": ""
    },
    {
        "id1": 2755,
        "id2": 2789,
        "phenotype_comparison": ""
    },
    {
        "id1": 2817,
        "id2": 2818,
        "phenotype_comparison": ""
    },
    {
        "id1": 2838,
        "id2": 2847,
        "phenotype_comparison": ""
    },
    {
        "id1": 2867,
        "id2": 2876,
        "phenotype_comparison": ""
    },
    {
        "id1": 2898,
        "id2": 2902,
        "phenotype_comparison": ""
    },
    {
        "id1": 2915,
        "id2": 2916,
        "phenotype_comparison": ""
    },
    {
        "id1": 2931,
        "id2": 2932,
        "phenotype_comparison": ""
    },
    {
        "id1": 2927,
        "id2": 2946,
        "phenotype_comparison": ""
    },
    {
        "id1": 2964,
        "id2": 2966,
        "phenotype_comparison": ""
    },
    {
        "id1": 2992,
        "id2": 2994,
        "phenotype_comparison": ""
    },
    {
        "id1": 3013,
        "id2": 3014,
        "phenotype_comparison": ""
    },
    {
        "id1": 3031,
        "id2": 3035,
        "phenotype_comparison": ""
    },
    {
        "id1": 3057,
        "id2": 3059,
        "phenotype_comparison": ""
    },
    {
        "id1": 3075,
        "id2": 3076,
        "phenotype_comparison": "Inactivation of ire-1 by a deletion mutation shortened the lifespan of daf-2 mutants. ire-1(ok799)\u2013null mutants had morphological and behavioral defects."
    },
    {
        "id1": 3090,
        "id2": 3084,
        "phenotype_comparison": "Inactivation of ire-1 by a deletion mutation shortened the lifespan of daf-2 mutants. ire-1(ok799)\u2013null mutants had morphological and behavioral defects."
    },
    {
        "id1": 3107,
        "id2": 3111,
        "phenotype_comparison": ""
    },
    {
        "id1": 3131,
        "id2": 3133,
        "phenotype_comparison": ""
    },
    {
        "id1": 3154,
        "id2": 3156,
        "phenotype_comparison": ""
    },
    {
        "id1": 3151,
        "id2": 3174,
        "phenotype_comparison": ""
    },
    {
        "id1": 3189,
        "id2": 3190,
        "phenotype_comparison": ""
    },
    {
        "id1": 3207,
        "id2": 3208,
        "phenotype_comparison": "Inactivation of dox-1 had a substantial effect on the lifespan of daf-2 mutants without affecting their apparent health. In four of six trials, dox-1 RNAi shortened the lifespan of daf-2 animals substantially more than it shortened wild-type lifespan. Thus, dox-1 contributes significantly to the longevity of daf-2 mutants."
    },
    {
        "id1": 3077,
        "id2": 3222,
        "phenotype_comparison": ""
    },
    {
        "id1": 3241,
        "id2": 3242,
        "phenotype_comparison": ""
    },
    {
        "id1": 3265,
        "id2": 3266,
        "phenotype_comparison": "Expression of UAS-reaper (UAS-rpr) under the control of the InsP3-GAL4 driver (InsP3GAL), which results in the ablation of median neurosecretary cells, results in females having a significantly longer median lifespan than controls. The same effect is however completely cancelled out in a dFoxo background, suggesting that the increase in lifespan by rpr expression is dependent on the existence of dFoxo. It should be noted that homozygotes dfoxo mutant (delta 94) female flies, which have delayed development time, are smaller in size with significant reductions in both body weight and wing area, are short leaved by ~33%."
    },
    {
        "id1": 3279,
        "id2": 3285,
        "phenotype_comparison": ""
    },
    {
        "id1": 3298,
        "id2": 3300,
        "phenotype_comparison": ""
    },
    {
        "id1": 3311,
        "id2": 3314,
        "phenotype_comparison": "Overexpression of Cat and Sod1 was carried out using the FLP-OUT system. Induction of the FLP1 recombinase with the heat-induced hsp70 promoter resulted in the removal of the stop sequence which acted like a blocker for Cat and/or Sod1's transcription. The study included 2 replicated experiments and 2 fly heterogeneous genetic backgrounds (T/D). In the second experiment, the transgenic line containing the gene combination Cat 2B2, Sod1 3A1 (insert location-specific) in the (T, short-lived) background resulted in a double mutant with a very small change to the lifespan."
    },
    {
        "id1": 3332,
        "id2": 3334,
        "phenotype_comparison": ""
    },
    {
        "id1": 3360,
        "id2": 3362,
        "phenotype_comparison": ""
    },
    {
        "id1": 1555,
        "id2": 1557,
        "phenotype_comparison": ""
    },
    {
        "id1": 1579,
        "id2": 1583,
        "phenotype_comparison": ""
    },
    {
        "id1": 1600,
        "id2": 1601,
        "phenotype_comparison": ""
    },
    {
        "id1": 1636,
        "id2": 1637,
        "phenotype_comparison": ""
    },
    {
        "id1": 1654,
        "id2": 1655,
        "phenotype_comparison": ""
    },
    {
        "id1": 1670,
        "id2": 1671,
        "phenotype_comparison": ""
    },
    {
        "id1": 1701,
        "id2": 1704,
        "phenotype_comparison": ""
    },
    {
        "id1": 1728,
        "id2": 1730,
        "phenotype_comparison": ""
    },
    {
        "id1": 1751,
        "id2": 1752,
        "phenotype_comparison": ""
    },
    {
        "id1": 1774,
        "id2": 1775,
        "phenotype_comparison": "Skn-1 was required at 15\u00b0C, 20\u00b0C, or 25\u00b0C for lifespan extension from daf-2 RNA interference (RNAi)."
    },
    {
        "id1": 1456,
        "id2": 1457,
        "phenotype_comparison": ""
    },
    {
        "id1": 1458,
        "id2": 1459,
        "phenotype_comparison": ""
    },
    {
        "id1": 1463,
        "id2": 1464,
        "phenotype_comparison": ""
    },
    {
        "id1": 1465,
        "id2": 1466,
        "phenotype_comparison": ""
    },
    {
        "id1": 1465,
        "id2": 1467,
        "phenotype_comparison": ""
    },
    {
        "id1": 1466,
        "id2": 1468,
        "phenotype_comparison": ""
    },
    {
        "id1": 1467,
        "id2": 1468,
        "phenotype_comparison": "Despite cancer resistance, the median lifespan of the G3/G4 Terc-/- Atm-/- mice was significantly shorter than that of G3/G4 Terc-/- Atm+/+ controls"
    },
    {
        "id1": 1469,
        "id2": 1471,
        "phenotype_comparison": ""
    },
    {
        "id1": 1470,
        "id2": 1471,
        "phenotype_comparison": "The Rad54(-/-) Atm (-/-) double mutant is shorter lived than both single mutants."
    },
    {
        "id1": 3375,
        "id2": 3376,
        "phenotype_comparison": ""
    },
    {
        "id1": 3375,
        "id2": 3378,
        "phenotype_comparison": ""
    },
    {
        "id1": 1480,
        "id2": 1481,
        "phenotype_comparison": "The average and maximum lifespan of the double mutants was increased in comparison to Trp53 +/- animals, suggestive of a slower initiation or growth of tumors."
    },
    {
        "id1": 1482,
        "id2": 1483,
        "phenotype_comparison": ""
    },
    {
        "id1": 1482,
        "id2": 1484,
        "phenotype_comparison": ""
    },
    {
        "id1": 1483,
        "id2": 1485,
        "phenotype_comparison": ""
    },
    {
        "id1": 1484,
        "id2": 1485,
        "phenotype_comparison": "Kv1.3 gene-targeted deletion improves longevity and fecundity. The decreased fecundity typically reported for MC4R-null mice was partially rectified in Kv/MC4R-null animals in comparison to the greater than 80% pregnancy rates of either WT or Kv-null mice. The mean lifespan of the Kv-null mice significantly increased by 22% over that of WT mice whereby lifespan of the MC4R-null mice, oppositely, was significantly reduced by 36% in comparison to that of WT mice. Gene-targeted deletion of Kv1.3 in MC4R-null mice returned the lifespan of these mice to approximately WT levels."
    },
    {
        "id1": 1486,
        "id2": 1487,
        "phenotype_comparison": ""
    },
    {
        "id1": 1486,
        "id2": 1488,
        "phenotype_comparison": ""
    },
    {
        "id1": 1487,
        "id2": 1489,
        "phenotype_comparison": ""
    },
    {
        "id1": 1488,
        "id2": 1489,
        "phenotype_comparison": "Loss of Rbm38 significantly reduces the tumor penetrance in p53-heterozygous mice (p53+/- and Rbm38-/-; p53+/-)"
    },
    {
        "id1": 1486,
        "id2": 1490,
        "phenotype_comparison": ""
    },
    {
        "id1": 1487,
        "id2": 1491,
        "phenotype_comparison": ""
    },
    {
        "id1": 1490,
        "id2": 1491,
        "phenotype_comparison": "Loss of Rbm38 Shortens the Life Span of, and Facilitates Lymphomagenesis in, p53-Null Mice (homozygousRBM38-/-; p53-/- mice)."
    },
    {
        "id1": 1492,
        "id2": 1493,
        "phenotype_comparison": ""
    },
    {
        "id1": 1492,
        "id2": 1494,
        "phenotype_comparison": ""
    },
    {
        "id1": 1495,
        "id2": 1496,
        "phenotype_comparison": ""
    },
    {
        "id1": 1497,
        "id2": 1498,
        "phenotype_comparison": ""
    },
    {
        "id1": 1499,
        "id2": 1500,
        "phenotype_comparison": ""
    },
    {
        "id1": 1499,
        "id2": 1501,
        "phenotype_comparison": ""
    },
    {
        "id1": 1502,
        "id2": 1503,
        "phenotype_comparison": ""
    },
    {
        "id1": 1504,
        "id2": 1505,
        "phenotype_comparison": ""
    },
    {
        "id1": 1504,
        "id2": 1506,
        "phenotype_comparison": ""
    },
    {
        "id1": 1505,
        "id2": 1507,
        "phenotype_comparison": ""
    },
    {
        "id1": 1506,
        "id2": 1507,
        "phenotype_comparison": "Double mutant mice developed much more aggressive lung cancers and higher tumor burden than K-rasLA1/+ mice, leading to shorter lifespans. p53R172H delta g/+ K-rasLA1/+ mice had significantly reduced survival compared with K-rasLA1/+, p53R172H delta g/+ and wild-type littermates. The p53+/- K-rasLA1/+ mice showed a very similar survival curve to published data, and indicated no difference in survival as compared to p53R172H delta g/+ K-rasLA1/+ mice."
    },
    {
        "id1": 1508,
        "id2": 1510,
        "phenotype_comparison": ""
    },
    {
        "id1": 1509,
        "id2": 1510,
        "phenotype_comparison": "The dna-pk mice live significantly longer compared to ku80-/- mice in both male (p = 0.01) and females (p = 8.7*10-6) mice.Survival of double knock out mice is identical to ku80-/-"
    },
    {
        "id1": 1511,
        "id2": 1513,
        "phenotype_comparison": ""
    },
    {
        "id1": 1512,
        "id2": 1513,
        "phenotype_comparison": "The dna-pk mice live significantly longer compared to ku80-/- mice in both male (p = 0.01) and females (p = 8.7*10-6) mice.Survival of double knock out mice is identical to ku80-/-"
    },
    {
        "id1": 1514,
        "id2": 1515,
        "phenotype_comparison": "Increased life span of Mobr/SOD1G86R double mutants. This difference represents a 9% increase in life span for the copper-deficient double-mutant Mobr/SOD1G86R compared with the nondeficient single-mutant SOD1G86R mice."
    },
    {
        "id1": 1516,
        "id2": 1518,
        "phenotype_comparison": ""
    },
    {
        "id1": 1517,
        "id2": 1518,
        "phenotype_comparison": "Overexpression of Mdm4 cooperates with p53R172H/+ in tumorigenesis with significant reduction of p53 LOH"
    },
    {
        "id1": 1519,
        "id2": 1520,
        "phenotype_comparison": ""
    },
    {
        "id1": 1517,
        "id2": 1520,
        "phenotype_comparison": "Overexpression of Mdm4 cooperates with p53R172H/+ in tumorigenesis with significant reduction of p53 LOH"
    },
    {
        "id1": 1519,
        "id2": 1522,
        "phenotype_comparison": ""
    },
    {
        "id1": 1521,
        "id2": 1522,
        "phenotype_comparison": "Mdm4 has p53-independent function in vivo"
    },
    {
        "id1": 1521,
        "id2": 1523,
        "phenotype_comparison": "Mdm4 has p53-independent function in vivo"
    },
    {
        "id1": 1519,
        "id2": 1525,
        "phenotype_comparison": ""
    },
    {
        "id1": 1524,
        "id2": 1525,
        "phenotype_comparison": "When the survival data were segregated in a gender-specific manner, the median survival of Mdm4Tg15, p53-/- (n=15) male mice was significantly shorter than p53-/- male mice (n=25) (98 vs 130 days, p=0.0042), but the median survival of p53-/- female mice was similar to Mdm4Tg15, p53-/- female mice"
    },
    {
        "id1": 1519,
        "id2": 1527,
        "phenotype_comparison": ""
    },
    {
        "id1": 1526,
        "id2": 1527,
        "phenotype_comparison": "Overexpression of Mdm4 cooperates with oncogenic K-ras in tumorigenesis"
    },
    {
        "id1": 1516,
        "id2": 1528,
        "phenotype_comparison": ""
    },
    {
        "id1": 1526,
        "id2": 1528,
        "phenotype_comparison": "Overexpression of Mdm4 cooperates with oncogenic K-ras in tumorigenesis"
    },
    {
        "id1": 1796,
        "id2": 1797,
        "phenotype_comparison": ""
    },
    {
        "id1": 1824,
        "id2": 1827,
        "phenotype_comparison": ""
    },
    {
        "id1": 1853,
        "id2": 1855,
        "phenotype_comparison": ""
    },
    {
        "id1": 1868,
        "id2": 1872,
        "phenotype_comparison": "Eak-7 null mutation enhances lifespan extension of glp-1(e2141) mutants."
    },
    {
        "id1": 1890,
        "id2": 1891,
        "phenotype_comparison": "Eak-7 mutants live longer than wild-type animals, and this phenotype requires daf-16/FoxO, as well as the protein phosphatase 4 regulatory subunit SMK-1 and the heat-shock transcription factor HSF-1"
    },
    {
        "id1": 1912,
        "id2": 1913,
        "phenotype_comparison": ""
    },
    {
        "id1": 1932,
        "id2": 1933,
        "phenotype_comparison": "par-5 RNAi does not significantly shorten the life span of daf-16(mgDf50) animals."
    },
    {
        "id1": 1951,
        "id2": 1952,
        "phenotype_comparison": ""
    },
    {
        "id1": 1967,
        "id2": 1969,
        "phenotype_comparison": ""
    },
    {
        "id1": 1984,
        "id2": 1986,
        "phenotype_comparison": ""
    },
    {
        "id1": 2001,
        "id2": 2002,
        "phenotype_comparison": ""
    },
    {
        "id1": 2022,
        "id2": 2024,
        "phenotype_comparison": ""
    },
    {
        "id1": 2046,
        "id2": 2047,
        "phenotype_comparison": ""
    },
    {
        "id1": 2068,
        "id2": 2070,
        "phenotype_comparison": ""
    },
    {
        "id1": 2099,
        "id2": 2100,
        "phenotype_comparison": ""
    },
    {
        "id1": 2120,
        "id2": 2122,
        "phenotype_comparison": ""
    },
    {
        "id1": 2142,
        "id2": 2143,
        "phenotype_comparison": ""
    },
    {
        "id1": 2160,
        "id2": 2161,
        "phenotype_comparison": ""
    },
    {
        "id1": 2182,
        "id2": 2183,
        "phenotype_comparison": ""
    },
    {
        "id1": 2180,
        "id2": 2199,
        "phenotype_comparison": "mekk-3 RNAi failed to extend lifespan in ahr-1(ia3) to the same extent as in WT worms."
    },
    {
        "id1": 2218,
        "id2": 2219,
        "phenotype_comparison": ""
    },
    {
        "id1": 2242,
        "id2": 2243,
        "phenotype_comparison": ""
    },
    {
        "id1": 2258,
        "id2": 2259,
        "phenotype_comparison": ""
    },
    {
        "id1": 2282,
        "id2": 2283,
        "phenotype_comparison": "When knocking down mekk-3 in glp-1(e2141ts), the lifespan extension was not to the same extent as in wild type."
    },
    {
        "id1": 2308,
        "id2": 2310,
        "phenotype_comparison": ""
    },
    {
        "id1": 2332,
        "id2": 2334,
        "phenotype_comparison": ""
    },
    {
        "id1": 2360,
        "id2": 2362,
        "phenotype_comparison": ""
    },
    {
        "id1": 2382,
        "id2": 2383,
        "phenotype_comparison": "pha-4 is not required for eIF4H/drr-2 inhibition to extend lifespan, as the RNAi of eIF4H/drr-2 extends lifespan to a similar extent in the pha-4(zu225) mutant background compared to that in wild types."
    },
    {
        "id1": 2436,
        "id2": 2437,
        "phenotype_comparison": ""
    },
    {
        "id1": 2460,
        "id2": 2461,
        "phenotype_comparison": ""
    },
    {
        "id1": 2461,
        "id2": 2480,
        "phenotype_comparison": ""
    },
    {
        "id1": 2518,
        "id2": 2519,
        "phenotype_comparison": ""
    },
    {
        "id1": 3376,
        "id2": 3377,
        "phenotype_comparison": ""
    },
    {
        "id1": 3376,
        "id2": 3379,
        "phenotype_comparison": ""
    },
    {
        "id1": 3378,
        "id2": 3379,
        "phenotype_comparison": "These data show that egl-27(we3) suppresses daf-2(e1370) longevity to approximately the same extent as daf-16(mu86)."
    },
    {
        "id1": 3380,
        "id2": 3381,
        "phenotype_comparison": ""
    },
    {
        "id1": 3380,
        "id2": 3382,
        "phenotype_comparison": ""
    },
    {
        "id1": 3381,
        "id2": 3383,
        "phenotype_comparison": ""
    },
    {
        "id1": 3382,
        "id2": 3383,
        "phenotype_comparison": "Longevity is further enhanced in double mutants of sgk-1(RNAi) with daf-2(e1370)."
    },
    {
        "id1": 3380,
        "id2": 3384,
        "phenotype_comparison": ""
    },
    {
        "id1": 3381,
        "id2": 3385,
        "phenotype_comparison": ""
    },
    {
        "id1": 3384,
        "id2": 3385,
        "phenotype_comparison": "Longevity is further enhanced in double mutants of sgk-1(RNAi) with age-1(mg44)."
    },
    {
        "id1": 3386,
        "id2": 3387,
        "phenotype_comparison": ""
    },
    {
        "id1": 3386,
        "id2": 3388,
        "phenotype_comparison": ""
    },
    {
        "id1": 3387,
        "id2": 3389,
        "phenotype_comparison": ""
    },
    {
        "id1": 3388,
        "id2": 3389,
        "phenotype_comparison": "daf-16(m26) partially suppresses sgk-1(RNAi) at 20\u00b0C."
    },
    {
        "id1": 3380,
        "id2": 3390,
        "phenotype_comparison": ""
    },
    {
        "id1": 3380,
        "id2": 3391,
        "phenotype_comparison": ""
    },
    {
        "id1": 3390,
        "id2": 3392,
        "phenotype_comparison": ""
    },
    {
        "id1": 3391,
        "id2": 3392,
        "phenotype_comparison": "Individual inactivation of neither akt-1 nor akt-2 had an effect on longevity (Table 2), and akt-1(RNAi);akt-2(ok393) animals only showed a weak life span extension by 19%. This suggests that, in contrast to their strong input into dauer regulation, neither akt-1 nor akt-2 plays a major role in the control of life span."
    },
    {
        "id1": 3393,
        "id2": 3394,
        "phenotype_comparison": ""
    },
    {
        "id1": 3380,
        "id2": 3395,
        "phenotype_comparison": ""
    },
    {
        "id1": 3395,
        "id2": 3396,
        "phenotype_comparison": ""
    },
    {
        "id1": 3381,
        "id2": 3396,
        "phenotype_comparison": "These data confirm that the level of sgk-1expression is a major determinant for longevity. daf-16(mgDf50), a putative null allele of daf-16, fully suppresses the life span extension of sgk-1, which is another confirmation that daf-16 is the major output of sgk-1."
    },
    {
        "id1": 3397,
        "id2": 3398,
        "phenotype_comparison": ""
    },
    {
        "id1": 3397,
        "id2": 3399,
        "phenotype_comparison": ""
    },
    {
        "id1": 3398,
        "id2": 3400,
        "phenotype_comparison": ""
    },
    {
        "id1": 3399,
        "id2": 3400,
        "phenotype_comparison": "Loss of daf-16 abolished the ability of trpa-1 transgenes to extend lifespan."
    },
    {
        "id1": 3397,
        "id2": 3401,
        "phenotype_comparison": ""
    },
    {
        "id1": 3401,
        "id2": 3402,
        "phenotype_comparison": ""
    },
    {
        "id1": 3399,
        "id2": 3402,
        "phenotype_comparison": "Loss of daf-16 abolished the ability of trpa-1 transgenes to extend lifespan."
    },
    {
        "id1": 3403,
        "id2": 3404,
        "phenotype_comparison": ""
    },
    {
        "id1": 3403,
        "id2": 3405,
        "phenotype_comparison": ""
    },
    {
        "id1": 3404,
        "id2": 3406,
        "phenotype_comparison": ""
    },
    {
        "id1": 3405,
        "id2": 3406,
        "phenotype_comparison": "Loss of daf-16 abolished the ability of trpa-1 transgenes to extend lifespan."
    },
    {
        "id1": 3407,
        "id2": 3409,
        "phenotype_comparison": ""
    },
    {
        "id1": 3408,
        "id2": 3409,
        "phenotype_comparison": "Loss of pkc-2 fully suppresses the long-lived phenotype of trpa-1 transgenic worms."
    },
    {
        "id1": 3407,
        "id2": 3411,
        "phenotype_comparison": ""
    },
    {
        "id1": 3410,
        "id2": 3411,
        "phenotype_comparison": "Loss of pkc-2 fully suppresses the long-lived phenotype of trpa-1 transgenic worms."
    },
    {
        "id1": 3412,
        "id2": 3414,
        "phenotype_comparison": ""
    },
    {
        "id1": 3413,
        "id2": 3414,
        "phenotype_comparison": "Loss of pkc-2 fully suppresses the long-lived phenotype of trpa-1 transgenic worms."
    },
    {
        "id1": 3412,
        "id2": 3411,
        "phenotype_comparison": ""
    },
    {
        "id1": 3415,
        "id2": 3411,
        "phenotype_comparison": "Loss of pkc-2 fully suppresses the long-lived phenotype of trpa-1 transgenic worms."
    },
    {
        "id1": 3416,
        "id2": 3417,
        "phenotype_comparison": ""
    },
    {
        "id1": 3416,
        "id2": 3418,
        "phenotype_comparison": ""
    },
    {
        "id1": 3417,
        "id2": 3419,
        "phenotype_comparison": ""
    },
    {
        "id1": 3418,
        "id2": 3419,
        "phenotype_comparison": "Overexpression of pkc-2 cDNA extends lifespan, which can be fully suppressed by loss of daf-16."
    },
    {
        "id1": 3416,
        "id2": 3420,
        "phenotype_comparison": ""
    },
    {
        "id1": 3417,
        "id2": 3421,
        "phenotype_comparison": ""
    },
    {
        "id1": 3420,
        "id2": 3421,
        "phenotype_comparison": "Overexpression of pkc-2 cDNA extends lifespan, which can be fully suppressed by loss of daf-16."
    },
    {
        "id1": 3422,
        "id2": 3423,
        "phenotype_comparison": ""
    },
    {
        "id1": 3422,
        "id2": 3424,
        "phenotype_comparison": ""
    },
    {
        "id1": 3423,
        "id2": 3425,
        "phenotype_comparison": ""
    },
    {
        "id1": 3424,
        "id2": 3425,
        "phenotype_comparison": "Overexpression of pkc-2 cDNA extends lifespan, which can be fully suppressed by loss of daf-16."
    },
    {
        "id1": 3422,
        "id2": 3426,
        "phenotype_comparison": ""
    },
    {
        "id1": 3423,
        "id2": 3427,
        "phenotype_comparison": ""
    },
    {
        "id1": 3426,
        "id2": 3427,
        "phenotype_comparison": "Overexpression of pkc-2 cDNA extends lifespan, which can be fully suppressed by loss of daf-16."
    },
    {
        "id1": 3428,
        "id2": 3429,
        "phenotype_comparison": ""
    },
    {
        "id1": 3428,
        "id2": 3430,
        "phenotype_comparison": ""
    },
    {
        "id1": 3429,
        "id2": 3431,
        "phenotype_comparison": ""
    },
    {
        "id1": 3430,
        "id2": 3431,
        "phenotype_comparison": "Loss of sgk-1 fully suppresses the long-lived phenotype of trpa-1 and pkc-2 transgenic animals."
    },
    {
        "id1": 3428,
        "id2": 3432,
        "phenotype_comparison": ""
    },
    {
        "id1": 3429,
        "id2": 3433,
        "phenotype_comparison": ""
    },
    {
        "id1": 3432,
        "id2": 3433,
        "phenotype_comparison": "Loss of sgk-1 fully suppresses the long-lived phenotype of trpa-1 and pkc-2 transgenic animals."
    },
    {
        "id1": 3434,
        "id2": 3435,
        "phenotype_comparison": ""
    },
    {
        "id1": 3434,
        "id2": 3436,
        "phenotype_comparison": ""
    },
    {
        "id1": 3435,
        "id2": 3437,
        "phenotype_comparison": ""
    },
    {
        "id1": 3436,
        "id2": 3437,
        "phenotype_comparison": "Loss of sgk-1 fully suppresses the long-lived phenotype of trpa-1 and pkc-2 transgenic animals."
    },
    {
        "id1": 3434,
        "id2": 3438,
        "phenotype_comparison": ""
    },
    {
        "id1": 3435,
        "id2": 3439,
        "phenotype_comparison": ""
    },
    {
        "id1": 3438,
        "id2": 3439,
        "phenotype_comparison": "Loss of sgk-1 fully suppresses the long-lived phenotype of trpa-1 and pkc-2 transgenic animals."
    },
    {
        "id1": 3440,
        "id2": 3441,
        "phenotype_comparison": ""
    },
    {
        "id1": 3440,
        "id2": 3442,
        "phenotype_comparison": ""
    },
    {
        "id1": 3441,
        "id2": 3443,
        "phenotype_comparison": ""
    },
    {
        "id1": 3442,
        "id2": 3443,
        "phenotype_comparison": "Overexpression of sgk-1 extends lifespan, which can be fully suppressed by loss of daf-16. Sgk-1 cDNA was expressed as a transgene in the intestine, a tissue in which endogenous sgk-1 gene is enriched"
    },
    {
        "id1": 3416,
        "id2": 3444,
        "phenotype_comparison": ""
    },
    {
        "id1": 3416,
        "id2": 3445,
        "phenotype_comparison": ""
    },
    {
        "id1": 3444,
        "id2": 3446,
        "phenotype_comparison": ""
    },
    {
        "id1": 3445,
        "id2": 3446,
        "phenotype_comparison": "Overexpression of sgk-1 extends lifespan, which can be fully suppressed by loss of daf-16. Sgk-1 cDNA was expressed as a transgene in the intestine, a tissue in which endogenous sgk-1 gene is enriched."
    },
    {
        "id1": 3447,
        "id2": 3449,
        "phenotype_comparison": ""
    },
    {
        "id1": 3448,
        "id2": 3449,
        "phenotype_comparison": "Upon daf-16 RNAi treatment, trpa-1 and pkc-2 mutant worms showed a lifespan similar to that of wild-type worms at all three different temperatures."
    },
    {
        "id1": 3450,
        "id2": 3452,
        "phenotype_comparison": ""
    },
    {
        "id1": 3451,
        "id2": 3452,
        "phenotype_comparison": "Upon daf-16 RNAi treatment, trpa-1 and pkc-2 mutant worms showed a lifespan similar to that of wild-type worms at all three different temperatures."
    },
    {
        "id1": 3453,
        "id2": 3455,
        "phenotype_comparison": ""
    },
    {
        "id1": 3454,
        "id2": 3455,
        "phenotype_comparison": "Upon daf-16 RNAi treatment, trpa-1 and pkc-2 mutant worms showed a lifespan similar to that of wild-type worms at all three different temperatures."
    },
    {
        "id1": 3456,
        "id2": 3457,
        "phenotype_comparison": ""
    },
    {
        "id1": 3457,
        "id2": 3458,
        "phenotype_comparison": ""
    },
    {
        "id1": 3457,
        "id2": 3459,
        "phenotype_comparison": ""
    },
    {
        "id1": 3460,
        "id2": 3461,
        "phenotype_comparison": ""
    },
    {
        "id1": 3461,
        "id2": 3462,
        "phenotype_comparison": ""
    },
    {
        "id1": 3461,
        "id2": 3463,
        "phenotype_comparison": ""
    },
    {
        "id1": 3464,
        "id2": 3465,
        "phenotype_comparison": ""
    },
    {
        "id1": 3465,
        "id2": 3466,
        "phenotype_comparison": ""
    },
    {
        "id1": 3465,
        "id2": 3467,
        "phenotype_comparison": ""
    },
    {
        "id1": 3468,
        "id2": 3469,
        "phenotype_comparison": ""
    },
    {
        "id1": 3468,
        "id2": 3470,
        "phenotype_comparison": ""
    },
    {
        "id1": 3471,
        "id2": 3472,
        "phenotype_comparison": ""
    },
    {
        "id1": 3471,
        "id2": 3473,
        "phenotype_comparison": ""
    },
    {
        "id1": 3474,
        "id2": 3475,
        "phenotype_comparison": ""
    },
    {
        "id1": 3474,
        "id2": 3476,
        "phenotype_comparison": ""
    },
    {
        "id1": 3475,
        "id2": 3477,
        "phenotype_comparison": ""
    },
    {
        "id1": 3476,
        "id2": 3477,
        "phenotype_comparison": "trpa-1 transgene can further extend the lifespan of cmk-1mutant worms."
    },
    {
        "id1": 3474,
        "id2": 3478,
        "phenotype_comparison": ""
    },
    {
        "id1": 3475,
        "id2": 3479,
        "phenotype_comparison": ""
    },
    {
        "id1": 3478,
        "id2": 3479,
        "phenotype_comparison": "trpa-1 transgene can further extend the lifespan of cmk-1mutant worms."
    },
    {
        "id1": 3480,
        "id2": 3481,
        "phenotype_comparison": ""
    },
    {
        "id1": 3480,
        "id2": 3482,
        "phenotype_comparison": ""
    },
    {
        "id1": 3481,
        "id2": 3483,
        "phenotype_comparison": ""
    },
    {
        "id1": 3482,
        "id2": 3483,
        "phenotype_comparison": "trpa-1 transgene can further extend the lifespan of unk-43 mutant worms."
    },
    {
        "id1": 3484,
        "id2": 3485,
        "phenotype_comparison": ""
    },
    {
        "id1": 3484,
        "id2": 3486,
        "phenotype_comparison": ""
    },
    {
        "id1": 3485,
        "id2": 3487,
        "phenotype_comparison": ""
    },
    {
        "id1": 3486,
        "id2": 3487,
        "phenotype_comparison": "pkc-2 transgene can fully suppress the short-lived phenotype of trpa-1 mutant worms, consistent with the model that PKC-2 acts downstream of TRPA-1."
    },
    {
        "id1": 3488,
        "id2": 3489,
        "phenotype_comparison": ""
    },
    {
        "id1": 3488,
        "id2": 3490,
        "phenotype_comparison": ""
    },
    {
        "id1": 3489,
        "id2": 3491,
        "phenotype_comparison": ""
    },
    {
        "id1": 3490,
        "id2": 3491,
        "phenotype_comparison": "The short-lived phenotype of pkc-2; trpa-1double mutant at low temperatures is similar to that of trpa-1 and pkc-2 single mutants, showing that the effect of these two genes on lifespan is not additive. This provides additional evidence that TRPA-1 and PKC-2 act in the same pathway."
    },
    {
        "id1": 3492,
        "id2": 3493,
        "phenotype_comparison": ""
    },
    {
        "id1": 3492,
        "id2": 3494,
        "phenotype_comparison": ""
    },
    {
        "id1": 3493,
        "id2": 3495,
        "phenotype_comparison": ""
    },
    {
        "id1": 3494,
        "id2": 3495,
        "phenotype_comparison": "The short-lived phenotype of pkc-2; trpa-1double mutant is similar to that of trpa-1 and pkc-2 single mutants, showing that the effect of these two genes on lifespan is not additive. This provides additional evidence that TRPA-1 and PKC-2 act in the same pathway."
    },
    {
        "id1": 3496,
        "id2": 3497,
        "phenotype_comparison": ""
    },
    {
        "id1": 3496,
        "id2": 3498,
        "phenotype_comparison": ""
    },
    {
        "id1": 3497,
        "id2": 3499,
        "phenotype_comparison": ""
    },
    {
        "id1": 3498,
        "id2": 3499,
        "phenotype_comparison": "The short-lived phenotype of pkc-2; trpa-1double mutant is similar to that of trpa-1 and pkc-2 single mutants, showing that the effect of these two genes on lifespan is not additive. This provides additional evidence that TRPA-1 and PKC-2 act in the same pathway."
    },
    {
        "id1": 3500,
        "id2": 3501,
        "phenotype_comparison": ""
    },
    {
        "id1": 3500,
        "id2": 3502,
        "phenotype_comparison": ""
    },
    {
        "id1": 3501,
        "id2": 3503,
        "phenotype_comparison": ""
    },
    {
        "id1": 3502,
        "id2": 3503,
        "phenotype_comparison": "trpa-1 transgene can further extend the lifespan of akt-1 mutant worms."
    },
    {
        "id1": 3504,
        "id2": 3505,
        "phenotype_comparison": ""
    },
    {
        "id1": 3504,
        "id2": 3506,
        "phenotype_comparison": ""
    },
    {
        "id1": 3505,
        "id2": 3507,
        "phenotype_comparison": ""
    },
    {
        "id1": 3506,
        "id2": 3507,
        "phenotype_comparison": "trpa-1 transgene can further extend the lifespan of akt-2 mutant worms."
    },
    {
        "id1": 3508,
        "id2": 3509,
        "phenotype_comparison": ""
    },
    {
        "id1": 3509,
        "id2": 3510,
        "phenotype_comparison": ""
    },
    {
        "id1": 3511,
        "id2": 3512,
        "phenotype_comparison": ""
    },
    {
        "id1": 3511,
        "id2": 3513,
        "phenotype_comparison": ""
    },
    {
        "id1": 3512,
        "id2": 3514,
        "phenotype_comparison": ""
    },
    {
        "id1": 3513,
        "id2": 3514,
        "phenotype_comparison": "sgk-1 transgene can fully suppress the short-lived phenotype of trpa-1mutant worms, consistent with the model that SGK-1 acts downstream of TRPA-1."
    },
    {
        "id1": 3511,
        "id2": 3515,
        "phenotype_comparison": ""
    },
    {
        "id1": 3515,
        "id2": 3516,
        "phenotype_comparison": ""
    },
    {
        "id1": 3513,
        "id2": 3516,
        "phenotype_comparison": "sgk-1 transgene can fully suppress the short-lived phenotype of pkc-2 mutant worms, consistent with the model that SGK-1 acts downstream of PKC-2."
    },
    {
        "id1": 3517,
        "id2": 3518,
        "phenotype_comparison": ""
    },
    {
        "id1": 3517,
        "id2": 3519,
        "phenotype_comparison": ""
    },
    {
        "id1": 3518,
        "id2": 3520,
        "phenotype_comparison": ""
    },
    {
        "id1": 3519,
        "id2": 3520,
        "phenotype_comparison": ""
    },
    {
        "id1": 3517,
        "id2": 3521,
        "phenotype_comparison": ""
    },
    {
        "id1": 3518,
        "id2": 3522,
        "phenotype_comparison": ""
    },
    {
        "id1": 3521,
        "id2": 3522,
        "phenotype_comparison": "Consistent with this model, transgenic expression of TRPA-1 can further extend the lifespan of daf-2(e1370) mutant worms"
    },
    {
        "id1": 3523,
        "id2": 3524,
        "phenotype_comparison": ""
    },
    {
        "id1": 3523,
        "id2": 3525,
        "phenotype_comparison": ""
    },
    {
        "id1": 3524,
        "id2": 3526,
        "phenotype_comparison": ""
    },
    {
        "id1": 3525,
        "id2": 3526,
        "phenotype_comparison": "RNAi against skn-1 did reduce tm1422 life span significantly about 17%. Inhibition of insulin/IGF-1-like signaling in tm1422 may explain this result. Like DAF-16, SKN-1 is also repressed by DAF-2 downstream kinases, AKT-1/2 and SGK-1 and possibly acts as a key player in a positive feedback loop to extend life span."
    },
    {
        "id1": 3523,
        "id2": 3527,
        "phenotype_comparison": ""
    },
    {
        "id1": 3524,
        "id2": 3528,
        "phenotype_comparison": ""
    },
    {
        "id1": 3527,
        "id2": 3528,
        "phenotype_comparison": "Mean life span in WT animals depleted of DAF-16 slightly decreased in comparison to the control. Surprisingly, daf-16(RNAi) in tm1422 eliminated vang-1 induced life span extension at 20\u00b0C and 25\u00b0C, suggesting that daf-16 is epistatic to vang-1."
    },
    {
        "id1": 3529,
        "id2": 3530,
        "phenotype_comparison": ""
    },
    {
        "id1": 3529,
        "id2": 3531,
        "phenotype_comparison": ""
    },
    {
        "id1": 3530,
        "id2": 3532,
        "phenotype_comparison": ""
    },
    {
        "id1": 3531,
        "id2": 3532,
        "phenotype_comparison": "Mean life span in WT animals depleted of DAF-16 slightly decreased in comparison to the control. Surprisingly, daf-16(RNAi) in tm1422 eliminated vang-1 induced life span extension at 20\u00b0C and 25\u00b0C, suggesting that daf-16 is epistatic to vang-1."
    },
    {
        "id1": 3523,
        "id2": 3533,
        "phenotype_comparison": ""
    },
    {
        "id1": 3524,
        "id2": 3534,
        "phenotype_comparison": ""
    },
    {
        "id1": 3533,
        "id2": 3534,
        "phenotype_comparison": "Depletion of DAF-2 by RNAi in tm1422 and WT causes an increase of mean life span to 25.6 and 25.8 which is in agreement with published results for daf-2 mutants. RNAi against daf-2 in WT and tm1422 worms resulted in nearly identical survival curves with no significant difference in mean life span, indicating that vang-1 may function in the insulin/IGF-1-like signaling pathway, rather than in parallel pathways, e.g., through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling."
    },
    {
        "id1": 3535,
        "id2": 3536,
        "phenotype_comparison": ""
    },
    {
        "id1": 3535,
        "id2": 3537,
        "phenotype_comparison": ""
    },
    {
        "id1": 3536,
        "id2": 3538,
        "phenotype_comparison": ""
    },
    {
        "id1": 3537,
        "id2": 3538,
        "phenotype_comparison": "Germline-specific RNAi against vang-1 effects C. elegans life span. After vang-1(RNAi) in germline-specific RNAi strain NL2098 a significant increase (13%) of mean life span (14.6 d) in comparison to the control (NL2098 kept on RNAi HT115 bacteria carrying the empty ''feeding''-vector) can be observed (12.9 d)."
    },
    {
        "id1": 3539,
        "id2": 3540,
        "phenotype_comparison": ""
    },
    {
        "id1": 3539,
        "id2": 3541,
        "phenotype_comparison": ""
    },
    {
        "id1": 3540,
        "id2": 3542,
        "phenotype_comparison": ""
    },
    {
        "id1": 3541,
        "id2": 3542,
        "phenotype_comparison": "sea-2 mutants have extended lifespan. The long-lived phenotype of sea-2 is suppressed by loss of function of daf-16."
    },
    {
        "id1": 3539,
        "id2": 3543,
        "phenotype_comparison": ""
    },
    {
        "id1": 3540,
        "id2": 3544,
        "phenotype_comparison": ""
    },
    {
        "id1": 3543,
        "id2": 3544,
        "phenotype_comparison": "Loss of function of sea-2 extends the lifespan of daf-2(e1370) mutants."
    },
    {
        "id1": 3544,
        "id2": 3545,
        "phenotype_comparison": ""
    },
    {
        "id1": 3562,
        "id2": 3563,
        "phenotype_comparison": ""
    },
    {
        "id1": 3562,
        "id2": 3564,
        "phenotype_comparison": ""
    },
    {
        "id1": 3563,
        "id2": 3565,
        "phenotype_comparison": ""
    },
    {
        "id1": 3564,
        "id2": 3565,
        "phenotype_comparison": "daf-3(e1376) has a wild-type life span, but it greatly enhanced the life span of daf-9(e1406) mutants. The mean life span of the double mutant was increased by 80%."
    },
    {
        "id1": 3566,
        "id2": 3567,
        "phenotype_comparison": ""
    },
    {
        "id1": 3566,
        "id2": 3568,
        "phenotype_comparison": ""
    },
    {
        "id1": 3567,
        "id2": 3569,
        "phenotype_comparison": ""
    },
    {
        "id1": 3568,
        "id2": 3569,
        "phenotype_comparison": "The daf-16 mutation suppress the longevity of daf-9(e1406)."
    },
    {
        "id1": 3570,
        "id2": 3571,
        "phenotype_comparison": ""
    },
    {
        "id1": 3570,
        "id2": 3572,
        "phenotype_comparison": ""
    },
    {
        "id1": 3571,
        "id2": 3573,
        "phenotype_comparison": ""
    },
    {
        "id1": 3572,
        "id2": 3573,
        "phenotype_comparison": "The daf-12(m20) mutation was found to suppress the extended longevity of daf-9(e1406). The daf-9(e1406) daf-12(m20) double mutants had wild-type life spans nd 15\u00b0C."
    },
    {
        "id1": 3580,
        "id2": 3581,
        "phenotype_comparison": ""
    },
    {
        "id1": 3581,
        "id2": 3582,
        "phenotype_comparison": ""
    },
    {
        "id1": 3580,
        "id2": 3583,
        "phenotype_comparison": ""
    },
    {
        "id1": 3583,
        "id2": 3584,
        "phenotype_comparison": ""
    },
    {
        "id1": 3585,
        "id2": 3583,
        "phenotype_comparison": ""
    },
    {
        "id1": 3585,
        "id2": 3586,
        "phenotype_comparison": ""
    },
    {
        "id1": 3583,
        "id2": 3587,
        "phenotype_comparison": ""
    },
    {
        "id1": 3586,
        "id2": 3587,
        "phenotype_comparison": "RNAi inactivation of daf-16 ablates the lifespan extension conferred by mxl-1(tm1530) null mutation."
    },
    {
        "id1": 3585,
        "id2": 3588,
        "phenotype_comparison": ""
    },
    {
        "id1": 3588,
        "id2": 3589,
        "phenotype_comparison": ""
    },
    {
        "id1": 3585,
        "id2": 3590,
        "phenotype_comparison": ""
    },
    {
        "id1": 3590,
        "id2": 3591,
        "phenotype_comparison": ""
    },
    {
        "id1": 3586,
        "id2": 3591,
        "phenotype_comparison": "RNAi inactivation of daf-16 does not further shorten the lifespan of mxl-2(tm1516) null mutants."
    },
    {
        "id1": 3588,
        "id2": 3592,
        "phenotype_comparison": ""
    },
    {
        "id1": 3593,
        "id2": 3594,
        "phenotype_comparison": ""
    },
    {
        "id1": 3593,
        "id2": 3595,
        "phenotype_comparison": ""
    },
    {
        "id1": 3594,
        "id2": 3596,
        "phenotype_comparison": ""
    },
    {
        "id1": 3595,
        "id2": 3596,
        "phenotype_comparison": "RNAi inactivation of mml-1 partially suppresses the lifespan of daf-2(e1370) mutant animals."
    },
    {
        "id1": 3594,
        "id2": 3597,
        "phenotype_comparison": ""
    },
    {
        "id1": 3598,
        "id2": 3594,
        "phenotype_comparison": ""
    },
    {
        "id1": 3598,
        "id2": 3590,
        "phenotype_comparison": ""
    },
    {
        "id1": 3594,
        "id2": 3599,
        "phenotype_comparison": ""
    },
    {
        "id1": 3590,
        "id2": 3599,
        "phenotype_comparison": "The mxl-2(tm1516) null mutation partially suppresses the extended lifespan observed in daf-2(e1370) mutant animals."
    },
    {
        "id1": 3598,
        "id2": 3600,
        "phenotype_comparison": ""
    },
    {
        "id1": 3600,
        "id2": 3601,
        "phenotype_comparison": ""
    },
    {
        "id1": 3601,
        "id2": 3602,
        "phenotype_comparison": ""
    },
    {
        "id1": 3603,
        "id2": 3604,
        "phenotype_comparison": ""
    },
    {
        "id1": 3603,
        "id2": 3605,
        "phenotype_comparison": ""
    },
    {
        "id1": 3604,
        "id2": 3606,
        "phenotype_comparison": ""
    },
    {
        "id1": 3605,
        "id2": 3606,
        "phenotype_comparison": "RNAi inactivation of pha-4 ablates the lifespan extension conferred by the mxl-1(tm1530) null mutation."
    },
    {
        "id1": 3603,
        "id2": 3607,
        "phenotype_comparison": ""
    },
    {
        "id1": 3607,
        "id2": 3608,
        "phenotype_comparison": ""
    },
    {
        "id1": 3605,
        "id2": 3608,
        "phenotype_comparison": "RNAi inactivation of pha-4 does not further shorten the lifespan of mxl- 2(tm1516) null mutant animals."
    },
    {
        "id1": 3598,
        "id2": 3609,
        "phenotype_comparison": ""
    },
    {
        "id1": 3598,
        "id2": 3610,
        "phenotype_comparison": ""
    },
    {
        "id1": 3609,
        "id2": 3611,
        "phenotype_comparison": ""
    },
    {
        "id1": 3610,
        "id2": 3611,
        "phenotype_comparison": "RNAi inactivation of mxl-2 partially suppresses the extended lifespan observed in eat-2(ad465) mutants."
    },
    {
        "id1": 3598,
        "id2": 3612,
        "phenotype_comparison": ""
    },
    {
        "id1": 3609,
        "id2": 3613,
        "phenotype_comparison": ""
    },
    {
        "id1": 3612,
        "id2": 3613,
        "phenotype_comparison": "RNAi inactivation of mml-1 partially suppresses the extended lifespan observed in eat-2(ad465) mutants."
    },
    {
        "id1": 3598,
        "id2": 3614,
        "phenotype_comparison": ""
    },
    {
        "id1": 3609,
        "id2": 3615,
        "phenotype_comparison": ""
    },
    {
        "id1": 3614,
        "id2": 3615,
        "phenotype_comparison": "The mxl-2(tm1516) null mutation partially suppresses the extended lifespan observed in eat-2(ad465) mutant animals."
    },
    {
        "id1": 3598,
        "id2": 3616,
        "phenotype_comparison": ""
    },
    {
        "id1": 3609,
        "id2": 3617,
        "phenotype_comparison": ""
    },
    {
        "id1": 3616,
        "id2": 3617,
        "phenotype_comparison": "The mxl-1(tm1530) null mutation does not further extend the lifespan of eat-2(ad465) mutant animals."
    },
    {
        "id1": 3609,
        "id2": 3618,
        "phenotype_comparison": ""
    },
    {
        "id1": 3609,
        "id2": 3619,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3622,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3623,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3624,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3625,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3626,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3627,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3628,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3629,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3630,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3631,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3632,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3633,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3634,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3635,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3636,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3637,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3638,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3639,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3640,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3641,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3642,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3643,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3644,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3645,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3646,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3647,
        "phenotype_comparison": ""
    },
    {
        "id1": 3620,
        "id2": 3648,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3649,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3651,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3652,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3653,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3654,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3655,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3656,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3657,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3658,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3659,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3660,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3661,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3662,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3663,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3664,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3665,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3666,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3667,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3668,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3669,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3670,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3671,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3672,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3673,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3674,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3675,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3676,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3677,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3678,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3679,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3680,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3681,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3682,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3683,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3684,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3685,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3686,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3687,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3688,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3689,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3690,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3691,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3692,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3693,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3694,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3695,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3696,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3697,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3698,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3699,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3700,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3701,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3703,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3705,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3707,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3709,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3711,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3713,
        "phenotype_comparison": ""
    },
    {
        "id1": 3650,
        "id2": 3715,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3718,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3719,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3720,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3721,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3722,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3723,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3724,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3725,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3726,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3727,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3728,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3729,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3730,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3731,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3732,
        "phenotype_comparison": ""
    },
    {
        "id1": 3717,
        "id2": 3733,
        "phenotype_comparison": ""
    },
    {
        "id1": 3734,
        "id2": 3735,
        "phenotype_comparison": ""
    },
    {
        "id1": 3734,
        "id2": 3736,
        "phenotype_comparison": ""
    },
    {
        "id1": 3734,
        "id2": 3737,
        "phenotype_comparison": ""
    },
    {
        "id1": 3734,
        "id2": 3738,
        "phenotype_comparison": ""
    },
    {
        "id1": 3734,
        "id2": 3739,
        "phenotype_comparison": ""
    },
    {
        "id1": 3734,
        "id2": 3740,
        "phenotype_comparison": ""
    },
    {
        "id1": 3734,
        "id2": 3741,
        "phenotype_comparison": ""
    },
    {
        "id1": 3742,
        "id2": 3743,
        "phenotype_comparison": ""
    },
    {
        "id1": 3742,
        "id2": 3744,
        "phenotype_comparison": ""
    },
    {
        "id1": 3743,
        "id2": 3745,
        "phenotype_comparison": ""
    },
    {
        "id1": 3744,
        "id2": 3745,
        "phenotype_comparison": "tor RNAi significantly extended the lifespan of WT animals; however, the same treatment failed to prolong the lifespan of hlh-30(tm1978) mutants suggesting that hlh-30 acts downstream of TOR."
    },
    {
        "id1": 3746,
        "id2": 3747,
        "phenotype_comparison": ""
    },
    {
        "id1": 3746,
        "id2": 3748,
        "phenotype_comparison": ""
    },
    {
        "id1": 3747,
        "id2": 3749,
        "phenotype_comparison": ""
    },
    {
        "id1": 3748,
        "id2": 3749,
        "phenotype_comparison": "tor RNAi significantly extended the lifespan of WT animals; however, the same treatment failed to prolong the lifespan of hlh-30(tm1978) mutants suggesting that hlh-30 acts downstream of TOR."
    },
    {
        "id1": 3750,
        "id2": 3751,
        "phenotype_comparison": ""
    },
    {
        "id1": 3750,
        "id2": 3752,
        "phenotype_comparison": ""
    },
    {
        "id1": 3751,
        "id2": 3753,
        "phenotype_comparison": ""
    },
    {
        "id1": 3752,
        "id2": 3753,
        "phenotype_comparison": "tor RNAi significantly extended the lifespan of WT animals; however, the same treatment failed to prolong the lifespan of hlh-30(tm1978) mutants suggesting that hlh-30 acts downstream of TOR."
    },
    {
        "id1": 3754,
        "id2": 3755,
        "phenotype_comparison": ""
    },
    {
        "id1": 3754,
        "id2": 3756,
        "phenotype_comparison": ""
    },
    {
        "id1": 3755,
        "id2": 3757,
        "phenotype_comparison": ""
    },
    {
        "id1": 3756,
        "id2": 3757,
        "phenotype_comparison": "glp-1(e2141); hlh-30(tm1978) double mutants to have mean lifespans similar to hlh-30(tm1978) single mutants."
    },
    {
        "id1": 3758,
        "id2": 3759,
        "phenotype_comparison": ""
    },
    {
        "id1": 3758,
        "id2": 3760,
        "phenotype_comparison": ""
    },
    {
        "id1": 3759,
        "id2": 3761,
        "phenotype_comparison": ""
    },
    {
        "id1": 3760,
        "id2": 3761,
        "phenotype_comparison": "glp-1(e2141); hlh-30(tm1978) double mutants to have mean lifespans similar to hlh-30(tm1978) single mutants."
    },
    {
        "id1": 3762,
        "id2": 3763,
        "phenotype_comparison": ""
    },
    {
        "id1": 3762,
        "id2": 3764,
        "phenotype_comparison": ""
    },
    {
        "id1": 3763,
        "id2": 3765,
        "phenotype_comparison": ""
    },
    {
        "id1": 3764,
        "id2": 3765,
        "phenotype_comparison": "glp-1(e2141); hlh-30(tm1978) double mutants to have mean lifespans similar to hlh-30(tm1978) single mutants."
    },
    {
        "id1": 3766,
        "id2": 3767,
        "phenotype_comparison": ""
    },
    {
        "id1": 3766,
        "id2": 3768,
        "phenotype_comparison": ""
    },
    {
        "id1": 3767,
        "id2": 3769,
        "phenotype_comparison": ""
    },
    {
        "id1": 3768,
        "id2": 3769,
        "phenotype_comparison": "glp-1(e2141); hlh-30(tm1978) double mutants to have mean lifespans similar to hlh-30(tm1978) single mutants."
    },
    {
        "id1": 3770,
        "id2": 3771,
        "phenotype_comparison": ""
    },
    {
        "id1": 3770,
        "id2": 3772,
        "phenotype_comparison": ""
    },
    {
        "id1": 3771,
        "id2": 3773,
        "phenotype_comparison": ""
    },
    {
        "id1": 3772,
        "id2": 3773,
        "phenotype_comparison": "RNAi-mediated inhibition of the lysosomal gene vha-16substantially reduced the long lifespan of glp-1(e2141) mutants supporting the notion that a subset of HLH-30-regulated genes, with functions relevant to autophagy, may contribute to lifespan extension."
    },
    {
        "id1": 3774,
        "id2": 3775,
        "phenotype_comparison": ""
    },
    {
        "id1": 3774,
        "id2": 3776,
        "phenotype_comparison": ""
    },
    {
        "id1": 3775,
        "id2": 3777,
        "phenotype_comparison": ""
    },
    {
        "id1": 3776,
        "id2": 3777,
        "phenotype_comparison": "RNAi-mediated inhibition of the lysosomal gene vha-16substantially reduced the long lifespan of glp-1(e2141) mutants supporting the notion that a subset of HLH-30-regulated genes, with functions relevant to autophagy, may contribute to lifespan extension."
    },
    {
        "id1": 3778,
        "id2": 3779,
        "phenotype_comparison": ""
    },
    {
        "id1": 3778,
        "id2": 3780,
        "phenotype_comparison": ""
    },
    {
        "id1": 3779,
        "id2": 3781,
        "phenotype_comparison": ""
    },
    {
        "id1": 3780,
        "id2": 3781,
        "phenotype_comparison": "RNAi-mediated inhibition of the lysosomal gene vha-16substantially reduced the long lifespan of glp-1(e2141) mutants supporting the notion that a subset of HLH-30-regulated genes, with functions relevant to autophagy, may contribute to lifespan extension."
    },
    {
        "id1": 3782,
        "id2": 3783,
        "phenotype_comparison": ""
    },
    {
        "id1": 3782,
        "id2": 3784,
        "phenotype_comparison": ""
    },
    {
        "id1": 3783,
        "id2": 3785,
        "phenotype_comparison": ""
    },
    {
        "id1": 3784,
        "id2": 3785,
        "phenotype_comparison": "RNAi-mediated inhibition of the lysosomal gene vha-16substantially reduced the long lifespan of glp-1(e2141) mutants supporting the notion that a subset of HLH-30-regulated genes, with functions relevant to autophagy, may contribute to lifespan extension."
    },
    {
        "id1": 3786,
        "id2": 3787,
        "phenotype_comparison": ""
    },
    {
        "id1": 3786,
        "id2": 3788,
        "phenotype_comparison": ""
    },
    {
        "id1": 3787,
        "id2": 3789,
        "phenotype_comparison": ""
    },
    {
        "id1": 3788,
        "id2": 3789,
        "phenotype_comparison": "Knockdown of the lysosomal glycoprotein lmp-1 did not shorten glp-1-mediated lifespan extension."
    },
    {
        "id1": 3790,
        "id2": 3791,
        "phenotype_comparison": ""
    },
    {
        "id1": 3790,
        "id2": 3792,
        "phenotype_comparison": ""
    },
    {
        "id1": 3791,
        "id2": 3793,
        "phenotype_comparison": ""
    },
    {
        "id1": 3792,
        "id2": 3793,
        "phenotype_comparison": "Knockdown of the lysosomal glycoprotein lmp-1 did not shorten glp-1-mediated lifespan extension."
    },
    {
        "id1": 3794,
        "id2": 3795,
        "phenotype_comparison": ""
    },
    {
        "id1": 3794,
        "id2": 3796,
        "phenotype_comparison": ""
    },
    {
        "id1": 3795,
        "id2": 3797,
        "phenotype_comparison": ""
    },
    {
        "id1": 3796,
        "id2": 3797,
        "phenotype_comparison": "Knockdown of the lysosomal glycoprotein lmp-1 did not shorten glp-1-mediated lifespan extension."
    },
    {
        "id1": 3798,
        "id2": 3799,
        "phenotype_comparison": ""
    },
    {
        "id1": 3798,
        "id2": 3800,
        "phenotype_comparison": ""
    },
    {
        "id1": 3799,
        "id2": 3801,
        "phenotype_comparison": ""
    },
    {
        "id1": 3800,
        "id2": 3801,
        "phenotype_comparison": "Knockdown of the lysosomal glycoprotein lmp-1 did not shorten glp-1-mediated lifespan extension."
    },
    {
        "id1": 3802,
        "id2": 3803,
        "phenotype_comparison": ""
    },
    {
        "id1": 3802,
        "id2": 3804,
        "phenotype_comparison": ""
    },
    {
        "id1": 3803,
        "id2": 3805,
        "phenotype_comparison": ""
    },
    {
        "id1": 3804,
        "id2": 3805,
        "phenotype_comparison": ""
    },
    {
        "id1": 3794,
        "id2": 3806,
        "phenotype_comparison": ""
    },
    {
        "id1": 3794,
        "id2": 3807,
        "phenotype_comparison": ""
    },
    {
        "id1": 3806,
        "id2": 3808,
        "phenotype_comparison": ""
    },
    {
        "id1": 3807,
        "id2": 3808,
        "phenotype_comparison": ""
    },
    {
        "id1": 3809,
        "id2": 3810,
        "phenotype_comparison": ""
    },
    {
        "id1": 3809,
        "id2": 3811,
        "phenotype_comparison": ""
    },
    {
        "id1": 3810,
        "id2": 3812,
        "phenotype_comparison": ""
    },
    {
        "id1": 3811,
        "id2": 3812,
        "phenotype_comparison": ""
    },
    {
        "id1": 3813,
        "id2": 3814,
        "phenotype_comparison": ""
    },
    {
        "id1": 3813,
        "id2": 3815,
        "phenotype_comparison": ""
    },
    {
        "id1": 3814,
        "id2": 3816,
        "phenotype_comparison": ""
    },
    {
        "id1": 3815,
        "id2": 3816,
        "phenotype_comparison": ""
    },
    {
        "id1": 3817,
        "id2": 3818,
        "phenotype_comparison": ""
    },
    {
        "id1": 3817,
        "id2": 3819,
        "phenotype_comparison": ""
    },
    {
        "id1": 3818,
        "id2": 3820,
        "phenotype_comparison": ""
    },
    {
        "id1": 3819,
        "id2": 3820,
        "phenotype_comparison": "hif-1(ia4) loss-of-function mutations decreased the longevity of clk-1(qm30)."
    },
    {
        "id1": 3821,
        "id2": 3822,
        "phenotype_comparison": ""
    },
    {
        "id1": 3821,
        "id2": 3823,
        "phenotype_comparison": ""
    },
    {
        "id1": 3822,
        "id2": 3824,
        "phenotype_comparison": ""
    },
    {
        "id1": 3823,
        "id2": 3824,
        "phenotype_comparison": "hif-1(ia4) loss-of-function mutations decreased the longevity of isp-1(qm150)."
    },
    {
        "id1": 3825,
        "id2": 3826,
        "phenotype_comparison": ""
    },
    {
        "id1": 3825,
        "id2": 3827,
        "phenotype_comparison": ""
    },
    {
        "id1": 3826,
        "id2": 3828,
        "phenotype_comparison": ""
    },
    {
        "id1": 3827,
        "id2": 3828,
        "phenotype_comparison": "The long lifespan of clk-1(qm30) mutants was significantly shortened by aha-1 [HIF1 beta] RNAi."
    },
    {
        "id1": 3829,
        "id2": 3830,
        "phenotype_comparison": ""
    },
    {
        "id1": 3829,
        "id2": 3831,
        "phenotype_comparison": ""
    },
    {
        "id1": 3830,
        "id2": 3832,
        "phenotype_comparison": ""
    },
    {
        "id1": 3831,
        "id2": 3832,
        "phenotype_comparison": "The long lifespan of isp-1(qm150) mutants was significantly shortened by aha-1 [HIF1 beta] RNAi."
    },
    {
        "id1": 3817,
        "id2": 3833,
        "phenotype_comparison": ""
    },
    {
        "id1": 3818,
        "id2": 3834,
        "phenotype_comparison": ""
    },
    {
        "id1": 3833,
        "id2": 3834,
        "phenotype_comparison": "Mutations in vhl-1 increased the lifespan of wild type but did not further extend the lifespan of clk-1(qm30) mutants."
    },
    {
        "id1": 3821,
        "id2": 3835,
        "phenotype_comparison": ""
    },
    {
        "id1": 3822,
        "id2": 3836,
        "phenotype_comparison": ""
    },
    {
        "id1": 3835,
        "id2": 3836,
        "phenotype_comparison": "Mutations in vhl-1 increased the lifespan of wild type but did not further extend the lifespan of isp-1(qm150) mutants."
    },
    {
        "id1": 3821,
        "id2": 3837,
        "phenotype_comparison": ""
    },
    {
        "id1": 3821,
        "id2": 3838,
        "phenotype_comparison": ""
    },
    {
        "id1": 3837,
        "id2": 3839,
        "phenotype_comparison": ""
    },
    {
        "id1": 3838,
        "id2": 3839,
        "phenotype_comparison": "The egl-9(sa307) mutation did not further increase the lifespans of clk-1(qm30) mutants."
    },
    {
        "id1": 3817,
        "id2": 3840,
        "phenotype_comparison": ""
    },
    {
        "id1": 3817,
        "id2": 3841,
        "phenotype_comparison": ""
    },
    {
        "id1": 3840,
        "id2": 3842,
        "phenotype_comparison": ""
    },
    {
        "id1": 3841,
        "id2": 3842,
        "phenotype_comparison": "The egl-9(sa307) mutation did not further increase the lifespans of isp-1(qm150) mutants."
    },
    {
        "id1": 3825,
        "id2": 3843,
        "phenotype_comparison": ""
    },
    {
        "id1": 3826,
        "id2": 3844,
        "phenotype_comparison": ""
    },
    {
        "id1": 3843,
        "id2": 3844,
        "phenotype_comparison": "RNAi knockdown of hif-1 partially but significantly suppressed the longevity of clk-1(qm30) mutant animals. hif-1 RNAi did not decrease the lifespan of wild-type animals."
    },
    {
        "id1": 3829,
        "id2": 3845,
        "phenotype_comparison": ""
    },
    {
        "id1": 3830,
        "id2": 3846,
        "phenotype_comparison": ""
    },
    {
        "id1": 3845,
        "id2": 3846,
        "phenotype_comparison": "RNAi knockdown of hif-1 partially but significantly suppressed the longevity of isp-1(qm150) mutant animals. hif-1 RNAi did not decrease the lifespan of wild-type animals."
    },
    {
        "id1": 3847,
        "id2": 3848,
        "phenotype_comparison": ""
    },
    {
        "id1": 3847,
        "id2": 3849,
        "phenotype_comparison": ""
    },
    {
        "id1": 3848,
        "id2": 3850,
        "phenotype_comparison": ""
    },
    {
        "id1": 3849,
        "id2": 3850,
        "phenotype_comparison": "RNAi knockdown of hif-1 only during adulthood partially suppressed the longevity of clk-1(qm30) mutant animals."
    },
    {
        "id1": 3847,
        "id2": 3851,
        "phenotype_comparison": ""
    },
    {
        "id1": 3851,
        "id2": 3852,
        "phenotype_comparison": ""
    },
    {
        "id1": 3849,
        "id2": 3852,
        "phenotype_comparison": "RNAi knockdown of hif-1 only during adulthood partially suppressed the longevity of isp-1(qm150) mutant animals."
    },
    {
        "id1": 3853,
        "id2": 3854,
        "phenotype_comparison": ""
    },
    {
        "id1": 3853,
        "id2": 3855,
        "phenotype_comparison": ""
    },
    {
        "id1": 3854,
        "id2": 3856,
        "phenotype_comparison": ""
    },
    {
        "id1": 3855,
        "id2": 3856,
        "phenotype_comparison": "Mutations in hif-1 slightly but significantly suppressed the long lifespan conferred by cyc-1(RNAi)."
    },
    {
        "id1": 3857,
        "id2": 3858,
        "phenotype_comparison": ""
    },
    {
        "id1": 3857,
        "id2": 3859,
        "phenotype_comparison": ""
    },
    {
        "id1": 3858,
        "id2": 3860,
        "phenotype_comparison": ""
    },
    {
        "id1": 3859,
        "id2": 3860,
        "phenotype_comparison": "Mutations in hif-1 slightly but significantly suppressed the long lifespan conferred by cco-1(RNAi)."
    },
    {
        "id1": 3825,
        "id2": 3861,
        "phenotype_comparison": ""
    },
    {
        "id1": 3861,
        "id2": 3862,
        "phenotype_comparison": ""
    },
    {
        "id1": 3843,
        "id2": 3862,
        "phenotype_comparison": "hif-1 RNAi treatment had little or no effect on the lifespans of many long-lived mutants."
    },
    {
        "id1": 3829,
        "id2": 3863,
        "phenotype_comparison": ""
    },
    {
        "id1": 3863,
        "id2": 3864,
        "phenotype_comparison": ""
    },
    {
        "id1": 3845,
        "id2": 3864,
        "phenotype_comparison": "hif-1 RNAi treatment had little or no effect on the lifespans of many long-lived mutants."
    },
    {
        "id1": 3825,
        "id2": 3865,
        "phenotype_comparison": ""
    },
    {
        "id1": 3865,
        "id2": 3866,
        "phenotype_comparison": ""
    },
    {
        "id1": 3843,
        "id2": 3866,
        "phenotype_comparison": "Chemosensory-defective osm-5(p813) mutants live long and their longevity was not shortened by hif-1 RNAi treatment."
    },
    {
        "id1": 3825,
        "id2": 3867,
        "phenotype_comparison": ""
    },
    {
        "id1": 3867,
        "id2": 3868,
        "phenotype_comparison": ""
    },
    {
        "id1": 3843,
        "id2": 3868,
        "phenotype_comparison": "hif-1 RNAi did not affect the long lifespan of the germline-deficient glp-1(e2141) mutants."
    },
    {
        "id1": 3825,
        "id2": 3869,
        "phenotype_comparison": ""
    },
    {
        "id1": 3826,
        "id2": 3870,
        "phenotype_comparison": ""
    },
    {
        "id1": 3869,
        "id2": 3870,
        "phenotype_comparison": "vhl-1(RNAi) extended the lifespan of wild type while not affecting the long lifespan of clk-1(qm30) mutants."
    },
    {
        "id1": 3825,
        "id2": 3830,
        "phenotype_comparison": ""
    },
    {
        "id1": 3830,
        "id2": 3871,
        "phenotype_comparison": ""
    },
    {
        "id1": 3869,
        "id2": 3871,
        "phenotype_comparison": "vhl-1(RNAi) extended the lifespan of wild type while not affecting the long lifespan of isp-1(qm150) mutants."
    },
    {
        "id1": 3825,
        "id2": 3872,
        "phenotype_comparison": ""
    },
    {
        "id1": 3826,
        "id2": 3873,
        "phenotype_comparison": ""
    },
    {
        "id1": 3872,
        "id2": 3873,
        "phenotype_comparison": "The longevity caused by the clk-1(qm30) mutants was not affected by egl-9 RNAi treatment, which significantly increased lifespan of wild type."
    },
    {
        "id1": 3825,
        "id2": 3822,
        "phenotype_comparison": ""
    },
    {
        "id1": 3822,
        "id2": 3874,
        "phenotype_comparison": ""
    },
    {
        "id1": 3872,
        "id2": 3874,
        "phenotype_comparison": "The longevity caused by the isp(qm150) mutants was not affected by egl-9 RNAi treatment, which significantly increased lifespan of wild type."
    },
    {
        "id1": 3875,
        "id2": 3876,
        "phenotype_comparison": ""
    },
    {
        "id1": 3875,
        "id2": 3877,
        "phenotype_comparison": ""
    },
    {
        "id1": 3876,
        "id2": 3878,
        "phenotype_comparison": ""
    },
    {
        "id1": 3877,
        "id2": 3878,
        "phenotype_comparison": ""
    },
    {
        "id1": 3875,
        "id2": 3879,
        "phenotype_comparison": ""
    },
    {
        "id1": 3876,
        "id2": 3880,
        "phenotype_comparison": ""
    },
    {
        "id1": 3879,
        "id2": 3880,
        "phenotype_comparison": ""
    },
    {
        "id1": 3881,
        "id2": 3882,
        "phenotype_comparison": ""
    },
    {
        "id1": 3881,
        "id2": 3883,
        "phenotype_comparison": ""
    },
    {
        "id1": 3882,
        "id2": 3884,
        "phenotype_comparison": ""
    },
    {
        "id1": 3883,
        "id2": 3884,
        "phenotype_comparison": ""
    },
    {
        "id1": 3875,
        "id2": 3885,
        "phenotype_comparison": ""
    },
    {
        "id1": 3876,
        "id2": 3886,
        "phenotype_comparison": ""
    },
    {
        "id1": 3885,
        "id2": 3886,
        "phenotype_comparison": ""
    },
    {
        "id1": 3887,
        "id2": 3888,
        "phenotype_comparison": ""
    },
    {
        "id1": 3887,
        "id2": 3889,
        "phenotype_comparison": ""
    },
    {
        "id1": 3888,
        "id2": 3890,
        "phenotype_comparison": ""
    },
    {
        "id1": 3889,
        "id2": 3890,
        "phenotype_comparison": ""
    },
    {
        "id1": 3887,
        "id2": 3891,
        "phenotype_comparison": ""
    },
    {
        "id1": 3888,
        "id2": 3892,
        "phenotype_comparison": ""
    },
    {
        "id1": 3891,
        "id2": 3892,
        "phenotype_comparison": ""
    },
    {
        "id1": 3893,
        "id2": 3894,
        "phenotype_comparison": ""
    },
    {
        "id1": 3893,
        "id2": 3895,
        "phenotype_comparison": ""
    },
    {
        "id1": 3894,
        "id2": 3896,
        "phenotype_comparison": ""
    },
    {
        "id1": 3895,
        "id2": 3896,
        "phenotype_comparison": ""
    },
    {
        "id1": 3897,
        "id2": 3898,
        "phenotype_comparison": ""
    },
    {
        "id1": 3897,
        "id2": 3899,
        "phenotype_comparison": ""
    },
    {
        "id1": 3898,
        "id2": 3900,
        "phenotype_comparison": ""
    },
    {
        "id1": 3899,
        "id2": 3900,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3902,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3903,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3904,
        "phenotype_comparison": ""
    },
    {
        "id1": 3903,
        "id2": 3904,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3905,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3906,
        "phenotype_comparison": ""
    },
    {
        "id1": 3905,
        "id2": 3906,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3907,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3908,
        "phenotype_comparison": ""
    },
    {
        "id1": 3907,
        "id2": 3908,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3909,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3910,
        "phenotype_comparison": ""
    },
    {
        "id1": 3909,
        "id2": 3910,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3911,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3912,
        "phenotype_comparison": ""
    },
    {
        "id1": 3911,
        "id2": 3912,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3913,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3914,
        "phenotype_comparison": ""
    },
    {
        "id1": 3913,
        "id2": 3914,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3915,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3916,
        "phenotype_comparison": ""
    },
    {
        "id1": 3915,
        "id2": 3916,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3917,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3918,
        "phenotype_comparison": ""
    },
    {
        "id1": 3917,
        "id2": 3918,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3919,
        "phenotype_comparison": ""
    },
    {
        "id1": 3902,
        "id2": 3920,
        "phenotype_comparison": ""
    },
    {
        "id1": 3919,
        "id2": 3920,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3921,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3922,
        "phenotype_comparison": ""
    },
    {
        "id1": 3903,
        "id2": 3922,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3923,
        "phenotype_comparison": ""
    },
    {
        "id1": 3905,
        "id2": 3923,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3924,
        "phenotype_comparison": ""
    },
    {
        "id1": 3907,
        "id2": 3924,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3925,
        "phenotype_comparison": ""
    },
    {
        "id1": 3909,
        "id2": 3925,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3926,
        "phenotype_comparison": ""
    },
    {
        "id1": 3911,
        "id2": 3926,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3927,
        "phenotype_comparison": ""
    },
    {
        "id1": 3913,
        "id2": 3927,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3928,
        "phenotype_comparison": ""
    },
    {
        "id1": 3915,
        "id2": 3928,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3929,
        "phenotype_comparison": ""
    },
    {
        "id1": 3917,
        "id2": 3929,
        "phenotype_comparison": ""
    },
    {
        "id1": 3921,
        "id2": 3930,
        "phenotype_comparison": ""
    },
    {
        "id1": 3919,
        "id2": 3930,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3931,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3932,
        "phenotype_comparison": ""
    },
    {
        "id1": 3903,
        "id2": 3932,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3933,
        "phenotype_comparison": ""
    },
    {
        "id1": 3905,
        "id2": 3933,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3934,
        "phenotype_comparison": ""
    },
    {
        "id1": 3907,
        "id2": 3934,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3935,
        "phenotype_comparison": ""
    },
    {
        "id1": 3909,
        "id2": 3935,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3936,
        "phenotype_comparison": ""
    },
    {
        "id1": 3911,
        "id2": 3936,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3937,
        "phenotype_comparison": ""
    },
    {
        "id1": 3913,
        "id2": 3937,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3938,
        "phenotype_comparison": ""
    },
    {
        "id1": 3915,
        "id2": 3938,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3939,
        "phenotype_comparison": ""
    },
    {
        "id1": 3917,
        "id2": 3939,
        "phenotype_comparison": ""
    },
    {
        "id1": 3931,
        "id2": 3940,
        "phenotype_comparison": ""
    },
    {
        "id1": 3919,
        "id2": 3940,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3941,
        "phenotype_comparison": ""
    },
    {
        "id1": 3941,
        "id2": 3942,
        "phenotype_comparison": ""
    },
    {
        "id1": 3907,
        "id2": 3942,
        "phenotype_comparison": ""
    },
    {
        "id1": 3941,
        "id2": 3943,
        "phenotype_comparison": ""
    },
    {
        "id1": 3909,
        "id2": 3943,
        "phenotype_comparison": "Expression of fasn-1 was crucial for the life span extension in the rsks-1(ok1255) mutant."
    },
    {
        "id1": 3941,
        "id2": 3944,
        "phenotype_comparison": ""
    },
    {
        "id1": 3911,
        "id2": 3944,
        "phenotype_comparison": ""
    },
    {
        "id1": 3941,
        "id2": 3945,
        "phenotype_comparison": ""
    },
    {
        "id1": 3913,
        "id2": 3945,
        "phenotype_comparison": ""
    },
    {
        "id1": 3941,
        "id2": 3946,
        "phenotype_comparison": ""
    },
    {
        "id1": 3915,
        "id2": 3946,
        "phenotype_comparison": ""
    },
    {
        "id1": 3941,
        "id2": 3947,
        "phenotype_comparison": ""
    },
    {
        "id1": 3917,
        "id2": 3947,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3948,
        "phenotype_comparison": ""
    },
    {
        "id1": 3948,
        "id2": 3949,
        "phenotype_comparison": ""
    },
    {
        "id1": 3903,
        "id2": 3949,
        "phenotype_comparison": ""
    },
    {
        "id1": 3948,
        "id2": 3950,
        "phenotype_comparison": ""
    },
    {
        "id1": 3905,
        "id2": 3950,
        "phenotype_comparison": ""
    },
    {
        "id1": 3948,
        "id2": 3951,
        "phenotype_comparison": ""
    },
    {
        "id1": 3907,
        "id2": 3951,
        "phenotype_comparison": "Life span was decreased by 20.2% in daf-2(e1370) upon RNAi of sca-1."
    },
    {
        "id1": 3948,
        "id2": 3952,
        "phenotype_comparison": ""
    },
    {
        "id1": 3909,
        "id2": 3952,
        "phenotype_comparison": ""
    },
    {
        "id1": 3948,
        "id2": 3953,
        "phenotype_comparison": ""
    },
    {
        "id1": 3911,
        "id2": 3953,
        "phenotype_comparison": ""
    },
    {
        "id1": 3948,
        "id2": 3954,
        "phenotype_comparison": ""
    },
    {
        "id1": 3913,
        "id2": 3954,
        "phenotype_comparison": ""
    },
    {
        "id1": 3948,
        "id2": 3955,
        "phenotype_comparison": ""
    },
    {
        "id1": 3915,
        "id2": 3955,
        "phenotype_comparison": ""
    },
    {
        "id1": 3948,
        "id2": 3956,
        "phenotype_comparison": ""
    },
    {
        "id1": 3917,
        "id2": 3956,
        "phenotype_comparison": "Life span was decreased by 39.9% in daf-2(e1370) upon RNAi of mdt-15."
    },
    {
        "id1": 3901,
        "id2": 3957,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3958,
        "phenotype_comparison": ""
    },
    {
        "id1": 3903,
        "id2": 3958,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3959,
        "phenotype_comparison": ""
    },
    {
        "id1": 3905,
        "id2": 3959,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3960,
        "phenotype_comparison": ""
    },
    {
        "id1": 3907,
        "id2": 3960,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3961,
        "phenotype_comparison": ""
    },
    {
        "id1": 3909,
        "id2": 3961,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3962,
        "phenotype_comparison": ""
    },
    {
        "id1": 3911,
        "id2": 3962,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3963,
        "phenotype_comparison": ""
    },
    {
        "id1": 3913,
        "id2": 3963,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3964,
        "phenotype_comparison": ""
    },
    {
        "id1": 3915,
        "id2": 3964,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3965,
        "phenotype_comparison": ""
    },
    {
        "id1": 3917,
        "id2": 3965,
        "phenotype_comparison": ""
    },
    {
        "id1": 3957,
        "id2": 3966,
        "phenotype_comparison": ""
    },
    {
        "id1": 3919,
        "id2": 3966,
        "phenotype_comparison": ""
    },
    {
        "id1": 3901,
        "id2": 3967,
        "phenotype_comparison": ""
    },
    {
        "id1": 3967,
        "id2": 3968,
        "phenotype_comparison": ""
    },
    {
        "id1": 3903,
        "id2": 3968,
        "phenotype_comparison": ""
    },
    {
        "id1": 3967,
        "id2": 3969,
        "phenotype_comparison": ""
    },
    {
        "id1": 3905,
        "id2": 3969,
        "phenotype_comparison": ""
    },
    {
        "id1": 3967,
        "id2": 3970,
        "phenotype_comparison": ""
    },
    {
        "id1": 3907,
        "id2": 3970,
        "phenotype_comparison": "sca-1 RNAi also dramatically reduced life span in the eat-2 mutant (33.4% overall reduction, corresponding to only 9.3% life span benefit relative to N2 on this treatment)."
    },
    {
        "id1": 3967,
        "id2": 3971,
        "phenotype_comparison": ""
    },
    {
        "id1": 3909,
        "id2": 3971,
        "phenotype_comparison": ""
    },
    {
        "id1": 3967,
        "id2": 3972,
        "phenotype_comparison": ""
    },
    {
        "id1": 3911,
        "id2": 3972,
        "phenotype_comparison": ""
    },
    {
        "id1": 3967,
        "id2": 3973,
        "phenotype_comparison": ""
    },
    {
        "id1": 3913,
        "id2": 3973,
        "phenotype_comparison": ""
    },
    {
        "id1": 3967,
        "id2": 3974,
        "phenotype_comparison": ""
    },
    {
        "id1": 3915,
        "id2": 3974,
        "phenotype_comparison": ""
    },
    {
        "id1": 3967,
        "id2": 3975,
        "phenotype_comparison": ""
    },
    {
        "id1": 3917,
        "id2": 3975,
        "phenotype_comparison": ""
    },
    {
        "id1": 3967,
        "id2": 3976,
        "phenotype_comparison": ""
    },
    {
        "id1": 3919,
        "id2": 3976,
        "phenotype_comparison": ""
    },
    {
        "id1": 3977,
        "id2": 3978,
        "phenotype_comparison": ""
    },
    {
        "id1": 3977,
        "id2": 3979,
        "phenotype_comparison": ""
    },
    {
        "id1": 3978,
        "id2": 3980,
        "phenotype_comparison": ""
    },
    {
        "id1": 3979,
        "id2": 3980,
        "phenotype_comparison": "RNAi inhibition of vps-34 significantly reduced the mean lifespan of germline-deficient mutant, mes-1(bn7)."
    },
    {
        "id1": 3981,
        "id2": 3982,
        "phenotype_comparison": ""
    },
    {
        "id1": 3981,
        "id2": 3983,
        "phenotype_comparison": ""
    },
    {
        "id1": 3982,
        "id2": 3984,
        "phenotype_comparison": ""
    },
    {
        "id1": 3983,
        "id2": 3984,
        "phenotype_comparison": "RNAi inhibition ofatg-18 significantly reduced the mean lifespan of germline-deficient mutant, mes-1(bn7)."
    },
    {
        "id1": 3985,
        "id2": 3986,
        "phenotype_comparison": ""
    },
    {
        "id1": 3985,
        "id2": 3987,
        "phenotype_comparison": ""
    },
    {
        "id1": 3986,
        "id2": 3988,
        "phenotype_comparison": ""
    },
    {
        "id1": 3987,
        "id2": 3988,
        "phenotype_comparison": ""
    },
    {
        "id1": 3989,
        "id2": 3990,
        "phenotype_comparison": ""
    },
    {
        "id1": 3989,
        "id2": 3991,
        "phenotype_comparison": ""
    },
    {
        "id1": 3993,
        "id2": 3994,
        "phenotype_comparison": ""
    },
    {
        "id1": 3993,
        "id2": 3995,
        "phenotype_comparison": ""
    },
    {
        "id1": 3997,
        "id2": 3998,
        "phenotype_comparison": ""
    },
    {
        "id1": 3997,
        "id2": 3999,
        "phenotype_comparison": ""
    },
    {
        "id1": 3998,
        "id2": 4000,
        "phenotype_comparison": ""
    },
    {
        "id1": 3999,
        "id2": 4000,
        "phenotype_comparison": "Knockdown of pha-4 in adult glp-1(e2141) mutants significantly decreased their mean lifespan, but only modestly affected the mean lifespan of wild-type animals."
    },
    {
        "id1": 4001,
        "id2": 4002,
        "phenotype_comparison": ""
    },
    {
        "id1": 4001,
        "id2": 4003,
        "phenotype_comparison": ""
    },
    {
        "id1": 4002,
        "id2": 4004,
        "phenotype_comparison": ""
    },
    {
        "id1": 4003,
        "id2": 4004,
        "phenotype_comparison": "Knockdown of pha-4 in adult glp-1(e2141) mutants significantly decreased their mean lifespan, but only modestly affected the mean lifespan of wild-type animals."
    },
    {
        "id1": 4005,
        "id2": 4006,
        "phenotype_comparison": ""
    },
    {
        "id1": 4005,
        "id2": 4007,
        "phenotype_comparison": ""
    },
    {
        "id1": 4006,
        "id2": 4008,
        "phenotype_comparison": ""
    },
    {
        "id1": 4007,
        "id2": 4008,
        "phenotype_comparison": "Knockdown of pha-4 in adult glp-1(e2141) mutants significantly decreased their mean lifespan, but only modestly affected the mean lifespan of wild-type animals."
    },
    {
        "id1": 4009,
        "id2": 4010,
        "phenotype_comparison": ""
    },
    {
        "id1": 4009,
        "id2": 4011,
        "phenotype_comparison": ""
    },
    {
        "id1": 4010,
        "id2": 4012,
        "phenotype_comparison": ""
    },
    {
        "id1": 4011,
        "id2": 4012,
        "phenotype_comparison": "RNAi inhibition of vps-34 significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4013,
        "id2": 4014,
        "phenotype_comparison": ""
    },
    {
        "id1": 4013,
        "id2": 4015,
        "phenotype_comparison": ""
    },
    {
        "id1": 4014,
        "id2": 4016,
        "phenotype_comparison": ""
    },
    {
        "id1": 4015,
        "id2": 4016,
        "phenotype_comparison": "RNAi inhibition of vps-34 significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4017,
        "id2": 4018,
        "phenotype_comparison": ""
    },
    {
        "id1": 4017,
        "id2": 4019,
        "phenotype_comparison": ""
    },
    {
        "id1": 4018,
        "id2": 4020,
        "phenotype_comparison": ""
    },
    {
        "id1": 4019,
        "id2": 4020,
        "phenotype_comparison": "RNAi inhibition of vps-34 significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4009,
        "id2": 4021,
        "phenotype_comparison": ""
    },
    {
        "id1": 4010,
        "id2": 4022,
        "phenotype_comparison": ""
    },
    {
        "id1": 4021,
        "id2": 4022,
        "phenotype_comparison": "RNAi inhibition of lgg-1significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4013,
        "id2": 4023,
        "phenotype_comparison": ""
    },
    {
        "id1": 4014,
        "id2": 4024,
        "phenotype_comparison": ""
    },
    {
        "id1": 4023,
        "id2": 4024,
        "phenotype_comparison": "RNAi inhibition of lgg-1significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4017,
        "id2": 4025,
        "phenotype_comparison": ""
    },
    {
        "id1": 4018,
        "id2": 4026,
        "phenotype_comparison": ""
    },
    {
        "id1": 4025,
        "id2": 4026,
        "phenotype_comparison": "RNAi inhibition of lgg-1significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4013,
        "id2": 4027,
        "phenotype_comparison": ""
    },
    {
        "id1": 4014,
        "id2": 4028,
        "phenotype_comparison": ""
    },
    {
        "id1": 4027,
        "id2": 4028,
        "phenotype_comparison": "RNAi inhibition of bec-1significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4029,
        "id2": 4030,
        "phenotype_comparison": ""
    },
    {
        "id1": 4029,
        "id2": 4031,
        "phenotype_comparison": ""
    },
    {
        "id1": 4030,
        "id2": 4032,
        "phenotype_comparison": ""
    },
    {
        "id1": 4031,
        "id2": 4032,
        "phenotype_comparison": "RNAi inhibition of lgg-1significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4017,
        "id2": 4033,
        "phenotype_comparison": ""
    },
    {
        "id1": 4018,
        "id2": 4034,
        "phenotype_comparison": ""
    },
    {
        "id1": 4033,
        "id2": 4034,
        "phenotype_comparison": "RNAi inhibition of lgg-1significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4009,
        "id2": 4035,
        "phenotype_comparison": ""
    },
    {
        "id1": 4010,
        "id2": 4036,
        "phenotype_comparison": ""
    },
    {
        "id1": 4035,
        "id2": 4036,
        "phenotype_comparison": "RNAi inhibition of unc-51significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4037,
        "id2": 4030,
        "phenotype_comparison": ""
    },
    {
        "id1": 4037,
        "id2": 4038,
        "phenotype_comparison": ""
    },
    {
        "id1": 4030,
        "id2": 4039,
        "phenotype_comparison": ""
    },
    {
        "id1": 4038,
        "id2": 4039,
        "phenotype_comparison": "RNAi inhibition of unc-51significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4040,
        "id2": 4041,
        "phenotype_comparison": ""
    },
    {
        "id1": 4040,
        "id2": 4042,
        "phenotype_comparison": ""
    },
    {
        "id1": 4041,
        "id2": 4043,
        "phenotype_comparison": ""
    },
    {
        "id1": 4042,
        "id2": 4043,
        "phenotype_comparison": "RNAi inhibition of unc-51significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4009,
        "id2": 4044,
        "phenotype_comparison": ""
    },
    {
        "id1": 4010,
        "id2": 4045,
        "phenotype_comparison": ""
    },
    {
        "id1": 4044,
        "id2": 4045,
        "phenotype_comparison": "RNAi inhibition of atg-18 significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4037,
        "id2": 4046,
        "phenotype_comparison": ""
    },
    {
        "id1": 4030,
        "id2": 4047,
        "phenotype_comparison": ""
    },
    {
        "id1": 4046,
        "id2": 4047,
        "phenotype_comparison": "RNAi inhibition of atg-18 significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4040,
        "id2": 4048,
        "phenotype_comparison": ""
    },
    {
        "id1": 4041,
        "id2": 4049,
        "phenotype_comparison": ""
    },
    {
        "id1": 4048,
        "id2": 4049,
        "phenotype_comparison": "RNAi inhibition of atg-18 significantly reduced the mean lifespan of glp-1(e2141) animals."
    },
    {
        "id1": 4013,
        "id2": 4050,
        "phenotype_comparison": ""
    },
    {
        "id1": 4014,
        "id2": 4051,
        "phenotype_comparison": ""
    },
    {
        "id1": 4050,
        "id2": 4051,
        "phenotype_comparison": "Consistent with the reduced levels of TOR in glp-1 animals, we found that the lifespan of glp-1(e2141) animals was not significantly affected by tor RNAi, whereas the lifespan of similarly treated wild-type worms was increased."
    },
    {
        "id1": 4029,
        "id2": 4050,
        "phenotype_comparison": ""
    },
    {
        "id1": 4030,
        "id2": 4052,
        "phenotype_comparison": ""
    },
    {
        "id1": 4050,
        "id2": 4052,
        "phenotype_comparison": "Consistent with the reduced levels of TOR in glp-1 animals, we found that the lifespan of glp-1(e2141) animals was not significantly affected by tor RNAi, whereas the lifespan of similarly treated wild-type worms was increased."
    },
    {
        "id1": 4017,
        "id2": 4053,
        "phenotype_comparison": ""
    },
    {
        "id1": 4018,
        "id2": 4054,
        "phenotype_comparison": ""
    },
    {
        "id1": 4053,
        "id2": 4054,
        "phenotype_comparison": "Consistent with the reduced levels of TOR in glp-1 animals, we found that the lifespan of glp-1(e2141) animals was not significantly affected by tor RNAi, whereas the lifespan of similarly treated wild-type worms was increased."
    },
    {
        "id1": 4055,
        "id2": 4006,
        "phenotype_comparison": ""
    },
    {
        "id1": 4055,
        "id2": 4056,
        "phenotype_comparison": ""
    },
    {
        "id1": 4006,
        "id2": 4057,
        "phenotype_comparison": ""
    },
    {
        "id1": 4056,
        "id2": 4057,
        "phenotype_comparison": "Consistent with the reduced levels of TOR in glp-1 animals, we found that the lifespan of glp-1(e2141) animals was not significantly affected by tor RNAi, whereas the lifespan of similarly treated wild-type worms was increased."
    },
    {
        "id1": 4017,
        "id2": 4058,
        "phenotype_comparison": ""
    },
    {
        "id1": 4017,
        "id2": 4059,
        "phenotype_comparison": ""
    },
    {
        "id1": 4058,
        "id2": 4060,
        "phenotype_comparison": ""
    },
    {
        "id1": 4059,
        "id2": 4060,
        "phenotype_comparison": "RNAi-mediated inhibition of bec-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4061,
        "id2": 4062,
        "phenotype_comparison": ""
    },
    {
        "id1": 4061,
        "id2": 4025,
        "phenotype_comparison": ""
    },
    {
        "id1": 4062,
        "id2": 4063,
        "phenotype_comparison": ""
    },
    {
        "id1": 4025,
        "id2": 4063,
        "phenotype_comparison": "RNAi-mediated inhibition of bec-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4029,
        "id2": 4064,
        "phenotype_comparison": ""
    },
    {
        "id1": 4029,
        "id2": 4065,
        "phenotype_comparison": ""
    },
    {
        "id1": 4064,
        "id2": 4066,
        "phenotype_comparison": ""
    },
    {
        "id1": 4065,
        "id2": 4066,
        "phenotype_comparison": "RNAi-mediated inhibition of bec-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4067,
        "id2": 4068,
        "phenotype_comparison": ""
    },
    {
        "id1": 4067,
        "id2": 4069,
        "phenotype_comparison": ""
    },
    {
        "id1": 4068,
        "id2": 4070,
        "phenotype_comparison": ""
    },
    {
        "id1": 4069,
        "id2": 4070,
        "phenotype_comparison": "RNAi-mediated inhibition of lgg-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4061,
        "id2": 4071,
        "phenotype_comparison": ""
    },
    {
        "id1": 4062,
        "id2": 4072,
        "phenotype_comparison": ""
    },
    {
        "id1": 4071,
        "id2": 4072,
        "phenotype_comparison": "RNAi-mediated inhibition of lgg-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4029,
        "id2": 4073,
        "phenotype_comparison": ""
    },
    {
        "id1": 4064,
        "id2": 4074,
        "phenotype_comparison": ""
    },
    {
        "id1": 4073,
        "id2": 4074,
        "phenotype_comparison": "RNAi-mediated inhibition of lgg-1 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4075,
        "id2": 4076,
        "phenotype_comparison": ""
    },
    {
        "id1": 4075,
        "id2": 4077,
        "phenotype_comparison": ""
    },
    {
        "id1": 4076,
        "id2": 4078,
        "phenotype_comparison": ""
    },
    {
        "id1": 4077,
        "id2": 4078,
        "phenotype_comparison": "RNAi-mediated inhibition of pha-4 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4061,
        "id2": 4079,
        "phenotype_comparison": ""
    },
    {
        "id1": 4062,
        "id2": 4080,
        "phenotype_comparison": ""
    },
    {
        "id1": 4079,
        "id2": 4080,
        "phenotype_comparison": "RNAi-mediated inhibition of pha-4 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4029,
        "id2": 3999,
        "phenotype_comparison": ""
    },
    {
        "id1": 4064,
        "id2": 4081,
        "phenotype_comparison": ""
    },
    {
        "id1": 3999,
        "id2": 4081,
        "phenotype_comparison": "RNAi-mediated inhibition of pha-4 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4075,
        "id2": 4082,
        "phenotype_comparison": ""
    },
    {
        "id1": 4076,
        "id2": 4083,
        "phenotype_comparison": ""
    },
    {
        "id1": 4082,
        "id2": 4083,
        "phenotype_comparison": "RNAi-mediated inhibition of vps-34 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4017,
        "id2": 4084,
        "phenotype_comparison": ""
    },
    {
        "id1": 4058,
        "id2": 4085,
        "phenotype_comparison": ""
    },
    {
        "id1": 4084,
        "id2": 4085,
        "phenotype_comparison": "RNAi-mediated inhibition of vps-34 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4061,
        "id2": 4086,
        "phenotype_comparison": ""
    },
    {
        "id1": 4062,
        "id2": 4087,
        "phenotype_comparison": ""
    },
    {
        "id1": 4086,
        "id2": 4087,
        "phenotype_comparison": "RNAi-mediated inhibition of vps-34 significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non-transgenic siblings."
    },
    {
        "id1": 4075,
        "id2": 4050,
        "phenotype_comparison": ""
    },
    {
        "id1": 4076,
        "id2": 4088,
        "phenotype_comparison": ""
    },
    {
        "id1": 4050,
        "id2": 4088,
        "phenotype_comparison": ""
    },
    {
        "id1": 4061,
        "id2": 4089,
        "phenotype_comparison": ""
    },
    {
        "id1": 4062,
        "id2": 4090,
        "phenotype_comparison": ""
    },
    {
        "id1": 4089,
        "id2": 4090,
        "phenotype_comparison": ""
    },
    {
        "id1": 4029,
        "id2": 4091,
        "phenotype_comparison": ""
    },
    {
        "id1": 4064,
        "id2": 4092,
        "phenotype_comparison": ""
    },
    {
        "id1": 4091,
        "id2": 4092,
        "phenotype_comparison": ""
    },
    {
        "id1": 4093,
        "id2": 4095,
        "phenotype_comparison": ""
    },
    {
        "id1": 4094,
        "id2": 4095,
        "phenotype_comparison": ""
    },
    {
        "id1": 4093,
        "id2": 4097,
        "phenotype_comparison": ""
    },
    {
        "id1": 4096,
        "id2": 4097,
        "phenotype_comparison": ""
    },
    {
        "id1": 4093,
        "id2": 4098,
        "phenotype_comparison": ""
    },
    {
        "id1": 4094,
        "id2": 4098,
        "phenotype_comparison": ""
    },
    {
        "id1": 4093,
        "id2": 4100,
        "phenotype_comparison": ""
    },
    {
        "id1": 4099,
        "id2": 4100,
        "phenotype_comparison": ""
    },
    {
        "id1": 4101,
        "id2": 4103,
        "phenotype_comparison": ""
    },
    {
        "id1": 4102,
        "id2": 4103,
        "phenotype_comparison": ""
    },
    {
        "id1": 4101,
        "id2": 4104,
        "phenotype_comparison": ""
    },
    {
        "id1": 4102,
        "id2": 4104,
        "phenotype_comparison": ""
    },
    {
        "id1": 4105,
        "id2": 4107,
        "phenotype_comparison": ""
    },
    {
        "id1": 4106,
        "id2": 4107,
        "phenotype_comparison": ""
    },
    {
        "id1": 4105,
        "id2": 4109,
        "phenotype_comparison": ""
    },
    {
        "id1": 4108,
        "id2": 4109,
        "phenotype_comparison": ""
    },
    {
        "id1": 4101,
        "id2": 4110,
        "phenotype_comparison": ""
    },
    {
        "id1": 4108,
        "id2": 4110,
        "phenotype_comparison": ""
    },
    {
        "id1": 4093,
        "id2": 4107,
        "phenotype_comparison": ""
    },
    {
        "id1": 4111,
        "id2": 4107,
        "phenotype_comparison": ""
    },
    {
        "id1": 4093,
        "id2": 4113,
        "phenotype_comparison": ""
    },
    {
        "id1": 4112,
        "id2": 4113,
        "phenotype_comparison": ""
    },
    {
        "id1": 4114,
        "id2": 4113,
        "phenotype_comparison": ""
    },
    {
        "id1": 4115,
        "id2": 4107,
        "phenotype_comparison": ""
    },
    {
        "id1": 4116,
        "id2": 4107,
        "phenotype_comparison": ""
    },
    {
        "id1": 4115,
        "id2": 4113,
        "phenotype_comparison": ""
    },
    {
        "id1": 4099,
        "id2": 4113,
        "phenotype_comparison": ""
    },
    {
        "id1": 4117,
        "id2": 4118,
        "phenotype_comparison": ""
    },
    {
        "id1": 4117,
        "id2": 4119,
        "phenotype_comparison": ""
    },
    {
        "id1": 4118,
        "id2": 4120,
        "phenotype_comparison": ""
    },
    {
        "id1": 4119,
        "id2": 4120,
        "phenotype_comparison": "Loss of nmur-1 still considerably increases the lifespan of daf-10 sensory mutants on OP50, which indicates that nmur-1 acts in parallel at least to some daf-10-expressing neurons. Surprisingly, loss of nmur-1 extends the lifespan of daf-10 mutants also on HT115, which may suggest that the lifespan of nmur-1 mutants becomes food source independent in the absence of daf-10 activity."
    },
    {
        "id1": 4121,
        "id2": 4122,
        "phenotype_comparison": ""
    },
    {
        "id1": 4121,
        "id2": 4123,
        "phenotype_comparison": ""
    },
    {
        "id1": 4122,
        "id2": 4124,
        "phenotype_comparison": ""
    },
    {
        "id1": 4123,
        "id2": 4124,
        "phenotype_comparison": "Loss of nmur-1 still considerably increases the lifespan of daf-10 sensory mutants on OP50, which indicates that nmur-1 acts in parallel at least to some daf-10-expressing neurons. Surprisingly, loss of nmur-1 extends the lifespan of daf-10 mutants also on HT115, which may suggest that the lifespan of nmur-1 mutants becomes food source independent in the absence of daf-10 activity."
    },
    {
        "id1": 4125,
        "id2": 4126,
        "phenotype_comparison": ""
    },
    {
        "id1": 4125,
        "id2": 4127,
        "phenotype_comparison": ""
    },
    {
        "id1": 4126,
        "id2": 4128,
        "phenotype_comparison": ""
    },
    {
        "id1": 4127,
        "id2": 4128,
        "phenotype_comparison": "Animals that carry both nmur-1 and osm-3 mutations have a lifespan phenotype similar to that of nmur-1 single mutants on OP50 and HT115. This suggests that nmur-1 acts with osm-3 either in a subset of osm-3-expressing sensory neurons or in downstream cells."
    },
    {
        "id1": 4129,
        "id2": 4130,
        "phenotype_comparison": ""
    },
    {
        "id1": 4129,
        "id2": 4131,
        "phenotype_comparison": ""
    },
    {
        "id1": 4130,
        "id2": 4132,
        "phenotype_comparison": ""
    },
    {
        "id1": 4131,
        "id2": 4132,
        "phenotype_comparison": "Animals that carry both nmur-1 and osm-3 mutations have a lifespan phenotype similar to that of nmur-1 single mutants on OP50 and HT115. This suggests that nmur-1 acts with osm-3 either in a subset of osm-3-expressing sensory neurons or in downstream cells."
    },
    {
        "id1": 4133,
        "id2": 4134,
        "phenotype_comparison": ""
    },
    {
        "id1": 4133,
        "id2": 4135,
        "phenotype_comparison": ""
    },
    {
        "id1": 4134,
        "id2": 4136,
        "phenotype_comparison": ""
    },
    {
        "id1": 4135,
        "id2": 4136,
        "phenotype_comparison": "Animals that carry both nmur-1 and osm-3 mutations have a lifespan phenotype similar to that of nmur-1 single mutants on OP50 and HT115. This suggests that nmur-1 acts with osm-3 either in a subset of osm-3-expressing sensory neurons or in downstream cells."
    },
    {
        "id1": 4137,
        "id2": 4138,
        "phenotype_comparison": ""
    },
    {
        "id1": 4137,
        "id2": 4139,
        "phenotype_comparison": ""
    },
    {
        "id1": 4138,
        "id2": 4140,
        "phenotype_comparison": ""
    },
    {
        "id1": 4139,
        "id2": 4140,
        "phenotype_comparison": "Animals that carry both nmur-1 and osm-3 mutations have a lifespan phenotype similar to that of nmur-1 single mutants on OP50 and HT115. This suggests that nmur-1 acts with osm-3 either in a subset of osm-3-expressing sensory neurons or in downstream cells."
    },
    {
        "id1": 4141,
        "id2": 4142,
        "phenotype_comparison": ""
    },
    {
        "id1": 4141,
        "id2": 4143,
        "phenotype_comparison": ""
    },
    {
        "id1": 4142,
        "id2": 4144,
        "phenotype_comparison": ""
    },
    {
        "id1": 4143,
        "id2": 4144,
        "phenotype_comparison": "Removing nmur-1 does not significantly increase the lifespan of insulin/IGF-1 receptor daf-2 mutant worms."
    },
    {
        "id1": 4129,
        "id2": 4145,
        "phenotype_comparison": ""
    },
    {
        "id1": 4129,
        "id2": 4146,
        "phenotype_comparison": ""
    },
    {
        "id1": 4145,
        "id2": 4147,
        "phenotype_comparison": ""
    },
    {
        "id1": 4146,
        "id2": 4147,
        "phenotype_comparison": "Removing nmur-1 does not significantly increase the lifespan of insulin/IGF-1 receptor daf-2 mutant worms."
    },
    {
        "id1": 4148,
        "id2": 4149,
        "phenotype_comparison": ""
    },
    {
        "id1": 4148,
        "id2": 4150,
        "phenotype_comparison": ""
    },
    {
        "id1": 4149,
        "id2": 4151,
        "phenotype_comparison": ""
    },
    {
        "id1": 4150,
        "id2": 4151,
        "phenotype_comparison": "Loss of nmur-1 can still extend the lifespan of worms carrying a null mutation in daf-16."
    },
    {
        "id1": 4152,
        "id2": 4153,
        "phenotype_comparison": ""
    },
    {
        "id1": 4152,
        "id2": 4146,
        "phenotype_comparison": ""
    },
    {
        "id1": 4153,
        "id2": 4154,
        "phenotype_comparison": ""
    },
    {
        "id1": 4146,
        "id2": 4154,
        "phenotype_comparison": "We found that loss of nmur-1 can still extend the lifespan of animals with a mutation in the AMP-dependent kinase aak-2, which regulatesenergy metabolism."
    },
    {
        "id1": 4155,
        "id2": 4156,
        "phenotype_comparison": ""
    },
    {
        "id1": 4155,
        "id2": 4157,
        "phenotype_comparison": ""
    },
    {
        "id1": 4156,
        "id2": 4158,
        "phenotype_comparison": ""
    },
    {
        "id1": 4157,
        "id2": 4158,
        "phenotype_comparison": "We found that loss of nmur-1 can still extend the lifespan of animals with a mutation in the heat shock transcription factor hsf-1, which regulates stress response."
    },
    {
        "id1": 4159,
        "id2": 4160,
        "phenotype_comparison": ""
    },
    {
        "id1": 4159,
        "id2": 4161,
        "phenotype_comparison": ""
    },
    {
        "id1": 4160,
        "id2": 4162,
        "phenotype_comparison": ""
    },
    {
        "id1": 4161,
        "id2": 4162,
        "phenotype_comparison": "We found that loss of nmur-1 can still extend the lifespan of animals with a mutation in the p38 MAPK pmk-1, which regulates innate immunity."
    },
    {
        "id1": 4163,
        "id2": 4164,
        "phenotype_comparison": ""
    },
    {
        "id1": 4163,
        "id2": 4165,
        "phenotype_comparison": ""
    },
    {
        "id1": 4164,
        "id2": 4166,
        "phenotype_comparison": ""
    },
    {
        "id1": 4165,
        "id2": 4166,
        "phenotype_comparison": "The life span for daf-28(sa191) is significantly different from the wild type and daf-28; daf-12. The life spans for wild type and daf-12 are not significantly different. The wild-type strain is the direct parent of the daf-28(sa191) mutant."
    },
    {
        "id1": 4163,
        "id2": 4167,
        "phenotype_comparison": ""
    },
    {
        "id1": 4164,
        "id2": 4168,
        "phenotype_comparison": ""
    },
    {
        "id1": 4167,
        "id2": 4168,
        "phenotype_comparison": "The life span for daf-28(sa191) is significantly different from the wild type and daf-28; daf-12. The life spans for wild type and daf-12 are not significantly different. The wild-type strain is the direct parent of the daf-28(sa191) mutant."
    },
    {
        "id1": 4169,
        "id2": 4170,
        "phenotype_comparison": ""
    },
    {
        "id1": 4169,
        "id2": 4171,
        "phenotype_comparison": ""
    },
    {
        "id1": 4170,
        "id2": 4172,
        "phenotype_comparison": ""
    },
    {
        "id1": 4171,
        "id2": 4172,
        "phenotype_comparison": "daf-16 RNAi recapitulated wild-type lifespan of long-lived daf-2 (e1370) mutants."
    },
    {
        "id1": 4169,
        "id2": 4173,
        "phenotype_comparison": ""
    },
    {
        "id1": 4173,
        "id2": 4174,
        "phenotype_comparison": ""
    },
    {
        "id1": 4171,
        "id2": 4174,
        "phenotype_comparison": "daf-16 RNAi inhibits lifespan extension of daf-18 (mg198)."
    },
    {
        "id1": 4175,
        "id2": 4176,
        "phenotype_comparison": ""
    },
    {
        "id1": 4175,
        "id2": 4177,
        "phenotype_comparison": ""
    },
    {
        "id1": 4176,
        "id2": 4178,
        "phenotype_comparison": ""
    },
    {
        "id1": 4177,
        "id2": 4178,
        "phenotype_comparison": "We measured the adult lifespan of ins-18(tm339) animals under an ins-7(tm1907) background, which provides a lifespan-extending condition. ins-7 is one of the insulin-like genes and its RNAi knockdown has been reported to induce an extended adult lifespan. As expected, the mean lifespan of ins-7(tm1907) animals was extended by 4.8 days. In contrast, the mean lifespan of ins-18;ins-7 double mutant animals was 2.7 days shorter than that for ins-7 animals."
    },
    {
        "id1": 4178,
        "id2": 4179,
        "phenotype_comparison": ""
    },
    {
        "id1": 4180,
        "id2": 4181,
        "phenotype_comparison": ""
    },
    {
        "id1": 4180,
        "id2": 4182,
        "phenotype_comparison": ""
    },
    {
        "id1": 4181,
        "id2": 4183,
        "phenotype_comparison": ""
    },
    {
        "id1": 4182,
        "id2": 4183,
        "phenotype_comparison": "The mean life span of ins-18;daf-2 double mutants was shortened by 7.0 days at 20 \u00b0C compared with daf-2 animals. These data indicate that INS-18 is required for longevity of daf-2 animals."
    },
    {
        "id1": 4184,
        "id2": 4185,
        "phenotype_comparison": ""
    },
    {
        "id1": 4184,
        "id2": 4186,
        "phenotype_comparison": ""
    },
    {
        "id1": 4185,
        "id2": 4187,
        "phenotype_comparison": ""
    },
    {
        "id1": 4186,
        "id2": 4187,
        "phenotype_comparison": "daf-2 and double mutant animals had the same lifespan at 25 \u00b0C, indicating that INS-18 does not affect longevity in the absence of DAF-2 activity."
    },
    {
        "id1": 4188,
        "id2": 4189,
        "phenotype_comparison": ""
    },
    {
        "id1": 4188,
        "id2": 4190,
        "phenotype_comparison": ""
    },
    {
        "id1": 4189,
        "id2": 4191,
        "phenotype_comparison": ""
    },
    {
        "id1": 4190,
        "id2": 4191,
        "phenotype_comparison": "utx-1 knockdown further extends the lifespan of both long-lived glp-1(e2141) worms and wild type (N2) worms."
    },
    {
        "id1": 4192,
        "id2": 4193,
        "phenotype_comparison": ""
    },
    {
        "id1": 4192,
        "id2": 4194,
        "phenotype_comparison": ""
    },
    {
        "id1": 4193,
        "id2": 4195,
        "phenotype_comparison": ""
    },
    {
        "id1": 4194,
        "id2": 4195,
        "phenotype_comparison": "utx-1 knock-down further extended the lifespan of both long-lived eat-2(ad1116) mutant worms and wild type (N2) worms, suggesting that utx-1 and eat-2 do not function in the same genetic pathway to regulate lifespan."
    },
    {
        "id1": 4196,
        "id2": 4197,
        "phenotype_comparison": ""
    },
    {
        "id1": 4196,
        "id2": 4198,
        "phenotype_comparison": ""
    },
    {
        "id1": 4197,
        "id2": 4199,
        "phenotype_comparison": ""
    },
    {
        "id1": 4198,
        "id2": 4199,
        "phenotype_comparison": "utx-1 knock-down extends the lifespan of wild type (N2) worms, but does not further extend the long lifespan of daf-2(e1370) mutant worms."
    },
    {
        "id1": 4200,
        "id2": 4201,
        "phenotype_comparison": ""
    },
    {
        "id1": 4200,
        "id2": 4202,
        "phenotype_comparison": ""
    },
    {
        "id1": 4201,
        "id2": 4203,
        "phenotype_comparison": ""
    },
    {
        "id1": 4202,
        "id2": 4203,
        "phenotype_comparison": "While utx-1 knockdown significantly extended the lifespan of wild type (N2) worms, utx-1 knock-down no longer extended the lifespan of the daf-16(mu86) mutant worms."
    },
    {
        "id1": 4204,
        "id2": 4205,
        "phenotype_comparison": ""
    },
    {
        "id1": 4204,
        "id2": 4206,
        "phenotype_comparison": ""
    },
    {
        "id1": 4205,
        "id2": 4207,
        "phenotype_comparison": ""
    },
    {
        "id1": 4206,
        "id2": 4207,
        "phenotype_comparison": "utx-1 knock-down extends the lifespan of wild type (N2) worms, but does not further extend the long lifespan of daf-2(e1370) mutant worms."
    },
    {
        "id1": 4208,
        "id2": 4209,
        "phenotype_comparison": ""
    },
    {
        "id1": 4208,
        "id2": 4210,
        "phenotype_comparison": ""
    },
    {
        "id1": 4209,
        "id2": 4211,
        "phenotype_comparison": ""
    },
    {
        "id1": 4210,
        "id2": 4211,
        "phenotype_comparison": "While utx-1 knockdown significantly extended the lifespan of wild type (N2) worms, utx-1 knock-down no longer extended the lifespan of the daf-16(mu86) mutant worms."
    },
    {
        "id1": 4212,
        "id2": 4213,
        "phenotype_comparison": ""
    },
    {
        "id1": 4212,
        "id2": 4214,
        "phenotype_comparison": ""
    },
    {
        "id1": 4213,
        "id2": 4215,
        "phenotype_comparison": ""
    },
    {
        "id1": 4214,
        "id2": 4215,
        "phenotype_comparison": "utx-1 knock-down further extended the lifespan of both long-lived eat-2(ad1116) mutant worms and wild type (N2) worms, suggesting that utx-1 and eat-2 do not function in the same genetic pathway to regulate lifespan."
    },
    {
        "id1": 4216,
        "id2": 4217,
        "phenotype_comparison": ""
    },
    {
        "id1": 4216,
        "id2": 4218,
        "phenotype_comparison": ""
    },
    {
        "id1": 4217,
        "id2": 4219,
        "phenotype_comparison": ""
    },
    {
        "id1": 4218,
        "id2": 4219,
        "phenotype_comparison": "utx-1 knockdown further extends the lifespan of both long-lived glp-1(e2141) worms and wild type (N2) worms."
    },
    {
        "id1": 4220,
        "id2": 4221,
        "phenotype_comparison": ""
    },
    {
        "id1": 4222,
        "id2": 4223,
        "phenotype_comparison": ""
    },
    {
        "id1": 4224,
        "id2": 4225,
        "phenotype_comparison": ""
    },
    {
        "id1": 4224,
        "id2": 4226,
        "phenotype_comparison": ""
    },
    {
        "id1": 4225,
        "id2": 4227,
        "phenotype_comparison": ""
    },
    {
        "id1": 4226,
        "id2": 4227,
        "phenotype_comparison": "We found that increased life span on flr-4 RNAi is suppressed when nsy-1(ag3) in the p38 MAPK pathway is mutated."
    },
    {
        "id1": 4224,
        "id2": 4228,
        "phenotype_comparison": ""
    },
    {
        "id1": 4228,
        "id2": 4229,
        "phenotype_comparison": ""
    },
    {
        "id1": 4226,
        "id2": 4229,
        "phenotype_comparison": "We found that increased life span on flr-4 RNAi is suppressed when nsy-1(ok593) in the p38 MAPK pathway is mutated."
    },
    {
        "id1": 4224,
        "id2": 4230,
        "phenotype_comparison": ""
    },
    {
        "id1": 4230,
        "id2": 4231,
        "phenotype_comparison": ""
    },
    {
        "id1": 4224,
        "id2": 4232,
        "phenotype_comparison": ""
    },
    {
        "id1": 4232,
        "id2": 4233,
        "phenotype_comparison": ""
    },
    {
        "id1": 4224,
        "id2": 4234,
        "phenotype_comparison": ""
    },
    {
        "id1": 4234,
        "id2": 4235,
        "phenotype_comparison": ""
    },
    {
        "id1": 4224,
        "id2": 4236,
        "phenotype_comparison": ""
    },
    {
        "id1": 4236,
        "id2": 4237,
        "phenotype_comparison": ""
    },
    {
        "id1": 4224,
        "id2": 4238,
        "phenotype_comparison": ""
    },
    {
        "id1": 4238,
        "id2": 4239,
        "phenotype_comparison": ""
    },
    {
        "id1": 4240,
        "id2": 4241,
        "phenotype_comparison": ""
    },
    {
        "id1": 4240,
        "id2": 4242,
        "phenotype_comparison": ""
    },
    {
        "id1": 4241,
        "id2": 4243,
        "phenotype_comparison": ""
    },
    {
        "id1": 4242,
        "id2": 4243,
        "phenotype_comparison": "The extended life span of flr-4(n2259) is suppressed by sek-1 RNAi."
    },
    {
        "id1": 4244,
        "id2": 4246,
        "phenotype_comparison": ""
    },
    {
        "id1": 4245,
        "id2": 4246,
        "phenotype_comparison": "The life span of flr-4(n2259) is suppressed to the levels of sek-1(km4) in the double mutant flr-4(n2259)."
    },
    {
        "id1": 4247,
        "id2": 4248,
        "phenotype_comparison": ""
    },
    {
        "id1": 4247,
        "id2": 4249,
        "phenotype_comparison": ""
    },
    {
        "id1": 4248,
        "id2": 4250,
        "phenotype_comparison": ""
    },
    {
        "id1": 4249,
        "id2": 4250,
        "phenotype_comparison": "The life span of flr-4(n2259) is suppressed to a greater extent (35% against 21%) compared to WT when these worms were grown on nhr-8 RNAi."
    },
    {
        "id1": 4251,
        "id2": 4252,
        "phenotype_comparison": ""
    },
    {
        "id1": 4251,
        "id2": 4253,
        "phenotype_comparison": ""
    },
    {
        "id1": 4252,
        "id2": 4254,
        "phenotype_comparison": ""
    },
    {
        "id1": 4253,
        "id2": 4254,
        "phenotype_comparison": "In the nhr-8(ok168) mutant, life span is not extended when flr-4 is knocked down."
    },
    {
        "id1": 4255,
        "id2": 4256,
        "phenotype_comparison": ""
    },
    {
        "id1": 4255,
        "id2": 4257,
        "phenotype_comparison": ""
    },
    {
        "id1": 4256,
        "id2": 4258,
        "phenotype_comparison": ""
    },
    {
        "id1": 4257,
        "id2": 4258,
        "phenotype_comparison": "The life span of daf-2(e1370) was further increased when flr-4 was knocked down using RNAi."
    },
    {
        "id1": 4259,
        "id2": 4260,
        "phenotype_comparison": ""
    },
    {
        "id1": 4259,
        "id2": 4261,
        "phenotype_comparison": ""
    },
    {
        "id1": 4260,
        "id2": 4262,
        "phenotype_comparison": ""
    },
    {
        "id1": 4261,
        "id2": 4262,
        "phenotype_comparison": "The extended life span of flr-4 RNAi worms is not dependent on daf-16."
    },
    {
        "id1": 4263,
        "id2": 4264,
        "phenotype_comparison": ""
    },
    {
        "id1": 4265,
        "id2": 4266,
        "phenotype_comparison": ""
    },
    {
        "id1": 4267,
        "id2": 4268,
        "phenotype_comparison": ""
    },
    {
        "id1": 4269,
        "id2": 4270,
        "phenotype_comparison": ""
    },
    {
        "id1": 4271,
        "id2": 4272,
        "phenotype_comparison": ""
    },
    {
        "id1": 4271,
        "id2": 4273,
        "phenotype_comparison": ""
    },
    {
        "id1": 4272,
        "id2": 4274,
        "phenotype_comparison": ""
    },
    {
        "id1": 4273,
        "id2": 4274,
        "phenotype_comparison": "Knocking down drl-1 by RNAi does not further prolong the extended life span of flr-4(n2259)."
    },
    {
        "id1": 4275,
        "id2": 4276,
        "phenotype_comparison": ""
    },
    {
        "id1": 4275,
        "id2": 4277,
        "phenotype_comparison": ""
    },
    {
        "id1": 4276,
        "id2": 4278,
        "phenotype_comparison": ""
    },
    {
        "id1": 4277,
        "id2": 4278,
        "phenotype_comparison": ""
    },
    {
        "id1": 4279,
        "id2": 4280,
        "phenotype_comparison": ""
    },
    {
        "id1": 4279,
        "id2": 4281,
        "phenotype_comparison": ""
    },
    {
        "id1": 4280,
        "id2": 4282,
        "phenotype_comparison": ""
    },
    {
        "id1": 4281,
        "id2": 4282,
        "phenotype_comparison": "The skn-1 RNAi suppresses life span of WT and flr-4(n2259) to similar extent."
    },
    {
        "id1": 4283,
        "id2": 4284,
        "phenotype_comparison": ""
    },
    {
        "id1": 4283,
        "id2": 4285,
        "phenotype_comparison": ""
    },
    {
        "id1": 4284,
        "id2": 4286,
        "phenotype_comparison": ""
    },
    {
        "id1": 4285,
        "id2": 4286,
        "phenotype_comparison": ""
    },
    {
        "id1": 4287,
        "id2": 4288,
        "phenotype_comparison": ""
    },
    {
        "id1": 4287,
        "id2": 4289,
        "phenotype_comparison": ""
    },
    {
        "id1": 4288,
        "id2": 4290,
        "phenotype_comparison": ""
    },
    {
        "id1": 4289,
        "id2": 4290,
        "phenotype_comparison": ""
    },
    {
        "id1": 4287,
        "id2": 4291,
        "phenotype_comparison": ""
    },
    {
        "id1": 4291,
        "id2": 4292,
        "phenotype_comparison": ""
    },
    {
        "id1": 4289,
        "id2": 4292,
        "phenotype_comparison": ""
    },
    {
        "id1": 4293,
        "id2": 4294,
        "phenotype_comparison": ""
    },
    {
        "id1": 4319,
        "id2": 4320,
        "phenotype_comparison": ""
    },
    {
        "id1": 4337,
        "id2": 4341,
        "phenotype_comparison": ""
    },
    {
        "id1": 4379,
        "id2": 4380,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4414,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4441,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4469,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4496,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4522,
        "phenotype_comparison": ""
    },
    {
        "id1": 4548,
        "id2": 4549,
        "phenotype_comparison": ""
    },
    {
        "id1": 4578,
        "id2": 4583,
        "phenotype_comparison": ""
    },
    {
        "id1": 4612,
        "id2": 4614,
        "phenotype_comparison": "Inactivation of cup-4 had no effect on life span of nlp-7(tm2984) mutants."
    },
    {
        "id1": 4632,
        "id2": 4636,
        "phenotype_comparison": ""
    },
    {
        "id1": 4651,
        "id2": 4652,
        "phenotype_comparison": ""
    },
    {
        "id1": 4664,
        "id2": 4672,
        "phenotype_comparison": "nhr-49 mutation had no impact on the extended lifespan of daf-2(e1370) mutants in two of three independent trials and caused a small suppression in longevity in the third."
    },
    {
        "id1": 4692,
        "id2": 4693,
        "phenotype_comparison": ""
    },
    {
        "id1": 4720,
        "id2": 4721,
        "phenotype_comparison": ""
    },
    {
        "id1": 4743,
        "id2": 4745,
        "phenotype_comparison": ""
    },
    {
        "id1": 4773,
        "id2": 4775,
        "phenotype_comparison": ""
    },
    {
        "id1": 4789,
        "id2": 4793,
        "phenotype_comparison": ""
    },
    {
        "id1": 4805,
        "id2": 4807,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4813,
        "id2": 4822,
        "phenotype_comparison": ""
    },
    {
        "id1": 4830,
        "id2": 4834,
        "phenotype_comparison": ""
    },
    {
        "id1": 4852,
        "id2": 4789,
        "phenotype_comparison": ""
    },
    {
        "id1": 4812,
        "id2": 4868,
        "phenotype_comparison": ""
    },
    {
        "id1": 4890,
        "id2": 4891,
        "phenotype_comparison": ""
    },
    {
        "id1": 4913,
        "id2": 4914,
        "phenotype_comparison": ""
    },
    {
        "id1": 4876,
        "id2": 4939,
        "phenotype_comparison": ""
    },
    {
        "id1": 4957,
        "id2": 4958,
        "phenotype_comparison": ""
    },
    {
        "id1": 4976,
        "id2": 4977,
        "phenotype_comparison": ""
    },
    {
        "id1": 5005,
        "id2": 5006,
        "phenotype_comparison": "Knockdown of the translation initiation factors eif-1 increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 5026,
        "id2": 5027,
        "phenotype_comparison": "Knockdown of raga-1 extended the lifespan of kri-1 mutants, in which the GSC pathway is blocked."
    },
    {
        "id1": 5048,
        "id2": 5049,
        "phenotype_comparison": ""
    },
    {
        "id1": 5063,
        "id2": 5066,
        "phenotype_comparison": ""
    },
    {
        "id1": 5078,
        "id2": 5080,
        "phenotype_comparison": ""
    },
    {
        "id1": 5097,
        "id2": 5099,
        "phenotype_comparison": ""
    },
    {
        "id1": 5131,
        "id2": 5133,
        "phenotype_comparison": ""
    },
    {
        "id1": 5142,
        "id2": 5156,
        "phenotype_comparison": ""
    },
    {
        "id1": 5177,
        "id2": 5179,
        "phenotype_comparison": ""
    },
    {
        "id1": 5196,
        "id2": 5197,
        "phenotype_comparison": "hsp-16.1/2/11 RNAi, which targets hsp-16.1, hsp-16.2, and hsp-16.11, suppressed the longevity conferred by rsks-1(tm1714) mutations in three of four trials (two of two trials at 20 \u00b0C and one of two trials at 22.5 \u00b0C.). We speculate that the inconsistency might originate from the differences in temperatures (20 \u00b0C vs. 22.5 \u00b0C). In addition, we cannot exclude the possibility that hsp-16.1/2/11 RNAi did not work for one trial that did not display the longevity suppression or the RNAi exhibited variations among trials. Note that hsp-16.1/2/11 RNAi was designed to target hsp-16.1, but because of over 88% sequence identity among hsp-16.1, hsp-16.2, and hsp-16.11 genes, the RNAi clone is expected to target hsp-16.1, hsp-16.2, and hsp-16.11 genes."
    },
    {
        "id1": 5134,
        "id2": 5222,
        "phenotype_comparison": ""
    },
    {
        "id1": 5241,
        "id2": 5242,
        "phenotype_comparison": ""
    },
    {
        "id1": 5266,
        "id2": 5267,
        "phenotype_comparison": ""
    },
    {
        "id1": 5295,
        "id2": 5296,
        "phenotype_comparison": "Further, ets-4(ok165) worms, when subjected to daf-16(RNAi), did not display an extended lifespan. Thus, daf-16 was required for the longevity phenotype of ets-4(ok165) worms suggesting that ets-4 functions upstream of, or in parallel to, daf-16 in lifespan regulation."
    },
    {
        "id1": 5319,
        "id2": 5321,
        "phenotype_comparison": ""
    },
    {
        "id1": 5333,
        "id2": 5345,
        "phenotype_comparison": ""
    },
    {
        "id1": 5373,
        "id2": 5375,
        "phenotype_comparison": ""
    },
    {
        "id1": 5396,
        "id2": 5400,
        "phenotype_comparison": ""
    },
    {
        "id1": 5421,
        "id2": 5422,
        "phenotype_comparison": ""
    },
    {
        "id1": 5454,
        "id2": 5455,
        "phenotype_comparison": ""
    },
    {
        "id1": 5464,
        "id2": 5469,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5480,
        "id2": 5488,
        "phenotype_comparison": ""
    },
    {
        "id1": 5510,
        "id2": 5511,
        "phenotype_comparison": ""
    },
    {
        "id1": 5532,
        "id2": 5533,
        "phenotype_comparison": "At 20\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived 20\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 20\u00b0C."
    },
    {
        "id1": 5555,
        "id2": 5557,
        "phenotype_comparison": ""
    },
    {
        "id1": 5526,
        "id2": 5576,
        "phenotype_comparison": ""
    },
    {
        "id1": 5555,
        "id2": 5593,
        "phenotype_comparison": ""
    },
    {
        "id1": 5612,
        "id2": 5613,
        "phenotype_comparison": ""
    },
    {
        "id1": 4293,
        "id2": 4295,
        "phenotype_comparison": ""
    },
    {
        "id1": 4319,
        "id2": 4321,
        "phenotype_comparison": ""
    },
    {
        "id1": 4341,
        "id2": 4342,
        "phenotype_comparison": ""
    },
    {
        "id1": 4381,
        "id2": 4382,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4415,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4442,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4470,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4497,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4523,
        "phenotype_comparison": ""
    },
    {
        "id1": 4548,
        "id2": 4550,
        "phenotype_comparison": ""
    },
    {
        "id1": 4581,
        "id2": 4584,
        "phenotype_comparison": ""
    },
    {
        "id1": 4606,
        "id2": 4615,
        "phenotype_comparison": ""
    },
    {
        "id1": 4635,
        "id2": 4636,
        "phenotype_comparison": "oga-1 mutant lifespan was significantly longer than that of wild type and double mutant analysis of oga-1;daf-2 did not show additional lifespan increases."
    },
    {
        "id1": 4651,
        "id2": 4653,
        "phenotype_comparison": ""
    },
    {
        "id1": 4655,
        "id2": 4673,
        "phenotype_comparison": ""
    },
    {
        "id1": 4655,
        "id2": 4694,
        "phenotype_comparison": ""
    },
    {
        "id1": 4720,
        "id2": 4722,
        "phenotype_comparison": ""
    },
    {
        "id1": 4744,
        "id2": 4745,
        "phenotype_comparison": "Overexpression of mek-1 had completely suppressed the reduced life span of the shc-1mutant."
    },
    {
        "id1": 4774,
        "id2": 4776,
        "phenotype_comparison": ""
    },
    {
        "id1": 4790,
        "id2": 4793,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4804,
        "id2": 4808,
        "phenotype_comparison": ""
    },
    {
        "id1": 4820,
        "id2": 4822,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4833,
        "id2": 4834,
        "phenotype_comparison": "Knocking down of ftt-2 alone did not substantially reduce hcf-1(pk924) lifespan."
    },
    {
        "id1": 4852,
        "id2": 4853,
        "phenotype_comparison": ""
    },
    {
        "id1": 4812,
        "id2": 4869,
        "phenotype_comparison": ""
    },
    {
        "id1": 4892,
        "id2": 4893,
        "phenotype_comparison": ""
    },
    {
        "id1": 4913,
        "id2": 4915,
        "phenotype_comparison": ""
    },
    {
        "id1": 4876,
        "id2": 4940,
        "phenotype_comparison": ""
    },
    {
        "id1": 4957,
        "id2": 4959,
        "phenotype_comparison": ""
    },
    {
        "id1": 4978,
        "id2": 4979,
        "phenotype_comparison": ""
    },
    {
        "id1": 5003,
        "id2": 5007,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5029,
        "phenotype_comparison": ""
    },
    {
        "id1": 5048,
        "id2": 5050,
        "phenotype_comparison": ""
    },
    {
        "id1": 5059,
        "id2": 5066,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than nuo-2 RNAi."
    },
    {
        "id1": 5057,
        "id2": 5080,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (kin-29) affected longevity induced by RNAi-mediated Mit mutants analyzed other than isp-1 RNAi."
    },
    {
        "id1": 5098,
        "id2": 5099,
        "phenotype_comparison": "lipl-4 RNAi partially suppressed the longevity of daf-2 mutants. These results suggest that lipid hydrolysis is also connected to life-span control in the daf-2 long-lived animals."
    },
    {
        "id1": 5134,
        "id2": 5135,
        "phenotype_comparison": ""
    },
    {
        "id1": 5144,
        "id2": 5157,
        "phenotype_comparison": ""
    },
    {
        "id1": 5178,
        "id2": 5180,
        "phenotype_comparison": ""
    },
    {
        "id1": 5198,
        "id2": 5199,
        "phenotype_comparison": "hsp-16.1/2/11 RNAi, which targets hsp-16.1, hsp-16.2, and hsp-16.11, suppressed the longevity conferred by rsks-1(tm1714) mutations in three of four trials (two of two trials at 20 \u00b0C and one of two trials at 22.5 \u00b0C.). We speculate that the inconsistency might originate from the differences in temperatures (20 \u00b0C vs. 22.5 \u00b0C). In addition, we cannot exclude the possibility that hsp-16.1/2/11 RNAi did not work for one trial that did not display the longevity suppression or the RNAi exhibited variations among trials. Note that hsp-16.1/2/11 RNAi was designed to target hsp-16.1, but because of over 88% sequence identity among hsp-16.1, hsp-16.2, and hsp-16.11 genes, the RNAi clone is expected to target hsp-16.1, hsp-16.2, and hsp-16.11 genes."
    },
    {
        "id1": 5135,
        "id2": 5223,
        "phenotype_comparison": ""
    },
    {
        "id1": 5241,
        "id2": 5233,
        "phenotype_comparison": ""
    },
    {
        "id1": 5268,
        "id2": 5269,
        "phenotype_comparison": ""
    },
    {
        "id1": 5297,
        "id2": 5298,
        "phenotype_comparison": ""
    },
    {
        "id1": 5320,
        "id2": 5321,
        "phenotype_comparison": "aakg-4 reduced lifespan in a daf-2(m577) background."
    },
    {
        "id1": 5344,
        "id2": 5345,
        "phenotype_comparison": "aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively)."
    },
    {
        "id1": 5376,
        "id2": 5377,
        "phenotype_comparison": ""
    },
    {
        "id1": 5399,
        "id2": 5400,
        "phenotype_comparison": "To test whether aakg-5 also contributed to daf-2 Age we used aakg-5(RNAi). Like aakg-4(RNAi), this too markedly reduced lifespan in daf-2 but not N2."
    },
    {
        "id1": 5423,
        "id2": 5424,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5454,
        "id2": 5456,
        "phenotype_comparison": ""
    },
    {
        "id1": 5470,
        "id2": 5471,
        "phenotype_comparison": ""
    },
    {
        "id1": 5481,
        "id2": 5489,
        "phenotype_comparison": ""
    },
    {
        "id1": 5510,
        "id2": 5512,
        "phenotype_comparison": ""
    },
    {
        "id1": 5534,
        "id2": 5535,
        "phenotype_comparison": ""
    },
    {
        "id1": 5556,
        "id2": 5557,
        "phenotype_comparison": "At 15\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 15\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals."
    },
    {
        "id1": 5527,
        "id2": 5577,
        "phenotype_comparison": ""
    },
    {
        "id1": 5592,
        "id2": 5593,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 15\u00b0C."
    },
    {
        "id1": 5612,
        "id2": 5614,
        "phenotype_comparison": ""
    },
    {
        "id1": 5608,
        "id2": 5633,
        "phenotype_comparison": ""
    },
    {
        "id1": 5655,
        "id2": 5657,
        "phenotype_comparison": ""
    },
    {
        "id1": 5665,
        "id2": 5674,
        "phenotype_comparison": ""
    },
    {
        "id1": 5689,
        "id2": 5690,
        "phenotype_comparison": "The hlh-30 mutants were modestly short lived and loss of hlh-30 function suppressed the longevity phenotype of mxl-3 mutants ."
    },
    {
        "id1": 5726,
        "id2": 5728,
        "phenotype_comparison": ""
    },
    {
        "id1": 5751,
        "id2": 5752,
        "phenotype_comparison": "daf-16 RNAi did shorten the life span of daf-2(e1370) mutants."
    },
    {
        "id1": 5771,
        "id2": 5783,
        "phenotype_comparison": "Both of two different bec-1 RNAi clones shortened the mean lifespan of eat-2(ad1116) mutants by ~15\u201330%, but did not shorten wild-type lifespan."
    },
    {
        "id1": 5797,
        "id2": 5790,
        "phenotype_comparison": ""
    },
    {
        "id1": 5825,
        "id2": 5827,
        "phenotype_comparison": ""
    },
    {
        "id1": 5853,
        "id2": 5854,
        "phenotype_comparison": ""
    },
    {
        "id1": 5886,
        "id2": 5888,
        "phenotype_comparison": ""
    },
    {
        "id1": 5914,
        "id2": 5916,
        "phenotype_comparison": ""
    },
    {
        "id1": 5940,
        "id2": 5942,
        "phenotype_comparison": ""
    },
    {
        "id1": 5964,
        "id2": 5966,
        "phenotype_comparison": ""
    },
    {
        "id1": 5982,
        "id2": 5983,
        "phenotype_comparison": "The longevity associated with cye-1(RNAi) was strongly suppressed by lack of kri-1(ok1251), shortening mean lifespan by up to 18%."
    },
    {
        "id1": 5981,
        "id2": 6003,
        "phenotype_comparison": ""
    },
    {
        "id1": 5963,
        "id2": 6020,
        "phenotype_comparison": ""
    },
    {
        "id1": 6034,
        "id2": 6036,
        "phenotype_comparison": ""
    },
    {
        "id1": 6050,
        "id2": 6052,
        "phenotype_comparison": ""
    },
    {
        "id1": 6065,
        "id2": 6066,
        "phenotype_comparison": "The longevity associated with cye-1(RNAi) was strongly suppressed by lack of kri-1(ok1251), shortening mean lifespan."
    },
    {
        "id1": 6078,
        "id2": 6079,
        "phenotype_comparison": "The longevity of cye-1(RNAi) was suppressed by daf-16(mu86) mutation."
    },
    {
        "id1": 6093,
        "id2": 6097,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6111,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6125,
        "phenotype_comparison": ""
    },
    {
        "id1": 6137,
        "id2": 6138,
        "phenotype_comparison": "RNAi inactivation of K11B4.1 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6141,
        "id2": 6158,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6172,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6182,
        "phenotype_comparison": ""
    },
    {
        "id1": 6194,
        "id2": 6196,
        "phenotype_comparison": ""
    },
    {
        "id1": 6210,
        "id2": 6211,
        "phenotype_comparison": ""
    },
    {
        "id1": 6228,
        "id2": 6230,
        "phenotype_comparison": ""
    },
    {
        "id1": 6247,
        "id2": 6249,
        "phenotype_comparison": ""
    },
    {
        "id1": 6267,
        "id2": 6269,
        "phenotype_comparison": ""
    },
    {
        "id1": 6282,
        "id2": 6284,
        "phenotype_comparison": ""
    },
    {
        "id1": 6297,
        "id2": 6298,
        "phenotype_comparison": ""
    },
    {
        "id1": 6310,
        "id2": 6311,
        "phenotype_comparison": ""
    },
    {
        "id1": 6328,
        "id2": 6329,
        "phenotype_comparison": ""
    },
    {
        "id1": 6345,
        "id2": 6347,
        "phenotype_comparison": ""
    },
    {
        "id1": 6356,
        "id2": 6372,
        "phenotype_comparison": ""
    },
    {
        "id1": 4294,
        "id2": 4296,
        "phenotype_comparison": ""
    },
    {
        "id1": 4320,
        "id2": 4322,
        "phenotype_comparison": ""
    },
    {
        "id1": 4339,
        "id2": 4342,
        "phenotype_comparison": "Combination of daf-16(mgDf50) and hsf-1(RNAi) did not lead to a further decrease in life span, suggesting that daf-16 and hsf-1 may function in a common pathway to regulate longevity."
    },
    {
        "id1": 4383,
        "id2": 4384,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4417,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4443,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4471,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4498,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4524,
        "phenotype_comparison": ""
    },
    {
        "id1": 4549,
        "id2": 4551,
        "phenotype_comparison": ""
    },
    {
        "id1": 4578,
        "id2": 4585,
        "phenotype_comparison": ""
    },
    {
        "id1": 4615,
        "id2": 4616,
        "phenotype_comparison": ""
    },
    {
        "id1": 4633,
        "id2": 4637,
        "phenotype_comparison": ""
    },
    {
        "id1": 4652,
        "id2": 4654,
        "phenotype_comparison": ""
    },
    {
        "id1": 4655,
        "id2": 4674,
        "phenotype_comparison": ""
    },
    {
        "id1": 4673,
        "id2": 4695,
        "phenotype_comparison": ""
    },
    {
        "id1": 4721,
        "id2": 4723,
        "phenotype_comparison": ""
    },
    {
        "id1": 4746,
        "id2": 4747,
        "phenotype_comparison": ""
    },
    {
        "id1": 4775,
        "id2": 4776,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4789,
        "id2": 4794,
        "phenotype_comparison": ""
    },
    {
        "id1": 4805,
        "id2": 4808,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4813,
        "id2": 4823,
        "phenotype_comparison": ""
    },
    {
        "id1": 4829,
        "id2": 4835,
        "phenotype_comparison": ""
    },
    {
        "id1": 4789,
        "id2": 4847,
        "phenotype_comparison": ""
    },
    {
        "id1": 4868,
        "id2": 4870,
        "phenotype_comparison": ""
    },
    {
        "id1": 4892,
        "id2": 4894,
        "phenotype_comparison": ""
    },
    {
        "id1": 4914,
        "id2": 4916,
        "phenotype_comparison": ""
    },
    {
        "id1": 4939,
        "id2": 4941,
        "phenotype_comparison": ""
    },
    {
        "id1": 4958,
        "id2": 4960,
        "phenotype_comparison": ""
    },
    {
        "id1": 4884,
        "id2": 4981,
        "phenotype_comparison": ""
    },
    {
        "id1": 5004,
        "id2": 5008,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5030,
        "phenotype_comparison": ""
    },
    {
        "id1": 5049,
        "id2": 5051,
        "phenotype_comparison": ""
    },
    {
        "id1": 5063,
        "id2": 5067,
        "phenotype_comparison": ""
    },
    {
        "id1": 5078,
        "id2": 5081,
        "phenotype_comparison": ""
    },
    {
        "id1": 5100,
        "id2": 5101,
        "phenotype_comparison": ""
    },
    {
        "id1": 5134,
        "id2": 5136,
        "phenotype_comparison": ""
    },
    {
        "id1": 5156,
        "id2": 5157,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was suppressed by daf-16(mu86) mutation."
    },
    {
        "id1": 5179,
        "id2": 5180,
        "phenotype_comparison": "hsf-1(sy441) mutation suppressed the prolonged lifespan caused by RNAi targeting daf-15/raptor."
    },
    {
        "id1": 5162,
        "id2": 5200,
        "phenotype_comparison": ""
    },
    {
        "id1": 5222,
        "id2": 5223,
        "phenotype_comparison": "daf-16 RNAi treatment for whole life shortened the lifespan of bothrsks-1(tm1714) and wild type animals."
    },
    {
        "id1": 5242,
        "id2": 5243,
        "phenotype_comparison": ""
    },
    {
        "id1": 5268,
        "id2": 5270,
        "phenotype_comparison": ""
    },
    {
        "id1": 5297,
        "id2": 5299,
        "phenotype_comparison": ""
    },
    {
        "id1": 5322,
        "id2": 5323,
        "phenotype_comparison": ""
    },
    {
        "id1": 5346,
        "id2": 5347,
        "phenotype_comparison": ""
    },
    {
        "id1": 5376,
        "id2": 5378,
        "phenotype_comparison": ""
    },
    {
        "id1": 5395,
        "id2": 5401,
        "phenotype_comparison": ""
    },
    {
        "id1": 5423,
        "id2": 5425,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5455,
        "id2": 5457,
        "phenotype_comparison": ""
    },
    {
        "id1": 5470,
        "id2": 5472,
        "phenotype_comparison": ""
    },
    {
        "id1": 5488,
        "id2": 5489,
        "phenotype_comparison": "The eak alleles did not enhance life span extension of akt-1(mg306), although they all strongly enhanced the dauer formation phenotype of akt-1(mg306)."
    },
    {
        "id1": 5511,
        "id2": 5513,
        "phenotype_comparison": ""
    },
    {
        "id1": 5534,
        "id2": 5536,
        "phenotype_comparison": ""
    },
    {
        "id1": 5490,
        "id2": 5558,
        "phenotype_comparison": ""
    },
    {
        "id1": 5576,
        "id2": 5577,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 20\u00b0C."
    },
    {
        "id1": 5594,
        "id2": 5595,
        "phenotype_comparison": ""
    },
    {
        "id1": 5613,
        "id2": 5615,
        "phenotype_comparison": ""
    },
    {
        "id1": 5632,
        "id2": 5634,
        "phenotype_comparison": ""
    },
    {
        "id1": 5656,
        "id2": 5658,
        "phenotype_comparison": ""
    },
    {
        "id1": 5669,
        "id2": 5675,
        "phenotype_comparison": ""
    },
    {
        "id1": 5691,
        "id2": 5692,
        "phenotype_comparison": ""
    },
    {
        "id1": 5727,
        "id2": 5729,
        "phenotype_comparison": ""
    },
    {
        "id1": 5750,
        "id2": 5754,
        "phenotype_comparison": ""
    },
    {
        "id1": 5769,
        "id2": 5784,
        "phenotype_comparison": ""
    },
    {
        "id1": 5790,
        "id2": 5801,
        "phenotype_comparison": ""
    },
    {
        "id1": 5775,
        "id2": 5827,
        "phenotype_comparison": "We measured the lifespan of rab-10(ok1494) animals fed with vps-34 RNAi during adulthood, and we found that vps-34 RNAi clones significantly shortened lifespan."
    },
    {
        "id1": 5855,
        "id2": 5856,
        "phenotype_comparison": ""
    },
    {
        "id1": 5889,
        "id2": 5891,
        "phenotype_comparison": ""
    },
    {
        "id1": 5915,
        "id2": 5917,
        "phenotype_comparison": ""
    },
    {
        "id1": 5941,
        "id2": 5942,
        "phenotype_comparison": "daf-2(e1370);pmk-1(km25) worms only exhibited a mild decrease in mean lifespan and no decrease in maximum lifespan."
    },
    {
        "id1": 5965,
        "id2": 5966,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) was able to extend the lifespan of fertile mes-1(bn7) worms (21%)."
    },
    {
        "id1": 5984,
        "id2": 5985,
        "phenotype_comparison": ""
    },
    {
        "id1": 6002,
        "id2": 6003,
        "phenotype_comparison": "KRI-1 contributes to cdk-2(RNAi) longevity. Survival of cdk-2(RNAi) worms was substantially reduced by kri-1(ok1251) mutation."
    },
    {
        "id1": 5963,
        "id2": 6021,
        "phenotype_comparison": ""
    },
    {
        "id1": 6035,
        "id2": 5966,
        "phenotype_comparison": ""
    },
    {
        "id1": 6051,
        "id2": 6052,
        "phenotype_comparison": "daf-16(mgDf47) null mutation significantly suppressed the longevity of cye-1(RNAi)."
    },
    {
        "id1": 5995,
        "id2": 6067,
        "phenotype_comparison": ""
    },
    {
        "id1": 5975,
        "id2": 6080,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6098,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6112,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6126,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6139,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6159,
        "phenotype_comparison": ""
    },
    {
        "id1": 6107,
        "id2": 6172,
        "phenotype_comparison": "RNAi inactivation of Y48G1A.4 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6127,
        "id2": 6182,
        "phenotype_comparison": "RNAi inactivation of F59A3.3 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6195,
        "id2": 6196,
        "phenotype_comparison": ""
    },
    {
        "id1": 6208,
        "id2": 6211,
        "phenotype_comparison": "nuo-6(RNAi) is only partially additive for lifespan to eat-2(ad1116)."
    },
    {
        "id1": 6229,
        "id2": 6230,
        "phenotype_comparison": "clk-7 (qm159) mutations exhibited additive effects on daf-2(e1370) life span in that extend daf-2(e1370) life span and wild-type life span by similar amounts."
    },
    {
        "id1": 6248,
        "id2": 6250,
        "phenotype_comparison": ""
    },
    {
        "id1": 6268,
        "id2": 6269,
        "phenotype_comparison": "The mean life-span of clk-1(e2519) clk-2(qm37) mutants is more than 50% greater than that of either clk-l (e2519) or clk-2(qm37) alone and almost 90% greater than that of the wild type."
    },
    {
        "id1": 6283,
        "id2": 6284,
        "phenotype_comparison": ""
    },
    {
        "id1": 6295,
        "id2": 6298,
        "phenotype_comparison": ""
    },
    {
        "id1": 6267,
        "id2": 6311,
        "phenotype_comparison": "A daf-2(el370);clk-1(e2519) strain lives longer than its component strains."
    },
    {
        "id1": 6330,
        "id2": 6331,
        "phenotype_comparison": ""
    },
    {
        "id1": 6346,
        "id2": 6347,
        "phenotype_comparison": "cyc-2.1 RNAi treatment extends lifespan in wild-type animals by 66%, whereas the mean lifespan extension is significantly decreased to 42% in the drp-1(tm1108) mutant."
    },
    {
        "id1": 6357,
        "id2": 6373,
        "phenotype_comparison": ""
    },
    {
        "id1": 6391,
        "id2": 6392,
        "phenotype_comparison": ""
    },
    {
        "id1": 6415,
        "id2": 6418,
        "phenotype_comparison": ""
    },
    {
        "id1": 6442,
        "id2": 6443,
        "phenotype_comparison": ""
    },
    {
        "id1": 6463,
        "id2": 6467,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6483,
        "phenotype_comparison": ""
    },
    {
        "id1": 6481,
        "id2": 6494,
        "phenotype_comparison": ""
    },
    {
        "id1": 6483,
        "id2": 6503,
        "phenotype_comparison": ""
    },
    {
        "id1": 6513,
        "id2": 6516,
        "phenotype_comparison": ""
    },
    {
        "id1": 6533,
        "id2": 6535,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6546,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6557,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6567,
        "phenotype_comparison": ""
    },
    {
        "id1": 5757,
        "id2": 5764,
        "phenotype_comparison": ""
    },
    {
        "id1": 6132,
        "id2": 6160,
        "phenotype_comparison": ""
    },
    {
        "id1": 4709,
        "id2": 4711,
        "phenotype_comparison": ""
    },
    {
        "id1": 5205,
        "id2": 5210,
        "phenotype_comparison": ""
    },
    {
        "id1": 6431,
        "id2": 6436,
        "phenotype_comparison": ""
    },
    {
        "id1": 6417,
        "id2": 6425,
        "phenotype_comparison": ""
    },
    {
        "id1": 6462,
        "id2": 6467,
        "phenotype_comparison": ""
    },
    {
        "id1": 6384,
        "id2": 6388,
        "phenotype_comparison": ""
    },
    {
        "id1": 6570,
        "id2": 651,
        "phenotype_comparison": ""
    },
    {
        "id1": 4600,
        "id2": 4603,
        "phenotype_comparison": ""
    },
    {
        "id1": 6403,
        "id2": 6411,
        "phenotype_comparison": ""
    },
    {
        "id1": 6458,
        "id2": 6463,
        "phenotype_comparison": ""
    },
    {
        "id1": 6377,
        "id2": 6389,
        "phenotype_comparison": ""
    },
    {
        "id1": 6579,
        "id2": 6576,
        "phenotype_comparison": ""
    },
    {
        "id1": 4295,
        "id2": 4296,
        "phenotype_comparison": "Vhl-1(ok161) animals are significantly longer-lived than wild type (N2) animals; vhl-1(ok161) hif-1(ia4) double mutant animals are not longer-lived than N2."
    },
    {
        "id1": 4321,
        "id2": 4322,
        "phenotype_comparison": "The daf-2(e1370) mutation extended the lifespan of daf-18(nr2037) animals at 25\u00b0C and restored lifespan to that found for wild type. These observations suggest that the lifespan-shortening phenotype caused by daf-18(nr2037) depends on the positive signal input from daf-2 gene activity. In addition, daf-18(nr2037) also completely suppressed the long-lived phenotype of daf-2(e1370)."
    },
    {
        "id1": 4343,
        "id2": 4344,
        "phenotype_comparison": ""
    },
    {
        "id1": 4385,
        "id2": 4386,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4418,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4444,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4472,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4499,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4525,
        "phenotype_comparison": ""
    },
    {
        "id1": 4550,
        "id2": 4551,
        "phenotype_comparison": "Inhibition of let-363 increased lifespan in both the N2 background and when ifg-1 was inhibited. These results could imply that lifespan extension by let-363 and ifg-1 involves different mechanisms."
    },
    {
        "id1": 4581,
        "id2": 4586,
        "phenotype_comparison": ""
    },
    {
        "id1": 4609,
        "id2": 4617,
        "phenotype_comparison": ""
    },
    {
        "id1": 4635,
        "id2": 4637,
        "phenotype_comparison": "Loss of O-GlcNAc modification, in the daf-2(e1370); ogt-1(ok1474) double mutant, reduces the extended lifespan of the daf-2(e1370) mutant."
    },
    {
        "id1": 4653,
        "id2": 4654,
        "phenotype_comparison": ""
    },
    {
        "id1": 4673,
        "id2": 4675,
        "phenotype_comparison": ""
    },
    {
        "id1": 4694,
        "id2": 4695,
        "phenotype_comparison": ""
    },
    {
        "id1": 4722,
        "id2": 4723,
        "phenotype_comparison": "The short life span of shc-1(ok198) was greatly increased by daf-2(e1368)."
    },
    {
        "id1": 4746,
        "id2": 4748,
        "phenotype_comparison": ""
    },
    {
        "id1": 4773,
        "id2": 4777,
        "phenotype_comparison": ""
    },
    {
        "id1": 4790,
        "id2": 4794,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4804,
        "id2": 4809,
        "phenotype_comparison": ""
    },
    {
        "id1": 4820,
        "id2": 4823,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4830,
        "id2": 4836,
        "phenotype_comparison": ""
    },
    {
        "id1": 4853,
        "id2": 4847,
        "phenotype_comparison": "Knocking down of ftt-2 alone did not substantially reduce hcf-1(pk924) lifespan."
    },
    {
        "id1": 4869,
        "id2": 4870,
        "phenotype_comparison": "A null mutation of ftt-2(n4426) was only able to slightly decrease the lifespan of hcf-1 mutants."
    },
    {
        "id1": 4893,
        "id2": 4895,
        "phenotype_comparison": ""
    },
    {
        "id1": 4915,
        "id2": 4916,
        "phenotype_comparison": "Knockdown of raga-1 extended the lifespan of kri-1 mutants, in which the GSC pathway is blocked."
    },
    {
        "id1": 4940,
        "id2": 4941,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (daf-15) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4959,
        "id2": 4960,
        "phenotype_comparison": "RNAi against ragc-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4980,
        "id2": 4982,
        "phenotype_comparison": ""
    },
    {
        "id1": 5007,
        "id2": 5008,
        "phenotype_comparison": "Knockdown of raga-1increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 5029,
        "id2": 5031,
        "phenotype_comparison": ""
    },
    {
        "id1": 5050,
        "id2": 5051,
        "phenotype_comparison": "RNAi of bec-1 shortened animal lifespan, and completely abolished the lifespan extension induced by frh-1 RNAi."
    },
    {
        "id1": 5061,
        "id2": 5067,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than cco-1 RNAi."
    },
    {
        "id1": 5059,
        "id2": 5081,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (kin-29) affected longevity induced by RNAi-mediated Mit mutants analyzed other than nuo-2 RNAi."
    },
    {
        "id1": 5100,
        "id2": 5102,
        "phenotype_comparison": ""
    },
    {
        "id1": 5135,
        "id2": 5137,
        "phenotype_comparison": ""
    },
    {
        "id1": 5158,
        "id2": 5159,
        "phenotype_comparison": ""
    },
    {
        "id1": 5173,
        "id2": 5181,
        "phenotype_comparison": ""
    },
    {
        "id1": 5166,
        "id2": 5201,
        "phenotype_comparison": ""
    },
    {
        "id1": 5224,
        "id2": 5225,
        "phenotype_comparison": ""
    },
    {
        "id1": 5233,
        "id2": 5243,
        "phenotype_comparison": "Reducing PQM-1 activity by mutation, shortens the lifespan of daf-2(?) animals substantially, by up to 45%."
    },
    {
        "id1": 5269,
        "id2": 5271,
        "phenotype_comparison": ""
    },
    {
        "id1": 5298,
        "id2": 5300,
        "phenotype_comparison": ""
    },
    {
        "id1": 5322,
        "id2": 5324,
        "phenotype_comparison": ""
    },
    {
        "id1": 5346,
        "id2": 5348,
        "phenotype_comparison": ""
    },
    {
        "id1": 5379,
        "id2": 5380,
        "phenotype_comparison": ""
    },
    {
        "id1": 5401,
        "id2": 5402,
        "phenotype_comparison": ""
    },
    {
        "id1": 5423,
        "id2": 5426,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5456,
        "id2": 5457,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5471,
        "id2": 5473,
        "phenotype_comparison": ""
    },
    {
        "id1": 5490,
        "id2": 5491,
        "phenotype_comparison": ""
    },
    {
        "id1": 5512,
        "id2": 5513,
        "phenotype_comparison": "At 20\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived 20\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 20\u00b0C."
    },
    {
        "id1": 5535,
        "id2": 5537,
        "phenotype_comparison": ""
    },
    {
        "id1": 5491,
        "id2": 5559,
        "phenotype_comparison": ""
    },
    {
        "id1": 5530,
        "id2": 5578,
        "phenotype_comparison": ""
    },
    {
        "id1": 5594,
        "id2": 5596,
        "phenotype_comparison": ""
    },
    {
        "id1": 5614,
        "id2": 5615,
        "phenotype_comparison": "Interestingly, the daf-2(e1370);hcf-1(ok559) double mutant lived considerably longer than either the daf-2(e1370) or hcf-1(ok559) single mutant."
    },
    {
        "id1": 5633,
        "id2": 5634,
        "phenotype_comparison": "We found that the glp-1(e2141);hcf-1(pk924) double mutant lived much longer than the glp-1(e2141) or hcf-1(pk924) single mutants at 25\u00b0C."
    },
    {
        "id1": 5657,
        "id2": 5658,
        "phenotype_comparison": "frh-1 RNAi increased lifespan on wild-type strains as well as on daf-16(mgDf50)."
    },
    {
        "id1": 5674,
        "id2": 5675,
        "phenotype_comparison": "Treatment of cep-1(gk138) mutant strain with undiluted cco-1 RNAi increased lifespan relative to wild-type animals fed with the same RNAi concentration."
    },
    {
        "id1": 5693,
        "id2": 5694,
        "phenotype_comparison": ""
    },
    {
        "id1": 5728,
        "id2": 5729,
        "phenotype_comparison": "sir-2.1(ok434) does not suppress the longevity of unc-64(e246)."
    },
    {
        "id1": 5753,
        "id2": 5754,
        "phenotype_comparison": "kri-1 RNAi did not shorten the life span of daf-2(e1370) mutants; instead, surprisingly, it increased lifespan by up to 23%."
    },
    {
        "id1": 5784,
        "id2": 5785,
        "phenotype_comparison": ""
    },
    {
        "id1": 5798,
        "id2": 5801,
        "phenotype_comparison": "Treating eat-2(ad1116) mutants with vps-34 RNAi on day-1 of adulthood significantly shortened their long lifespan, but not that of wild type."
    },
    {
        "id1": 5769,
        "id2": 5828,
        "phenotype_comparison": ""
    },
    {
        "id1": 5855,
        "id2": 5857,
        "phenotype_comparison": ""
    },
    {
        "id1": 5890,
        "id2": 5892,
        "phenotype_comparison": ""
    },
    {
        "id1": 5916,
        "id2": 5917,
        "phenotype_comparison": "daf-16(mu86) suppressed the long life span of tax-6(p675) mutant animals."
    },
    {
        "id1": 5943,
        "id2": 5944,
        "phenotype_comparison": ""
    },
    {
        "id1": 5963,
        "id2": 5967,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 5986,
        "phenotype_comparison": ""
    },
    {
        "id1": 6004,
        "id2": 6005,
        "phenotype_comparison": ""
    },
    {
        "id1": 6020,
        "id2": 6022,
        "phenotype_comparison": ""
    },
    {
        "id1": 6036,
        "id2": 5966,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) was able to extend the lifespan of fertile mes-1(bn7) worms (21%)."
    },
    {
        "id1": 6049,
        "id2": 6053,
        "phenotype_comparison": ""
    },
    {
        "id1": 6064,
        "id2": 6068,
        "phenotype_comparison": ""
    },
    {
        "id1": 5975,
        "id2": 6081,
        "phenotype_comparison": ""
    },
    {
        "id1": 6097,
        "id2": 6098,
        "phenotype_comparison": "RNAi inactivation of D2085.3 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6111,
        "id2": 6112,
        "phenotype_comparison": "RNAi inactivation of F22D6.3 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 4297,
        "id2": 4298,
        "phenotype_comparison": ""
    },
    {
        "id1": 4323,
        "id2": 4324,
        "phenotype_comparison": ""
    },
    {
        "id1": 4343,
        "id2": 4345,
        "phenotype_comparison": ""
    },
    {
        "id1": 4387,
        "id2": 4388,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4419,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4445,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4473,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4500,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4526,
        "phenotype_comparison": ""
    },
    {
        "id1": 4548,
        "id2": 4552,
        "phenotype_comparison": ""
    },
    {
        "id1": 4587,
        "id2": 4588,
        "phenotype_comparison": ""
    },
    {
        "id1": 4617,
        "id2": 4618,
        "phenotype_comparison": ""
    },
    {
        "id1": 4631,
        "id2": 4638,
        "phenotype_comparison": ""
    },
    {
        "id1": 4655,
        "id2": 4656,
        "phenotype_comparison": ""
    },
    {
        "id1": 4674,
        "id2": 4675,
        "phenotype_comparison": ""
    },
    {
        "id1": 4696,
        "id2": 4697,
        "phenotype_comparison": ""
    },
    {
        "id1": 4724,
        "id2": 4725,
        "phenotype_comparison": ""
    },
    {
        "id1": 4747,
        "id2": 4749,
        "phenotype_comparison": ""
    },
    {
        "id1": 4774,
        "id2": 4778,
        "phenotype_comparison": ""
    },
    {
        "id1": 4788,
        "id2": 4777,
        "phenotype_comparison": ""
    },
    {
        "id1": 4805,
        "id2": 4809,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4813,
        "id2": 4806,
        "phenotype_comparison": ""
    },
    {
        "id1": 4835,
        "id2": 4836,
        "phenotype_comparison": ""
    },
    {
        "id1": 4852,
        "id2": 4854,
        "phenotype_comparison": ""
    },
    {
        "id1": 4868,
        "id2": 4871,
        "phenotype_comparison": ""
    },
    {
        "id1": 4894,
        "id2": 4895,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (rheb-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4917,
        "id2": 4918,
        "phenotype_comparison": "Knockdown of eif-1 extended the lifespan of kri-1 mutants, in which the GSC pathway is blocked."
    },
    {
        "id1": 4942,
        "id2": 4943,
        "phenotype_comparison": ""
    },
    {
        "id1": 4961,
        "id2": 4962,
        "phenotype_comparison": ""
    },
    {
        "id1": 4983,
        "id2": 4985,
        "phenotype_comparison": ""
    },
    {
        "id1": 5009,
        "id2": 5010,
        "phenotype_comparison": ""
    },
    {
        "id1": 5030,
        "id2": 5031,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi."
    },
    {
        "id1": 5048,
        "id2": 5052,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5068,
        "phenotype_comparison": ""
    },
    {
        "id1": 5078,
        "id2": 5082,
        "phenotype_comparison": ""
    },
    {
        "id1": 5101,
        "id2": 5103,
        "phenotype_comparison": ""
    },
    {
        "id1": 5136,
        "id2": 5137,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was completely suppressed by hsf-1 RNA."
    },
    {
        "id1": 5158,
        "id2": 5160,
        "phenotype_comparison": ""
    },
    {
        "id1": 5174,
        "id2": 5182,
        "phenotype_comparison": ""
    },
    {
        "id1": 5200,
        "id2": 5201,
        "phenotype_comparison": "RNAi knockdown of hsp-70 did not decrease the lifespan of rsks-1(tm1714) mutants or the wild-type. Note that hsp-70 RNAi increased the lifespan of wild-type at 22.5 \u00b0C, while having no effects at 20 \u00b0C."
    },
    {
        "id1": 5224,
        "id2": 5226,
        "phenotype_comparison": ""
    },
    {
        "id1": 5244,
        "id2": 5245,
        "phenotype_comparison": ""
    },
    {
        "id1": 5270,
        "id2": 5271,
        "phenotype_comparison": "Longevity extension by ifg-1(eIF4F) RNAi was not substantially decreased by skn-1 mutation."
    },
    {
        "id1": 5299,
        "id2": 5300,
        "phenotype_comparison": "daf-2(RNAi); ets-4(ok165) animals lived longer than either ets-4(ok165) or daf-2(RNAi) worms alone."
    },
    {
        "id1": 5325,
        "id2": 5326,
        "phenotype_comparison": ""
    },
    {
        "id1": 5347,
        "id2": 5349,
        "phenotype_comparison": ""
    },
    {
        "id1": 5379,
        "id2": 5381,
        "phenotype_comparison": ""
    },
    {
        "id1": 5399,
        "id2": 5402,
        "phenotype_comparison": ""
    },
    {
        "id1": 5427,
        "id2": 5428,
        "phenotype_comparison": ""
    },
    {
        "id1": 5455,
        "id2": 5458,
        "phenotype_comparison": ""
    },
    {
        "id1": 5472,
        "id2": 5473,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5490,
        "id2": 5492,
        "phenotype_comparison": ""
    },
    {
        "id1": 5514,
        "id2": 5515,
        "phenotype_comparison": ""
    },
    {
        "id1": 5536,
        "id2": 5537,
        "phenotype_comparison": "At 20\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived 20\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 20\u00b0C."
    },
    {
        "id1": 5558,
        "id2": 5559,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 25\u00b0C."
    },
    {
        "id1": 5531,
        "id2": 5579,
        "phenotype_comparison": ""
    },
    {
        "id1": 5595,
        "id2": 5597,
        "phenotype_comparison": ""
    },
    {
        "id1": 5616,
        "id2": 5617,
        "phenotype_comparison": ""
    },
    {
        "id1": 5635,
        "id2": 5636,
        "phenotype_comparison": ""
    },
    {
        "id1": 5651,
        "id2": 5659,
        "phenotype_comparison": ""
    },
    {
        "id1": 5647,
        "id2": 5676,
        "phenotype_comparison": ""
    },
    {
        "id1": 5695,
        "id2": 5696,
        "phenotype_comparison": ""
    },
    {
        "id1": 5730,
        "id2": 5731,
        "phenotype_comparison": ""
    },
    {
        "id1": 5755,
        "id2": 5757,
        "phenotype_comparison": ""
    },
    {
        "id1": 5771,
        "id2": 5785,
        "phenotype_comparison": "Both of two different bec-1 RNAi clones shortened the mean lifespan of eat-2(ad1116) mutants by ~15\u201330%, but did not shorten wild-type lifespan."
    },
    {
        "id1": 5790,
        "id2": 5802,
        "phenotype_comparison": ""
    },
    {
        "id1": 5769,
        "id2": 5829,
        "phenotype_comparison": ""
    },
    {
        "id1": 5858,
        "id2": 5859,
        "phenotype_comparison": ""
    },
    {
        "id1": 5893,
        "id2": 5895,
        "phenotype_comparison": ""
    },
    {
        "id1": 5918,
        "id2": 5919,
        "phenotype_comparison": ""
    },
    {
        "id1": 5945,
        "id2": 5946,
        "phenotype_comparison": "Deletion of gpdh-1(ok1558) and gpdh-2(ok1733) markedly increased the already long lifespan of daf-2(e1370) worms and also increased the lifespan of WT worms."
    },
    {
        "id1": 5967,
        "id2": 5968,
        "phenotype_comparison": ""
    },
    {
        "id1": 5985,
        "id2": 5987,
        "phenotype_comparison": ""
    },
    {
        "id1": 6004,
        "id2": 6002,
        "phenotype_comparison": ""
    },
    {
        "id1": 6021,
        "id2": 6022,
        "phenotype_comparison": "Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms."
    },
    {
        "id1": 6034,
        "id2": 6037,
        "phenotype_comparison": ""
    },
    {
        "id1": 6053,
        "id2": 6054,
        "phenotype_comparison": ""
    },
    {
        "id1": 6067,
        "id2": 6068,
        "phenotype_comparison": "KRI-1 contributes to cdk-2(RNAi) longevity. Survival of cdk-2(RNAi) worms was substantially reduced by kri-1(ok1251) mutation."
    },
    {
        "id1": 6080,
        "id2": 6082,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6099,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6113,
        "phenotype_comparison": ""
    },
    {
        "id1": 6125,
        "id2": 6126,
        "phenotype_comparison": "RNAi inactivation of K01C8.6 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6094,
        "id2": 6140,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6160,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6173,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6183,
        "phenotype_comparison": ""
    },
    {
        "id1": 6197,
        "id2": 6198,
        "phenotype_comparison": ""
    },
    {
        "id1": 6212,
        "id2": 6213,
        "phenotype_comparison": ""
    },
    {
        "id1": 6216,
        "id2": 6231,
        "phenotype_comparison": ""
    },
    {
        "id1": 6249,
        "id2": 6250,
        "phenotype_comparison": ""
    },
    {
        "id1": 6266,
        "id2": 6270,
        "phenotype_comparison": ""
    },
    {
        "id1": 6281,
        "id2": 6285,
        "phenotype_comparison": ""
    },
    {
        "id1": 6299,
        "id2": 6300,
        "phenotype_comparison": ""
    },
    {
        "id1": 6312,
        "id2": 6313,
        "phenotype_comparison": ""
    },
    {
        "id1": 6316,
        "id2": 6332,
        "phenotype_comparison": ""
    },
    {
        "id1": 6348,
        "id2": 6349,
        "phenotype_comparison": ""
    },
    {
        "id1": 6360,
        "id2": 6374,
        "phenotype_comparison": ""
    },
    {
        "id1": 6393,
        "id2": 6394,
        "phenotype_comparison": ""
    },
    {
        "id1": 6419,
        "id2": 6420,
        "phenotype_comparison": ""
    },
    {
        "id1": 6442,
        "id2": 6444,
        "phenotype_comparison": ""
    },
    {
        "id1": 6468,
        "id2": 6469,
        "phenotype_comparison": ""
    },
    {
        "id1": 6474,
        "id2": 6484,
        "phenotype_comparison": ""
    },
    {
        "id1": 6491,
        "id2": 6495,
        "phenotype_comparison": ""
    },
    {
        "id1": 6499,
        "id2": 6504,
        "phenotype_comparison": ""
    },
    {
        "id1": 6517,
        "id2": 6518,
        "phenotype_comparison": ""
    },
    {
        "id1": 5261,
        "id2": 5263,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6547,
        "phenotype_comparison": ""
    },
    {
        "id1": 6556,
        "id2": 6557,
        "phenotype_comparison": "RNAi inactivation of a B0261.4 gene, key to mitochondrial function, markedly extended C. elegans lifespan onboth daf-16 (mgDf47) and wild type."
    },
    {
        "id1": 6566,
        "id2": 6567,
        "phenotype_comparison": "RNAi inactivation of a F57B10.3 gene, key to mitochondrial function, did not extend C. elegans lifespan in wild type."
    },
    {
        "id1": 6130,
        "id2": 6159,
        "phenotype_comparison": ""
    },
    {
        "id1": 6134,
        "id2": 6161,
        "phenotype_comparison": ""
    },
    {
        "id1": 4726,
        "id2": 4727,
        "phenotype_comparison": ""
    },
    {
        "id1": 6543,
        "id2": 5211,
        "phenotype_comparison": ""
    },
    {
        "id1": 6431,
        "id2": 6441,
        "phenotype_comparison": ""
    },
    {
        "id1": 6418,
        "id2": 6426,
        "phenotype_comparison": ""
    },
    {
        "id1": 6459,
        "id2": 6469,
        "phenotype_comparison": ""
    },
    {
        "id1": 6382,
        "id2": 6390,
        "phenotype_comparison": ""
    },
    {
        "id1": 6569,
        "id2": 665,
        "phenotype_comparison": ""
    },
    {
        "id1": 4597,
        "id2": 4604,
        "phenotype_comparison": ""
    },
    {
        "id1": 6415,
        "id2": 6419,
        "phenotype_comparison": ""
    },
    {
        "id1": 6574,
        "id2": 4265,
        "phenotype_comparison": ""
    },
    {
        "id1": 6385,
        "id2": 6389,
        "phenotype_comparison": ""
    },
    {
        "id1": 6579,
        "id2": 6577,
        "phenotype_comparison": ""
    },
    {
        "id1": 6583,
        "id2": 6584,
        "phenotype_comparison": "In adult females, the extension of life span mediated by D-NAAM overexpression is completely abolished if the Sir2 gene is mutated."
    },
    {
        "id1": 4297,
        "id2": 4299,
        "phenotype_comparison": ""
    },
    {
        "id1": 4323,
        "id2": 4325,
        "phenotype_comparison": ""
    },
    {
        "id1": 4344,
        "id2": 4346,
        "phenotype_comparison": ""
    },
    {
        "id1": 4389,
        "id2": 4390,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4420,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4447,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4474,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4501,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4527,
        "phenotype_comparison": ""
    },
    {
        "id1": 4552,
        "id2": 4553,
        "phenotype_comparison": ""
    },
    {
        "id1": 4588,
        "id2": 4589,
        "phenotype_comparison": ""
    },
    {
        "id1": 4615,
        "id2": 4619,
        "phenotype_comparison": ""
    },
    {
        "id1": 4632,
        "id2": 4639,
        "phenotype_comparison": ""
    },
    {
        "id1": 4655,
        "id2": 4657,
        "phenotype_comparison": ""
    },
    {
        "id1": 4652,
        "id2": 4676,
        "phenotype_comparison": ""
    },
    {
        "id1": 4696,
        "id2": 4698,
        "phenotype_comparison": ""
    },
    {
        "id1": 4724,
        "id2": 4726,
        "phenotype_comparison": ""
    },
    {
        "id1": 4748,
        "id2": 4749,
        "phenotype_comparison": "RNAi inactivation of mpk-1 shortened the life span of germ line-defective glp-4(bn2ts) worms, indicating that the MPK-1 cascade functions to extend life span in C. elegans, independently of its role in germ line development."
    },
    {
        "id1": 4777,
        "id2": 4778,
        "phenotype_comparison": "hcf-1(pk924) mutant worms displayed a mean lifespan >20% longer than that of wild type and the hcf-1(pk924) long-lived phenotype was fully suppressed by daf-16(mgDf47) mutation."
    },
    {
        "id1": 4789,
        "id2": 4795,
        "phenotype_comparison": ""
    },
    {
        "id1": 4804,
        "id2": 4810,
        "phenotype_comparison": ""
    },
    {
        "id1": 4820,
        "id2": 4806,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4829,
        "id2": 4837,
        "phenotype_comparison": ""
    },
    {
        "id1": 4854,
        "id2": 4855,
        "phenotype_comparison": ""
    },
    {
        "id1": 4869,
        "id2": 4871,
        "phenotype_comparison": "A null mutation of ftt-2(n4426) was only able to slightly decrease the lifespan of hcf-1 mutants."
    },
    {
        "id1": 4892,
        "id2": 4896,
        "phenotype_comparison": ""
    },
    {
        "id1": 4919,
        "id2": 4920,
        "phenotype_comparison": ""
    },
    {
        "id1": 4942,
        "id2": 4944,
        "phenotype_comparison": ""
    },
    {
        "id1": 4961,
        "id2": 4963,
        "phenotype_comparison": ""
    },
    {
        "id1": 4984,
        "id2": 4986,
        "phenotype_comparison": ""
    },
    {
        "id1": 5009,
        "id2": 5011,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5032,
        "phenotype_comparison": ""
    },
    {
        "id1": 5052,
        "id2": 5053,
        "phenotype_comparison": ""
    },
    {
        "id1": 5068,
        "id2": 5069,
        "phenotype_comparison": ""
    },
    {
        "id1": 5061,
        "id2": 5082,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (kin-29) affected longevity induced by RNAi-mediated Mit mutants analyzed other than cco-1 RNAi."
    },
    {
        "id1": 5102,
        "id2": 5103,
        "phenotype_comparison": "The aak-2(ok524) null allele fully suppressed rsks-1 mutant longevity. This effect is likely to be specific since several other modes of C. elegans longevity are not aak-2 dependent."
    },
    {
        "id1": 5138,
        "id2": 5139,
        "phenotype_comparison": ""
    },
    {
        "id1": 5159,
        "id2": 5161,
        "phenotype_comparison": ""
    },
    {
        "id1": 5181,
        "id2": 5182,
        "phenotype_comparison": "hsf-1(sy441) mutation suppressed the prolonged lifespan caused by RNAi targeting ragc-1/RagGTPase."
    },
    {
        "id1": 5169,
        "id2": 5202,
        "phenotype_comparison": ""
    },
    {
        "id1": 5225,
        "id2": 5227,
        "phenotype_comparison": ""
    },
    {
        "id1": 5246,
        "id2": 5247,
        "phenotype_comparison": ""
    },
    {
        "id1": 5272,
        "id2": 5273,
        "phenotype_comparison": ""
    },
    {
        "id1": 5301,
        "id2": 5302,
        "phenotype_comparison": "RNAi against the kinases akt-1/akt-2 further extended the life span of the long-lived ets-4(ok165) worms."
    },
    {
        "id1": 5325,
        "id2": 5327,
        "phenotype_comparison": ""
    },
    {
        "id1": 5348,
        "id2": 5349,
        "phenotype_comparison": "aakg-4 reduced lifespan in a daf-2(m577) background."
    },
    {
        "id1": 5382,
        "id2": 5383,
        "phenotype_comparison": ""
    },
    {
        "id1": 5396,
        "id2": 5403,
        "phenotype_comparison": ""
    },
    {
        "id1": 5429,
        "id2": 5430,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5456,
        "id2": 5458,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5471,
        "id2": 5474,
        "phenotype_comparison": ""
    },
    {
        "id1": 5491,
        "id2": 5493,
        "phenotype_comparison": ""
    },
    {
        "id1": 5514,
        "id2": 5516,
        "phenotype_comparison": ""
    },
    {
        "id1": 5538,
        "id2": 5539,
        "phenotype_comparison": ""
    },
    {
        "id1": 5560,
        "id2": 5561,
        "phenotype_comparison": ""
    },
    {
        "id1": 5578,
        "id2": 5579,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 20\u00b0C."
    },
    {
        "id1": 5596,
        "id2": 5597,
        "phenotype_comparison": "The ftt-2 RNAi knock down worms had a much shorter adult lifespan compared to the control RNAi worms. Interestingly, ftt-2 RNAi did not appear to affect the extended lifespan phenotype of daf-2(e1370) worms."
    },
    {
        "id1": 5616,
        "id2": 5618,
        "phenotype_comparison": ""
    },
    {
        "id1": 5637,
        "id2": 5638,
        "phenotype_comparison": ""
    },
    {
        "id1": 5651,
        "id2": 5660,
        "phenotype_comparison": ""
    },
    {
        "id1": 5647,
        "id2": 5677,
        "phenotype_comparison": ""
    },
    {
        "id1": 5697,
        "id2": 5698,
        "phenotype_comparison": ""
    },
    {
        "id1": 5731,
        "id2": 5732,
        "phenotype_comparison": ""
    },
    {
        "id1": 5756,
        "id2": 5757,
        "phenotype_comparison": "daf-16 RNAi did shorten the life span of daf-2(e1370) mutants."
    },
    {
        "id1": 5773,
        "id2": 5786,
        "phenotype_comparison": ""
    },
    {
        "id1": 5798,
        "id2": 5802,
        "phenotype_comparison": "Treating eat-2(ad1116) mutants with vps-34 RNAi on day-1 of adulthood significantly shortened their long lifespan, but not that of wild type."
    },
    {
        "id1": 5828,
        "id2": 5830,
        "phenotype_comparison": ""
    },
    {
        "id1": 5860,
        "id2": 5861,
        "phenotype_comparison": ""
    },
    {
        "id1": 5894,
        "id2": 5896,
        "phenotype_comparison": ""
    },
    {
        "id1": 5918,
        "id2": 5920,
        "phenotype_comparison": ""
    },
    {
        "id1": 5947,
        "id2": 5948,
        "phenotype_comparison": ""
    },
    {
        "id1": 5965,
        "id2": 5968,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) was not able to extend the lifespan of sterile mes-1(bn7) animals."
    },
    {
        "id1": 5986,
        "id2": 5987,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) in daf-2(e1370) mutants further increased their longevity indicating that cell cycle genes act in the DAF-16-dependent germline longevity pathway but not in the insulin signaling pathway."
    },
    {
        "id1": 6005,
        "id2": 6006,
        "phenotype_comparison": ""
    },
    {
        "id1": 5963,
        "id2": 6023,
        "phenotype_comparison": ""
    },
    {
        "id1": 6037,
        "id2": 6038,
        "phenotype_comparison": ""
    },
    {
        "id1": 6051,
        "id2": 6054,
        "phenotype_comparison": "The pro-longevity effect of cye-1 was essentially prevented by mutation of skn-1(zu67)."
    },
    {
        "id1": 5959,
        "id2": 5985,
        "phenotype_comparison": ""
    },
    {
        "id1": 6081,
        "id2": 6082,
        "phenotype_comparison": "The longevity of cye-1(RNAi) was suppressed by daf-16(mu86) mutation."
    },
    {
        "id1": 6094,
        "id2": 6100,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6114,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6127,
        "phenotype_comparison": ""
    },
    {
        "id1": 6139,
        "id2": 6140,
        "phenotype_comparison": "RNAi inactivation of B0491.5 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6141,
        "id2": 6161,
        "phenotype_comparison": ""
    },
    {
        "id1": 6109,
        "id2": 6173,
        "phenotype_comparison": "RNAi inactivation of C47D12.6 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6129,
        "id2": 6183,
        "phenotype_comparison": "RNAi inactivation of B0511.8 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6197,
        "id2": 6199,
        "phenotype_comparison": ""
    },
    {
        "id1": 6212,
        "id2": 6214,
        "phenotype_comparison": ""
    },
    {
        "id1": 6216,
        "id2": 6232,
        "phenotype_comparison": ""
    },
    {
        "id1": 6247,
        "id2": 6251,
        "phenotype_comparison": ""
    },
    {
        "id1": 6270,
        "id2": 6271,
        "phenotype_comparison": ""
    },
    {
        "id1": 6285,
        "id2": 6286,
        "phenotype_comparison": ""
    },
    {
        "id1": 6294,
        "id2": 6300,
        "phenotype_comparison": ""
    },
    {
        "id1": 6312,
        "id2": 6314,
        "phenotype_comparison": ""
    },
    {
        "id1": 6332,
        "id2": 6333,
        "phenotype_comparison": ""
    },
    {
        "id1": 6348,
        "id2": 6350,
        "phenotype_comparison": ""
    },
    {
        "id1": 6361,
        "id2": 6375,
        "phenotype_comparison": ""
    },
    {
        "id1": 6395,
        "id2": 6396,
        "phenotype_comparison": ""
    },
    {
        "id1": 6419,
        "id2": 6421,
        "phenotype_comparison": ""
    },
    {
        "id1": 6442,
        "id2": 6445,
        "phenotype_comparison": ""
    },
    {
        "id1": 6468,
        "id2": 6470,
        "phenotype_comparison": ""
    },
    {
        "id1": 6483,
        "id2": 6484,
        "phenotype_comparison": ""
    },
    {
        "id1": 6483,
        "id2": 6495,
        "phenotype_comparison": ""
    },
    {
        "id1": 6485,
        "id2": 6504,
        "phenotype_comparison": ""
    },
    {
        "id1": 6517,
        "id2": 6519,
        "phenotype_comparison": ""
    },
    {
        "id1": 6536,
        "id2": 5204,
        "phenotype_comparison": ""
    },
    {
        "id1": 6546,
        "id2": 6547,
        "phenotype_comparison": "RNAi inactivation of a D2030.4 gene, key to mitochondrial function, markedly extended C. elegans lifespan on both daf-16 (mgDf47) and wild type."
    },
    {
        "id1": 6544,
        "id2": 6558,
        "phenotype_comparison": ""
    },
    {
        "id1": 4415,
        "id2": 4398,
        "phenotype_comparison": ""
    },
    {
        "id1": 6096,
        "id2": 6142,
        "phenotype_comparison": ""
    },
    {
        "id1": 6136,
        "id2": 6162,
        "phenotype_comparison": ""
    },
    {
        "id1": 5290,
        "id2": 5292,
        "phenotype_comparison": ""
    },
    {
        "id1": 5207,
        "id2": 5211,
        "phenotype_comparison": ""
    },
    {
        "id1": 6447,
        "id2": 6451,
        "phenotype_comparison": ""
    },
    {
        "id1": 6428,
        "id2": 6433,
        "phenotype_comparison": ""
    },
    {
        "id1": 6460,
        "id2": 6470,
        "phenotype_comparison": ""
    },
    {
        "id1": 4298,
        "id2": 4300,
        "phenotype_comparison": ""
    },
    {
        "id1": 4324,
        "id2": 4326,
        "phenotype_comparison": ""
    },
    {
        "id1": 4345,
        "id2": 4346,
        "phenotype_comparison": "Knockdown of daf-16 resulted in an de creased lifespan in the wild-type N2 worms. Downregulation of daf-16 did not abrogate the life-extending effect of vhl-1 deletion, indicating that pVHL acts in a pathway distinct from insulin-FOXO signaling."
    },
    {
        "id1": 4391,
        "id2": 4392,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4421,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4448,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4475,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4502,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4528,
        "phenotype_comparison": ""
    },
    {
        "id1": 4552,
        "id2": 4554,
        "phenotype_comparison": ""
    },
    {
        "id1": 4590,
        "id2": 4591,
        "phenotype_comparison": ""
    },
    {
        "id1": 4612,
        "id2": 4619,
        "phenotype_comparison": "Inactivation of cup-4 had no effect on life span of nlp-7(tm2990) mutants."
    },
    {
        "id1": 4638,
        "id2": 4639,
        "phenotype_comparison": "Lifespan extension in the oga-1 mutant is DAF-16-dependent, as seen in the reduced lifespan of the oga-1(ok1207); daf-16(mu86) double mutant relative to the oga-1(ok1207) single mutant."
    },
    {
        "id1": 4656,
        "id2": 4658,
        "phenotype_comparison": ""
    },
    {
        "id1": 4677,
        "id2": 4678,
        "phenotype_comparison": ""
    },
    {
        "id1": 4697,
        "id2": 4699,
        "phenotype_comparison": ""
    },
    {
        "id1": 4725,
        "id2": 4727,
        "phenotype_comparison": ""
    },
    {
        "id1": 4750,
        "id2": 4751,
        "phenotype_comparison": ""
    },
    {
        "id1": 4779,
        "id2": 4780,
        "phenotype_comparison": ""
    },
    {
        "id1": 4777,
        "id2": 4795,
        "phenotype_comparison": "hcf-1(pk924) mutant worms displayed a mean lifespan >20% longer than that of wild type and the hcf-1(pk924) long-lived phenotype was fully suppressed by daf-16(mgDf47) mutation."
    },
    {
        "id1": 4805,
        "id2": 4810,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4820,
        "id2": 4824,
        "phenotype_comparison": ""
    },
    {
        "id1": 4829,
        "id2": 4838,
        "phenotype_comparison": ""
    },
    {
        "id1": 4853,
        "id2": 4855,
        "phenotype_comparison": ""
    },
    {
        "id1": 4872,
        "id2": 4873,
        "phenotype_comparison": ""
    },
    {
        "id1": 4896,
        "id2": 4897,
        "phenotype_comparison": ""
    },
    {
        "id1": 4921,
        "id2": 4922,
        "phenotype_comparison": ""
    },
    {
        "id1": 4943,
        "id2": 4945,
        "phenotype_comparison": ""
    },
    {
        "id1": 4962,
        "id2": 4964,
        "phenotype_comparison": ""
    },
    {
        "id1": 4884,
        "id2": 4987,
        "phenotype_comparison": ""
    },
    {
        "id1": 5010,
        "id2": 5012,
        "phenotype_comparison": ""
    },
    {
        "id1": 5032,
        "id2": 5033,
        "phenotype_comparison": ""
    },
    {
        "id1": 5049,
        "id2": 5053,
        "phenotype_comparison": "Genetic suppression of bec-1 shortened animal lifespan, and completely abolished the lifespan extension induced by frh-1 RNAi."
    },
    {
        "id1": 5055,
        "id2": 5069,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5083,
        "phenotype_comparison": ""
    },
    {
        "id1": 5104,
        "id2": 5105,
        "phenotype_comparison": ""
    },
    {
        "id1": 5138,
        "id2": 5140,
        "phenotype_comparison": ""
    },
    {
        "id1": 5160,
        "id2": 5161,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was suppressed by aak-2(ok524) mutation."
    },
    {
        "id1": 5177,
        "id2": 5183,
        "phenotype_comparison": ""
    },
    {
        "id1": 5170,
        "id2": 5203,
        "phenotype_comparison": ""
    },
    {
        "id1": 5226,
        "id2": 5227,
        "phenotype_comparison": "daf-16 RNAi treatment for whole life shortened the lifespan of bothrsks-1(tm1714) and wild type animals."
    },
    {
        "id1": 5248,
        "id2": 5249,
        "phenotype_comparison": ""
    },
    {
        "id1": 5272,
        "id2": 5274,
        "phenotype_comparison": ""
    },
    {
        "id1": 5303,
        "id2": 5304,
        "phenotype_comparison": ""
    },
    {
        "id1": 5328,
        "id2": 5329,
        "phenotype_comparison": ""
    },
    {
        "id1": 5350,
        "id2": 5351,
        "phenotype_comparison": ""
    },
    {
        "id1": 5384,
        "id2": 5385,
        "phenotype_comparison": ""
    },
    {
        "id1": 5401,
        "id2": 5403,
        "phenotype_comparison": ""
    },
    {
        "id1": 5429,
        "id2": 5431,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5455,
        "id2": 5459,
        "phenotype_comparison": ""
    },
    {
        "id1": 5472,
        "id2": 5474,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5492,
        "id2": 5493,
        "phenotype_comparison": "The hif-1(ia4) animals lived significantly longer than N2 animals at 25\u00b0C. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 25\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 25\u00b0C."
    },
    {
        "id1": 5515,
        "id2": 5517,
        "phenotype_comparison": ""
    },
    {
        "id1": 5538,
        "id2": 5540,
        "phenotype_comparison": ""
    },
    {
        "id1": 5560,
        "id2": 5562,
        "phenotype_comparison": ""
    },
    {
        "id1": 5580,
        "id2": 5581,
        "phenotype_comparison": ""
    },
    {
        "id1": 5594,
        "id2": 5598,
        "phenotype_comparison": ""
    },
    {
        "id1": 5617,
        "id2": 5619,
        "phenotype_comparison": ""
    },
    {
        "id1": 5639,
        "id2": 5640,
        "phenotype_comparison": ""
    },
    {
        "id1": 5659,
        "id2": 5661,
        "phenotype_comparison": ""
    },
    {
        "id1": 5676,
        "id2": 5678,
        "phenotype_comparison": ""
    },
    {
        "id1": 5699,
        "id2": 5700,
        "phenotype_comparison": ""
    },
    {
        "id1": 5730,
        "id2": 5733,
        "phenotype_comparison": ""
    },
    {
        "id1": 5755,
        "id2": 5759,
        "phenotype_comparison": ""
    },
    {
        "id1": 5773,
        "id2": 5787,
        "phenotype_comparison": ""
    },
    {
        "id1": 5803,
        "id2": 5804,
        "phenotype_comparison": ""
    },
    {
        "id1": 5829,
        "id2": 5830,
        "phenotype_comparison": ""
    },
    {
        "id1": 5862,
        "id2": 5863,
        "phenotype_comparison": ""
    },
    {
        "id1": 5897,
        "id2": 5898,
        "phenotype_comparison": ""
    },
    {
        "id1": 5918,
        "id2": 5921,
        "phenotype_comparison": ""
    },
    {
        "id1": 5947,
        "id2": 5949,
        "phenotype_comparison": ""
    },
    {
        "id1": 5969,
        "id2": 5970,
        "phenotype_comparison": ""
    },
    {
        "id1": 5988,
        "id2": 5989,
        "phenotype_comparison": ""
    },
    {
        "id1": 6002,
        "id2": 6006,
        "phenotype_comparison": "cdk-2(RNAi) fails to extend lifespan in the skn-1(zu67) mutant."
    },
    {
        "id1": 6020,
        "id2": 6024,
        "phenotype_comparison": ""
    },
    {
        "id1": 6036,
        "id2": 6038,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) was not able to extend the lifespan of sterile mes-1(bn7) animals."
    },
    {
        "id1": 5995,
        "id2": 6055,
        "phenotype_comparison": ""
    },
    {
        "id1": 5959,
        "id2": 6069,
        "phenotype_comparison": ""
    },
    {
        "id1": 5963,
        "id2": 6083,
        "phenotype_comparison": ""
    },
    {
        "id1": 6099,
        "id2": 6100,
        "phenotype_comparison": "RNAi inactivation of D2013.7 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6113,
        "id2": 6114,
        "phenotype_comparison": "RNAi inactivation of C48E7.2 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6094,
        "id2": 6128,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6142,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6162,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6174,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6184,
        "phenotype_comparison": ""
    },
    {
        "id1": 6198,
        "id2": 6200,
        "phenotype_comparison": ""
    },
    {
        "id1": 6213,
        "id2": 6215,
        "phenotype_comparison": ""
    },
    {
        "id1": 6231,
        "id2": 6233,
        "phenotype_comparison": ""
    },
    {
        "id1": 6247,
        "id2": 6252,
        "phenotype_comparison": ""
    },
    {
        "id1": 6268,
        "id2": 6271,
        "phenotype_comparison": "The mean life-span of clk-1(qm30) clk-2(qm37) mutants is more than 50% greater than that of either clk-l (e2519) or clk-2(qm37) alone and almost 90% greater than that of the wild type."
    },
    {
        "id1": 6283,
        "id2": 6286,
        "phenotype_comparison": ""
    },
    {
        "id1": 6299,
        "id2": 6301,
        "phenotype_comparison": ""
    },
    {
        "id1": 6313,
        "id2": 6315,
        "phenotype_comparison": ""
    },
    {
        "id1": 6318,
        "id2": 6333,
        "phenotype_comparison": "The cyc-2.1 RNAi-induced longevity phenotype is suppressed by a deletion mutant of atfs-1(gk3094)."
    },
    {
        "id1": 6349,
        "id2": 6351,
        "phenotype_comparison": ""
    },
    {
        "id1": 6376,
        "id2": 6377,
        "phenotype_comparison": ""
    },
    {
        "id1": 6395,
        "id2": 6397,
        "phenotype_comparison": ""
    },
    {
        "id1": 6419,
        "id2": 6422,
        "phenotype_comparison": ""
    },
    {
        "id1": 6446,
        "id2": 6447,
        "phenotype_comparison": ""
    },
    {
        "id1": 6468,
        "id2": 6471,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6485,
        "phenotype_comparison": ""
    },
    {
        "id1": 6491,
        "id2": 6496,
        "phenotype_comparison": ""
    },
    {
        "id1": 6499,
        "id2": 6505,
        "phenotype_comparison": ""
    },
    {
        "id1": 6518,
        "id2": 6520,
        "phenotype_comparison": ""
    },
    {
        "id1": 6536,
        "id2": 6537,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6548,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6559,
        "phenotype_comparison": ""
    },
    {
        "id1": 4397,
        "id2": 4398,
        "phenotype_comparison": ""
    },
    {
        "id1": 6098,
        "id2": 6143,
        "phenotype_comparison": ""
    },
    {
        "id1": 6138,
        "id2": 6163,
        "phenotype_comparison": ""
    },
    {
        "id1": 5285,
        "id2": 5287,
        "phenotype_comparison": ""
    },
    {
        "id1": 5216,
        "id2": 5218,
        "phenotype_comparison": ""
    },
    {
        "id1": 6447,
        "id2": 6455,
        "phenotype_comparison": ""
    },
    {
        "id1": 6429,
        "id2": 6439,
        "phenotype_comparison": ""
    },
    {
        "id1": 6461,
        "id2": 6471,
        "phenotype_comparison": ""
    },
    {
        "id1": 6386,
        "id2": 6390,
        "phenotype_comparison": ""
    },
    {
        "id1": 6570,
        "id2": 666,
        "phenotype_comparison": ""
    },
    {
        "id1": 4600,
        "id2": 4605,
        "phenotype_comparison": ""
    },
    {
        "id1": 6415,
        "id2": 6423,
        "phenotype_comparison": ""
    },
    {
        "id1": 6317,
        "id2": 6328,
        "phenotype_comparison": ""
    },
    {
        "id1": 6575,
        "id2": 6576,
        "phenotype_comparison": ""
    },
    {
        "id1": 6576,
        "id2": 6580,
        "phenotype_comparison": ""
    },
    {
        "id1": 6585,
        "id2": 6586,
        "phenotype_comparison": ""
    },
    {
        "id1": 6590,
        "id2": 6592,
        "phenotype_comparison": ""
    },
    {
        "id1": 6594,
        "id2": 6596,
        "phenotype_comparison": ""
    },
    {
        "id1": 6593,
        "id2": 6597,
        "phenotype_comparison": ""
    },
    {
        "id1": 4299,
        "id2": 4300,
        "phenotype_comparison": "Hif-1(RNAi) does not significantly alter the lifespan extension of eat-2(ad465) animals."
    },
    {
        "id1": 4325,
        "id2": 4326,
        "phenotype_comparison": "The daf-2(e1370) mutation extended the lifespan of daf-18(nr2037) animals at 20\u00b0C and restored lifespan to that found for wild type. These observations suggest that the lifespan-shortening phenotype caused by daf-18(nr2037) depends on the positive signal input from daf-2 gene activity. In addition, daf-18(nr2037) also completely suppressed the long-lived phenotype of daf-2(e1370)."
    },
    {
        "id1": 4343,
        "id2": 4347,
        "phenotype_comparison": ""
    },
    {
        "id1": 4393,
        "id2": 4394,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4422,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4449,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4476,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4503,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4529,
        "phenotype_comparison": ""
    },
    {
        "id1": 4555,
        "id2": 4556,
        "phenotype_comparison": ""
    },
    {
        "id1": 4591,
        "id2": 4589,
        "phenotype_comparison": ""
    },
    {
        "id1": 4617,
        "id2": 4620,
        "phenotype_comparison": ""
    },
    {
        "id1": 4633,
        "id2": 4640,
        "phenotype_comparison": ""
    },
    {
        "id1": 4657,
        "id2": 4658,
        "phenotype_comparison": "nhr-49 mutation had no impact on the extended lifespan of daf-2(e1368) mutants in two of three independent trials and caused a small suppression in longevity in the third."
    },
    {
        "id1": 4677,
        "id2": 4679,
        "phenotype_comparison": ""
    },
    {
        "id1": 4698,
        "id2": 4699,
        "phenotype_comparison": "Loss of both osm-9 and ocr-2 resulted in a robust extension of lifespan up to 32% compared to control animals."
    },
    {
        "id1": 4716,
        "id2": 4728,
        "phenotype_comparison": ""
    },
    {
        "id1": 4752,
        "id2": 4753,
        "phenotype_comparison": ""
    },
    {
        "id1": 4779,
        "id2": 4781,
        "phenotype_comparison": ""
    },
    {
        "id1": 4767,
        "id2": 4796,
        "phenotype_comparison": ""
    },
    {
        "id1": 4805,
        "id2": 4811,
        "phenotype_comparison": ""
    },
    {
        "id1": 4812,
        "id2": 4825,
        "phenotype_comparison": ""
    },
    {
        "id1": 4837,
        "id2": 4839,
        "phenotype_comparison": ""
    },
    {
        "id1": 4852,
        "id2": 4856,
        "phenotype_comparison": ""
    },
    {
        "id1": 4872,
        "id2": 4874,
        "phenotype_comparison": ""
    },
    {
        "id1": 4894,
        "id2": 4897,
        "phenotype_comparison": "RNAi against rheb-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4921,
        "id2": 4923,
        "phenotype_comparison": ""
    },
    {
        "id1": 4944,
        "id2": 4945,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (daf-15) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4963,
        "id2": 4964,
        "phenotype_comparison": "RNAi against ragc-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4980,
        "id2": 4988,
        "phenotype_comparison": ""
    },
    {
        "id1": 5011,
        "id2": 5012,
        "phenotype_comparison": "Knockdown of raga-1increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 5030,
        "id2": 5033,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi."
    },
    {
        "id1": 5028,
        "id2": 5054,
        "phenotype_comparison": ""
    },
    {
        "id1": 5068,
        "id2": 5070,
        "phenotype_comparison": ""
    },
    {
        "id1": 5083,
        "id2": 5084,
        "phenotype_comparison": ""
    },
    {
        "id1": 5105,
        "id2": 5106,
        "phenotype_comparison": ""
    },
    {
        "id1": 5139,
        "id2": 5141,
        "phenotype_comparison": ""
    },
    {
        "id1": 5162,
        "id2": 5163,
        "phenotype_comparison": ""
    },
    {
        "id1": 5178,
        "id2": 5184,
        "phenotype_comparison": ""
    },
    {
        "id1": 5202,
        "id2": 5203,
        "phenotype_comparison": "RNAi knockdown of hsp-70 did not decrease the lifespan of rsks-1(tm1714) mutants or the wild-type. Note that hsp-70 RNAi increased the lifespan of wild-type at 22.5 \u00b0C, while having no effects at 20 \u00b0C."
    },
    {
        "id1": 5162,
        "id2": 5228,
        "phenotype_comparison": ""
    },
    {
        "id1": 5248,
        "id2": 5250,
        "phenotype_comparison": ""
    },
    {
        "id1": 5273,
        "id2": 5275,
        "phenotype_comparison": ""
    },
    {
        "id1": 5303,
        "id2": 5305,
        "phenotype_comparison": ""
    },
    {
        "id1": 5328,
        "id2": 5330,
        "phenotype_comparison": ""
    },
    {
        "id1": 5350,
        "id2": 5352,
        "phenotype_comparison": ""
    },
    {
        "id1": 5384,
        "id2": 5386,
        "phenotype_comparison": ""
    },
    {
        "id1": 5403,
        "id2": 5404,
        "phenotype_comparison": ""
    },
    {
        "id1": 5429,
        "id2": 5432,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5456,
        "id2": 5459,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5475,
        "id2": 5476,
        "phenotype_comparison": ""
    },
    {
        "id1": 5494,
        "id2": 5495,
        "phenotype_comparison": ""
    },
    {
        "id1": 5516,
        "id2": 5517,
        "phenotype_comparison": "At 20\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived 20\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 20\u00b0C."
    },
    {
        "id1": 5539,
        "id2": 5541,
        "phenotype_comparison": ""
    },
    {
        "id1": 5561,
        "id2": 5563,
        "phenotype_comparison": ""
    },
    {
        "id1": 5580,
        "id2": 5582,
        "phenotype_comparison": ""
    },
    {
        "id1": 5595,
        "id2": 5599,
        "phenotype_comparison": ""
    },
    {
        "id1": 5618,
        "id2": 5619,
        "phenotype_comparison": "RNAi knock down of daf-2 in the hcf-1(ok559) mutant lived considerably longer than either the hcf-1(ok559) or daf-2 RNAi single mutant."
    },
    {
        "id1": 5639,
        "id2": 5641,
        "phenotype_comparison": ""
    },
    {
        "id1": 5660,
        "id2": 5661,
        "phenotype_comparison": "frh-1 RNAi increased lifespan on wild-type strains as well as on sir2.1(ok434)."
    },
    {
        "id1": 5677,
        "id2": 5678,
        "phenotype_comparison": ""
    },
    {
        "id1": 5701,
        "id2": 5702,
        "phenotype_comparison": ""
    },
    {
        "id1": 5733,
        "id2": 5734,
        "phenotype_comparison": ""
    },
    {
        "id1": 5758,
        "id2": 5759,
        "phenotype_comparison": "kri-1 RNAi did not shorten the life span of daf-2(e1370) mutants; instead, surprisingly, it increased lifespan by up to 23%."
    },
    {
        "id1": 5786,
        "id2": 5788,
        "phenotype_comparison": ""
    },
    {
        "id1": 5805,
        "id2": 5806,
        "phenotype_comparison": ""
    },
    {
        "id1": 5769,
        "id2": 5831,
        "phenotype_comparison": ""
    },
    {
        "id1": 5860,
        "id2": 5864,
        "phenotype_comparison": ""
    },
    {
        "id1": 5897,
        "id2": 5899,
        "phenotype_comparison": ""
    },
    {
        "id1": 5918,
        "id2": 5922,
        "phenotype_comparison": ""
    },
    {
        "id1": 5948,
        "id2": 5950,
        "phenotype_comparison": ""
    },
    {
        "id1": 5969,
        "id2": 5971,
        "phenotype_comparison": ""
    },
    {
        "id1": 5988,
        "id2": 5990,
        "phenotype_comparison": ""
    },
    {
        "id1": 6007,
        "id2": 6008,
        "phenotype_comparison": ""
    },
    {
        "id1": 6023,
        "id2": 6024,
        "phenotype_comparison": "cdk-2(RNAi) has no effect on longevity of germless glp-1(e2141) mutants."
    },
    {
        "id1": 6039,
        "id2": 6040,
        "phenotype_comparison": ""
    },
    {
        "id1": 5995,
        "id2": 5965,
        "phenotype_comparison": ""
    },
    {
        "id1": 6069,
        "id2": 5987,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) in daf-2(e1370) mutants further increased their longevity indicating that cell cycle genes act in the DAF-16-dependent germline longevity pathway but not in the insulin signaling pathway."
    },
    {
        "id1": 5963,
        "id2": 6084,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6101,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6115,
        "phenotype_comparison": ""
    },
    {
        "id1": 6127,
        "id2": 6128,
        "phenotype_comparison": "RNAi inactivation of F59A3.3 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6141,
        "id2": 6143,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6163,
        "phenotype_comparison": ""
    },
    {
        "id1": 6111,
        "id2": 6174,
        "phenotype_comparison": "RNAi inactivation of F22D6.3 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6131,
        "id2": 6184,
        "phenotype_comparison": "RNAi inactivation of Y47G6A.10 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6199,
        "id2": 6200,
        "phenotype_comparison": "The combination of nuo-6(qm200) and eat-2(ad1116) is fully additive."
    },
    {
        "id1": 6214,
        "id2": 6215,
        "phenotype_comparison": "clk-2 (qm37) mutation was found to dramatically increase the life span of daf-2(e1370) worms despite only marginally increasing life span in a wild-type background."
    },
    {
        "id1": 6232,
        "id2": 6233,
        "phenotype_comparison": ""
    },
    {
        "id1": 6251,
        "id2": 6253,
        "phenotype_comparison": ""
    },
    {
        "id1": 6266,
        "id2": 6272,
        "phenotype_comparison": ""
    },
    {
        "id1": 6281,
        "id2": 6287,
        "phenotype_comparison": ""
    },
    {
        "id1": 6297,
        "id2": 6301,
        "phenotype_comparison": ""
    },
    {
        "id1": 6314,
        "id2": 6315,
        "phenotype_comparison": ""
    },
    {
        "id1": 6320,
        "id2": 6334,
        "phenotype_comparison": ""
    },
    {
        "id1": 6350,
        "id2": 6351,
        "phenotype_comparison": "cyc-2.1 RNAi treatment extends lifespan in wild-type animals by 66%, whereas the mean lifespan extension is significantly decreased to 42% in the drp-1(tm1108) mutant."
    },
    {
        "id1": 6376,
        "id2": 6378,
        "phenotype_comparison": ""
    },
    {
        "id1": 6396,
        "id2": 6398,
        "phenotype_comparison": ""
    },
    {
        "id1": 6423,
        "id2": 6424,
        "phenotype_comparison": ""
    },
    {
        "id1": 6446,
        "id2": 6448,
        "phenotype_comparison": ""
    },
    {
        "id1": 6468,
        "id2": 6472,
        "phenotype_comparison": ""
    },
    {
        "id1": 6474,
        "id2": 6486,
        "phenotype_comparison": ""
    },
    {
        "id1": 4301,
        "id2": 4302,
        "phenotype_comparison": ""
    },
    {
        "id1": 4327,
        "id2": 4328,
        "phenotype_comparison": ""
    },
    {
        "id1": 4344,
        "id2": 4348,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4396,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4423,
        "phenotype_comparison": ""
    },
    {
        "id1": 4450,
        "id2": 4451,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4477,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4504,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4530,
        "phenotype_comparison": ""
    },
    {
        "id1": 4555,
        "id2": 4557,
        "phenotype_comparison": ""
    },
    {
        "id1": 4588,
        "id2": 4592,
        "phenotype_comparison": ""
    },
    {
        "id1": 4612,
        "id2": 4620,
        "phenotype_comparison": "Inactivation of cup-4 had no effect on life span of nlp-7(tm2990) mutants."
    },
    {
        "id1": 4638,
        "id2": 4640,
        "phenotype_comparison": ""
    },
    {
        "id1": 4659,
        "id2": 4660,
        "phenotype_comparison": ""
    },
    {
        "id1": 4678,
        "id2": 4680,
        "phenotype_comparison": ""
    },
    {
        "id1": 4700,
        "id2": 4702,
        "phenotype_comparison": ""
    },
    {
        "id1": 4717,
        "id2": 4729,
        "phenotype_comparison": ""
    },
    {
        "id1": 4754,
        "id2": 4755,
        "phenotype_comparison": ""
    },
    {
        "id1": 4780,
        "id2": 4782,
        "phenotype_comparison": ""
    },
    {
        "id1": 4767,
        "id2": 4797,
        "phenotype_comparison": ""
    },
    {
        "id1": 4812,
        "id2": 4813,
        "phenotype_comparison": ""
    },
    {
        "id1": 4812,
        "id2": 4826,
        "phenotype_comparison": ""
    },
    {
        "id1": 4838,
        "id2": 4839,
        "phenotype_comparison": "Knocking down of par-5 alone did not substantially reduce hcf-1(pk924) lifespan."
    },
    {
        "id1": 4856,
        "id2": 4857,
        "phenotype_comparison": ""
    },
    {
        "id1": 4873,
        "id2": 4875,
        "phenotype_comparison": ""
    },
    {
        "id1": 4892,
        "id2": 4898,
        "phenotype_comparison": ""
    },
    {
        "id1": 4922,
        "id2": 4924,
        "phenotype_comparison": ""
    },
    {
        "id1": 4876,
        "id2": 4946,
        "phenotype_comparison": ""
    },
    {
        "id1": 4876,
        "id2": 4965,
        "phenotype_comparison": ""
    },
    {
        "id1": 4983,
        "id2": 4989,
        "phenotype_comparison": ""
    },
    {
        "id1": 5013,
        "id2": 5014,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5034,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5055,
        "phenotype_comparison": ""
    },
    {
        "id1": 5057,
        "id2": 5070,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (par-4) affected longevity induced by RNAi-mediated Mit mutants analyzed other than isp-1 RNAi."
    },
    {
        "id1": 5055,
        "id2": 5084,
        "phenotype_comparison": ""
    },
    {
        "id1": 5105,
        "id2": 5107,
        "phenotype_comparison": ""
    },
    {
        "id1": 5140,
        "id2": 5141,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was completely suppressed by hsf-1(sy441) mutations."
    },
    {
        "id1": 5162,
        "id2": 5164,
        "phenotype_comparison": ""
    },
    {
        "id1": 5183,
        "id2": 5184,
        "phenotype_comparison": "hsf-1(sy441) mutation suppressed the prolonged lifespan caused by RNAi targeting ragc-1/RagGTPase."
    },
    {
        "id1": 5204,
        "id2": 5205,
        "phenotype_comparison": ""
    },
    {
        "id1": 5166,
        "id2": 5229,
        "phenotype_comparison": ""
    },
    {
        "id1": 5249,
        "id2": 5251,
        "phenotype_comparison": ""
    },
    {
        "id1": 5274,
        "id2": 5275,
        "phenotype_comparison": "The longevity associated with inhibiting eif-1gene was decreased but not eliminated by skn-1 mutation."
    },
    {
        "id1": 5304,
        "id2": 5306,
        "phenotype_comparison": ""
    },
    {
        "id1": 5329,
        "id2": 5331,
        "phenotype_comparison": ""
    },
    {
        "id1": 5351,
        "id2": 5353,
        "phenotype_comparison": ""
    },
    {
        "id1": 5387,
        "id2": 5388,
        "phenotype_comparison": ""
    },
    {
        "id1": 5405,
        "id2": 5406,
        "phenotype_comparison": ""
    },
    {
        "id1": 5429,
        "id2": 5433,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5455,
        "id2": 5460,
        "phenotype_comparison": ""
    },
    {
        "id1": 5475,
        "id2": 5477,
        "phenotype_comparison": ""
    },
    {
        "id1": 5494,
        "id2": 5496,
        "phenotype_comparison": ""
    },
    {
        "id1": 5518,
        "id2": 5519,
        "phenotype_comparison": ""
    },
    {
        "id1": 5540,
        "id2": 5541,
        "phenotype_comparison": "At 15\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 15\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals."
    },
    {
        "id1": 5562,
        "id2": 5563,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 25\u00b0C."
    },
    {
        "id1": 5581,
        "id2": 5583,
        "phenotype_comparison": ""
    },
    {
        "id1": 5598,
        "id2": 5599,
        "phenotype_comparison": "The par-5 RNAi knock down worms exhibited normal lifespan."
    },
    {
        "id1": 5616,
        "id2": 5620,
        "phenotype_comparison": ""
    },
    {
        "id1": 5640,
        "id2": 5642,
        "phenotype_comparison": ""
    },
    {
        "id1": 5651,
        "id2": 5662,
        "phenotype_comparison": ""
    },
    {
        "id1": 5679,
        "id2": 5680,
        "phenotype_comparison": ""
    },
    {
        "id1": 5703,
        "id2": 5704,
        "phenotype_comparison": ""
    },
    {
        "id1": 5731,
        "id2": 5735,
        "phenotype_comparison": ""
    },
    {
        "id1": 5760,
        "id2": 5761,
        "phenotype_comparison": ""
    },
    {
        "id1": 5787,
        "id2": 5788,
        "phenotype_comparison": "Both of two different bec-1 RNAi clones shortened the mean lifespan of eat-2(ad1116) mutants by ~15\u201330%, but did not shorten wild-type lifespan."
    },
    {
        "id1": 5803,
        "id2": 5807,
        "phenotype_comparison": ""
    },
    {
        "id1": 5828,
        "id2": 5832,
        "phenotype_comparison": ""
    },
    {
        "id1": 5862,
        "id2": 5865,
        "phenotype_comparison": ""
    },
    {
        "id1": 5898,
        "id2": 5900,
        "phenotype_comparison": ""
    },
    {
        "id1": 5923,
        "id2": 5924,
        "phenotype_comparison": ""
    },
    {
        "id1": 5949,
        "id2": 5950,
        "phenotype_comparison": ""
    },
    {
        "id1": 5970,
        "id2": 5972,
        "phenotype_comparison": ""
    },
    {
        "id1": 5989,
        "id2": 5991,
        "phenotype_comparison": ""
    },
    {
        "id1": 6007,
        "id2": 5990,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 6025,
        "phenotype_comparison": ""
    },
    {
        "id1": 6039,
        "id2": 6041,
        "phenotype_comparison": ""
    },
    {
        "id1": 6055,
        "id2": 6056,
        "phenotype_comparison": ""
    },
    {
        "id1": 6070,
        "id2": 5985,
        "phenotype_comparison": ""
    },
    {
        "id1": 6083,
        "id2": 6085,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6102,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6116,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6129,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6144,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6164,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6175,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6185,
        "phenotype_comparison": ""
    },
    {
        "id1": 6197,
        "id2": 6201,
        "phenotype_comparison": ""
    },
    {
        "id1": 6216,
        "id2": 6217,
        "phenotype_comparison": ""
    },
    {
        "id1": 6234,
        "id2": 6235,
        "phenotype_comparison": ""
    },
    {
        "id1": 6252,
        "id2": 6253,
        "phenotype_comparison": ""
    },
    {
        "id1": 6272,
        "id2": 6273,
        "phenotype_comparison": ""
    },
    {
        "id1": 6287,
        "id2": 6288,
        "phenotype_comparison": ""
    },
    {
        "id1": 6299,
        "id2": 6302,
        "phenotype_comparison": ""
    },
    {
        "id1": 6316,
        "id2": 6317,
        "phenotype_comparison": ""
    },
    {
        "id1": 6334,
        "id2": 6335,
        "phenotype_comparison": ""
    },
    {
        "id1": 6352,
        "id2": 6354,
        "phenotype_comparison": ""
    },
    {
        "id1": 6377,
        "id2": 6379,
        "phenotype_comparison": ""
    },
    {
        "id1": 6397,
        "id2": 6398,
        "phenotype_comparison": "Prolonged longevity by cyc-2.1 RNAi can be suppressed by an atfs-1(gk3094) deletion mutant."
    },
    {
        "id1": 6423,
        "id2": 6425,
        "phenotype_comparison": ""
    },
    {
        "id1": 6446,
        "id2": 6449,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6474,
        "phenotype_comparison": ""
    },
    {
        "id1": 6485,
        "id2": 6486,
        "phenotype_comparison": ""
    },
    {
        "id1": 6485,
        "id2": 6496,
        "phenotype_comparison": ""
    },
    {
        "id1": 6487,
        "id2": 6505,
        "phenotype_comparison": "RNAi inactivation of isw-1 could partially suppress the enhanced longevity of daf-2/InsR mutants."
    },
    {
        "id1": 6519,
        "id2": 6520,
        "phenotype_comparison": "eat2(ad1116);daf-9(rh50) double mutants exhibited a lifespan comparable to that of daf-9(rh50) mutants and shorter than that of eat-2(ad1116) mutants."
    },
    {
        "id1": 6537,
        "id2": 5205,
        "phenotype_comparison": "The very long lifespan of daf-2(e1370) mutants was suppressed by hsf-1 RNAi."
    },
    {
        "id1": 6545,
        "id2": 6549,
        "phenotype_comparison": ""
    },
    {
        "id1": 6558,
        "id2": 6559,
        "phenotype_comparison": "RNAi inactivation of a T06D8.6 gene, key to mitochondrial function, markedly extended C. elegans lifespan on both daf-16 (mgDf47) and wild type."
    },
    {
        "id1": 4414,
        "id2": 4416,
        "phenotype_comparison": ""
    },
    {
        "id1": 6100,
        "id2": 6144,
        "phenotype_comparison": ""
    },
    {
        "id1": 6140,
        "id2": 6164,
        "phenotype_comparison": ""
    },
    {
        "id1": 4924,
        "id2": 4977,
        "phenotype_comparison": ""
    },
    {
        "id1": 5217,
        "id2": 5219,
        "phenotype_comparison": ""
    },
    {
        "id1": 6448,
        "id2": 6456,
        "phenotype_comparison": ""
    },
    {
        "id1": 6430,
        "id2": 6440,
        "phenotype_comparison": ""
    },
    {
        "id1": 6462,
        "id2": 6472,
        "phenotype_comparison": ""
    },
    {
        "id1": 5760,
        "id2": 5766,
        "phenotype_comparison": ""
    },
    {
        "id1": 5790,
        "id2": 5803,
        "phenotype_comparison": ""
    },
    {
        "id1": 5284,
        "id2": 5286,
        "phenotype_comparison": ""
    },
    {
        "id1": 6427,
        "id2": 6432,
        "phenotype_comparison": ""
    },
    {
        "id1": 6324,
        "id2": 6328,
        "phenotype_comparison": ""
    },
    {
        "id1": 6575,
        "id2": 6577,
        "phenotype_comparison": ""
    },
    {
        "id1": 6577,
        "id2": 6580,
        "phenotype_comparison": "Complementation tests with females, the X-chromosome location of snz precluded this analysis in males, and observed lifespan extension in transheterozygotes of C32 with either G1409 or SZ4089."
    },
    {
        "id1": 6585,
        "id2": 6587,
        "phenotype_comparison": ""
    },
    {
        "id1": 6587,
        "id2": 6588,
        "phenotype_comparison": "In adult males, the extension of life span mediated by D-NAAM overexpression is completely abolished if the Sir2 gene is mutated."
    },
    {
        "id1": 6591,
        "id2": 6592,
        "phenotype_comparison": "Cardiac-specific vinculin overexpression substantially prolonged median organismal life span by as much as 150%. These data suggest that VincHE hearts produce greater contractile forces, that vinculin overexpression can rescue diminished force production, and that cardiac-specific vinculin overexpression can increase longevity."
    },
    {
        "id1": 4301,
        "id2": 4303,
        "phenotype_comparison": ""
    },
    {
        "id1": 4327,
        "id2": 4329,
        "phenotype_comparison": ""
    },
    {
        "id1": 4347,
        "id2": 4348,
        "phenotype_comparison": "Knockdown of daf-2 resulted in an increased lifespan in the wild-type N2 worms."
    },
    {
        "id1": 4395,
        "id2": 4397,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4424,
        "phenotype_comparison": ""
    },
    {
        "id1": 4450,
        "id2": 4452,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4478,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4505,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4531,
        "phenotype_comparison": ""
    },
    {
        "id1": 4558,
        "id2": 4559,
        "phenotype_comparison": ""
    },
    {
        "id1": 4591,
        "id2": 4593,
        "phenotype_comparison": ""
    },
    {
        "id1": 4606,
        "id2": 4621,
        "phenotype_comparison": ""
    },
    {
        "id1": 4631,
        "id2": 4641,
        "phenotype_comparison": ""
    },
    {
        "id1": 4659,
        "id2": 4661,
        "phenotype_comparison": ""
    },
    {
        "id1": 4679,
        "id2": 4680,
        "phenotype_comparison": "nhr-49 overexpression in daf-16 mutants caused a small additional increment in their longevity."
    },
    {
        "id1": 4701,
        "id2": 4703,
        "phenotype_comparison": ""
    },
    {
        "id1": 4728,
        "id2": 4729,
        "phenotype_comparison": "The jnk-1(gk7) mutant animals showed a shorter life span compared with wild type, and knockdown of jnk-1 did not further decrease the life span of short-lived shc-1 animals. The shc-1;jnk-1 double mutant displayed a mean life span similar to jnk-1(gk7)"
    },
    {
        "id1": 4756,
        "id2": 4757,
        "phenotype_comparison": ""
    },
    {
        "id1": 4781,
        "id2": 4782,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4796,
        "id2": 4798,
        "phenotype_comparison": ""
    },
    {
        "id1": 4812,
        "id2": 4814,
        "phenotype_comparison": ""
    },
    {
        "id1": 4825,
        "id2": 4821,
        "phenotype_comparison": ""
    },
    {
        "id1": 4829,
        "id2": 4840,
        "phenotype_comparison": ""
    },
    {
        "id1": 4853,
        "id2": 4857,
        "phenotype_comparison": ""
    },
    {
        "id1": 4874,
        "id2": 4875,
        "phenotype_comparison": "A null mutation of ftt-2(n4426) was only able to slightly decrease the lifespan of hcf-1 mutants."
    },
    {
        "id1": 4893,
        "id2": 4899,
        "phenotype_comparison": ""
    },
    {
        "id1": 4923,
        "id2": 4924,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (raga-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4939,
        "id2": 4947,
        "phenotype_comparison": ""
    },
    {
        "id1": 4965,
        "id2": 4966,
        "phenotype_comparison": ""
    },
    {
        "id1": 4984,
        "id2": 4990,
        "phenotype_comparison": ""
    },
    {
        "id1": 5013,
        "id2": 5015,
        "phenotype_comparison": ""
    },
    {
        "id1": 5034,
        "id2": 5035,
        "phenotype_comparison": ""
    },
    {
        "id1": 5054,
        "id2": 5056,
        "phenotype_comparison": ""
    },
    {
        "id1": 5068,
        "id2": 5071,
        "phenotype_comparison": ""
    },
    {
        "id1": 5083,
        "id2": 5085,
        "phenotype_comparison": ""
    },
    {
        "id1": 5108,
        "id2": 5109,
        "phenotype_comparison": ""
    },
    {
        "id1": 5142,
        "id2": 5143,
        "phenotype_comparison": ""
    },
    {
        "id1": 5163,
        "id2": 5165,
        "phenotype_comparison": ""
    },
    {
        "id1": 5185,
        "id2": 5186,
        "phenotype_comparison": ""
    },
    {
        "id1": 5206,
        "id2": 5207,
        "phenotype_comparison": ""
    },
    {
        "id1": 5228,
        "id2": 5229,
        "phenotype_comparison": "daf-16 RNAi treatment for during adulthood shortened the lifespan of both rsks-1(tm1714) and wild type animals."
    },
    {
        "id1": 5250,
        "id2": 5251,
        "phenotype_comparison": ""
    },
    {
        "id1": 5276,
        "id2": 5277,
        "phenotype_comparison": ""
    },
    {
        "id1": 5305,
        "id2": 5306,
        "phenotype_comparison": "skn-1(RNAi) on ets-4(ok165) worms did not alter the extended life span phenotype of these worms."
    },
    {
        "id1": 5330,
        "id2": 5331,
        "phenotype_comparison": "aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively)."
    },
    {
        "id1": 5352,
        "id2": 5353,
        "phenotype_comparison": "aakg-4 reduced lifespan in a daf-2(m577) background."
    },
    {
        "id1": 5387,
        "id2": 5389,
        "phenotype_comparison": ""
    },
    {
        "id1": 5405,
        "id2": 5407,
        "phenotype_comparison": ""
    },
    {
        "id1": 5429,
        "id2": 5434,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5456,
        "id2": 5460,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5476,
        "id2": 5478,
        "phenotype_comparison": ""
    },
    {
        "id1": 5495,
        "id2": 5497,
        "phenotype_comparison": ""
    },
    {
        "id1": 5518,
        "id2": 5520,
        "phenotype_comparison": ""
    },
    {
        "id1": 5542,
        "id2": 5543,
        "phenotype_comparison": ""
    },
    {
        "id1": 5502,
        "id2": 5564,
        "phenotype_comparison": ""
    },
    {
        "id1": 5582,
        "id2": 5583,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 20\u00b0C."
    },
    {
        "id1": 5594,
        "id2": 5600,
        "phenotype_comparison": ""
    },
    {
        "id1": 5617,
        "id2": 5621,
        "phenotype_comparison": ""
    },
    {
        "id1": 5641,
        "id2": 5642,
        "phenotype_comparison": "atm-1(gk186) play no apparent role in the life extension that occurs following mild frh-1 RNAi treatment."
    },
    {
        "id1": 5651,
        "id2": 5663,
        "phenotype_comparison": ""
    },
    {
        "id1": 5679,
        "id2": 5681,
        "phenotype_comparison": ""
    },
    {
        "id1": 5705,
        "id2": 5706,
        "phenotype_comparison": ""
    },
    {
        "id1": 5733,
        "id2": 5736,
        "phenotype_comparison": ""
    },
    {
        "id1": 5760,
        "id2": 5762,
        "phenotype_comparison": ""
    },
    {
        "id1": 5789,
        "id2": 5790,
        "phenotype_comparison": ""
    },
    {
        "id1": 5808,
        "id2": 5810,
        "phenotype_comparison": ""
    },
    {
        "id1": 5831,
        "id2": 5832,
        "phenotype_comparison": ""
    },
    {
        "id1": 5866,
        "id2": 5867,
        "phenotype_comparison": ""
    },
    {
        "id1": 5899,
        "id2": 5900,
        "phenotype_comparison": ""
    },
    {
        "id1": 5923,
        "id2": 5925,
        "phenotype_comparison": ""
    },
    {
        "id1": 5951,
        "id2": 5952,
        "phenotype_comparison": ""
    },
    {
        "id1": 5971,
        "id2": 5972,
        "phenotype_comparison": "daf-12(rh61rh411);cye-1(RNAi) animals have significantly shortened lifespans compared with cye-1(RNAi)."
    },
    {
        "id1": 5990,
        "id2": 5991,
        "phenotype_comparison": "cdk-2(RNAi) has no effect on longevity of germless glp-1(e2141) mutants."
    },
    {
        "id1": 6008,
        "id2": 6009,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 6026,
        "phenotype_comparison": ""
    },
    {
        "id1": 6040,
        "id2": 6042,
        "phenotype_comparison": ""
    },
    {
        "id1": 5965,
        "id2": 6056,
        "phenotype_comparison": "daf-16(mgDf47) null mutation significantly suppressed the longevity of cye-1(RNAi)."
    },
    {
        "id1": 6070,
        "id2": 6041,
        "phenotype_comparison": ""
    },
    {
        "id1": 6084,
        "id2": 6085,
        "phenotype_comparison": "The longevity of cye-1(RNAi) was suppressed by daf-16(mu86) mutation."
    },
    {
        "id1": 6101,
        "id2": 6102,
        "phenotype_comparison": "RNAi inactivation of C09D4.5 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6115,
        "id2": 6116,
        "phenotype_comparison": "RNAi inactivation of F14B4.3 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6094,
        "id2": 6130,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6145,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6165,
        "phenotype_comparison": ""
    },
    {
        "id1": 6113,
        "id2": 6175,
        "phenotype_comparison": "RNAi inactivation of C48E7.2 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6133,
        "id2": 6185,
        "phenotype_comparison": "RNAi inactivation of F26E4.4 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6201,
        "id2": 6202,
        "phenotype_comparison": ""
    },
    {
        "id1": 6216,
        "id2": 6218,
        "phenotype_comparison": ""
    },
    {
        "id1": 6234,
        "id2": 6236,
        "phenotype_comparison": ""
    },
    {
        "id1": 6254,
        "id2": 6255,
        "phenotype_comparison": ""
    },
    {
        "id1": 6267,
        "id2": 6273,
        "phenotype_comparison": ""
    },
    {
        "id1": 6282,
        "id2": 6288,
        "phenotype_comparison": ""
    },
    {
        "id1": 6295,
        "id2": 6302,
        "phenotype_comparison": ""
    },
    {
        "id1": 6316,
        "id2": 6318,
        "phenotype_comparison": ""
    },
    {
        "id1": 6322,
        "id2": 6335,
        "phenotype_comparison": "The cyc-2.1 RNAi-induced longevity phenotype is suppressed by a deletion mutant of atfs-1(gk3094)."
    },
    {
        "id1": 6353,
        "id2": 6355,
        "phenotype_comparison": ""
    },
    {
        "id1": 6378,
        "id2": 6379,
        "phenotype_comparison": "Knockdown of gld-1 significantly decreases lifespan of the rsks-1(ok1255) mutant."
    },
    {
        "id1": 6399,
        "id2": 6400,
        "phenotype_comparison": ""
    },
    {
        "id1": 6423,
        "id2": 6426,
        "phenotype_comparison": ""
    },
    {
        "id1": 6450,
        "id2": 6451,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6475,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6487,
        "phenotype_comparison": ""
    },
    {
        "id1": 6491,
        "id2": 6497,
        "phenotype_comparison": ""
    },
    {
        "id1": 6499,
        "id2": 6506,
        "phenotype_comparison": ""
    },
    {
        "id1": 6521,
        "id2": 6522,
        "phenotype_comparison": ""
    },
    {
        "id1": 6538,
        "id2": 5206,
        "phenotype_comparison": ""
    },
    {
        "id1": 6548,
        "id2": 6549,
        "phenotype_comparison": "RNAi inactivation of a T02H6.11 gene, key to mitochondrial function, markedly extended C. elegans lifespan on both daf-16 (mgDf47) and wild type."
    },
    {
        "id1": 6544,
        "id2": 6560,
        "phenotype_comparison": ""
    },
    {
        "id1": 4427,
        "id2": 4416,
        "phenotype_comparison": ""
    },
    {
        "id1": 6112,
        "id2": 6150,
        "phenotype_comparison": ""
    },
    {
        "id1": 6102,
        "id2": 6145,
        "phenotype_comparison": ""
    },
    {
        "id1": 4951,
        "id2": 4977,
        "phenotype_comparison": ""
    },
    {
        "id1": 5400,
        "id2": 5404,
        "phenotype_comparison": ""
    },
    {
        "id1": 6404,
        "id2": 6408,
        "phenotype_comparison": ""
    },
    {
        "id1": 6428,
        "id2": 6438,
        "phenotype_comparison": ""
    },
    {
        "id1": 6568,
        "id2": 4266,
        "phenotype_comparison": ""
    },
    {
        "id1": 5756,
        "id2": 5761,
        "phenotype_comparison": ""
    },
    {
        "id1": 5791,
        "id2": 5871,
        "phenotype_comparison": ""
    },
    {
        "id1": 5289,
        "id2": 5291,
        "phenotype_comparison": ""
    },
    {
        "id1": 6427,
        "id2": 6437,
        "phenotype_comparison": ""
    },
    {
        "id1": 6321,
        "id2": 6330,
        "phenotype_comparison": ""
    },
    {
        "id1": 6576,
        "id2": 6578,
        "phenotype_comparison": ""
    },
    {
        "id1": 6581,
        "id2": 6582,
        "phenotype_comparison": ""
    },
    {
        "id1": 6586,
        "id2": 6588,
        "phenotype_comparison": ""
    },
    {
        "id1": 6589,
        "id2": 6590,
        "phenotype_comparison": ""
    },
    {
        "id1": 6593,
        "id2": 6594,
        "phenotype_comparison": ""
    },
    {
        "id1": 4302,
        "id2": 4304,
        "phenotype_comparison": ""
    },
    {
        "id1": 4328,
        "id2": 4330,
        "phenotype_comparison": ""
    },
    {
        "id1": 4349,
        "id2": 4350,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4399,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4425,
        "phenotype_comparison": ""
    },
    {
        "id1": 4450,
        "id2": 4453,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4479,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4506,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4532,
        "phenotype_comparison": ""
    },
    {
        "id1": 4558,
        "id2": 4560,
        "phenotype_comparison": ""
    },
    {
        "id1": 4588,
        "id2": 4594,
        "phenotype_comparison": ""
    },
    {
        "id1": 4621,
        "id2": 4622,
        "phenotype_comparison": ""
    },
    {
        "id1": 4632,
        "id2": 4642,
        "phenotype_comparison": ""
    },
    {
        "id1": 4660,
        "id2": 4662,
        "phenotype_comparison": ""
    },
    {
        "id1": 4681,
        "id2": 4682,
        "phenotype_comparison": ""
    },
    {
        "id1": 4704,
        "id2": 4705,
        "phenotype_comparison": ""
    },
    {
        "id1": 4717,
        "id2": 4731,
        "phenotype_comparison": ""
    },
    {
        "id1": 4756,
        "id2": 4758,
        "phenotype_comparison": ""
    },
    {
        "id1": 4780,
        "id2": 4783,
        "phenotype_comparison": ""
    },
    {
        "id1": 4797,
        "id2": 4798,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4813,
        "id2": 4815,
        "phenotype_comparison": ""
    },
    {
        "id1": 4826,
        "id2": 4821,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4837,
        "id2": 4841,
        "phenotype_comparison": ""
    },
    {
        "id1": 4852,
        "id2": 4858,
        "phenotype_comparison": ""
    },
    {
        "id1": 4876,
        "id2": 4877,
        "phenotype_comparison": ""
    },
    {
        "id1": 4898,
        "id2": 4899,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (daf-15) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4925,
        "id2": 4926,
        "phenotype_comparison": ""
    },
    {
        "id1": 4946,
        "id2": 4947,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (rheb-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4940,
        "id2": 4966,
        "phenotype_comparison": "RNAi against daf-15 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4991,
        "id2": 4992,
        "phenotype_comparison": ""
    },
    {
        "id1": 5014,
        "id2": 5016,
        "phenotype_comparison": ""
    },
    {
        "id1": 5030,
        "id2": 5035,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi."
    },
    {
        "id1": 5055,
        "id2": 5056,
        "phenotype_comparison": ""
    },
    {
        "id1": 5059,
        "id2": 5071,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (par-4) affected longevity induced by RNAi-mediated Mit mutants analyzed other than nuo-2 RNAi."
    },
    {
        "id1": 5057,
        "id2": 5085,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (mml-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than isp-1 RNAi."
    },
    {
        "id1": 5109,
        "id2": 5110,
        "phenotype_comparison": ""
    },
    {
        "id1": 5142,
        "id2": 5144,
        "phenotype_comparison": ""
    },
    {
        "id1": 5164,
        "id2": 5165,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was suppressed by aak-2(ok524) mutation."
    },
    {
        "id1": 5185,
        "id2": 5187,
        "phenotype_comparison": ""
    },
    {
        "id1": 5204,
        "id2": 5208,
        "phenotype_comparison": ""
    },
    {
        "id1": 5169,
        "id2": 5230,
        "phenotype_comparison": ""
    },
    {
        "id1": 5248,
        "id2": 5252,
        "phenotype_comparison": ""
    },
    {
        "id1": 5276,
        "id2": 5278,
        "phenotype_comparison": ""
    },
    {
        "id1": 5307,
        "id2": 5298,
        "phenotype_comparison": ""
    },
    {
        "id1": 5332,
        "id2": 5333,
        "phenotype_comparison": ""
    },
    {
        "id1": 5354,
        "id2": 5355,
        "phenotype_comparison": ""
    },
    {
        "id1": 5388,
        "id2": 5390,
        "phenotype_comparison": ""
    },
    {
        "id1": 5407,
        "id2": 5408,
        "phenotype_comparison": ""
    },
    {
        "id1": 5429,
        "id2": 5435,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5455,
        "id2": 5461,
        "phenotype_comparison": ""
    },
    {
        "id1": 5477,
        "id2": 5478,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5496,
        "id2": 5497,
        "phenotype_comparison": "The hif-1(ia4) animals lived significantly longer than N2 animals at 25\u00b0C. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 25\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 25\u00b0C."
    },
    {
        "id1": 5519,
        "id2": 5521,
        "phenotype_comparison": ""
    },
    {
        "id1": 5542,
        "id2": 5544,
        "phenotype_comparison": ""
    },
    {
        "id1": 5503,
        "id2": 5565,
        "phenotype_comparison": ""
    },
    {
        "id1": 5538,
        "id2": 5584,
        "phenotype_comparison": ""
    },
    {
        "id1": 5595,
        "id2": 5601,
        "phenotype_comparison": ""
    },
    {
        "id1": 5620,
        "id2": 5621,
        "phenotype_comparison": "RNAi knock down of age-1 in the hcf-1(ok559) mutant lived considerably longer than either the hcf-1(ok559) or age-1 RNAi single mutant."
    },
    {
        "id1": 5643,
        "id2": 5644,
        "phenotype_comparison": ""
    },
    {
        "id1": 5662,
        "id2": 5664,
        "phenotype_comparison": ""
    },
    {
        "id1": 5680,
        "id2": 5682,
        "phenotype_comparison": ""
    },
    {
        "id1": 5707,
        "id2": 5708,
        "phenotype_comparison": ""
    },
    {
        "id1": 5735,
        "id2": 5737,
        "phenotype_comparison": ""
    },
    {
        "id1": 5763,
        "id2": 5764,
        "phenotype_comparison": ""
    },
    {
        "id1": 5789,
        "id2": 5791,
        "phenotype_comparison": ""
    },
    {
        "id1": 5809,
        "id2": 5811,
        "phenotype_comparison": ""
    },
    {
        "id1": 5833,
        "id2": 5834,
        "phenotype_comparison": ""
    },
    {
        "id1": 5868,
        "id2": 5869,
        "phenotype_comparison": ""
    },
    {
        "id1": 5901,
        "id2": 5902,
        "phenotype_comparison": ""
    },
    {
        "id1": 5923,
        "id2": 5926,
        "phenotype_comparison": ""
    },
    {
        "id1": 5951,
        "id2": 5953,
        "phenotype_comparison": ""
    },
    {
        "id1": 5969,
        "id2": 5973,
        "phenotype_comparison": ""
    },
    {
        "id1": 5988,
        "id2": 5992,
        "phenotype_comparison": ""
    },
    {
        "id1": 5990,
        "id2": 6009,
        "phenotype_comparison": "The dramatic lifespan extension associated with knockdown of cdk-2 was not fully eliminated in daf-16(mgDf47) null mutants indicating that DAF-16 is central for the influence of cell cycle regulators on longevity."
    },
    {
        "id1": 6025,
        "id2": 5962,
        "phenotype_comparison": ""
    },
    {
        "id1": 6041,
        "id2": 6042,
        "phenotype_comparison": "daf-12(rh61rh411);cye-1(RNAi) animals have significantly shortened lifespans compared with cye-1(RNAi)."
    },
    {
        "id1": 5995,
        "id2": 6057,
        "phenotype_comparison": ""
    },
    {
        "id1": 5985,
        "id2": 6071,
        "phenotype_comparison": ""
    },
    {
        "id1": 6086,
        "id2": 6087,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6103,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6117,
        "phenotype_comparison": ""
    },
    {
        "id1": 6129,
        "id2": 6130,
        "phenotype_comparison": "RNAi inactivation of B0511.8 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6141,
        "id2": 6146,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6166,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6176,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6186,
        "phenotype_comparison": ""
    },
    {
        "id1": 6198,
        "id2": 6202,
        "phenotype_comparison": "The longevity of the isp-1(qm150);nuo-6(qm200) double mutants was very similar, although slightly shorter, than that of each of the constituent mutants."
    },
    {
        "id1": 6217,
        "id2": 6219,
        "phenotype_comparison": ""
    },
    {
        "id1": 6235,
        "id2": 6237,
        "phenotype_comparison": ""
    },
    {
        "id1": 6256,
        "id2": 6257,
        "phenotype_comparison": ""
    },
    {
        "id1": 6272,
        "id2": 6274,
        "phenotype_comparison": ""
    },
    {
        "id1": 6287,
        "id2": 6289,
        "phenotype_comparison": ""
    },
    {
        "id1": 6303,
        "id2": 6304,
        "phenotype_comparison": ""
    },
    {
        "id1": 6317,
        "id2": 6319,
        "phenotype_comparison": ""
    },
    {
        "id1": 6316,
        "id2": 6336,
        "phenotype_comparison": ""
    },
    {
        "id1": 6356,
        "id2": 6358,
        "phenotype_comparison": ""
    },
    {
        "id1": 6380,
        "id2": 6377,
        "phenotype_comparison": ""
    },
    {
        "id1": 6401,
        "id2": 6402,
        "phenotype_comparison": ""
    },
    {
        "id1": 6427,
        "id2": 6428,
        "phenotype_comparison": ""
    },
    {
        "id1": 6450,
        "id2": 6452,
        "phenotype_comparison": ""
    },
    {
        "id1": 6474,
        "id2": 6476,
        "phenotype_comparison": ""
    },
    {
        "id1": 6474,
        "id2": 6488,
        "phenotype_comparison": ""
    },
    {
        "id1": 6487,
        "id2": 6497,
        "phenotype_comparison": "RNAi inactivation of isw-1 could partially suppress the enhanced longevity of daf-2/InsR mutants."
    },
    {
        "id1": 6489,
        "id2": 6506,
        "phenotype_comparison": "RNAi inactivation of mes-4 could partially suppress the enhanced longevity of daf-2/InsR mutants."
    },
    {
        "id1": 6521,
        "id2": 6523,
        "phenotype_comparison": ""
    },
    {
        "id1": 6538,
        "id2": 6539,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6550,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6561,
        "phenotype_comparison": ""
    },
    {
        "id1": 5732,
        "id2": 5737,
        "phenotype_comparison": ""
    },
    {
        "id1": 6116,
        "id2": 6152,
        "phenotype_comparison": ""
    },
    {
        "id1": 6104,
        "id2": 6146,
        "phenotype_comparison": ""
    },
    {
        "id1": 4887,
        "id2": 4891,
        "phenotype_comparison": ""
    },
    {
        "id1": 5402,
        "id2": 5404,
        "phenotype_comparison": ""
    },
    {
        "id1": 6405,
        "id2": 6409,
        "phenotype_comparison": ""
    },
    {
        "id1": 6448,
        "id2": 6452,
        "phenotype_comparison": ""
    },
    {
        "id1": 6319,
        "id2": 6329,
        "phenotype_comparison": ""
    },
    {
        "id1": 5758,
        "id2": 5762,
        "phenotype_comparison": ""
    },
    {
        "id1": 5829,
        "id2": 5877,
        "phenotype_comparison": ""
    },
    {
        "id1": 5032,
        "id2": 5036,
        "phenotype_comparison": ""
    },
    {
        "id1": 4303,
        "id2": 4304,
        "phenotype_comparison": "daf-2(RNAi) further extended the already long lifespan of vhl-1(ok161) animals."
    },
    {
        "id1": 4329,
        "id2": 4330,
        "phenotype_comparison": "Down-regulation of hsf-1 in adulthood suppressed longevity of age-1(hx546) animals."
    },
    {
        "id1": 4351,
        "id2": 4352,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4400,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4426,
        "phenotype_comparison": ""
    },
    {
        "id1": 4450,
        "id2": 4454,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4480,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4507,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4533,
        "phenotype_comparison": ""
    },
    {
        "id1": 4561,
        "id2": 4562,
        "phenotype_comparison": ""
    },
    {
        "id1": 4591,
        "id2": 4595,
        "phenotype_comparison": ""
    },
    {
        "id1": 4609,
        "id2": 4623,
        "phenotype_comparison": ""
    },
    {
        "id1": 4641,
        "id2": 4642,
        "phenotype_comparison": "The adult lifespan extension associated with the oga-1(ok1207) mutant is not synergistic or additive with mutations of the long-lived insulin signaling pathway kinase age-1."
    },
    {
        "id1": 4661,
        "id2": 4662,
        "phenotype_comparison": "nhr-49 mutation had no impact on the extended lifespan of daf-2(e1368) mutants in two of three independent trials and caused a small suppression in longevity in the third."
    },
    {
        "id1": 4682,
        "id2": 4683,
        "phenotype_comparison": ""
    },
    {
        "id1": 4704,
        "id2": 4706,
        "phenotype_comparison": ""
    },
    {
        "id1": 4730,
        "id2": 4731,
        "phenotype_comparison": "Expression of an additional, genomically inserted copy of jnk-1 in the shc-1(ok198) mutant significantly increased life span."
    },
    {
        "id1": 4757,
        "id2": 4759,
        "phenotype_comparison": ""
    },
    {
        "id1": 4781,
        "id2": 4783,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4796,
        "id2": 4799,
        "phenotype_comparison": ""
    },
    {
        "id1": 4814,
        "id2": 4815,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4825,
        "id2": 4827,
        "phenotype_comparison": ""
    },
    {
        "id1": 4840,
        "id2": 4841,
        "phenotype_comparison": "Knocking down of par-5 alone did not substantially reduce hcf-1(pk924) lifespan."
    },
    {
        "id1": 4852,
        "id2": 4859,
        "phenotype_comparison": ""
    },
    {
        "id1": 4876,
        "id2": 4878,
        "phenotype_comparison": ""
    },
    {
        "id1": 4896,
        "id2": 4900,
        "phenotype_comparison": ""
    },
    {
        "id1": 4925,
        "id2": 4927,
        "phenotype_comparison": ""
    },
    {
        "id1": 4942,
        "id2": 4948,
        "phenotype_comparison": ""
    },
    {
        "id1": 4967,
        "id2": 4968,
        "phenotype_comparison": ""
    },
    {
        "id1": 4991,
        "id2": 4993,
        "phenotype_comparison": ""
    },
    {
        "id1": 5015,
        "id2": 5016,
        "phenotype_comparison": "Knockdown of raga-1increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 5036,
        "id2": 5037,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5057,
        "phenotype_comparison": ""
    },
    {
        "id1": 5068,
        "id2": 5072,
        "phenotype_comparison": ""
    },
    {
        "id1": 5083,
        "id2": 5086,
        "phenotype_comparison": ""
    },
    {
        "id1": 5109,
        "id2": 5111,
        "phenotype_comparison": ""
    },
    {
        "id1": 5143,
        "id2": 5145,
        "phenotype_comparison": ""
    },
    {
        "id1": 5162,
        "id2": 5166,
        "phenotype_comparison": ""
    },
    {
        "id1": 5186,
        "id2": 5188,
        "phenotype_comparison": ""
    },
    {
        "id1": 5206,
        "id2": 5209,
        "phenotype_comparison": ""
    },
    {
        "id1": 5170,
        "id2": 5231,
        "phenotype_comparison": ""
    },
    {
        "id1": 5248,
        "id2": 5253,
        "phenotype_comparison": ""
    },
    {
        "id1": 5277,
        "id2": 5279,
        "phenotype_comparison": ""
    },
    {
        "id1": 5307,
        "id2": 5308,
        "phenotype_comparison": ""
    },
    {
        "id1": 5332,
        "id2": 5334,
        "phenotype_comparison": ""
    },
    {
        "id1": 5355,
        "id2": 5356,
        "phenotype_comparison": ""
    },
    {
        "id1": 5389,
        "id2": 5390,
        "phenotype_comparison": ""
    },
    {
        "id1": 5360,
        "id2": 5409,
        "phenotype_comparison": ""
    },
    {
        "id1": 5436,
        "id2": 5437,
        "phenotype_comparison": ""
    },
    {
        "id1": 5456,
        "id2": 5461,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5476,
        "id2": 5479,
        "phenotype_comparison": ""
    },
    {
        "id1": 5498,
        "id2": 5499,
        "phenotype_comparison": ""
    },
    {
        "id1": 5520,
        "id2": 5521,
        "phenotype_comparison": "At 20\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived 20\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 20\u00b0C."
    },
    {
        "id1": 5543,
        "id2": 5545,
        "phenotype_comparison": ""
    },
    {
        "id1": 5564,
        "id2": 5565,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 25\u00b0C."
    },
    {
        "id1": 5539,
        "id2": 5585,
        "phenotype_comparison": ""
    },
    {
        "id1": 5600,
        "id2": 5601,
        "phenotype_comparison": ""
    },
    {
        "id1": 5622,
        "id2": 5623,
        "phenotype_comparison": ""
    },
    {
        "id1": 5643,
        "id2": 5645,
        "phenotype_comparison": ""
    },
    {
        "id1": 5663,
        "id2": 5664,
        "phenotype_comparison": "cep-1(gk138) significantly shortened the increase in lifespan induced by frh-1 RNAi."
    },
    {
        "id1": 5681,
        "id2": 5682,
        "phenotype_comparison": ""
    },
    {
        "id1": 5709,
        "id2": 5710,
        "phenotype_comparison": "In double mutants, raga-1(ok386) further increased rsks-1(ok1255) lifespan, suggesting that these genes may act at least partially in different pathways to exert lifespan effects."
    },
    {
        "id1": 5736,
        "id2": 5738,
        "phenotype_comparison": ""
    },
    {
        "id1": 5763,
        "id2": 5765,
        "phenotype_comparison": ""
    },
    {
        "id1": 5790,
        "id2": 5792,
        "phenotype_comparison": ""
    },
    {
        "id1": 5809,
        "id2": 5812,
        "phenotype_comparison": ""
    },
    {
        "id1": 5833,
        "id2": 5835,
        "phenotype_comparison": ""
    },
    {
        "id1": 5866,
        "id2": 5870,
        "phenotype_comparison": ""
    },
    {
        "id1": 5901,
        "id2": 5903,
        "phenotype_comparison": ""
    },
    {
        "id1": 5927,
        "id2": 5928,
        "phenotype_comparison": ""
    },
    {
        "id1": 5952,
        "id2": 5954,
        "phenotype_comparison": ""
    },
    {
        "id1": 5973,
        "id2": 5974,
        "phenotype_comparison": ""
    },
    {
        "id1": 5988,
        "id2": 5993,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 6010,
        "phenotype_comparison": ""
    },
    {
        "id1": 6026,
        "id2": 5962,
        "phenotype_comparison": "Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms."
    },
    {
        "id1": 6039,
        "id2": 6043,
        "phenotype_comparison": ""
    },
    {
        "id1": 6057,
        "id2": 6058,
        "phenotype_comparison": ""
    },
    {
        "id1": 6041,
        "id2": 6071,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) in daf-2(e1370) mutants further increased their longevity indicating that cell cycle genes act in the DAF-16-dependent germline longevity pathway but not in the insulin signaling pathway."
    },
    {
        "id1": 6086,
        "id2": 6088,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6104,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6118,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6131,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6147,
        "phenotype_comparison": ""
    },
    {
        "id1": 6095,
        "id2": 6166,
        "phenotype_comparison": "RNAi inactivation of Y39G10AR.8 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6115,
        "id2": 6176,
        "phenotype_comparison": "RNAi inactivation of F14B4.3 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6135,
        "id2": 6186,
        "phenotype_comparison": "RNAi inactivation of C56E6.1 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6199,
        "id2": 6203,
        "phenotype_comparison": ""
    },
    {
        "id1": 6218,
        "id2": 6219,
        "phenotype_comparison": "clk-3 (qm38) mutations exhibited additive effects on daf-2(e1370) life span in that extend daf-2(e1370) life span and wild-type life span by similar amounts."
    },
    {
        "id1": 6236,
        "id2": 6237,
        "phenotype_comparison": "clk-9 (qm164) mutations exhibited additive effects on daf-2(e1370) life span in that extend daf-2(e1370) life span and wild-type life span by similar amounts."
    },
    {
        "id1": 6257,
        "id2": 6258,
        "phenotype_comparison": ""
    },
    {
        "id1": 6270,
        "id2": 6274,
        "phenotype_comparison": "The clk-3(qm38); clk-l(qm3O) double mutants have a very long mean life-span, up to three and four times that of the wild type."
    },
    {
        "id1": 6285,
        "id2": 6289,
        "phenotype_comparison": ""
    },
    {
        "id1": 6295,
        "id2": 6304,
        "phenotype_comparison": ""
    },
    {
        "id1": 6318,
        "id2": 6319,
        "phenotype_comparison": "Knockdown of cyc-2.1 robustly extends lifespan in the wild-type and rsks-1(ok1255) mutant backgrounds."
    },
    {
        "id1": 6336,
        "id2": 6337,
        "phenotype_comparison": ""
    },
    {
        "id1": 6357,
        "id2": 6359,
        "phenotype_comparison": ""
    },
    {
        "id1": 6380,
        "id2": 6381,
        "phenotype_comparison": ""
    },
    {
        "id1": 6403,
        "id2": 6404,
        "phenotype_comparison": ""
    },
    {
        "id1": 6427,
        "id2": 6429,
        "phenotype_comparison": ""
    },
    {
        "id1": 6450,
        "id2": 6453,
        "phenotype_comparison": ""
    },
    {
        "id1": 6475,
        "id2": 6476,
        "phenotype_comparison": ""
    },
    {
        "id1": 6487,
        "id2": 6488,
        "phenotype_comparison": "RNAi inactivation of isw-1 could partially suppress the enhanced longevity of daf-2/InsR mutants."
    },
    {
        "id1": 6491,
        "id2": 6498,
        "phenotype_comparison": ""
    },
    {
        "id1": 6507,
        "id2": 6508,
        "phenotype_comparison": ""
    },
    {
        "id1": 6522,
        "id2": 6524,
        "phenotype_comparison": ""
    },
    {
        "id1": 6539,
        "id2": 5207,
        "phenotype_comparison": "The very long lifespan of daf-2(e1370) mutants was suppressed by hsf-1 RNAi."
    },
    {
        "id1": 4305,
        "id2": 4306,
        "phenotype_comparison": ""
    },
    {
        "id1": 4327,
        "id2": 4331,
        "phenotype_comparison": ""
    },
    {
        "id1": 4353,
        "id2": 4354,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4401,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4427,
        "phenotype_comparison": ""
    },
    {
        "id1": 4450,
        "id2": 4455,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4481,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4508,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4534,
        "phenotype_comparison": ""
    },
    {
        "id1": 4561,
        "id2": 4563,
        "phenotype_comparison": ""
    },
    {
        "id1": 4596,
        "id2": 4597,
        "phenotype_comparison": ""
    },
    {
        "id1": 4623,
        "id2": 4624,
        "phenotype_comparison": ""
    },
    {
        "id1": 4633,
        "id2": 4643,
        "phenotype_comparison": ""
    },
    {
        "id1": 4659,
        "id2": 4663,
        "phenotype_comparison": ""
    },
    {
        "id1": 4682,
        "id2": 4684,
        "phenotype_comparison": ""
    },
    {
        "id1": 4705,
        "id2": 4707,
        "phenotype_comparison": ""
    },
    {
        "id1": 4732,
        "id2": 4733,
        "phenotype_comparison": ""
    },
    {
        "id1": 4758,
        "id2": 4759,
        "phenotype_comparison": "RNAi of skn-1, which targeted skn-1a and -c isoforms, reduced the life span of N2 worms significantly (by about 20%), consistent with the shorter life span of skn-1 mutant worms. In contrast, the same skn-1 RNAi treatment failed to reduce the life span of daf-16(mgDf50) worms."
    },
    {
        "id1": 4780,
        "id2": 4784,
        "phenotype_comparison": ""
    },
    {
        "id1": 4797,
        "id2": 4799,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4813,
        "id2": 4807,
        "phenotype_comparison": ""
    },
    {
        "id1": 4826,
        "id2": 4827,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4829,
        "id2": 4842,
        "phenotype_comparison": ""
    },
    {
        "id1": 4858,
        "id2": 4847,
        "phenotype_comparison": ""
    },
    {
        "id1": 4877,
        "id2": 4879,
        "phenotype_comparison": ""
    },
    {
        "id1": 4898,
        "id2": 4900,
        "phenotype_comparison": "RNAi against daf-15 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4926,
        "id2": 4928,
        "phenotype_comparison": ""
    },
    {
        "id1": 4943,
        "id2": 4949,
        "phenotype_comparison": ""
    },
    {
        "id1": 4967,
        "id2": 4969,
        "phenotype_comparison": ""
    },
    {
        "id1": 4992,
        "id2": 4994,
        "phenotype_comparison": ""
    },
    {
        "id1": 5017,
        "id2": 5018,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5038,
        "phenotype_comparison": ""
    },
    {
        "id1": 5054,
        "id2": 5058,
        "phenotype_comparison": ""
    },
    {
        "id1": 5061,
        "id2": 5072,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (par-4) affected longevity induced by RNAi-mediated Mit mutants analyzed other than cco-1 RNAi."
    },
    {
        "id1": 5059,
        "id2": 5086,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (mml-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than nuo-2 RNAi."
    },
    {
        "id1": 5112,
        "id2": 5113,
        "phenotype_comparison": ""
    },
    {
        "id1": 5144,
        "id2": 5145,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was completely suppressed by hsf-1(sy441) mutations."
    },
    {
        "id1": 5162,
        "id2": 5167,
        "phenotype_comparison": ""
    },
    {
        "id1": 5187,
        "id2": 5188,
        "phenotype_comparison": "We found that increased lifespan conferred by knockdown of rps-6 was suppressed by hsf-1 mutations."
    },
    {
        "id1": 5208,
        "id2": 5210,
        "phenotype_comparison": ""
    },
    {
        "id1": 5230,
        "id2": 5231,
        "phenotype_comparison": "daf-16 RNAi treatment for during adulthood shortened the lifespan of both rsks-1(tm1714) and wild type animals."
    },
    {
        "id1": 5252,
        "id2": 5254,
        "phenotype_comparison": ""
    },
    {
        "id1": 5278,
        "id2": 5279,
        "phenotype_comparison": "The longevity associated with inhibiting eif-1A gene was decreased but not eliminated by skn-1 mutation."
    },
    {
        "id1": 5298,
        "id2": 5309,
        "phenotype_comparison": ""
    },
    {
        "id1": 5333,
        "id2": 5335,
        "phenotype_comparison": ""
    },
    {
        "id1": 5357,
        "id2": 5358,
        "phenotype_comparison": ""
    },
    {
        "id1": 5387,
        "id2": 5391,
        "phenotype_comparison": ""
    },
    {
        "id1": 5360,
        "id2": 5410,
        "phenotype_comparison": ""
    },
    {
        "id1": 5438,
        "id2": 5439,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5462,
        "id2": 5463,
        "phenotype_comparison": ""
    },
    {
        "id1": 5477,
        "id2": 5479,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5498,
        "id2": 5500,
        "phenotype_comparison": ""
    },
    {
        "id1": 5522,
        "id2": 5523,
        "phenotype_comparison": ""
    },
    {
        "id1": 5544,
        "id2": 5545,
        "phenotype_comparison": "At 15\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 15\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals."
    },
    {
        "id1": 5566,
        "id2": 5567,
        "phenotype_comparison": ""
    },
    {
        "id1": 5584,
        "id2": 5585,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 15\u00b0C."
    },
    {
        "id1": 5594,
        "id2": 5602,
        "phenotype_comparison": ""
    },
    {
        "id1": 5622,
        "id2": 5624,
        "phenotype_comparison": ""
    },
    {
        "id1": 5644,
        "id2": 5646,
        "phenotype_comparison": ""
    },
    {
        "id1": 5665,
        "id2": 5666,
        "phenotype_comparison": ""
    },
    {
        "id1": 5679,
        "id2": 5683,
        "phenotype_comparison": ""
    },
    {
        "id1": 5711,
        "id2": 5712,
        "phenotype_comparison": "In double mutants, raga-1(ok386) further increased rsks-1(ok1255) lifespan, suggesting that these genes may act at least partially in different pathways to exert lifespan effects."
    },
    {
        "id1": 5726,
        "id2": 5739,
        "phenotype_comparison": ""
    },
    {
        "id1": 5766,
        "id2": 5767,
        "phenotype_comparison": ""
    },
    {
        "id1": 5791,
        "id2": 5792,
        "phenotype_comparison": "Both of two different bec-1 RNAi clones shortened the mean lifespan of eat-2(ad1116) mutants by ~15\u201330%, but did not shorten wild-type lifespan."
    },
    {
        "id1": 5813,
        "id2": 5815,
        "phenotype_comparison": ""
    },
    {
        "id1": 5833,
        "id2": 5836,
        "phenotype_comparison": ""
    },
    {
        "id1": 5790,
        "id2": 5871,
        "phenotype_comparison": ""
    },
    {
        "id1": 5902,
        "id2": 5904,
        "phenotype_comparison": ""
    },
    {
        "id1": 5927,
        "id2": 5929,
        "phenotype_comparison": ""
    },
    {
        "id1": 5953,
        "id2": 5954,
        "phenotype_comparison": "daf-2(e1370);nhl-1(gk15) worms exhibited a markedly increased lifespan compared to daf-2(e1370) mutants."
    },
    {
        "id1": 5971,
        "id2": 5974,
        "phenotype_comparison": "The lifespan extension of cye-1(RNAi) was strongly suppressed in the daf-9(rh50) mutant background."
    },
    {
        "id1": 5992,
        "id2": 5994,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 6011,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 6027,
        "phenotype_comparison": ""
    },
    {
        "id1": 6043,
        "id2": 6044,
        "phenotype_comparison": ""
    },
    {
        "id1": 5965,
        "id2": 6058,
        "phenotype_comparison": "The pro-longevity effect of cye-1 was essentially prevented by mutation of skn-1(zu67)."
    },
    {
        "id1": 5959,
        "id2": 6072,
        "phenotype_comparison": ""
    },
    {
        "id1": 6087,
        "id2": 6089,
        "phenotype_comparison": ""
    },
    {
        "id1": 6103,
        "id2": 6104,
        "phenotype_comparison": "RNAi inactivation of W01B11.3 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6117,
        "id2": 6118,
        "phenotype_comparison": "RNAi inactivation of R53.4 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6094,
        "id2": 6132,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6148,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6167,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6177,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6187,
        "phenotype_comparison": ""
    },
    {
        "id1": 6201,
        "id2": 6203,
        "phenotype_comparison": ""
    },
    {
        "id1": 6216,
        "id2": 6220,
        "phenotype_comparison": ""
    },
    {
        "id1": 6216,
        "id2": 6238,
        "phenotype_comparison": ""
    },
    {
        "id1": 6259,
        "id2": 6260,
        "phenotype_comparison": ""
    },
    {
        "id1": 6272,
        "id2": 6275,
        "phenotype_comparison": ""
    },
    {
        "id1": 6287,
        "id2": 6290,
        "phenotype_comparison": ""
    },
    {
        "id1": 6299,
        "id2": 6305,
        "phenotype_comparison": ""
    },
    {
        "id1": 6320,
        "id2": 6321,
        "phenotype_comparison": ""
    },
    {
        "id1": 6318,
        "id2": 6337,
        "phenotype_comparison": "Consistently, cyc-2.1 RNAi fails to extend lifespan of the aak-2(ok524) deletion mutant."
    },
    {
        "id1": 6360,
        "id2": 6362,
        "phenotype_comparison": ""
    },
    {
        "id1": 6377,
        "id2": 6382,
        "phenotype_comparison": ""
    },
    {
        "id1": 6403,
        "id2": 6405,
        "phenotype_comparison": ""
    },
    {
        "id1": 6427,
        "id2": 6430,
        "phenotype_comparison": ""
    },
    {
        "id1": 6454,
        "id2": 6455,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6477,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6489,
        "phenotype_comparison": ""
    },
    {
        "id1": 6489,
        "id2": 6498,
        "phenotype_comparison": "RNAi inactivation of mes-4 could partially suppress the enhanced longevity of daf-2/InsR mutants."
    },
    {
        "id1": 6507,
        "id2": 6509,
        "phenotype_comparison": ""
    },
    {
        "id1": 6523,
        "id2": 6524,
        "phenotype_comparison": "eat2(ad1116);daf-9(rh50) double mutants exhibited a lifespan comparable to that of daf-9(rh50) mutants and shorter than that of eat-2(ad1116) mutants."
    },
    {
        "id1": 6536,
        "id2": 6540,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6551,
        "phenotype_comparison": ""
    },
    {
        "id1": 4305,
        "id2": 4307,
        "phenotype_comparison": ""
    },
    {
        "id1": 4328,
        "id2": 4332,
        "phenotype_comparison": ""
    },
    {
        "id1": 4355,
        "id2": 4356,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4402,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4428,
        "phenotype_comparison": ""
    },
    {
        "id1": 4450,
        "id2": 4456,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4482,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4509,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4535,
        "phenotype_comparison": ""
    },
    {
        "id1": 4564,
        "id2": 4565,
        "phenotype_comparison": ""
    },
    {
        "id1": 4597,
        "id2": 4598,
        "phenotype_comparison": ""
    },
    {
        "id1": 4606,
        "id2": 4625,
        "phenotype_comparison": ""
    },
    {
        "id1": 4641,
        "id2": 4643,
        "phenotype_comparison": "Lifespan of age-1(hx546) mutants is dependent on protein O-GlcNAc modification as seen in age-1; ogt-1 double mutants."
    },
    {
        "id1": 4659,
        "id2": 4664,
        "phenotype_comparison": ""
    },
    {
        "id1": 4685,
        "id2": 4686,
        "phenotype_comparison": ""
    },
    {
        "id1": 4706,
        "id2": 4707,
        "phenotype_comparison": "Animals treated with daf-16(RNAi) indeed lived as long as shc-1 mutants, and daf-16(RNAi) did not further reduce shc-1-shortened life span."
    },
    {
        "id1": 4732,
        "id2": 4734,
        "phenotype_comparison": ""
    },
    {
        "id1": 4760,
        "id2": 4761,
        "phenotype_comparison": ""
    },
    {
        "id1": 4781,
        "id2": 4784,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4796,
        "id2": 4800,
        "phenotype_comparison": ""
    },
    {
        "id1": 4814,
        "id2": 4807,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4825,
        "id2": 4816,
        "phenotype_comparison": ""
    },
    {
        "id1": 4837,
        "id2": 4843,
        "phenotype_comparison": ""
    },
    {
        "id1": 4859,
        "id2": 4847,
        "phenotype_comparison": "Knocking down of ftt-2 alone did not substantially reduce hcf-1(pk924) lifespan."
    },
    {
        "id1": 4878,
        "id2": 4879,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (ragc-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4901,
        "id2": 4902,
        "phenotype_comparison": ""
    },
    {
        "id1": 4927,
        "id2": 4928,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (raga-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4948,
        "id2": 4949,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (rheb-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4968,
        "id2": 4900,
        "phenotype_comparison": ""
    },
    {
        "id1": 4993,
        "id2": 4994,
        "phenotype_comparison": ""
    },
    {
        "id1": 5017,
        "id2": 5019,
        "phenotype_comparison": ""
    },
    {
        "id1": 5038,
        "id2": 5039,
        "phenotype_comparison": ""
    },
    {
        "id1": 5057,
        "id2": 5058,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than isp-1 RNAi."
    },
    {
        "id1": 5028,
        "id2": 5073,
        "phenotype_comparison": ""
    },
    {
        "id1": 5083,
        "id2": 5087,
        "phenotype_comparison": ""
    },
    {
        "id1": 5114,
        "id2": 5115,
        "phenotype_comparison": ""
    },
    {
        "id1": 5146,
        "id2": 5147,
        "phenotype_comparison": ""
    },
    {
        "id1": 5166,
        "id2": 5168,
        "phenotype_comparison": ""
    },
    {
        "id1": 5158,
        "id2": 5189,
        "phenotype_comparison": ""
    },
    {
        "id1": 5209,
        "id2": 5211,
        "phenotype_comparison": ""
    },
    {
        "id1": 5232,
        "id2": 5233,
        "phenotype_comparison": ""
    },
    {
        "id1": 5253,
        "id2": 5254,
        "phenotype_comparison": "daf-9 RNAi had no effect on the AMP/ATP ratio in either fed or food-deprived wild-type and aak-2/AMPK-overexpressing animals."
    },
    {
        "id1": 5280,
        "id2": 5281,
        "phenotype_comparison": ""
    },
    {
        "id1": 5308,
        "id2": 5309,
        "phenotype_comparison": "skn-1(RNAi) on ets-4(ok165) worms did not alter the extended life span phenotype of these worms."
    },
    {
        "id1": 5334,
        "id2": 5335,
        "phenotype_comparison": "aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively)."
    },
    {
        "id1": 5358,
        "id2": 5359,
        "phenotype_comparison": ""
    },
    {
        "id1": 5387,
        "id2": 5392,
        "phenotype_comparison": ""
    },
    {
        "id1": 5360,
        "id2": 5411,
        "phenotype_comparison": ""
    },
    {
        "id1": 5438,
        "id2": 5440,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5462,
        "id2": 5464,
        "phenotype_comparison": ""
    },
    {
        "id1": 5480,
        "id2": 5481,
        "phenotype_comparison": ""
    },
    {
        "id1": 5499,
        "id2": 5501,
        "phenotype_comparison": ""
    },
    {
        "id1": 5522,
        "id2": 5524,
        "phenotype_comparison": ""
    },
    {
        "id1": 5546,
        "id2": 5547,
        "phenotype_comparison": ""
    },
    {
        "id1": 5566,
        "id2": 5568,
        "phenotype_comparison": ""
    },
    {
        "id1": 5542,
        "id2": 5586,
        "phenotype_comparison": ""
    },
    {
        "id1": 5595,
        "id2": 5603,
        "phenotype_comparison": ""
    },
    {
        "id1": 5623,
        "id2": 5625,
        "phenotype_comparison": ""
    },
    {
        "id1": 5645,
        "id2": 5646,
        "phenotype_comparison": "egl-1(n487) play no apparent role in the life extension that occurs following mild frh-1 RNAi treatment."
    },
    {
        "id1": 5665,
        "id2": 5667,
        "phenotype_comparison": ""
    },
    {
        "id1": 5680,
        "id2": 5684,
        "phenotype_comparison": ""
    },
    {
        "id1": 5713,
        "id2": 5714,
        "phenotype_comparison": "Double mutants with eat-2 (ad1116) indicated that raga-1(ok386) was not susceptible to the lifespan extension effects of dietary restriction using this genetic model, as the double mutants had similar lifespan extension to the respective single eat-2 mutants."
    },
    {
        "id1": 5739,
        "id2": 5740,
        "phenotype_comparison": ""
    },
    {
        "id1": 5766,
        "id2": 5768,
        "phenotype_comparison": ""
    },
    {
        "id1": 5793,
        "id2": 5794,
        "phenotype_comparison": ""
    },
    {
        "id1": 5814,
        "id2": 5816,
        "phenotype_comparison": ""
    },
    {
        "id1": 5837,
        "id2": 5838,
        "phenotype_comparison": ""
    },
    {
        "id1": 5803,
        "id2": 5872,
        "phenotype_comparison": ""
    },
    {
        "id1": 5903,
        "id2": 5904,
        "phenotype_comparison": ""
    },
    {
        "id1": 5928,
        "id2": 5930,
        "phenotype_comparison": ""
    },
    {
        "id1": 5955,
        "id2": 5956,
        "phenotype_comparison": ""
    },
    {
        "id1": 5975,
        "id2": 5976,
        "phenotype_comparison": ""
    },
    {
        "id1": 5993,
        "id2": 5994,
        "phenotype_comparison": "cye-1(RNAi) increases lifespan in rrf-1(pk1417) mutants to a similar extend as in wild type worms (18% compared to 24%, respectively)."
    },
    {
        "id1": 6010,
        "id2": 6012,
        "phenotype_comparison": ""
    },
    {
        "id1": 6025,
        "id2": 6028,
        "phenotype_comparison": ""
    },
    {
        "id1": 6041,
        "id2": 6044,
        "phenotype_comparison": "The lifespan extension of cye-1(RNAi) was strongly suppressed in the daf-9(rh50) mutant background."
    },
    {
        "id1": 6049,
        "id2": 6059,
        "phenotype_comparison": ""
    },
    {
        "id1": 5959,
        "id2": 5965,
        "phenotype_comparison": ""
    },
    {
        "id1": 6088,
        "id2": 6089,
        "phenotype_comparison": "cdk-2(RNAi) fails to extend lifespan in the skn-1(zu67) mutant."
    },
    {
        "id1": 6093,
        "id2": 6105,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6119,
        "phenotype_comparison": ""
    },
    {
        "id1": 6131,
        "id2": 6132,
        "phenotype_comparison": "RNAi inactivation of Y47G6A.10 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6141,
        "id2": 6149,
        "phenotype_comparison": ""
    },
    {
        "id1": 6097,
        "id2": 6167,
        "phenotype_comparison": "RNAi inactivation of D2085.3 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6117,
        "id2": 6177,
        "phenotype_comparison": "RNAi inactivation of R53.4 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6137,
        "id2": 6187,
        "phenotype_comparison": "RNAi inactivation of K11B4.1 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6204,
        "id2": 6205,
        "phenotype_comparison": ""
    },
    {
        "id1": 6216,
        "id2": 6221,
        "phenotype_comparison": ""
    },
    {
        "id1": 6220,
        "id2": 6239,
        "phenotype_comparison": ""
    },
    {
        "id1": 6259,
        "id2": 6261,
        "phenotype_comparison": ""
    },
    {
        "id1": 6268,
        "id2": 6275,
        "phenotype_comparison": ""
    },
    {
        "id1": 6283,
        "id2": 6290,
        "phenotype_comparison": ""
    },
    {
        "id1": 6303,
        "id2": 6305,
        "phenotype_comparison": ""
    },
    {
        "id1": 6320,
        "id2": 6322,
        "phenotype_comparison": ""
    },
    {
        "id1": 6320,
        "id2": 6338,
        "phenotype_comparison": ""
    },
    {
        "id1": 6361,
        "id2": 6363,
        "phenotype_comparison": ""
    },
    {
        "id1": 6381,
        "id2": 6382,
        "phenotype_comparison": "Knockdown of gld-1 significantly decreases lifespan of the rsks-1(ok1255) mutant."
    },
    {
        "id1": 6403,
        "id2": 6406,
        "phenotype_comparison": ""
    },
    {
        "id1": 6427,
        "id2": 6431,
        "phenotype_comparison": ""
    },
    {
        "id1": 6454,
        "id2": 6456,
        "phenotype_comparison": ""
    },
    {
        "id1": 6474,
        "id2": 6478,
        "phenotype_comparison": ""
    },
    {
        "id1": 6474,
        "id2": 6490,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6499,
        "phenotype_comparison": ""
    },
    {
        "id1": 6508,
        "id2": 6510,
        "phenotype_comparison": ""
    },
    {
        "id1": 6525,
        "id2": 6526,
        "phenotype_comparison": ""
    },
    {
        "id1": 6540,
        "id2": 5208,
        "phenotype_comparison": "rsks-1(tm1714) mutations further increased the long lifespan of daf-2(e1370) mutants."
    },
    {
        "id1": 6550,
        "id2": 6551,
        "phenotype_comparison": "RNAi inactivation of a F26E4.6 gene, key to mitochondrial function, markedly extended C. elegans lifespan on both daf-16 (mgDf47) and wild type."
    },
    {
        "id1": 6560,
        "id2": 6561,
        "phenotype_comparison": "RNAi inactivation of a F13G3.7 gene, key to mitochondrial function, markedly extended C. elegans lifespan in daf-16 (mgDf47), and modestly extended lifespan in wild type."
    },
    {
        "id1": 5734,
        "id2": 5738,
        "phenotype_comparison": ""
    },
    {
        "id1": 6124,
        "id2": 6156,
        "phenotype_comparison": ""
    },
    {
        "id1": 6106,
        "id2": 6147,
        "phenotype_comparison": ""
    },
    {
        "id1": 4889,
        "id2": 4891,
        "phenotype_comparison": ""
    },
    {
        "id1": 5406,
        "id2": 5408,
        "phenotype_comparison": ""
    },
    {
        "id1": 6404,
        "id2": 6412,
        "phenotype_comparison": ""
    },
    {
        "id1": 4306,
        "id2": 4308,
        "phenotype_comparison": ""
    },
    {
        "id1": 4331,
        "id2": 4332,
        "phenotype_comparison": "Down-regulation of daf-16 in adulthood suppressed longevity of age-1(hx546) animals."
    },
    {
        "id1": 4357,
        "id2": 4358,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4403,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4429,
        "phenotype_comparison": ""
    },
    {
        "id1": 4450,
        "id2": 4457,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4483,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4510,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4536,
        "phenotype_comparison": ""
    },
    {
        "id1": 4564,
        "id2": 4566,
        "phenotype_comparison": ""
    },
    {
        "id1": 4599,
        "id2": 4600,
        "phenotype_comparison": ""
    },
    {
        "id1": 4621,
        "id2": 4626,
        "phenotype_comparison": ""
    },
    {
        "id1": 4631,
        "id2": 4644,
        "phenotype_comparison": ""
    },
    {
        "id1": 4663,
        "id2": 4665,
        "phenotype_comparison": ""
    },
    {
        "id1": 4685,
        "id2": 4687,
        "phenotype_comparison": ""
    },
    {
        "id1": 4708,
        "id2": 4709,
        "phenotype_comparison": ""
    },
    {
        "id1": 4733,
        "id2": 4735,
        "phenotype_comparison": ""
    },
    {
        "id1": 4762,
        "id2": 4763,
        "phenotype_comparison": ""
    },
    {
        "id1": 4780,
        "id2": 4785,
        "phenotype_comparison": ""
    },
    {
        "id1": 4797,
        "id2": 4800,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4813,
        "id2": 4816,
        "phenotype_comparison": ""
    },
    {
        "id1": 4826,
        "id2": 4816,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4842,
        "id2": 4843,
        "phenotype_comparison": ""
    },
    {
        "id1": 4854,
        "id2": 4860,
        "phenotype_comparison": ""
    },
    {
        "id1": 4880,
        "id2": 4881,
        "phenotype_comparison": ""
    },
    {
        "id1": 4901,
        "id2": 4903,
        "phenotype_comparison": ""
    },
    {
        "id1": 4929,
        "id2": 4930,
        "phenotype_comparison": ""
    },
    {
        "id1": 4921,
        "id2": 4950,
        "phenotype_comparison": ""
    },
    {
        "id1": 4969,
        "id2": 4900,
        "phenotype_comparison": "RNAi against daf-15 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4995,
        "id2": 4996,
        "phenotype_comparison": ""
    },
    {
        "id1": 5018,
        "id2": 5020,
        "phenotype_comparison": ""
    },
    {
        "id1": 5030,
        "id2": 5039,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (par-4) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi."
    },
    {
        "id1": 5028,
        "id2": 5059,
        "phenotype_comparison": ""
    },
    {
        "id1": 5073,
        "id2": 5074,
        "phenotype_comparison": ""
    },
    {
        "id1": 5061,
        "id2": 5087,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (mml-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than cco-1 RNAi."
    },
    {
        "id1": 5116,
        "id2": 5117,
        "phenotype_comparison": ""
    },
    {
        "id1": 5146,
        "id2": 5148,
        "phenotype_comparison": ""
    },
    {
        "id1": 5167,
        "id2": 5168,
        "phenotype_comparison": "hsf-1 RNAi treatment only during adulthood (adult-only RNAi) suppressed the longevity of rsks-1(tm1714) mutants."
    },
    {
        "id1": 5158,
        "id2": 5190,
        "phenotype_comparison": ""
    },
    {
        "id1": 5212,
        "id2": 5213,
        "phenotype_comparison": ""
    },
    {
        "id1": 5232,
        "id2": 5234,
        "phenotype_comparison": ""
    },
    {
        "id1": 5248,
        "id2": 5255,
        "phenotype_comparison": ""
    },
    {
        "id1": 5281,
        "id2": 5282,
        "phenotype_comparison": ""
    },
    {
        "id1": 5310,
        "id2": 5311,
        "phenotype_comparison": ""
    },
    {
        "id1": 5336,
        "id2": 5337,
        "phenotype_comparison": ""
    },
    {
        "id1": 5360,
        "id2": 5361,
        "phenotype_comparison": ""
    },
    {
        "id1": 5391,
        "id2": 5393,
        "phenotype_comparison": ""
    },
    {
        "id1": 5365,
        "id2": 5412,
        "phenotype_comparison": ""
    },
    {
        "id1": 5438,
        "id2": 5441,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5463,
        "id2": 5465,
        "phenotype_comparison": ""
    },
    {
        "id1": 5480,
        "id2": 5482,
        "phenotype_comparison": ""
    },
    {
        "id1": 5500,
        "id2": 5501,
        "phenotype_comparison": "The hif-1(ia4) animals lived significantly longer than N2 animals at 25\u00b0C. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 25\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 25\u00b0C."
    },
    {
        "id1": 5523,
        "id2": 5525,
        "phenotype_comparison": ""
    },
    {
        "id1": 5546,
        "id2": 5548,
        "phenotype_comparison": ""
    },
    {
        "id1": 5567,
        "id2": 5569,
        "phenotype_comparison": ""
    },
    {
        "id1": 5543,
        "id2": 5587,
        "phenotype_comparison": ""
    },
    {
        "id1": 5602,
        "id2": 5603,
        "phenotype_comparison": ""
    },
    {
        "id1": 5624,
        "id2": 5625,
        "phenotype_comparison": "The daf-16(mgDf47);hcf-1(pk924) double mutant had a lifespan indistinguishable from that of the daf-16(mgDf47) single mutant, which is ~20% shorter than wild-type worms."
    },
    {
        "id1": 5647,
        "id2": 5648,
        "phenotype_comparison": ""
    },
    {
        "id1": 5666,
        "id2": 5668,
        "phenotype_comparison": ""
    },
    {
        "id1": 5683,
        "id2": 5684,
        "phenotype_comparison": "The atm-1(gk186) plays no obvious role in the life shortening that occurs following treatment with undiluted atp-3 RNAi."
    },
    {
        "id1": 5715,
        "id2": 5716,
        "phenotype_comparison": ""
    },
    {
        "id1": 5728,
        "id2": 5740,
        "phenotype_comparison": "sir-2.1(ok434) significantly suppresses the longevity of eat-2(ad465)."
    },
    {
        "id1": 5769,
        "id2": 5771,
        "phenotype_comparison": ""
    },
    {
        "id1": 5793,
        "id2": 5795,
        "phenotype_comparison": ""
    },
    {
        "id1": 5817,
        "id2": 5815,
        "phenotype_comparison": ""
    },
    {
        "id1": 5839,
        "id2": 5840,
        "phenotype_comparison": ""
    },
    {
        "id1": 5833,
        "id2": 5873,
        "phenotype_comparison": ""
    },
    {
        "id1": 5897,
        "id2": 5905,
        "phenotype_comparison": ""
    },
    {
        "id1": 5929,
        "id2": 5930,
        "phenotype_comparison": "daf-16(mu86) suppressed the long life span of tax-6(p675) mutant animals."
    },
    {
        "id1": 5955,
        "id2": 5957,
        "phenotype_comparison": ""
    },
    {
        "id1": 5975,
        "id2": 5977,
        "phenotype_comparison": ""
    },
    {
        "id1": 5995,
        "id2": 5996,
        "phenotype_comparison": ""
    },
    {
        "id1": 6011,
        "id2": 6012,
        "phenotype_comparison": "The dramatic lifespan extension associated with knockdown of cdk-2 was not fully eliminated in daf-16(mgDf47) null mutants indicating that DAF-16 is central for the influence of cell cycle regulators on longevity."
    },
    {
        "id1": 6027,
        "id2": 6028,
        "phenotype_comparison": "cdk-2(RNAi) has no effect on longevity of germless glp-1(e2141) mutants."
    },
    {
        "id1": 5984,
        "id2": 6045,
        "phenotype_comparison": ""
    },
    {
        "id1": 6049,
        "id2": 6060,
        "phenotype_comparison": ""
    },
    {
        "id1": 6072,
        "id2": 6073,
        "phenotype_comparison": ""
    },
    {
        "id1": 6039,
        "id2": 6090,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6106,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6120,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6133,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6150,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6168,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6178,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6188,
        "phenotype_comparison": ""
    },
    {
        "id1": 6204,
        "id2": 6206,
        "phenotype_comparison": ""
    },
    {
        "id1": 6220,
        "id2": 6222,
        "phenotype_comparison": ""
    },
    {
        "id1": 6238,
        "id2": 6239,
        "phenotype_comparison": "clk-10 (qm169) mutations did not increase the life span of daf-2(e1370) worms and thus are non-additive."
    },
    {
        "id1": 6260,
        "id2": 6262,
        "phenotype_comparison": ""
    },
    {
        "id1": 6266,
        "id2": 6276,
        "phenotype_comparison": ""
    },
    {
        "id1": 6281,
        "id2": 6291,
        "phenotype_comparison": ""
    },
    {
        "id1": 6266,
        "id2": 6306,
        "phenotype_comparison": ""
    },
    {
        "id1": 6321,
        "id2": 6323,
        "phenotype_comparison": ""
    },
    {
        "id1": 6338,
        "id2": 6339,
        "phenotype_comparison": ""
    },
    {
        "id1": 6352,
        "id2": 6364,
        "phenotype_comparison": ""
    },
    {
        "id1": 6376,
        "id2": 6383,
        "phenotype_comparison": ""
    },
    {
        "id1": 6407,
        "id2": 6408,
        "phenotype_comparison": ""
    },
    {
        "id1": 6432,
        "id2": 6433,
        "phenotype_comparison": ""
    },
    {
        "id1": 6454,
        "id2": 6457,
        "phenotype_comparison": ""
    },
    {
        "id1": 6477,
        "id2": 6478,
        "phenotype_comparison": ""
    },
    {
        "id1": 6489,
        "id2": 6490,
        "phenotype_comparison": "RNAi inactivation of mes-4 could partially suppress the enhanced longevity of daf-2/InsR mutants."
    },
    {
        "id1": 6499,
        "id2": 6500,
        "phenotype_comparison": ""
    },
    {
        "id1": 6509,
        "id2": 6510,
        "phenotype_comparison": "daf-28(tm2308) or ins-1(tm2416) alone had little or no effect on adult lifespan. Similarly, loss of both ins-6 and daf-28 had little effect on the lifespan of animals."
    },
    {
        "id1": 6526,
        "id2": 6527,
        "phenotype_comparison": ""
    },
    {
        "id1": 6538,
        "id2": 6541,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6552,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6562,
        "phenotype_comparison": ""
    },
    {
        "id1": 5759,
        "id2": 5765,
        "phenotype_comparison": ""
    },
    {
        "id1": 6118,
        "id2": 6153,
        "phenotype_comparison": ""
    },
    {
        "id1": 6108,
        "id2": 6148,
        "phenotype_comparison": ""
    },
    {
        "id1": 4928,
        "id2": 4979,
        "phenotype_comparison": ""
    },
    {
        "id1": 5262,
        "id2": 5264,
        "phenotype_comparison": ""
    },
    {
        "id1": 6406,
        "id2": 6414,
        "phenotype_comparison": ""
    },
    {
        "id1": 6449,
        "id2": 6453,
        "phenotype_comparison": ""
    },
    {
        "id1": 6325,
        "id2": 6329,
        "phenotype_comparison": ""
    },
    {
        "id1": 5750,
        "id2": 5763,
        "phenotype_comparison": ""
    },
    {
        "id1": 6571,
        "id2": 4709,
        "phenotype_comparison": ""
    },
    {
        "id1": 5034,
        "id2": 5036,
        "phenotype_comparison": ""
    },
    {
        "id1": 6446,
        "id2": 6450,
        "phenotype_comparison": ""
    },
    {
        "id1": 6326,
        "id2": 6330,
        "phenotype_comparison": ""
    },
    {
        "id1": 6581,
        "id2": 6583,
        "phenotype_comparison": ""
    },
    {
        "id1": 6589,
        "id2": 6591,
        "phenotype_comparison": ""
    },
    {
        "id1": 6593,
        "id2": 6595,
        "phenotype_comparison": ""
    },
    {
        "id1": 4307,
        "id2": 4308,
        "phenotype_comparison": "Daf-16(RNAi) does not prevent lifespan extension from deletion of vhl-1."
    },
    {
        "id1": 4327,
        "id2": 4333,
        "phenotype_comparison": ""
    },
    {
        "id1": 4359,
        "id2": 4360,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4404,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4430,
        "phenotype_comparison": ""
    },
    {
        "id1": 4450,
        "id2": 4458,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4485,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4511,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4537,
        "phenotype_comparison": ""
    },
    {
        "id1": 4567,
        "id2": 4568,
        "phenotype_comparison": ""
    },
    {
        "id1": 4600,
        "id2": 4601,
        "phenotype_comparison": ""
    },
    {
        "id1": 4625,
        "id2": 4626,
        "phenotype_comparison": "RNAi of nlp-7 failed to show a significant effect on life span of cup-4(ok837)."
    },
    {
        "id1": 4632,
        "id2": 4645,
        "phenotype_comparison": ""
    },
    {
        "id1": 4664,
        "id2": 4665,
        "phenotype_comparison": "nhr-49 mutation had no impact on the extended lifespan of daf-2(e1368) mutants in two of three independent trials and caused a small suppression in longevity in the third."
    },
    {
        "id1": 4686,
        "id2": 4688,
        "phenotype_comparison": ""
    },
    {
        "id1": 4708,
        "id2": 4710,
        "phenotype_comparison": ""
    },
    {
        "id1": 4734,
        "id2": 4735,
        "phenotype_comparison": "The jkk-1(km2)-null mutants have a short life span compared with wild type, and jkk-1 further reduced the already short life span of shc-1(ok198). The shc-1;jkk-1 double mutant displayed a shorter life span than each single mutant."
    },
    {
        "id1": 4762,
        "id2": 4764,
        "phenotype_comparison": ""
    },
    {
        "id1": 4781,
        "id2": 4785,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4796,
        "id2": 4801,
        "phenotype_comparison": ""
    },
    {
        "id1": 4814,
        "id2": 4816,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4825,
        "id2": 4817,
        "phenotype_comparison": ""
    },
    {
        "id1": 4844,
        "id2": 4845,
        "phenotype_comparison": ""
    },
    {
        "id1": 4859,
        "id2": 4860,
        "phenotype_comparison": ""
    },
    {
        "id1": 4880,
        "id2": 4882,
        "phenotype_comparison": ""
    },
    {
        "id1": 4902,
        "id2": 4904,
        "phenotype_comparison": ""
    },
    {
        "id1": 4929,
        "id2": 4931,
        "phenotype_comparison": ""
    },
    {
        "id1": 4950,
        "id2": 4951,
        "phenotype_comparison": ""
    },
    {
        "id1": 4942,
        "id2": 4970,
        "phenotype_comparison": ""
    },
    {
        "id1": 4905,
        "id2": 4997,
        "phenotype_comparison": ""
    },
    {
        "id1": 5019,
        "id2": 5020,
        "phenotype_comparison": "Knockdown of eif-1 extended the lifespan of kri-1 mutants, in which the GSC pathway is blocked."
    },
    {
        "id1": 5040,
        "id2": 5041,
        "phenotype_comparison": ""
    },
    {
        "id1": 5054,
        "id2": 5060,
        "phenotype_comparison": ""
    },
    {
        "id1": 5055,
        "id2": 5074,
        "phenotype_comparison": ""
    },
    {
        "id1": 5088,
        "id2": 5089,
        "phenotype_comparison": ""
    },
    {
        "id1": 5118,
        "id2": 5119,
        "phenotype_comparison": ""
    },
    {
        "id1": 5147,
        "id2": 5149,
        "phenotype_comparison": ""
    },
    {
        "id1": 5169,
        "id2": 5170,
        "phenotype_comparison": ""
    },
    {
        "id1": 5189,
        "id2": 5191,
        "phenotype_comparison": ""
    },
    {
        "id1": 5214,
        "id2": 5215,
        "phenotype_comparison": ""
    },
    {
        "id1": 5233,
        "id2": 5235,
        "phenotype_comparison": ""
    },
    {
        "id1": 5255,
        "id2": 5256,
        "phenotype_comparison": ""
    },
    {
        "id1": 5283,
        "id2": 5284,
        "phenotype_comparison": ""
    },
    {
        "id1": 5310,
        "id2": 5312,
        "phenotype_comparison": ""
    },
    {
        "id1": 5336,
        "id2": 5338,
        "phenotype_comparison": ""
    },
    {
        "id1": 5360,
        "id2": 5362,
        "phenotype_comparison": ""
    },
    {
        "id1": 5392,
        "id2": 5393,
        "phenotype_comparison": "Abrogated aakg-4 expression using RNAi, and observed a greater reduction in lifespan in daf-2 than in wild-type worms."
    },
    {
        "id1": 5365,
        "id2": 5413,
        "phenotype_comparison": ""
    },
    {
        "id1": 5442,
        "id2": 5443,
        "phenotype_comparison": ""
    },
    {
        "id1": 5464,
        "id2": 5465,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5481,
        "id2": 5483,
        "phenotype_comparison": ""
    },
    {
        "id1": 5502,
        "id2": 5503,
        "phenotype_comparison": ""
    },
    {
        "id1": 5524,
        "id2": 5525,
        "phenotype_comparison": "At 20\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived 20\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 20\u00b0C."
    },
    {
        "id1": 5547,
        "id2": 5549,
        "phenotype_comparison": ""
    },
    {
        "id1": 5568,
        "id2": 5569,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 25\u00b0C."
    },
    {
        "id1": 5586,
        "id2": 5587,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 15\u00b0C."
    },
    {
        "id1": 5604,
        "id2": 5605,
        "phenotype_comparison": ""
    },
    {
        "id1": 5622,
        "id2": 5626,
        "phenotype_comparison": ""
    },
    {
        "id1": 5647,
        "id2": 5649,
        "phenotype_comparison": ""
    },
    {
        "id1": 5667,
        "id2": 5668,
        "phenotype_comparison": "frh-1 RNAi increased lifespan on wild-type strains as well as on skn-1(zu67)."
    },
    {
        "id1": 5679,
        "id2": 5685,
        "phenotype_comparison": ""
    },
    {
        "id1": 5717,
        "id2": 5718,
        "phenotype_comparison": ""
    },
    {
        "id1": 5741,
        "id2": 5742,
        "phenotype_comparison": ""
    },
    {
        "id1": 5770,
        "id2": 5772,
        "phenotype_comparison": ""
    },
    {
        "id1": 5794,
        "id2": 5796,
        "phenotype_comparison": ""
    },
    {
        "id1": 5818,
        "id2": 5819,
        "phenotype_comparison": ""
    },
    {
        "id1": 5841,
        "id2": 5842,
        "phenotype_comparison": ""
    },
    {
        "id1": 5833,
        "id2": 5874,
        "phenotype_comparison": ""
    },
    {
        "id1": 5897,
        "id2": 5906,
        "phenotype_comparison": ""
    },
    {
        "id1": 5931,
        "id2": 5932,
        "phenotype_comparison": ""
    },
    {
        "id1": 5956,
        "id2": 5958,
        "phenotype_comparison": ""
    },
    {
        "id1": 5976,
        "id2": 5978,
        "phenotype_comparison": ""
    },
    {
        "id1": 5995,
        "id2": 5997,
        "phenotype_comparison": ""
    },
    {
        "id1": 6013,
        "id2": 6014,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 6029,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 5993,
        "phenotype_comparison": ""
    },
    {
        "id1": 6059,
        "id2": 6061,
        "phenotype_comparison": ""
    },
    {
        "id1": 5965,
        "id2": 6073,
        "phenotype_comparison": "cye-1(RNAi) increases lifespan in rrf-1(pk1417) mutants to a similar extend as in wild type worms."
    },
    {
        "id1": 6039,
        "id2": 6091,
        "phenotype_comparison": ""
    },
    {
        "id1": 6105,
        "id2": 6106,
        "phenotype_comparison": "RNAi inactivation of F59C6.4 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6119,
        "id2": 6120,
        "phenotype_comparison": "RNAi inactivation of F59C6.5 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6094,
        "id2": 6134,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6151,
        "phenotype_comparison": ""
    },
    {
        "id1": 6099,
        "id2": 6168,
        "phenotype_comparison": "RNAi inactivation of D2013.7 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6119,
        "id2": 6178,
        "phenotype_comparison": "RNAi inactivation of F59C6.5 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6139,
        "id2": 6188,
        "phenotype_comparison": "RNAi inactivation of B0491.5 shortens lifespan of eat-2(ad465) mutants."
    },
    {
        "id1": 6205,
        "id2": 6207,
        "phenotype_comparison": ""
    },
    {
        "id1": 6221,
        "id2": 6222,
        "phenotype_comparison": "clk-4 (qm151) mutation was found to dramatically increase the life span of daf-2(e1370) and wild-type background."
    },
    {
        "id1": 6240,
        "id2": 6241,
        "phenotype_comparison": ""
    },
    {
        "id1": 6261,
        "id2": 6262,
        "phenotype_comparison": "The effects of daf-2(e1370) and isp-1(qm150) on life span are almost identical in magnitude but are not additive as the double mutants live only marginally longer than either of the single mutants. Although there is a slight increase in the life span of the double mutants, it is only a fraction of what their life span would be if the two mutations were increasing life span independently."
    },
    {
        "id1": 6276,
        "id2": 6277,
        "phenotype_comparison": ""
    },
    {
        "id1": 6287,
        "id2": 6292,
        "phenotype_comparison": ""
    },
    {
        "id1": 6306,
        "id2": 6307,
        "phenotype_comparison": ""
    },
    {
        "id1": 6322,
        "id2": 6323,
        "phenotype_comparison": "Knockdown of cyc-2.1 robustly extends lifespan in the wild-type and rsks-1(ok1255) mutant backgrounds."
    },
    {
        "id1": 6322,
        "id2": 6339,
        "phenotype_comparison": "Consistently, cyc-2.1 RNAi fails to extend lifespan of the aak-2(ok524) deletion mutant."
    },
    {
        "id1": 6353,
        "id2": 6365,
        "phenotype_comparison": ""
    },
    {
        "id1": 6383,
        "id2": 6384,
        "phenotype_comparison": ""
    },
    {
        "id1": 6407,
        "id2": 6409,
        "phenotype_comparison": ""
    },
    {
        "id1": 6432,
        "id2": 6434,
        "phenotype_comparison": ""
    },
    {
        "id1": 6458,
        "id2": 6459,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6479,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6491,
        "phenotype_comparison": ""
    },
    {
        "id1": 6477,
        "id2": 6500,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6141,
        "phenotype_comparison": ""
    },
    {
        "id1": 6528,
        "id2": 6529,
        "phenotype_comparison": ""
    },
    {
        "id1": 6541,
        "id2": 5209,
        "phenotype_comparison": "rsks-1(tm1714) mutations further increased the long lifespan of daf-2(e1370) mutants."
    },
    {
        "id1": 6545,
        "id2": 6553,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6563,
        "phenotype_comparison": ""
    },
    {
        "id1": 4309,
        "id2": 4310,
        "phenotype_comparison": ""
    },
    {
        "id1": 4333,
        "id2": 4334,
        "phenotype_comparison": ""
    },
    {
        "id1": 4361,
        "id2": 4362,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4405,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4431,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4460,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4486,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4512,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4538,
        "phenotype_comparison": ""
    },
    {
        "id1": 4567,
        "id2": 4569,
        "phenotype_comparison": ""
    },
    {
        "id1": 4606,
        "id2": 4607,
        "phenotype_comparison": ""
    },
    {
        "id1": 4609,
        "id2": 4627,
        "phenotype_comparison": ""
    },
    {
        "id1": 4644,
        "id2": 4645,
        "phenotype_comparison": "The adult lifespan extension associated with the oga-1(ok1207) mutant is not synergistic or additive with mutations of the long-lived insulin signaling pathway kinase sgk-1."
    },
    {
        "id1": 4655,
        "id2": 4666,
        "phenotype_comparison": ""
    },
    {
        "id1": 4687,
        "id2": 4688,
        "phenotype_comparison": ""
    },
    {
        "id1": 4710,
        "id2": 4711,
        "phenotype_comparison": ""
    },
    {
        "id1": 4736,
        "id2": 4737,
        "phenotype_comparison": ""
    },
    {
        "id1": 4765,
        "id2": 4766,
        "phenotype_comparison": ""
    },
    {
        "id1": 4779,
        "id2": 4786,
        "phenotype_comparison": ""
    },
    {
        "id1": 4797,
        "id2": 4801,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4813,
        "id2": 4817,
        "phenotype_comparison": ""
    },
    {
        "id1": 4826,
        "id2": 4817,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4844,
        "id2": 4846,
        "phenotype_comparison": ""
    },
    {
        "id1": 4852,
        "id2": 4861,
        "phenotype_comparison": ""
    },
    {
        "id1": 4881,
        "id2": 4883,
        "phenotype_comparison": ""
    },
    {
        "id1": 4903,
        "id2": 4904,
        "phenotype_comparison": "Knockdown of raga-1increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 4930,
        "id2": 4932,
        "phenotype_comparison": ""
    },
    {
        "id1": 4923,
        "id2": 4951,
        "phenotype_comparison": "RNAi against raga-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4970,
        "id2": 4971,
        "phenotype_comparison": ""
    },
    {
        "id1": 4906,
        "id2": 4998,
        "phenotype_comparison": ""
    },
    {
        "id1": 4913,
        "id2": 5021,
        "phenotype_comparison": ""
    },
    {
        "id1": 5040,
        "id2": 5042,
        "phenotype_comparison": ""
    },
    {
        "id1": 5059,
        "id2": 5060,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than nuo-2 RNAi."
    },
    {
        "id1": 5073,
        "id2": 5075,
        "phenotype_comparison": ""
    },
    {
        "id1": 5088,
        "id2": 5090,
        "phenotype_comparison": ""
    },
    {
        "id1": 5120,
        "id2": 5121,
        "phenotype_comparison": ""
    },
    {
        "id1": 5148,
        "id2": 5149,
        "phenotype_comparison": "Knockdown of hsf-1 using RNAi only during adulthood completely suppressed the long lifespan of rsks-1 mutants."
    },
    {
        "id1": 5169,
        "id2": 5171,
        "phenotype_comparison": ""
    },
    {
        "id1": 5190,
        "id2": 5191,
        "phenotype_comparison": "We found that increased lifespan conferred by knockdown of rps-6 was suppressed by hsf-1 mutations."
    },
    {
        "id1": 5212,
        "id2": 5216,
        "phenotype_comparison": ""
    },
    {
        "id1": 5234,
        "id2": 5235,
        "phenotype_comparison": "Loss of pqm-1 partially suppresses the life span extension of daf-2 mutants, while pqm-1(?) has no significant effect on wild type."
    },
    {
        "id1": 5250,
        "id2": 5256,
        "phenotype_comparison": "daf-2 RNAi treatment extended the lifespan of control animals and nhr-8(ok186) mutants to a similar extent."
    },
    {
        "id1": 5284,
        "id2": 5285,
        "phenotype_comparison": ""
    },
    {
        "id1": 5311,
        "id2": 5313,
        "phenotype_comparison": ""
    },
    {
        "id1": 5337,
        "id2": 5339,
        "phenotype_comparison": ""
    },
    {
        "id1": 5363,
        "id2": 5364,
        "phenotype_comparison": ""
    },
    {
        "id1": 5391,
        "id2": 5394,
        "phenotype_comparison": ""
    },
    {
        "id1": 5365,
        "id2": 5414,
        "phenotype_comparison": ""
    },
    {
        "id1": 5444,
        "id2": 5445,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5463,
        "id2": 5466,
        "phenotype_comparison": ""
    },
    {
        "id1": 5482,
        "id2": 5483,
        "phenotype_comparison": "The eak alleles did not enhance life span extension of akt-1(mg306), although they all strongly enhanced the dauer formation phenotype of akt-1(mg306)."
    },
    {
        "id1": 5502,
        "id2": 5504,
        "phenotype_comparison": ""
    },
    {
        "id1": 5526,
        "id2": 5527,
        "phenotype_comparison": ""
    },
    {
        "id1": 5548,
        "id2": 5549,
        "phenotype_comparison": "At 15\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 15\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals."
    },
    {
        "id1": 5570,
        "id2": 5571,
        "phenotype_comparison": ""
    },
    {
        "id1": 5546,
        "id2": 5588,
        "phenotype_comparison": ""
    },
    {
        "id1": 5604,
        "id2": 5606,
        "phenotype_comparison": ""
    },
    {
        "id1": 5626,
        "id2": 5627,
        "phenotype_comparison": ""
    },
    {
        "id1": 5648,
        "id2": 5650,
        "phenotype_comparison": ""
    },
    {
        "id1": 5665,
        "id2": 5669,
        "phenotype_comparison": ""
    },
    {
        "id1": 5685,
        "id2": 5646,
        "phenotype_comparison": ""
    },
    {
        "id1": 5719,
        "id2": 5721,
        "phenotype_comparison": ""
    },
    {
        "id1": 5741,
        "id2": 5743,
        "phenotype_comparison": ""
    },
    {
        "id1": 5773,
        "id2": 5775,
        "phenotype_comparison": ""
    },
    {
        "id1": 5795,
        "id2": 5796,
        "phenotype_comparison": "Both of two different bec-1 RNAi clones shortened the mean lifespan of eat-2(ad1116) mutants by ~15\u201330%, but did not shorten wild-type lifespan."
    },
    {
        "id1": 5808,
        "id2": 5821,
        "phenotype_comparison": ""
    },
    {
        "id1": 5843,
        "id2": 5844,
        "phenotype_comparison": ""
    },
    {
        "id1": 5833,
        "id2": 5875,
        "phenotype_comparison": ""
    },
    {
        "id1": 5905,
        "id2": 5907,
        "phenotype_comparison": ""
    },
    {
        "id1": 5931,
        "id2": 5933,
        "phenotype_comparison": ""
    },
    {
        "id1": 5957,
        "id2": 5958,
        "phenotype_comparison": "Disruption of egl-27(we3) shortens daf-2(e1370) lifespan."
    },
    {
        "id1": 5977,
        "id2": 5978,
        "phenotype_comparison": "daf-16(mgDf47) null mutation significantly suppressed the longevity of cye-1(RNAi)."
    },
    {
        "id1": 5996,
        "id2": 5998,
        "phenotype_comparison": ""
    },
    {
        "id1": 6013,
        "id2": 6015,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 6030,
        "phenotype_comparison": ""
    },
    {
        "id1": 6045,
        "id2": 6046,
        "phenotype_comparison": ""
    },
    {
        "id1": 6060,
        "id2": 6061,
        "phenotype_comparison": "The longevity associated with cye-1(RNAi) was strongly suppressed by lack of kri-1(ok1251), shortening mean lifespan."
    },
    {
        "id1": 5988,
        "id2": 6074,
        "phenotype_comparison": ""
    },
    {
        "id1": 6090,
        "id2": 6092,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6107,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6121,
        "phenotype_comparison": ""
    },
    {
        "id1": 6133,
        "id2": 6134,
        "phenotype_comparison": "RNAi inactivation of F26E4.4 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6141,
        "id2": 6152,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6169,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6179,
        "phenotype_comparison": ""
    },
    {
        "id1": 6189,
        "id2": 6190,
        "phenotype_comparison": ""
    },
    {
        "id1": 6206,
        "id2": 6207,
        "phenotype_comparison": "The treatment of nuo-6(qm200) with isp-1(RNAi) at 25% RNAi had a strong additivity for lifespan."
    },
    {
        "id1": 6223,
        "id2": 6224,
        "phenotype_comparison": ""
    },
    {
        "id1": 6240,
        "id2": 6242,
        "phenotype_comparison": ""
    },
    {
        "id1": 6261,
        "id2": 6263,
        "phenotype_comparison": ""
    },
    {
        "id1": 6268,
        "id2": 6277,
        "phenotype_comparison": "gro-1(e2400); clk-2(qm37) double mutants have a mean life-span similar to that of the wild type."
    },
    {
        "id1": 6291,
        "id2": 6292,
        "phenotype_comparison": ""
    },
    {
        "id1": 6267,
        "id2": 6307,
        "phenotype_comparison": "daf-16(m26) does not suppress the life-span extension seen in clk-1(e2519)."
    },
    {
        "id1": 6316,
        "id2": 6324,
        "phenotype_comparison": ""
    },
    {
        "id1": 6340,
        "id2": 6341,
        "phenotype_comparison": ""
    },
    {
        "id1": 6356,
        "id2": 6366,
        "phenotype_comparison": ""
    },
    {
        "id1": 6378,
        "id2": 6384,
        "phenotype_comparison": "gld-1 RNAi treatment has little effect on lifespan in the wild-type and daf-2(e1370) mutant backgrounds."
    },
    {
        "id1": 6407,
        "id2": 6410,
        "phenotype_comparison": ""
    },
    {
        "id1": 6432,
        "id2": 6435,
        "phenotype_comparison": ""
    },
    {
        "id1": 6458,
        "id2": 6460,
        "phenotype_comparison": ""
    },
    {
        "id1": 6474,
        "id2": 6480,
        "phenotype_comparison": ""
    },
    {
        "id1": 6491,
        "id2": 6492,
        "phenotype_comparison": ""
    },
    {
        "id1": 6499,
        "id2": 6501,
        "phenotype_comparison": ""
    },
    {
        "id1": 6511,
        "id2": 6512,
        "phenotype_comparison": ""
    },
    {
        "id1": 6529,
        "id2": 6530,
        "phenotype_comparison": ""
    },
    {
        "id1": 6540,
        "id2": 6542,
        "phenotype_comparison": ""
    },
    {
        "id1": 6552,
        "id2": 6553,
        "phenotype_comparison": "RNAi inactivation of a F26E4.9 gene, key to mitochondrial function, markedly extended C. elegans lifespan on both daf-16 (mgDf47) and wild type."
    },
    {
        "id1": 6562,
        "id2": 6563,
        "phenotype_comparison": "RNAi inactivation of a K01C8.7 gene, key to mitochondrial function, markedly extended C. elegans lifespan on both daf-16 (mgDf47) mutant and wild type."
    },
    {
        "id1": 4309,
        "id2": 4311,
        "phenotype_comparison": ""
    },
    {
        "id1": 4329,
        "id2": 4334,
        "phenotype_comparison": "hsf-1(RNAi) also suppressed longevity associated with other components of the insulin-like signaling pathway including daf-2(e1370) mutants."
    },
    {
        "id1": 4363,
        "id2": 4364,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4406,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4432,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4461,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4487,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4513,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4539,
        "phenotype_comparison": ""
    },
    {
        "id1": 4570,
        "id2": 4571,
        "phenotype_comparison": ""
    },
    {
        "id1": 4607,
        "id2": 4608,
        "phenotype_comparison": ""
    },
    {
        "id1": 4623,
        "id2": 4628,
        "phenotype_comparison": ""
    },
    {
        "id1": 4633,
        "id2": 4646,
        "phenotype_comparison": ""
    },
    {
        "id1": 4666,
        "id2": 4667,
        "phenotype_comparison": ""
    },
    {
        "id1": 4685,
        "id2": 4689,
        "phenotype_comparison": ""
    },
    {
        "id1": 4712,
        "id2": 4713,
        "phenotype_comparison": ""
    },
    {
        "id1": 4736,
        "id2": 4738,
        "phenotype_comparison": ""
    },
    {
        "id1": 4767,
        "id2": 4768,
        "phenotype_comparison": ""
    },
    {
        "id1": 4780,
        "id2": 4787,
        "phenotype_comparison": ""
    },
    {
        "id1": 4767,
        "id2": 4777,
        "phenotype_comparison": ""
    },
    {
        "id1": 4814,
        "id2": 4817,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4825,
        "id2": 4806,
        "phenotype_comparison": ""
    },
    {
        "id1": 4845,
        "id2": 4847,
        "phenotype_comparison": ""
    },
    {
        "id1": 4861,
        "id2": 4862,
        "phenotype_comparison": ""
    },
    {
        "id1": 4882,
        "id2": 4883,
        "phenotype_comparison": "RNAi against ragc-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4905,
        "id2": 4906,
        "phenotype_comparison": ""
    },
    {
        "id1": 4931,
        "id2": 4932,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (raga-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4925,
        "id2": 4952,
        "phenotype_comparison": ""
    },
    {
        "id1": 4944,
        "id2": 4971,
        "phenotype_comparison": "RNAi against daf-15 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4997,
        "id2": 4998,
        "phenotype_comparison": "Knockdown of the translation initiation factors eif-1 increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 4913,
        "id2": 5022,
        "phenotype_comparison": ""
    },
    {
        "id1": 5041,
        "id2": 5043,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5061,
        "phenotype_comparison": ""
    },
    {
        "id1": 5057,
        "id2": 5075,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (sad-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than isp-1 RNAi."
    },
    {
        "id1": 5089,
        "id2": 5091,
        "phenotype_comparison": ""
    },
    {
        "id1": 5120,
        "id2": 5122,
        "phenotype_comparison": ""
    },
    {
        "id1": 5150,
        "id2": 5151,
        "phenotype_comparison": ""
    },
    {
        "id1": 5170,
        "id2": 5172,
        "phenotype_comparison": ""
    },
    {
        "id1": 5185,
        "id2": 5192,
        "phenotype_comparison": ""
    },
    {
        "id1": 5214,
        "id2": 5217,
        "phenotype_comparison": ""
    },
    {
        "id1": 5232,
        "id2": 5236,
        "phenotype_comparison": ""
    },
    {
        "id1": 5257,
        "id2": 5258,
        "phenotype_comparison": ""
    },
    {
        "id1": 5286,
        "id2": 5287,
        "phenotype_comparison": ""
    },
    {
        "id1": 5312,
        "id2": 5313,
        "phenotype_comparison": "No evidence that the elt-3(vp1) mutation is able to reverse the lifespan extension induced by the daf-2(e1370) mutation."
    },
    {
        "id1": 5338,
        "id2": 5339,
        "phenotype_comparison": "aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively)."
    },
    {
        "id1": 5365,
        "id2": 5366,
        "phenotype_comparison": ""
    },
    {
        "id1": 5389,
        "id2": 5394,
        "phenotype_comparison": "To test whether aakg-5 also contributed to daf-2 Age we used aakg-5(RNAi). Like aakg-4(RNAi), this too markedly reduced lifespan in daf-2 but not N2."
    },
    {
        "id1": 5370,
        "id2": 5415,
        "phenotype_comparison": ""
    },
    {
        "id1": 5444,
        "id2": 5446,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5464,
        "id2": 5466,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5480,
        "id2": 5484,
        "phenotype_comparison": ""
    },
    {
        "id1": 5503,
        "id2": 5505,
        "phenotype_comparison": ""
    },
    {
        "id1": 5526,
        "id2": 5528,
        "phenotype_comparison": ""
    },
    {
        "id1": 5550,
        "id2": 5551,
        "phenotype_comparison": ""
    },
    {
        "id1": 5570,
        "id2": 5572,
        "phenotype_comparison": ""
    },
    {
        "id1": 5547,
        "id2": 5589,
        "phenotype_comparison": ""
    },
    {
        "id1": 5605,
        "id2": 5607,
        "phenotype_comparison": ""
    },
    {
        "id1": 5624,
        "id2": 5627,
        "phenotype_comparison": "Interestingly, the daf-2(e1370);hcf-1(pk924) double mutant lived considerably longer than either the daf-2(e1370) or hcf-1(pk924) single mutant."
    },
    {
        "id1": 5649,
        "id2": 5650,
        "phenotype_comparison": "atm-1 plays no obvious role in the life shortening that occurs following treatment with undiluted atp-3 RNAi."
    },
    {
        "id1": 5665,
        "id2": 5670,
        "phenotype_comparison": ""
    },
    {
        "id1": 5681,
        "id2": 5646,
        "phenotype_comparison": ""
    },
    {
        "id1": 5720,
        "id2": 5721,
        "phenotype_comparison": "The lifespan of sir-2.1 OE animals was reduced lifespan of daf-16(mgDf50);sir-2.1 OE animals, similar to the lifespan of daf-16(mgDf50) mutants alone."
    },
    {
        "id1": 5742,
        "id2": 5744,
        "phenotype_comparison": ""
    },
    {
        "id1": 5774,
        "id2": 5776,
        "phenotype_comparison": ""
    },
    {
        "id1": 5797,
        "id2": 5794,
        "phenotype_comparison": ""
    },
    {
        "id1": 5820,
        "id2": 5822,
        "phenotype_comparison": ""
    },
    {
        "id1": 5845,
        "id2": 5846,
        "phenotype_comparison": ""
    },
    {
        "id1": 5876,
        "id2": 5877,
        "phenotype_comparison": ""
    },
    {
        "id1": 5906,
        "id2": 5907,
        "phenotype_comparison": ""
    },
    {
        "id1": 5932,
        "id2": 5934,
        "phenotype_comparison": ""
    },
    {
        "id1": 5959,
        "id2": 5960,
        "phenotype_comparison": ""
    },
    {
        "id1": 5975,
        "id2": 5979,
        "phenotype_comparison": ""
    },
    {
        "id1": 5997,
        "id2": 5998,
        "phenotype_comparison": "The dramatic lifespan extension associated with knockdown of cdk-2 was not fully eliminated in daf-16(mgDf47) null mutants indicating that DAF-16 is central for the influence of cell cycle regulators on longevity."
    },
    {
        "id1": 6014,
        "id2": 6016,
        "phenotype_comparison": ""
    },
    {
        "id1": 6029,
        "id2": 6031,
        "phenotype_comparison": ""
    },
    {
        "id1": 5993,
        "id2": 6046,
        "phenotype_comparison": "daf-12(rh61rh411);cye-1(RNAi) animals have significantly shortened lifespans compared with cye-1(RNAi)."
    },
    {
        "id1": 6049,
        "id2": 6062,
        "phenotype_comparison": ""
    },
    {
        "id1": 5988,
        "id2": 6075,
        "phenotype_comparison": ""
    },
    {
        "id1": 6091,
        "id2": 6092,
        "phenotype_comparison": "cdk-2(RNAi) fails to extend lifespan in the skn-1(zu67) mutant."
    },
    {
        "id1": 6094,
        "id2": 6108,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6122,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6135,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6153,
        "phenotype_comparison": ""
    },
    {
        "id1": 6101,
        "id2": 6169,
        "phenotype_comparison": "RNAi inactivation of C09D4.5 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6121,
        "id2": 6179,
        "phenotype_comparison": "RNAi inactivation of ZK973.10 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6189,
        "id2": 6191,
        "phenotype_comparison": ""
    },
    {
        "id1": 6204,
        "id2": 6201,
        "phenotype_comparison": ""
    },
    {
        "id1": 6223,
        "id2": 6225,
        "phenotype_comparison": ""
    },
    {
        "id1": 6241,
        "id2": 6243,
        "phenotype_comparison": ""
    },
    {
        "id1": 6259,
        "id2": 6264,
        "phenotype_comparison": ""
    },
    {
        "id1": 6272,
        "id2": 6278,
        "phenotype_comparison": ""
    },
    {
        "id1": 6293,
        "id2": 6294,
        "phenotype_comparison": ""
    },
    {
        "id1": 6306,
        "id2": 6308,
        "phenotype_comparison": ""
    },
    {
        "id1": 6324,
        "id2": 6325,
        "phenotype_comparison": ""
    },
    {
        "id1": 6340,
        "id2": 6342,
        "phenotype_comparison": ""
    },
    {
        "id1": 6357,
        "id2": 6367,
        "phenotype_comparison": ""
    },
    {
        "id1": 6380,
        "id2": 6385,
        "phenotype_comparison": ""
    },
    {
        "id1": 6411,
        "id2": 6412,
        "phenotype_comparison": ""
    },
    {
        "id1": 6432,
        "id2": 6436,
        "phenotype_comparison": ""
    },
    {
        "id1": 6458,
        "id2": 6461,
        "phenotype_comparison": ""
    },
    {
        "id1": 6479,
        "id2": 6480,
        "phenotype_comparison": ""
    },
    {
        "id1": 6477,
        "id2": 6492,
        "phenotype_comparison": ""
    },
    {
        "id1": 6479,
        "id2": 6501,
        "phenotype_comparison": ""
    },
    {
        "id1": 6512,
        "id2": 6513,
        "phenotype_comparison": ""
    },
    {
        "id1": 5248,
        "id2": 6531,
        "phenotype_comparison": ""
    },
    {
        "id1": 6537,
        "id2": 6542,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6554,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6564,
        "phenotype_comparison": ""
    },
    {
        "id1": 5754,
        "id2": 5765,
        "phenotype_comparison": ""
    },
    {
        "id1": 6120,
        "id2": 6154,
        "phenotype_comparison": ""
    },
    {
        "id1": 6110,
        "id2": 6149,
        "phenotype_comparison": ""
    },
    {
        "id1": 4953,
        "id2": 4979,
        "phenotype_comparison": ""
    },
    {
        "id1": 6406,
        "id2": 6410,
        "phenotype_comparison": ""
    },
    {
        "id1": 6416,
        "id2": 6420,
        "phenotype_comparison": ""
    },
    {
        "id1": 6449,
        "id2": 6457,
        "phenotype_comparison": ""
    },
    {
        "id1": 6323,
        "id2": 6331,
        "phenotype_comparison": ""
    },
    {
        "id1": 4549,
        "id2": 4553,
        "phenotype_comparison": ""
    },
    {
        "id1": 6572,
        "id2": 4725,
        "phenotype_comparison": ""
    },
    {
        "id1": 5234,
        "id2": 6573,
        "phenotype_comparison": ""
    },
    {
        "id1": 6458,
        "id2": 6468,
        "phenotype_comparison": ""
    },
    {
        "id1": 6377,
        "id2": 6387,
        "phenotype_comparison": ""
    },
    {
        "id1": 4310,
        "id2": 4312,
        "phenotype_comparison": ""
    },
    {
        "id1": 4327,
        "id2": 4335,
        "phenotype_comparison": ""
    },
    {
        "id1": 4365,
        "id2": 4366,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4407,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4434,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4462,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4488,
        "phenotype_comparison": ""
    },
    {
        "id1": 4446,
        "id2": 4514,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4540,
        "phenotype_comparison": ""
    },
    {
        "id1": 4571,
        "id2": 4572,
        "phenotype_comparison": ""
    },
    {
        "id1": 4609,
        "id2": 4610,
        "phenotype_comparison": ""
    },
    {
        "id1": 4627,
        "id2": 4628,
        "phenotype_comparison": "RNAi of nlp-7 failed to show a significant effect on life span of cup-4(ok837)."
    },
    {
        "id1": 4644,
        "id2": 4646,
        "phenotype_comparison": "Lifespan of sgk-1(ok538) mutants is dependent on protein O-GlcNAc modification as seen in sgk-1; ogt-1 (B) double mutants."
    },
    {
        "id1": 4657,
        "id2": 4667,
        "phenotype_comparison": "nhr-49 mutation had no impact on the extended lifespan of daf-2(e1370) mutants in two of three independent trials and caused a small suppression in longevity in the third."
    },
    {
        "id1": 4686,
        "id2": 4675,
        "phenotype_comparison": ""
    },
    {
        "id1": 4712,
        "id2": 4714,
        "phenotype_comparison": ""
    },
    {
        "id1": 4737,
        "id2": 4739,
        "phenotype_comparison": ""
    },
    {
        "id1": 4767,
        "id2": 4769,
        "phenotype_comparison": ""
    },
    {
        "id1": 4786,
        "id2": 4787,
        "phenotype_comparison": "hcf-1(pk924) mutant worms displayed a mean lifespan >20% longer than that of wild type and the hcf-1(pk924) long-lived phenotype was fully suppressed by daf-16(mgDf47) mutation."
    },
    {
        "id1": 4796,
        "id2": 4802,
        "phenotype_comparison": ""
    },
    {
        "id1": 4813,
        "id2": 4818,
        "phenotype_comparison": ""
    },
    {
        "id1": 4826,
        "id2": 4806,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4846,
        "id2": 4847,
        "phenotype_comparison": "Knocking down of ftt-2 alone did not substantially reduce hcf-1(pk924) lifespan."
    },
    {
        "id1": 4859,
        "id2": 4862,
        "phenotype_comparison": ""
    },
    {
        "id1": 4884,
        "id2": 4885,
        "phenotype_comparison": ""
    },
    {
        "id1": 4905,
        "id2": 4907,
        "phenotype_comparison": ""
    },
    {
        "id1": 4933,
        "id2": 4934,
        "phenotype_comparison": ""
    },
    {
        "id1": 4952,
        "id2": 4953,
        "phenotype_comparison": ""
    },
    {
        "id1": 4965,
        "id2": 4972,
        "phenotype_comparison": ""
    },
    {
        "id1": 4999,
        "id2": 5000,
        "phenotype_comparison": ""
    },
    {
        "id1": 5021,
        "id2": 5023,
        "phenotype_comparison": ""
    },
    {
        "id1": 5042,
        "id2": 5043,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (sad-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi."
    },
    {
        "id1": 5054,
        "id2": 5062,
        "phenotype_comparison": ""
    },
    {
        "id1": 5073,
        "id2": 5076,
        "phenotype_comparison": ""
    },
    {
        "id1": 5090,
        "id2": 5091,
        "phenotype_comparison": "GSC arrest caused by glp-1 loss of function resulted in extended life span; lipl-4 RNAi suppressed this increased longevity but did not reduce wild-type life span."
    },
    {
        "id1": 5123,
        "id2": 5124,
        "phenotype_comparison": ""
    },
    {
        "id1": 5150,
        "id2": 5152,
        "phenotype_comparison": ""
    },
    {
        "id1": 5171,
        "id2": 5172,
        "phenotype_comparison": "hsf-1 RNAi treatment only during adulthood (adult-only RNAi) suppressed the longevity of rsks-1(tm1714) mutants."
    },
    {
        "id1": 5186,
        "id2": 5193,
        "phenotype_comparison": ""
    },
    {
        "id1": 5213,
        "id2": 5218,
        "phenotype_comparison": ""
    },
    {
        "id1": 5232,
        "id2": 5237,
        "phenotype_comparison": ""
    },
    {
        "id1": 5257,
        "id2": 5259,
        "phenotype_comparison": ""
    },
    {
        "id1": 5288,
        "id2": 5289,
        "phenotype_comparison": ""
    },
    {
        "id1": 5314,
        "id2": 5315,
        "phenotype_comparison": ""
    },
    {
        "id1": 5340,
        "id2": 5329,
        "phenotype_comparison": ""
    },
    {
        "id1": 5365,
        "id2": 5367,
        "phenotype_comparison": ""
    },
    {
        "id1": 5395,
        "id2": 5396,
        "phenotype_comparison": ""
    },
    {
        "id1": 5370,
        "id2": 5416,
        "phenotype_comparison": ""
    },
    {
        "id1": 5444,
        "id2": 5447,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5463,
        "id2": 5467,
        "phenotype_comparison": ""
    },
    {
        "id1": 5481,
        "id2": 5485,
        "phenotype_comparison": ""
    },
    {
        "id1": 5504,
        "id2": 5505,
        "phenotype_comparison": "The hif-1(ia4) animals lived significantly longer than N2 animals at 25\u00b0C. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 25\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 25\u00b0C."
    },
    {
        "id1": 5527,
        "id2": 5529,
        "phenotype_comparison": ""
    },
    {
        "id1": 5550,
        "id2": 5552,
        "phenotype_comparison": ""
    },
    {
        "id1": 5571,
        "id2": 5573,
        "phenotype_comparison": ""
    },
    {
        "id1": 5588,
        "id2": 5589,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 15\u00b0C."
    },
    {
        "id1": 5606,
        "id2": 5607,
        "phenotype_comparison": "The daf-16(mgDf47);hcf-1(ok559) double mutant had a lifespan indistinguishable from that of the daf-16(mgDf47) single mutant, which is ~20% shorter than wild-type worms."
    },
    {
        "id1": 5628,
        "id2": 5629,
        "phenotype_comparison": ""
    },
    {
        "id1": 5651,
        "id2": 5652,
        "phenotype_comparison": ""
    },
    {
        "id1": 5669,
        "id2": 5671,
        "phenotype_comparison": ""
    },
    {
        "id1": 5685,
        "id2": 5686,
        "phenotype_comparison": ""
    },
    {
        "id1": 5722,
        "id2": 5723,
        "phenotype_comparison": ""
    },
    {
        "id1": 5743,
        "id2": 5744,
        "phenotype_comparison": "sir-2.1(ok434) significantly suppresses the longevity of eat-2(ad1113)."
    },
    {
        "id1": 5777,
        "id2": 5778,
        "phenotype_comparison": ""
    },
    {
        "id1": 5797,
        "id2": 5798,
        "phenotype_comparison": ""
    },
    {
        "id1": 5817,
        "id2": 5823,
        "phenotype_comparison": ""
    },
    {
        "id1": 5847,
        "id2": 5848,
        "phenotype_comparison": ""
    },
    {
        "id1": 5876,
        "id2": 5878,
        "phenotype_comparison": ""
    },
    {
        "id1": 5908,
        "id2": 5909,
        "phenotype_comparison": ""
    },
    {
        "id1": 5933,
        "id2": 5934,
        "phenotype_comparison": "daf-2(e1370);hsf-1(sy441) worms have decreased lifespan compared to daf-2 worms."
    },
    {
        "id1": 5959,
        "id2": 5961,
        "phenotype_comparison": ""
    },
    {
        "id1": 5979,
        "id2": 5980,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 5999,
        "phenotype_comparison": ""
    },
    {
        "id1": 6015,
        "id2": 6016,
        "phenotype_comparison": "Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms."
    },
    {
        "id1": 6030,
        "id2": 6031,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) was able to extend the lifespan of fertile mes-1(bn7) worms (21%)."
    },
    {
        "id1": 5984,
        "id2": 6047,
        "phenotype_comparison": ""
    },
    {
        "id1": 6059,
        "id2": 6063,
        "phenotype_comparison": ""
    },
    {
        "id1": 6074,
        "id2": 6076,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6094,
        "phenotype_comparison": ""
    },
    {
        "id1": 6107,
        "id2": 6108,
        "phenotype_comparison": "RNAi inactivation of Y48G1A.4 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6121,
        "id2": 6122,
        "phenotype_comparison": "RNAi inactivation of ZK973.10 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6094,
        "id2": 6136,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6154,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6170,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6180,
        "phenotype_comparison": ""
    },
    {
        "id1": 6190,
        "id2": 6192,
        "phenotype_comparison": ""
    },
    {
        "id1": 6204,
        "id2": 6208,
        "phenotype_comparison": ""
    },
    {
        "id1": 6224,
        "id2": 6226,
        "phenotype_comparison": ""
    },
    {
        "id1": 6242,
        "id2": 6243,
        "phenotype_comparison": "The gro-1(e2400) mutation exhibited an additive effect on daf-2(e1370) lifespan."
    },
    {
        "id1": 6264,
        "id2": 6265,
        "phenotype_comparison": ""
    },
    {
        "id1": 6276,
        "id2": 6278,
        "phenotype_comparison": "clk-3(qm38); gro-1(e2400) double mutants have a mean life-span similar to that of the wild type."
    },
    {
        "id1": 6293,
        "id2": 6295,
        "phenotype_comparison": ""
    },
    {
        "id1": 6272,
        "id2": 6308,
        "phenotype_comparison": "daf-16(m26) does not suppress the life-span extension seen in clk-3(qm38)."
    },
    {
        "id1": 6318,
        "id2": 6325,
        "phenotype_comparison": "Knockdown of cyc-2.1 robustly extends lifespan in the wild-type and daf-2(e1370) mutant backgrounds."
    },
    {
        "id1": 6341,
        "id2": 6343,
        "phenotype_comparison": ""
    },
    {
        "id1": 6360,
        "id2": 6368,
        "phenotype_comparison": ""
    },
    {
        "id1": 6385,
        "id2": 6386,
        "phenotype_comparison": ""
    },
    {
        "id1": 6411,
        "id2": 6413,
        "phenotype_comparison": ""
    },
    {
        "id1": 6437,
        "id2": 6438,
        "phenotype_comparison": ""
    },
    {
        "id1": 6458,
        "id2": 6462,
        "phenotype_comparison": ""
    },
    {
        "id1": 6473,
        "id2": 6481,
        "phenotype_comparison": ""
    },
    {
        "id1": 6491,
        "id2": 6493,
        "phenotype_comparison": ""
    },
    {
        "id1": 6499,
        "id2": 6502,
        "phenotype_comparison": ""
    },
    {
        "id1": 6511,
        "id2": 6514,
        "phenotype_comparison": ""
    },
    {
        "id1": 6531,
        "id2": 6532,
        "phenotype_comparison": ""
    },
    {
        "id1": 6541,
        "id2": 6543,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6555,
        "phenotype_comparison": ""
    },
    {
        "id1": 6545,
        "id2": 6565,
        "phenotype_comparison": ""
    },
    {
        "id1": 5761,
        "id2": 5767,
        "phenotype_comparison": ""
    },
    {
        "id1": 6122,
        "id2": 6155,
        "phenotype_comparison": ""
    },
    {
        "id1": 6114,
        "id2": 6151,
        "phenotype_comparison": ""
    },
    {
        "id1": 5033,
        "id2": 5037,
        "phenotype_comparison": ""
    },
    {
        "id1": 6405,
        "id2": 6413,
        "phenotype_comparison": ""
    },
    {
        "id1": 6417,
        "id2": 6421,
        "phenotype_comparison": ""
    },
    {
        "id1": 6459,
        "id2": 6464,
        "phenotype_comparison": ""
    },
    {
        "id1": 6327,
        "id2": 6331,
        "phenotype_comparison": ""
    },
    {
        "id1": 4550,
        "id2": 4554,
        "phenotype_comparison": ""
    },
    {
        "id1": 4311,
        "id2": 4312,
        "phenotype_comparison": "RNAi knock-down of daf-16 does not block life span extension from deletion of vhl-1, but is sufficient to prevent life span extension from mutation of daf-2."
    },
    {
        "id1": 4335,
        "id2": 4336,
        "phenotype_comparison": ""
    },
    {
        "id1": 4367,
        "id2": 4368,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4408,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4435,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4463,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4489,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4516,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4541,
        "phenotype_comparison": ""
    },
    {
        "id1": 4574,
        "id2": 4575,
        "phenotype_comparison": ""
    },
    {
        "id1": 4610,
        "id2": 4611,
        "phenotype_comparison": ""
    },
    {
        "id1": 4629,
        "id2": 4630,
        "phenotype_comparison": ""
    },
    {
        "id1": 4631,
        "id2": 4647,
        "phenotype_comparison": ""
    },
    {
        "id1": 4659,
        "id2": 4668,
        "phenotype_comparison": ""
    },
    {
        "id1": 4689,
        "id2": 4675,
        "phenotype_comparison": ""
    },
    {
        "id1": 4713,
        "id2": 4715,
        "phenotype_comparison": ""
    },
    {
        "id1": 4738,
        "id2": 4739,
        "phenotype_comparison": "Transgenic expression of jkk-1 modestly extended the short life span of the shc-1 mutant. These data suggest an additive effect of shc-1 and jkk-1 on life-span regulation."
    },
    {
        "id1": 4768,
        "id2": 4770,
        "phenotype_comparison": ""
    },
    {
        "id1": 4788,
        "id2": 4789,
        "phenotype_comparison": ""
    },
    {
        "id1": 4777,
        "id2": 4802,
        "phenotype_comparison": "hcf-1(pk924) mutant worms displayed a mean lifespan >20% longer than that of wild type and the hcf-1(pk924) long-lived phenotype was fully suppressed by daf-16(mgDf47) mutation."
    },
    {
        "id1": 4814,
        "id2": 4818,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4826,
        "id2": 4828,
        "phenotype_comparison": ""
    },
    {
        "id1": 4844,
        "id2": 4848,
        "phenotype_comparison": ""
    },
    {
        "id1": 4863,
        "id2": 4864,
        "phenotype_comparison": ""
    },
    {
        "id1": 4884,
        "id2": 4886,
        "phenotype_comparison": ""
    },
    {
        "id1": 4906,
        "id2": 4908,
        "phenotype_comparison": ""
    },
    {
        "id1": 4933,
        "id2": 4935,
        "phenotype_comparison": ""
    },
    {
        "id1": 4927,
        "id2": 4953,
        "phenotype_comparison": "RNAi against raga-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4946,
        "id2": 4972,
        "phenotype_comparison": "RNAi against rheb-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4999,
        "id2": 5001,
        "phenotype_comparison": ""
    },
    {
        "id1": 5022,
        "id2": 5023,
        "phenotype_comparison": "Knockdown of eif-1 extended the lifespan of kri-1 mutants, in which the GSC pathway is blocked."
    },
    {
        "id1": 5040,
        "id2": 5044,
        "phenotype_comparison": ""
    },
    {
        "id1": 5061,
        "id2": 5062,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than cco-1 RNAi."
    },
    {
        "id1": 5059,
        "id2": 5076,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (sad-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than nuo-2 RNAi."
    },
    {
        "id1": 5092,
        "id2": 5093,
        "phenotype_comparison": ""
    },
    {
        "id1": 5123,
        "id2": 5125,
        "phenotype_comparison": ""
    },
    {
        "id1": 5151,
        "id2": 5153,
        "phenotype_comparison": ""
    },
    {
        "id1": 5173,
        "id2": 5174,
        "phenotype_comparison": ""
    },
    {
        "id1": 5192,
        "id2": 5193,
        "phenotype_comparison": "We found that increased lifespan conferred by knockdown of rps-15 was suppressed by hsf-1 mutations."
    },
    {
        "id1": 5215,
        "id2": 5219,
        "phenotype_comparison": ""
    },
    {
        "id1": 5236,
        "id2": 5238,
        "phenotype_comparison": ""
    },
    {
        "id1": 5258,
        "id2": 5260,
        "phenotype_comparison": ""
    },
    {
        "id1": 5289,
        "id2": 5290,
        "phenotype_comparison": ""
    },
    {
        "id1": 5314,
        "id2": 5316,
        "phenotype_comparison": ""
    },
    {
        "id1": 5340,
        "id2": 5341,
        "phenotype_comparison": ""
    },
    {
        "id1": 5368,
        "id2": 5369,
        "phenotype_comparison": ""
    },
    {
        "id1": 5395,
        "id2": 5397,
        "phenotype_comparison": ""
    },
    {
        "id1": 5370,
        "id2": 5417,
        "phenotype_comparison": ""
    },
    {
        "id1": 5448,
        "id2": 5449,
        "phenotype_comparison": ""
    },
    {
        "id1": 5464,
        "id2": 5467,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5484,
        "id2": 5485,
        "phenotype_comparison": ""
    },
    {
        "id1": 5506,
        "id2": 5507,
        "phenotype_comparison": ""
    },
    {
        "id1": 5528,
        "id2": 5529,
        "phenotype_comparison": "At 20\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived 20\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 20\u00b0C."
    },
    {
        "id1": 5551,
        "id2": 5553,
        "phenotype_comparison": ""
    },
    {
        "id1": 5572,
        "id2": 5573,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 20\u00b0C."
    },
    {
        "id1": 5550,
        "id2": 5590,
        "phenotype_comparison": ""
    },
    {
        "id1": 5608,
        "id2": 5609,
        "phenotype_comparison": ""
    },
    {
        "id1": 5628,
        "id2": 5630,
        "phenotype_comparison": ""
    },
    {
        "id1": 5651,
        "id2": 5653,
        "phenotype_comparison": ""
    },
    {
        "id1": 5670,
        "id2": 5671,
        "phenotype_comparison": "Specifically, undiluted atp-3 RNAi decreased the lifespan of the wild-type strain below that of control RNAi-treated animals, while in the cep-1(gk138) mutant strain lifespan was increased with the same RNAi treatment."
    },
    {
        "id1": 5683,
        "id2": 5686,
        "phenotype_comparison": "Loss of egl-1, on the other hand, shortens the lifespan of control fed animal but partially reverted the lifespan shortening effect caused by growth on undiluted atp-3 RNAi."
    },
    {
        "id1": 5722,
        "id2": 5724,
        "phenotype_comparison": ""
    },
    {
        "id1": 5745,
        "id2": 5746,
        "phenotype_comparison": ""
    },
    {
        "id1": 5779,
        "id2": 5780,
        "phenotype_comparison": ""
    },
    {
        "id1": 5794,
        "id2": 5799,
        "phenotype_comparison": ""
    },
    {
        "id1": 5818,
        "id2": 5824,
        "phenotype_comparison": ""
    },
    {
        "id1": 5841,
        "id2": 5849,
        "phenotype_comparison": ""
    },
    {
        "id1": 5879,
        "id2": 5880,
        "phenotype_comparison": ""
    },
    {
        "id1": 5908,
        "id2": 5910,
        "phenotype_comparison": ""
    },
    {
        "id1": 5935,
        "id2": 5936,
        "phenotype_comparison": ""
    },
    {
        "id1": 5960,
        "id2": 5962,
        "phenotype_comparison": ""
    },
    {
        "id1": 5977,
        "id2": 5980,
        "phenotype_comparison": "The pro-longevity effect of cye-1 was essentially prevented by mutation of skn-1(zu67)."
    },
    {
        "id1": 5984,
        "id2": 6000,
        "phenotype_comparison": ""
    },
    {
        "id1": 6004,
        "id2": 6017,
        "phenotype_comparison": ""
    },
    {
        "id1": 5984,
        "id2": 6032,
        "phenotype_comparison": ""
    },
    {
        "id1": 6047,
        "id2": 6048,
        "phenotype_comparison": ""
    },
    {
        "id1": 6062,
        "id2": 6063,
        "phenotype_comparison": "KRI-1 contributes to cdk-2(RNAi) longevity. Survival of cdk-2(RNAi) worms was substantially reduced by kri-1(ok1251) mutation."
    },
    {
        "id1": 6075,
        "id2": 6076,
        "phenotype_comparison": "cye-1(RNAi) increases lifespan in rrf-1(pk1417) mutants to a similar extend as in wild type worms."
    },
    {
        "id1": 6093,
        "id2": 6095,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6109,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6123,
        "phenotype_comparison": ""
    },
    {
        "id1": 6135,
        "id2": 6136,
        "phenotype_comparison": "RNAi inactivation of C56E6.1 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6141,
        "id2": 6155,
        "phenotype_comparison": ""
    },
    {
        "id1": 6103,
        "id2": 6170,
        "phenotype_comparison": "RNAi inactivation of W01B11.3 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6123,
        "id2": 6180,
        "phenotype_comparison": "RNAi inactivation of C01F1.2 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6191,
        "id2": 6192,
        "phenotype_comparison": ""
    },
    {
        "id1": 6201,
        "id2": 6209,
        "phenotype_comparison": ""
    },
    {
        "id1": 6225,
        "id2": 6226,
        "phenotype_comparison": "clk-5 (qm152) mutations did not increase the life span of daf-2(e1370) worms and thus are non-additive."
    },
    {
        "id1": 6244,
        "id2": 6245,
        "phenotype_comparison": ""
    },
    {
        "id1": 6261,
        "id2": 6265,
        "phenotype_comparison": "The life span of the double mutant is shorter than the life span of isp-1(qm150), it is still dramatically longer than the life span of daf-16."
    },
    {
        "id1": 6279,
        "id2": 6280,
        "phenotype_comparison": ""
    },
    {
        "id1": 6294,
        "id2": 6296,
        "phenotype_comparison": ""
    },
    {
        "id1": 6306,
        "id2": 6309,
        "phenotype_comparison": ""
    },
    {
        "id1": 6320,
        "id2": 6326,
        "phenotype_comparison": ""
    },
    {
        "id1": 6342,
        "id2": 6343,
        "phenotype_comparison": "cyc-2.1 RNAi treatment extends lifespan in wild-type animals by 66%, whereas the mean lifespan extension is significantly decreased to 42% in the drp-1(tm1108) mutant."
    },
    {
        "id1": 6361,
        "id2": 6369,
        "phenotype_comparison": ""
    },
    {
        "id1": 6381,
        "id2": 6386,
        "phenotype_comparison": "gld-1 RNAi treatment has little effect on lifespan in the wild-type and daf-2(e1370) mutant backgrounds."
    },
    {
        "id1": 6411,
        "id2": 6414,
        "phenotype_comparison": ""
    },
    {
        "id1": 6437,
        "id2": 6439,
        "phenotype_comparison": ""
    },
    {
        "id1": 6463,
        "id2": 6464,
        "phenotype_comparison": ""
    },
    {
        "id1": 4313,
        "id2": 4314,
        "phenotype_comparison": ""
    },
    {
        "id1": 4329,
        "id2": 4336,
        "phenotype_comparison": "hsf-1(RNAi) also suppressed longevity associated with other components of the insulin-like signaling pathway including OLD overexpressing animals."
    },
    {
        "id1": 4369,
        "id2": 4370,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4409,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4436,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4464,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4490,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4517,
        "phenotype_comparison": ""
    },
    {
        "id1": 4542,
        "id2": 4543,
        "phenotype_comparison": ""
    },
    {
        "id1": 4574,
        "id2": 4576,
        "phenotype_comparison": ""
    },
    {
        "id1": 4606,
        "id2": 4612,
        "phenotype_comparison": ""
    },
    {
        "id1": 4631,
        "id2": 4632,
        "phenotype_comparison": ""
    },
    {
        "id1": 4632,
        "id2": 4648,
        "phenotype_comparison": ""
    },
    {
        "id1": 4668,
        "id2": 4669,
        "phenotype_comparison": ""
    },
    {
        "id1": 4685,
        "id2": 4690,
        "phenotype_comparison": ""
    },
    {
        "id1": 4714,
        "id2": 4715,
        "phenotype_comparison": "Overexpression of daf-16 extended the life span of shc-1 mutant animals. However, the animals carrying integrated daf-16::gfp did not live as long as wild-type animals, suggesting that either daf-16::gfp on its own results in a phenotype or SHC-1 may have additional effects on other lifespan-promoting factors that have to be identified."
    },
    {
        "id1": 4736,
        "id2": 4740,
        "phenotype_comparison": ""
    },
    {
        "id1": 4769,
        "id2": 4770,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4788,
        "id2": 4790,
        "phenotype_comparison": ""
    },
    {
        "id1": 4803,
        "id2": 4804,
        "phenotype_comparison": ""
    },
    {
        "id1": 4814,
        "id2": 4811,
        "phenotype_comparison": ""
    },
    {
        "id1": 4829,
        "id2": 4830,
        "phenotype_comparison": ""
    },
    {
        "id1": 4848,
        "id2": 4849,
        "phenotype_comparison": ""
    },
    {
        "id1": 4863,
        "id2": 4865,
        "phenotype_comparison": ""
    },
    {
        "id1": 4885,
        "id2": 4887,
        "phenotype_comparison": ""
    },
    {
        "id1": 4907,
        "id2": 4908,
        "phenotype_comparison": "Knockdown of the translation initiation factors ifg-1 increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 4934,
        "id2": 4936,
        "phenotype_comparison": ""
    },
    {
        "id1": 4929,
        "id2": 4954,
        "phenotype_comparison": ""
    },
    {
        "id1": 4967,
        "id2": 4973,
        "phenotype_comparison": ""
    },
    {
        "id1": 5000,
        "id2": 5002,
        "phenotype_comparison": ""
    },
    {
        "id1": 5017,
        "id2": 5024,
        "phenotype_comparison": ""
    },
    {
        "id1": 5044,
        "id2": 5045,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5063,
        "phenotype_comparison": ""
    },
    {
        "id1": 5073,
        "id2": 5077,
        "phenotype_comparison": ""
    },
    {
        "id1": 5092,
        "id2": 5094,
        "phenotype_comparison": ""
    },
    {
        "id1": 5126,
        "id2": 5127,
        "phenotype_comparison": ""
    },
    {
        "id1": 5152,
        "id2": 5153,
        "phenotype_comparison": "Knockdown of hsf-1 using RNAi only during adulthood completely suppressed the long lifespan of rsks-1 mutants."
    },
    {
        "id1": 5173,
        "id2": 5175,
        "phenotype_comparison": ""
    },
    {
        "id1": 5158,
        "id2": 5194,
        "phenotype_comparison": ""
    },
    {
        "id1": 5146,
        "id2": 5220,
        "phenotype_comparison": ""
    },
    {
        "id1": 5237,
        "id2": 5238,
        "phenotype_comparison": ""
    },
    {
        "id1": 5259,
        "id2": 5260,
        "phenotype_comparison": "eat-2(ad1116);daf-9(rh50) double mutants and daf-9(rh50) single mutants exhibit similar mean lifespans."
    },
    {
        "id1": 5291,
        "id2": 5292,
        "phenotype_comparison": ""
    },
    {
        "id1": 5315,
        "id2": 5317,
        "phenotype_comparison": ""
    },
    {
        "id1": 5329,
        "id2": 5342,
        "phenotype_comparison": ""
    },
    {
        "id1": 5370,
        "id2": 5371,
        "phenotype_comparison": ""
    },
    {
        "id1": 5396,
        "id2": 5398,
        "phenotype_comparison": ""
    },
    {
        "id1": 5376,
        "id2": 5418,
        "phenotype_comparison": ""
    },
    {
        "id1": 5450,
        "id2": 5451,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5463,
        "id2": 5468,
        "phenotype_comparison": ""
    },
    {
        "id1": 5480,
        "id2": 5486,
        "phenotype_comparison": ""
    },
    {
        "id1": 5506,
        "id2": 5508,
        "phenotype_comparison": ""
    },
    {
        "id1": 5530,
        "id2": 5531,
        "phenotype_comparison": ""
    },
    {
        "id1": 5552,
        "id2": 5553,
        "phenotype_comparison": "At 15\u00b0C, the life span of hif-1(ia4) animals was not significantly different from N2 animals. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 15\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals."
    },
    {
        "id1": 5522,
        "id2": 5574,
        "phenotype_comparison": ""
    },
    {
        "id1": 5551,
        "id2": 5591,
        "phenotype_comparison": ""
    },
    {
        "id1": 5608,
        "id2": 5610,
        "phenotype_comparison": ""
    },
    {
        "id1": 5629,
        "id2": 5631,
        "phenotype_comparison": ""
    },
    {
        "id1": 5652,
        "id2": 5654,
        "phenotype_comparison": ""
    },
    {
        "id1": 5665,
        "id2": 5672,
        "phenotype_comparison": ""
    },
    {
        "id1": 5687,
        "id2": 5688,
        "phenotype_comparison": ""
    },
    {
        "id1": 5723,
        "id2": 5725,
        "phenotype_comparison": ""
    },
    {
        "id1": 5747,
        "id2": 5748,
        "phenotype_comparison": ""
    },
    {
        "id1": 5777,
        "id2": 5781,
        "phenotype_comparison": ""
    },
    {
        "id1": 5798,
        "id2": 5799,
        "phenotype_comparison": "Treating eat-2(ad1116) mutants with vps-34 RNAi on day-1 of adulthood significantly shortened their long lifespan, but not that of wild type."
    },
    {
        "id1": 5773,
        "id2": 5825,
        "phenotype_comparison": ""
    },
    {
        "id1": 5843,
        "id2": 5850,
        "phenotype_comparison": ""
    },
    {
        "id1": 5881,
        "id2": 5883,
        "phenotype_comparison": ""
    },
    {
        "id1": 5908,
        "id2": 5911,
        "phenotype_comparison": ""
    },
    {
        "id1": 5937,
        "id2": 5938,
        "phenotype_comparison": "Deletion of the five sod genes significantly decreased daf-2 lifespan, daf-2(e1370); sod-1(tm783);sod-2(ok1030);sod-3(tm760);sod-4(gk101);sod-5(tm1146) worms still exhibited a markedly elongated lifespan compared to WT worms."
    },
    {
        "id1": 5961,
        "id2": 5962,
        "phenotype_comparison": "Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms."
    },
    {
        "id1": 5975,
        "id2": 5981,
        "phenotype_comparison": ""
    },
    {
        "id1": 5999,
        "id2": 6001,
        "phenotype_comparison": ""
    },
    {
        "id1": 6004,
        "id2": 6018,
        "phenotype_comparison": ""
    },
    {
        "id1": 6032,
        "id2": 6033,
        "phenotype_comparison": ""
    },
    {
        "id1": 5993,
        "id2": 6048,
        "phenotype_comparison": "The lifespan extension of cye-1(RNAi) was strongly suppressed in the daf-9(rh50) mutant background."
    },
    {
        "id1": 5995,
        "id2": 6064,
        "phenotype_comparison": ""
    },
    {
        "id1": 6004,
        "id2": 6077,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6096,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6110,
        "phenotype_comparison": ""
    },
    {
        "id1": 6094,
        "id2": 6124,
        "phenotype_comparison": ""
    },
    {
        "id1": 6093,
        "id2": 6137,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6156,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6171,
        "phenotype_comparison": ""
    },
    {
        "id1": 6165,
        "id2": 6181,
        "phenotype_comparison": ""
    },
    {
        "id1": 6193,
        "id2": 6194,
        "phenotype_comparison": ""
    },
    {
        "id1": 6208,
        "id2": 6209,
        "phenotype_comparison": "The treatment of isp-1(qm150) with nuo-6(RNAi) at 50% RNAi had a strong additivity for lifespan."
    },
    {
        "id1": 6227,
        "id2": 6228,
        "phenotype_comparison": ""
    },
    {
        "id1": 6244,
        "id2": 6246,
        "phenotype_comparison": ""
    },
    {
        "id1": 6266,
        "id2": 6267,
        "phenotype_comparison": ""
    },
    {
        "id1": 6281,
        "id2": 6282,
        "phenotype_comparison": ""
    },
    {
        "id1": 6295,
        "id2": 6296,
        "phenotype_comparison": ""
    },
    {
        "id1": 6276,
        "id2": 6309,
        "phenotype_comparison": "daf-16(m26) does not suppress the life-span extension seen in gro-1(e2400)."
    },
    {
        "id1": 6326,
        "id2": 6327,
        "phenotype_comparison": ""
    },
    {
        "id1": 6344,
        "id2": 6345,
        "phenotype_comparison": ""
    },
    {
        "id1": 6352,
        "id2": 6370,
        "phenotype_comparison": ""
    },
    {
        "id1": 6387,
        "id2": 6388,
        "phenotype_comparison": ""
    },
    {
        "id1": 6415,
        "id2": 6416,
        "phenotype_comparison": ""
    },
    {
        "id1": 6437,
        "id2": 6440,
        "phenotype_comparison": ""
    },
    {
        "id1": 6463,
        "id2": 6465,
        "phenotype_comparison": ""
    },
    {
        "id1": 6474,
        "id2": 6482,
        "phenotype_comparison": ""
    },
    {
        "id1": 6479,
        "id2": 6493,
        "phenotype_comparison": ""
    },
    {
        "id1": 6481,
        "id2": 6502,
        "phenotype_comparison": ""
    },
    {
        "id1": 6512,
        "id2": 6515,
        "phenotype_comparison": ""
    },
    {
        "id1": 5255,
        "id2": 6532,
        "phenotype_comparison": ""
    },
    {
        "id1": 6539,
        "id2": 6543,
        "phenotype_comparison": ""
    },
    {
        "id1": 6554,
        "id2": 6555,
        "phenotype_comparison": "RNAi inactivation of a W09C5.8 gene, key to mitochondrial function, markedly extended C. elegans lifespan on both daf-16 (mgDf47) and wild type."
    },
    {
        "id1": 6564,
        "id2": 6565,
        "phenotype_comparison": "RNAi inactivation of a F28B3.5 gene, key to mitochondrial function, markedly decreased C. elegans lifespan on daf-16 (mgDf47) mutant."
    },
    {
        "id1": 5762,
        "id2": 5768,
        "phenotype_comparison": ""
    },
    {
        "id1": 6126,
        "id2": 6157,
        "phenotype_comparison": ""
    },
    {
        "id1": 5788,
        "id2": 5807,
        "phenotype_comparison": ""
    },
    {
        "id1": 5035,
        "id2": 5037,
        "phenotype_comparison": ""
    },
    {
        "id1": 6429,
        "id2": 6434,
        "phenotype_comparison": ""
    },
    {
        "id1": 6418,
        "id2": 6422,
        "phenotype_comparison": ""
    },
    {
        "id1": 6460,
        "id2": 6465,
        "phenotype_comparison": ""
    },
    {
        "id1": 6379,
        "id2": 6388,
        "phenotype_comparison": ""
    },
    {
        "id1": 6569,
        "id2": 650,
        "phenotype_comparison": ""
    },
    {
        "id1": 4597,
        "id2": 4602,
        "phenotype_comparison": ""
    },
    {
        "id1": 6403,
        "id2": 6407,
        "phenotype_comparison": ""
    },
    {
        "id1": 6446,
        "id2": 6454,
        "phenotype_comparison": ""
    },
    {
        "id1": 6383,
        "id2": 6387,
        "phenotype_comparison": ""
    },
    {
        "id1": 6577,
        "id2": 6578,
        "phenotype_comparison": "Complementation tests with females, the X-chromosome location of snz precluded this analysis in males, and observed lifespan extension in transheterozygotes of C32 with either G1409 or SZ4089."
    },
    {
        "id1": 6582,
        "id2": 6584,
        "phenotype_comparison": ""
    },
    {
        "id1": 4315,
        "id2": 4316,
        "phenotype_comparison": ""
    },
    {
        "id1": 4337,
        "id2": 4338,
        "phenotype_comparison": ""
    },
    {
        "id1": 4371,
        "id2": 4372,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4410,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4437,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4465,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4491,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4518,
        "phenotype_comparison": ""
    },
    {
        "id1": 4542,
        "id2": 4544,
        "phenotype_comparison": ""
    },
    {
        "id1": 4577,
        "id2": 4578,
        "phenotype_comparison": ""
    },
    {
        "id1": 4607,
        "id2": 4613,
        "phenotype_comparison": ""
    },
    {
        "id1": 4631,
        "id2": 4633,
        "phenotype_comparison": ""
    },
    {
        "id1": 4647,
        "id2": 4648,
        "phenotype_comparison": "The combination of pdk-1(mg142) gain-of-function mutant alleles with the long-lived oga-1(ok1207) allele failed to suppress the lifespan extension associated with the oga-1 mutant. pdk-1(mg142) gain-of-function mutant lifespans are shorter than that of wild type."
    },
    {
        "id1": 4661,
        "id2": 4669,
        "phenotype_comparison": "nhr-49 mutation had no impact on the extended lifespan of daf-2(e1370) mutants in two of three independent trials and caused a small suppression in longevity in the third."
    },
    {
        "id1": 4686,
        "id2": 4691,
        "phenotype_comparison": ""
    },
    {
        "id1": 4716,
        "id2": 4717,
        "phenotype_comparison": ""
    },
    {
        "id1": 4737,
        "id2": 4741,
        "phenotype_comparison": ""
    },
    {
        "id1": 4767,
        "id2": 4771,
        "phenotype_comparison": ""
    },
    {
        "id1": 4789,
        "id2": 4791,
        "phenotype_comparison": ""
    },
    {
        "id1": 4803,
        "id2": 4805,
        "phenotype_comparison": ""
    },
    {
        "id1": 4819,
        "id2": 4813,
        "phenotype_comparison": ""
    },
    {
        "id1": 4829,
        "id2": 4831,
        "phenotype_comparison": ""
    },
    {
        "id1": 4846,
        "id2": 4849,
        "phenotype_comparison": ""
    },
    {
        "id1": 4864,
        "id2": 4866,
        "phenotype_comparison": ""
    },
    {
        "id1": 4886,
        "id2": 4887,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (raga-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4909,
        "id2": 4910,
        "phenotype_comparison": ""
    },
    {
        "id1": 4935,
        "id2": 4936,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (ragc-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 4954,
        "id2": 4955,
        "phenotype_comparison": ""
    },
    {
        "id1": 4968,
        "id2": 4974,
        "phenotype_comparison": ""
    },
    {
        "id1": 5001,
        "id2": 5002,
        "phenotype_comparison": "Knockdown of the translation initiation factors eif-1 increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 5018,
        "id2": 5025,
        "phenotype_comparison": ""
    },
    {
        "id1": 5042,
        "id2": 5045,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (kin-29) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi."
    },
    {
        "id1": 5063,
        "id2": 5064,
        "phenotype_comparison": ""
    },
    {
        "id1": 5061,
        "id2": 5077,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (sad-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than cco-1 RNAi."
    },
    {
        "id1": 5093,
        "id2": 5095,
        "phenotype_comparison": ""
    },
    {
        "id1": 5127,
        "id2": 5128,
        "phenotype_comparison": ""
    },
    {
        "id1": 5138,
        "id2": 5154,
        "phenotype_comparison": ""
    },
    {
        "id1": 5174,
        "id2": 5176,
        "phenotype_comparison": ""
    },
    {
        "id1": 5189,
        "id2": 5195,
        "phenotype_comparison": ""
    },
    {
        "id1": 5220,
        "id2": 5149,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was suppressed by hsf-1 RNAi treatment only during adulthood (adult-only RNAi) without FUdR."
    },
    {
        "id1": 5232,
        "id2": 5239,
        "phenotype_comparison": ""
    },
    {
        "id1": 5261,
        "id2": 5262,
        "phenotype_comparison": ""
    },
    {
        "id1": 5293,
        "id2": 5294,
        "phenotype_comparison": ""
    },
    {
        "id1": 5316,
        "id2": 5317,
        "phenotype_comparison": "The cep-1(gk138) allele partially suppresses isp-1(qm150)-extended longevity."
    },
    {
        "id1": 5341,
        "id2": 5342,
        "phenotype_comparison": "aakb-1 proved to shorten lifespan in daf-2(m577) and wild type worms to a similar degree (12% and 11%,respectively)."
    },
    {
        "id1": 5370,
        "id2": 5372,
        "phenotype_comparison": ""
    },
    {
        "id1": 5397,
        "id2": 5398,
        "phenotype_comparison": "Abrogated aakg-4 expression using RNAi, and observed a greater reduction in lifespan in daf-2 than in wild-type worms."
    },
    {
        "id1": 5376,
        "id2": 5419,
        "phenotype_comparison": ""
    },
    {
        "id1": 5450,
        "id2": 5452,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5464,
        "id2": 5468,
        "phenotype_comparison": "isp-1(qm150) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150) mutants. Loss of ceh-23 decreased the lifespan of isp-1 mutant by ~20%."
    },
    {
        "id1": 5481,
        "id2": 5487,
        "phenotype_comparison": ""
    },
    {
        "id1": 5507,
        "id2": 5509,
        "phenotype_comparison": ""
    },
    {
        "id1": 5530,
        "id2": 5532,
        "phenotype_comparison": ""
    },
    {
        "id1": 5554,
        "id2": 5555,
        "phenotype_comparison": ""
    },
    {
        "id1": 5523,
        "id2": 5575,
        "phenotype_comparison": ""
    },
    {
        "id1": 5590,
        "id2": 5591,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 15\u00b0C."
    },
    {
        "id1": 5609,
        "id2": 5611,
        "phenotype_comparison": ""
    },
    {
        "id1": 5630,
        "id2": 5631,
        "phenotype_comparison": "The age-1(mg44);hcf-1(ok559) double mutant worms lived considerably longer than either the age-1(mg44) or hcf-1(ok559) single mutant."
    },
    {
        "id1": 5653,
        "id2": 5654,
        "phenotype_comparison": "frh-1 RNAi increased lifespan on wild-type strains as well as on skn-1(zu67)."
    },
    {
        "id1": 5669,
        "id2": 5673,
        "phenotype_comparison": ""
    },
    {
        "id1": 5687,
        "id2": 5689,
        "phenotype_comparison": ""
    },
    {
        "id1": 5724,
        "id2": 5725,
        "phenotype_comparison": "sir-2.1(ok434) does not suppress the longevity of daf-2(e1370)."
    },
    {
        "id1": 5745,
        "id2": 5749,
        "phenotype_comparison": ""
    },
    {
        "id1": 5769,
        "id2": 5782,
        "phenotype_comparison": ""
    },
    {
        "id1": 5794,
        "id2": 5800,
        "phenotype_comparison": ""
    },
    {
        "id1": 5825,
        "id2": 5826,
        "phenotype_comparison": ""
    },
    {
        "id1": 5845,
        "id2": 5851,
        "phenotype_comparison": ""
    },
    {
        "id1": 5882,
        "id2": 5884,
        "phenotype_comparison": ""
    },
    {
        "id1": 5912,
        "id2": 5913,
        "phenotype_comparison": ""
    },
    {
        "id1": 5939,
        "id2": 5940,
        "phenotype_comparison": ""
    },
    {
        "id1": 5963,
        "id2": 5964,
        "phenotype_comparison": ""
    },
    {
        "id1": 5975,
        "id2": 5982,
        "phenotype_comparison": ""
    },
    {
        "id1": 6000,
        "id2": 6001,
        "phenotype_comparison": "The longevity of cye-1(RNAi) was suppressed by daf-16(mu86) mutation."
    },
    {
        "id1": 6017,
        "id2": 6019,
        "phenotype_comparison": ""
    },
    {
        "id1": 6030,
        "id2": 6033,
        "phenotype_comparison": "Knockdown of cye-1(RNAi) was not able to extend the lifespan of sterile mes-1(bn7) animals."
    },
    {
        "id1": 6049,
        "id2": 6050,
        "phenotype_comparison": ""
    },
    {
        "id1": 5995,
        "id2": 6065,
        "phenotype_comparison": ""
    },
    {
        "id1": 6004,
        "id2": 6078,
        "phenotype_comparison": ""
    },
    {
        "id1": 6095,
        "id2": 6096,
        "phenotype_comparison": "RNAi inactivation of Y39G10AR.8 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6109,
        "id2": 6110,
        "phenotype_comparison": "RNAi inactivation of C47D12.6 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6123,
        "id2": 6124,
        "phenotype_comparison": "RNAi inactivation of C01F1.2 further extends longevity of control and daf-2(e1370) mutants."
    },
    {
        "id1": 6094,
        "id2": 6138,
        "phenotype_comparison": ""
    },
    {
        "id1": 6141,
        "id2": 6157,
        "phenotype_comparison": ""
    },
    {
        "id1": 6105,
        "id2": 6171,
        "phenotype_comparison": "RNAi inactivation of F59C6.4 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6125,
        "id2": 6181,
        "phenotype_comparison": "RNAi inactivation of K01C8.6 further extends longevity of control and eat-2(ad465) mutants."
    },
    {
        "id1": 6193,
        "id2": 6195,
        "phenotype_comparison": ""
    },
    {
        "id1": 6204,
        "id2": 6210,
        "phenotype_comparison": ""
    },
    {
        "id1": 6227,
        "id2": 6229,
        "phenotype_comparison": ""
    },
    {
        "id1": 6247,
        "id2": 6248,
        "phenotype_comparison": ""
    },
    {
        "id1": 6266,
        "id2": 6268,
        "phenotype_comparison": ""
    },
    {
        "id1": 6281,
        "id2": 6283,
        "phenotype_comparison": ""
    },
    {
        "id1": 6293,
        "id2": 6297,
        "phenotype_comparison": ""
    },
    {
        "id1": 6266,
        "id2": 6310,
        "phenotype_comparison": ""
    },
    {
        "id1": 6322,
        "id2": 6327,
        "phenotype_comparison": "Knockdown of cyc-2.1 robustly extends lifespan in the wild-type and daf-2(e1370) mutant backgrounds."
    },
    {
        "id1": 6344,
        "id2": 6346,
        "phenotype_comparison": ""
    },
    {
        "id1": 6353,
        "id2": 6371,
        "phenotype_comparison": ""
    },
    {
        "id1": 6389,
        "id2": 6390,
        "phenotype_comparison": ""
    },
    {
        "id1": 6415,
        "id2": 6417,
        "phenotype_comparison": ""
    },
    {
        "id1": 6437,
        "id2": 6441,
        "phenotype_comparison": ""
    },
    {
        "id1": 6463,
        "id2": 6466,
        "phenotype_comparison": ""
    },
    {
        "id1": 6481,
        "id2": 6482,
        "phenotype_comparison": ""
    },
    {
        "id1": 6491,
        "id2": 6494,
        "phenotype_comparison": ""
    },
    {
        "id1": 6499,
        "id2": 6503,
        "phenotype_comparison": ""
    },
    {
        "id1": 6514,
        "id2": 6515,
        "phenotype_comparison": ""
    },
    {
        "id1": 6533,
        "id2": 6534,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6545,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6556,
        "phenotype_comparison": ""
    },
    {
        "id1": 6544,
        "id2": 6566,
        "phenotype_comparison": ""
    },
    {
        "id1": 5752,
        "id2": 5764,
        "phenotype_comparison": ""
    },
    {
        "id1": 6128,
        "id2": 6158,
        "phenotype_comparison": ""
    },
    {
        "id1": 5792,
        "id2": 5807,
        "phenotype_comparison": ""
    },
    {
        "id1": 6542,
        "id2": 5210,
        "phenotype_comparison": ""
    },
    {
        "id1": 6430,
        "id2": 6435,
        "phenotype_comparison": ""
    },
    {
        "id1": 6416,
        "id2": 6424,
        "phenotype_comparison": ""
    },
    {
        "id1": 6461,
        "id2": 6466,
        "phenotype_comparison": ""
    },
    {
        "id1": 4315,
        "id2": 4317,
        "phenotype_comparison": ""
    },
    {
        "id1": 4337,
        "id2": 4339,
        "phenotype_comparison": ""
    },
    {
        "id1": 4373,
        "id2": 4374,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4411,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4438,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4466,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4492,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4519,
        "phenotype_comparison": ""
    },
    {
        "id1": 4542,
        "id2": 4545,
        "phenotype_comparison": ""
    },
    {
        "id1": 4578,
        "id2": 4579,
        "phenotype_comparison": ""
    },
    {
        "id1": 4612,
        "id2": 4613,
        "phenotype_comparison": "Inactivation of cup-4 had no effect on life span of nlp-7(tm2984) mutants."
    },
    {
        "id1": 4632,
        "id2": 4634,
        "phenotype_comparison": ""
    },
    {
        "id1": 4631,
        "id2": 4649,
        "phenotype_comparison": ""
    },
    {
        "id1": 4670,
        "id2": 4671,
        "phenotype_comparison": ""
    },
    {
        "id1": 4690,
        "id2": 4691,
        "phenotype_comparison": ""
    },
    {
        "id1": 4716,
        "id2": 4718,
        "phenotype_comparison": ""
    },
    {
        "id1": 4740,
        "id2": 4741,
        "phenotype_comparison": "shc-1;mek-1 double mutant had a short life span that was indistinguishable from that of each single mutant."
    },
    {
        "id1": 4768,
        "id2": 4772,
        "phenotype_comparison": ""
    },
    {
        "id1": 4790,
        "id2": 4791,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4804,
        "id2": 4806,
        "phenotype_comparison": ""
    },
    {
        "id1": 4819,
        "id2": 4820,
        "phenotype_comparison": ""
    },
    {
        "id1": 4830,
        "id2": 4832,
        "phenotype_comparison": ""
    },
    {
        "id1": 4844,
        "id2": 4850,
        "phenotype_comparison": ""
    },
    {
        "id1": 4865,
        "id2": 4866,
        "phenotype_comparison": "A null mutation of ftt-2(n4426) was only able to slightly decrease the lifespan of hcf-1 mutants."
    },
    {
        "id1": 4884,
        "id2": 4888,
        "phenotype_comparison": ""
    },
    {
        "id1": 4909,
        "id2": 4911,
        "phenotype_comparison": ""
    },
    {
        "id1": 4929,
        "id2": 4937,
        "phenotype_comparison": ""
    },
    {
        "id1": 4931,
        "id2": 4955,
        "phenotype_comparison": "RNAi against raga-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4973,
        "id2": 4974,
        "phenotype_comparison": "RNAi against rheb-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 5003,
        "id2": 5004,
        "phenotype_comparison": ""
    },
    {
        "id1": 5024,
        "id2": 5025,
        "phenotype_comparison": "Knockdown of raga-1 extended the lifespan of kri-1 mutants, in which the GSC pathway is blocked."
    },
    {
        "id1": 5040,
        "id2": 5046,
        "phenotype_comparison": ""
    },
    {
        "id1": 5055,
        "id2": 5064,
        "phenotype_comparison": ""
    },
    {
        "id1": 5028,
        "id2": 5078,
        "phenotype_comparison": ""
    },
    {
        "id1": 5094,
        "id2": 5095,
        "phenotype_comparison": "GSC arrest caused by glp-1 loss of function resulted in extended life span; lipl-4 RNAi suppressed this increased longevity but did not reduce wild-type life span."
    },
    {
        "id1": 5127,
        "id2": 5129,
        "phenotype_comparison": ""
    },
    {
        "id1": 5140,
        "id2": 5155,
        "phenotype_comparison": ""
    },
    {
        "id1": 5175,
        "id2": 5176,
        "phenotype_comparison": "hsf-1(sy441) mutation suppressed the prolonged lifespan caused by RNAi targeting daf-15/raptor."
    },
    {
        "id1": 5194,
        "id2": 5195,
        "phenotype_comparison": "We found that increased lifespan conferred by knockdown of rps-15 was suppressed by hsf-1 mutations."
    },
    {
        "id1": 5150,
        "id2": 5221,
        "phenotype_comparison": ""
    },
    {
        "id1": 5236,
        "id2": 5240,
        "phenotype_comparison": ""
    },
    {
        "id1": 5263,
        "id2": 5264,
        "phenotype_comparison": ""
    },
    {
        "id1": 5293,
        "id2": 5295,
        "phenotype_comparison": ""
    },
    {
        "id1": 5318,
        "id2": 5319,
        "phenotype_comparison": ""
    },
    {
        "id1": 5343,
        "id2": 5333,
        "phenotype_comparison": ""
    },
    {
        "id1": 5373,
        "id2": 5374,
        "phenotype_comparison": ""
    },
    {
        "id1": 5395,
        "id2": 5399,
        "phenotype_comparison": ""
    },
    {
        "id1": 5376,
        "id2": 5420,
        "phenotype_comparison": ""
    },
    {
        "id1": 5450,
        "id2": 5453,
        "phenotype_comparison": "isp-1(qm150);ctb-1(qm189) mutants exhibited longer mean lifespan than ceh-23(ms23);isp-1(qm150);ctb-1(qm189) mutants. Loss of ceh-23 decreased the lifespan of isp-1;ctb-1 mutant by 10%."
    },
    {
        "id1": 5463,
        "id2": 5469,
        "phenotype_comparison": ""
    },
    {
        "id1": 5486,
        "id2": 5487,
        "phenotype_comparison": ""
    },
    {
        "id1": 5508,
        "id2": 5509,
        "phenotype_comparison": "The hif-1(ia4) animals lived significantly longer than N2 animals at 25\u00b0C. In contrast to hif-1(ia4) animals, vhl-1(ok161) animals were long-lived at 25\u00b0C, relative to N2. At this temperature, vhl-1(ok161) animals were also significantly longer lived than hif-1(ia4) animals. The hif-1(ia4);vhl-1(ok161) animals were slightly longer-lived than hif-1(ia4) animals at 25\u00b0C."
    },
    {
        "id1": 5531,
        "id2": 5533,
        "phenotype_comparison": ""
    },
    {
        "id1": 5554,
        "id2": 5556,
        "phenotype_comparison": ""
    },
    {
        "id1": 5574,
        "id2": 5575,
        "phenotype_comparison": "Relative to daf-16(mu86) single mutants, daf-16(mu86);hif-1(ia4) double mutant animals were not long-lived at 20\u00b0C."
    },
    {
        "id1": 5554,
        "id2": 5592,
        "phenotype_comparison": ""
    },
    {
        "id1": 5610,
        "id2": 5611,
        "phenotype_comparison": "The hcf-1(ok559);daf-16(RNAi) double mutant had a lifespan indistinguishable from that of the daf-16(RNAi) single mutant."
    },
    {
        "id1": 5608,
        "id2": 5632,
        "phenotype_comparison": ""
    },
    {
        "id1": 5655,
        "id2": 5656,
        "phenotype_comparison": ""
    },
    {
        "id1": 5672,
        "id2": 5673,
        "phenotype_comparison": "Treatment of cep-1(gk138) mutant strain with undiluted isp-1 RNAi increased lifespan relative to wild-type animals fed with the same RNAi concentration."
    },
    {
        "id1": 5688,
        "id2": 5690,
        "phenotype_comparison": ""
    },
    {
        "id1": 5726,
        "id2": 5727,
        "phenotype_comparison": ""
    },
    {
        "id1": 5750,
        "id2": 5752,
        "phenotype_comparison": ""
    },
    {
        "id1": 5782,
        "id2": 5783,
        "phenotype_comparison": ""
    },
    {
        "id1": 5798,
        "id2": 5800,
        "phenotype_comparison": "Treating eat-2(ad1116) mutants with vps-34 RNAi on day-1 of adulthood significantly shortened their long lifespan, but not that of wild type."
    },
    {
        "id1": 57,
        "id2": 61,
        "phenotype_comparison": ""
    },
    {
        "id1": 54,
        "id2": 61,
        "phenotype_comparison": ""
    },
    {
        "id1": 90,
        "id2": 93,
        "phenotype_comparison": ""
    },
    {
        "id1": 83,
        "id2": 87,
        "phenotype_comparison": ""
    },
    {
        "id1": 85,
        "id2": 87,
        "phenotype_comparison": ""
    },
    {
        "id1": 83,
        "id2": 92,
        "phenotype_comparison": ""
    },
    {
        "id1": 5787,
        "id2": 5826,
        "phenotype_comparison": "We measured the lifespan of rab-10(ok1494) animals fed with bec-1 RNAi during adulthood, and we found that bec-1 RNAi clones significantly shortened lifespan."
    },
    {
        "id1": 5845,
        "id2": 5852,
        "phenotype_comparison": ""
    },
    {
        "id1": 5885,
        "id2": 5887,
        "phenotype_comparison": ""
    },
    {
        "id1": 5914,
        "id2": 5915,
        "phenotype_comparison": ""
    },
    {
        "id1": 5939,
        "id2": 5941,
        "phenotype_comparison": ""
    },
    {
        "id1": 5963,
        "id2": 5965,
        "phenotype_comparison": ""
    },
    {
        "id1": 5981,
        "id2": 5983,
        "phenotype_comparison": ""
    },
    {
        "id1": 5975,
        "id2": 6002,
        "phenotype_comparison": ""
    },
    {
        "id1": 210,
        "id2": 211,
        "phenotype_comparison": ""
    },
    {
        "id1": 213,
        "id2": 214,
        "phenotype_comparison": ""
    },
    {
        "id1": 6018,
        "id2": 6019,
        "phenotype_comparison": "Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms."
    },
    {
        "id1": 6034,
        "id2": 6035,
        "phenotype_comparison": ""
    },
    {
        "id1": 6049,
        "id2": 6051,
        "phenotype_comparison": ""
    },
    {
        "id1": 6064,
        "id2": 6066,
        "phenotype_comparison": ""
    },
    {
        "id1": 6077,
        "id2": 6079,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3702,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3704,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3706,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3708,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3710,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3712,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3714,
        "phenotype_comparison": ""
    },
    {
        "id1": 3621,
        "id2": 3716,
        "phenotype_comparison": ""
    },
    {
        "id1": 796,
        "id2": 854,
        "phenotype_comparison": ""
    },
    {
        "id1": 798,
        "id2": 855,
        "phenotype_comparison": ""
    },
    {
        "id1": 800,
        "id2": 856,
        "phenotype_comparison": ""
    },
    {
        "id1": 802,
        "id2": 857,
        "phenotype_comparison": ""
    },
    {
        "id1": 804,
        "id2": 858,
        "phenotype_comparison": ""
    },
    {
        "id1": 824,
        "id2": 869,
        "phenotype_comparison": ""
    },
    {
        "id1": 826,
        "id2": 870,
        "phenotype_comparison": ""
    },
    {
        "id1": 766,
        "id2": 838,
        "phenotype_comparison": ""
    },
    {
        "id1": 768,
        "id2": 839,
        "phenotype_comparison": ""
    },
    {
        "id1": 770,
        "id2": 840,
        "phenotype_comparison": ""
    },
    {
        "id1": 772,
        "id2": 841,
        "phenotype_comparison": ""
    },
    {
        "id1": 774,
        "id2": 842,
        "phenotype_comparison": ""
    },
    {
        "id1": 776,
        "id2": 843,
        "phenotype_comparison": ""
    },
    {
        "id1": 777,
        "id2": 844,
        "phenotype_comparison": ""
    },
    {
        "id1": 779,
        "id2": 845,
        "phenotype_comparison": ""
    },
    {
        "id1": 781,
        "id2": 846,
        "phenotype_comparison": ""
    },
    {
        "id1": 783,
        "id2": 847,
        "phenotype_comparison": ""
    },
    {
        "id1": 785,
        "id2": 848,
        "phenotype_comparison": ""
    },
    {
        "id1": 786,
        "id2": 849,
        "phenotype_comparison": ""
    },
    {
        "id1": 788,
        "id2": 850,
        "phenotype_comparison": ""
    },
    {
        "id1": 790,
        "id2": 851,
        "phenotype_comparison": ""
    },
    {
        "id1": 792,
        "id2": 852,
        "phenotype_comparison": ""
    },
    {
        "id1": 794,
        "id2": 853,
        "phenotype_comparison": ""
    },
    {
        "id1": 806,
        "id2": 859,
        "phenotype_comparison": ""
    },
    {
        "id1": 808,
        "id2": 860,
        "phenotype_comparison": ""
    },
    {
        "id1": 809,
        "id2": 861,
        "phenotype_comparison": ""
    },
    {
        "id1": 811,
        "id2": 862,
        "phenotype_comparison": ""
    },
    {
        "id1": 813,
        "id2": 863,
        "phenotype_comparison": ""
    },
    {
        "id1": 815,
        "id2": 864,
        "phenotype_comparison": ""
    },
    {
        "id1": 817,
        "id2": 865,
        "phenotype_comparison": ""
    },
    {
        "id1": 819,
        "id2": 866,
        "phenotype_comparison": ""
    },
    {
        "id1": 820,
        "id2": 867,
        "phenotype_comparison": ""
    },
    {
        "id1": 822,
        "id2": 868,
        "phenotype_comparison": ""
    },
    {
        "id1": 827,
        "id2": 871,
        "phenotype_comparison": ""
    },
    {
        "id1": 828,
        "id2": 872,
        "phenotype_comparison": ""
    },
    {
        "id1": 830,
        "id2": 873,
        "phenotype_comparison": ""
    },
    {
        "id1": 831,
        "id2": 874,
        "phenotype_comparison": ""
    },
    {
        "id1": 833,
        "id2": 875,
        "phenotype_comparison": ""
    },
    {
        "id1": 834,
        "id2": 876,
        "phenotype_comparison": ""
    },
    {
        "id1": 836,
        "id2": 877,
        "phenotype_comparison": ""
    },
    {
        "id1": 878,
        "id2": 886,
        "phenotype_comparison": ""
    },
    {
        "id1": 880,
        "id2": 887,
        "phenotype_comparison": ""
    },
    {
        "id1": 882,
        "id2": 888,
        "phenotype_comparison": ""
    },
    {
        "id1": 883,
        "id2": 889,
        "phenotype_comparison": ""
    },
    {
        "id1": 884,
        "id2": 890,
        "phenotype_comparison": ""
    },
    {
        "id1": 885,
        "id2": 891,
        "phenotype_comparison": ""
    },
    {
        "id1": 893,
        "id2": 993,
        "phenotype_comparison": ""
    },
    {
        "id1": 895,
        "id2": 994,
        "phenotype_comparison": ""
    },
    {
        "id1": 897,
        "id2": 995,
        "phenotype_comparison": ""
    },
    {
        "id1": 899,
        "id2": 996,
        "phenotype_comparison": ""
    },
    {
        "id1": 901,
        "id2": 997,
        "phenotype_comparison": ""
    },
    {
        "id1": 902,
        "id2": 998,
        "phenotype_comparison": ""
    },
    {
        "id1": 904,
        "id2": 999,
        "phenotype_comparison": ""
    },
    {
        "id1": 906,
        "id2": 1000,
        "phenotype_comparison": ""
    },
    {
        "id1": 908,
        "id2": 1001,
        "phenotype_comparison": ""
    },
    {
        "id1": 909,
        "id2": 1002,
        "phenotype_comparison": ""
    },
    {
        "id1": 911,
        "id2": 1003,
        "phenotype_comparison": ""
    },
    {
        "id1": 912,
        "id2": 1004,
        "phenotype_comparison": ""
    },
    {
        "id1": 914,
        "id2": 1005,
        "phenotype_comparison": ""
    },
    {
        "id1": 916,
        "id2": 1006,
        "phenotype_comparison": ""
    },
    {
        "id1": 918,
        "id2": 1007,
        "phenotype_comparison": ""
    },
    {
        "id1": 920,
        "id2": 1008,
        "phenotype_comparison": ""
    },
    {
        "id1": 921,
        "id2": 1009,
        "phenotype_comparison": ""
    },
    {
        "id1": 923,
        "id2": 1010,
        "phenotype_comparison": ""
    },
    {
        "id1": 925,
        "id2": 1011,
        "phenotype_comparison": ""
    },
    {
        "id1": 927,
        "id2": 1012,
        "phenotype_comparison": ""
    },
    {
        "id1": 928,
        "id2": 1013,
        "phenotype_comparison": ""
    },
    {
        "id1": 930,
        "id2": 1014,
        "phenotype_comparison": ""
    },
    {
        "id1": 932,
        "id2": 1015,
        "phenotype_comparison": ""
    },
    {
        "id1": 934,
        "id2": 1016,
        "phenotype_comparison": ""
    },
    {
        "id1": 936,
        "id2": 1017,
        "phenotype_comparison": ""
    },
    {
        "id1": 938,
        "id2": 1018,
        "phenotype_comparison": ""
    },
    {
        "id1": 939,
        "id2": 1019,
        "phenotype_comparison": ""
    },
    {
        "id1": 941,
        "id2": 1020,
        "phenotype_comparison": ""
    },
    {
        "id1": 942,
        "id2": 1021,
        "phenotype_comparison": ""
    },
    {
        "id1": 944,
        "id2": 1022,
        "phenotype_comparison": ""
    },
    {
        "id1": 946,
        "id2": 1023,
        "phenotype_comparison": ""
    },
    {
        "id1": 948,
        "id2": 1024,
        "phenotype_comparison": ""
    },
    {
        "id1": 949,
        "id2": 1025,
        "phenotype_comparison": ""
    },
    {
        "id1": 951,
        "id2": 1026,
        "phenotype_comparison": ""
    },
    {
        "id1": 953,
        "id2": 1027,
        "phenotype_comparison": ""
    },
    {
        "id1": 954,
        "id2": 1028,
        "phenotype_comparison": ""
    },
    {
        "id1": 956,
        "id2": 1029,
        "phenotype_comparison": ""
    },
    {
        "id1": 958,
        "id2": 1030,
        "phenotype_comparison": ""
    },
    {
        "id1": 960,
        "id2": 1031,
        "phenotype_comparison": ""
    },
    {
        "id1": 962,
        "id2": 1032,
        "phenotype_comparison": ""
    },
    {
        "id1": 964,
        "id2": 1033,
        "phenotype_comparison": ""
    },
    {
        "id1": 966,
        "id2": 1034,
        "phenotype_comparison": ""
    },
    {
        "id1": 968,
        "id2": 1035,
        "phenotype_comparison": ""
    },
    {
        "id1": 970,
        "id2": 1036,
        "phenotype_comparison": ""
    },
    {
        "id1": 971,
        "id2": 1037,
        "phenotype_comparison": ""
    },
    {
        "id1": 973,
        "id2": 1038,
        "phenotype_comparison": ""
    },
    {
        "id1": 975,
        "id2": 1039,
        "phenotype_comparison": ""
    },
    {
        "id1": 977,
        "id2": 1040,
        "phenotype_comparison": ""
    },
    {
        "id1": 979,
        "id2": 1041,
        "phenotype_comparison": ""
    },
    {
        "id1": 980,
        "id2": 1042,
        "phenotype_comparison": ""
    },
    {
        "id1": 982,
        "id2": 1043,
        "phenotype_comparison": ""
    },
    {
        "id1": 984,
        "id2": 1044,
        "phenotype_comparison": ""
    },
    {
        "id1": 986,
        "id2": 1045,
        "phenotype_comparison": ""
    },
    {
        "id1": 988,
        "id2": 1046,
        "phenotype_comparison": ""
    },
    {
        "id1": 990,
        "id2": 1047,
        "phenotype_comparison": ""
    },
    {
        "id1": 991,
        "id2": 1048,
        "phenotype_comparison": ""
    },
    {
        "id1": 992,
        "id2": 1049,
        "phenotype_comparison": ""
    },
    {
        "id1": 1050,
        "id2": 1052,
        "phenotype_comparison": ""
    },
    {
        "id1": 1051,
        "id2": 1053,
        "phenotype_comparison": ""
    },
    {
        "id1": 4316,
        "id2": 4318,
        "phenotype_comparison": ""
    },
    {
        "id1": 4338,
        "id2": 4340,
        "phenotype_comparison": ""
    },
    {
        "id1": 1606,
        "id2": 1608,
        "phenotype_comparison": ""
    },
    {
        "id1": 1606,
        "id2": 1610,
        "phenotype_comparison": ""
    },
    {
        "id1": 1606,
        "id2": 1612,
        "phenotype_comparison": ""
    },
    {
        "id1": 1601,
        "id2": 1603,
        "phenotype_comparison": ""
    },
    {
        "id1": 1090,
        "id2": 1091,
        "phenotype_comparison": ""
    },
    {
        "id1": 4375,
        "id2": 4376,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4412,
        "phenotype_comparison": ""
    },
    {
        "id1": 1122,
        "id2": 1129,
        "phenotype_comparison": ""
    },
    {
        "id1": 1118,
        "id2": 1129,
        "phenotype_comparison": ""
    },
    {
        "id1": 1124,
        "id2": 1130,
        "phenotype_comparison": ""
    },
    {
        "id1": 1120,
        "id2": 1130,
        "phenotype_comparison": ""
    },
    {
        "id1": 1127,
        "id2": 1131,
        "phenotype_comparison": ""
    },
    {
        "id1": 1125,
        "id2": 1131,
        "phenotype_comparison": ""
    },
    {
        "id1": 2966,
        "id2": 2970,
        "phenotype_comparison": ""
    },
    {
        "id1": 2958,
        "id2": 2970,
        "phenotype_comparison": ""
    },
    {
        "id1": 2967,
        "id2": 2971,
        "phenotype_comparison": ""
    },
    {
        "id1": 2959,
        "id2": 2971,
        "phenotype_comparison": ""
    },
    {
        "id1": 2965,
        "id2": 2969,
        "phenotype_comparison": ""
    },
    {
        "id1": 2957,
        "id2": 2969,
        "phenotype_comparison": ""
    },
    {
        "id1": 1390,
        "id2": 1381,
        "phenotype_comparison": ""
    },
    {
        "id1": 1389,
        "id2": 1381,
        "phenotype_comparison": ""
    },
    {
        "id1": 1394,
        "id2": 1383,
        "phenotype_comparison": ""
    },
    {
        "id1": 1395,
        "id2": 1383,
        "phenotype_comparison": ""
    },
    {
        "id1": 1394,
        "id2": 1384,
        "phenotype_comparison": ""
    },
    {
        "id1": 1395,
        "id2": 1384,
        "phenotype_comparison": ""
    },
    {
        "id1": 1397,
        "id2": 1384,
        "phenotype_comparison": ""
    },
    {
        "id1": 1394,
        "id2": 1385,
        "phenotype_comparison": ""
    },
    {
        "id1": 1395,
        "id2": 1385,
        "phenotype_comparison": ""
    },
    {
        "id1": 1390,
        "id2": 1382,
        "phenotype_comparison": ""
    },
    {
        "id1": 1389,
        "id2": 1382,
        "phenotype_comparison": ""
    },
    {
        "id1": 3131,
        "id2": 3135,
        "phenotype_comparison": ""
    },
    {
        "id1": 3139,
        "id2": 3142,
        "phenotype_comparison": ""
    },
    {
        "id1": 3140,
        "id2": 3143,
        "phenotype_comparison": ""
    },
    {
        "id1": 3132,
        "id2": 3134,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4439,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4467,
        "phenotype_comparison": ""
    },
    {
        "id1": 1280,
        "id2": 1284,
        "phenotype_comparison": ""
    },
    {
        "id1": 1292,
        "id2": 1294,
        "phenotype_comparison": ""
    },
    {
        "id1": 1290,
        "id2": 1294,
        "phenotype_comparison": ""
    },
    {
        "id1": 3542,
        "id2": 3545,
        "phenotype_comparison": ""
    },
    {
        "id1": 3990,
        "id2": 3992,
        "phenotype_comparison": ""
    },
    {
        "id1": 3991,
        "id2": 3992,
        "phenotype_comparison": ""
    },
    {
        "id1": 3994,
        "id2": 3996,
        "phenotype_comparison": ""
    },
    {
        "id1": 3995,
        "id2": 3996,
        "phenotype_comparison": ""
    },
    {
        "id1": 4484,
        "id2": 4493,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4520,
        "phenotype_comparison": ""
    },
    {
        "id1": 4542,
        "id2": 4546,
        "phenotype_comparison": ""
    },
    {
        "id1": 4580,
        "id2": 4581,
        "phenotype_comparison": ""
    },
    {
        "id1": 4609,
        "id2": 4612,
        "phenotype_comparison": ""
    },
    {
        "id1": 4633,
        "id2": 4634,
        "phenotype_comparison": "The adult lifespan of the oga-1; ogt-1 double mutant is similar to that of wild type, confirming that lifespan extension observed in oga-1 mutants is dependent on excessive O-GlcNAc-modified protein levels."
    },
    {
        "id1": 4632,
        "id2": 4650,
        "phenotype_comparison": ""
    },
    {
        "id1": 4670,
        "id2": 4664,
        "phenotype_comparison": ""
    },
    {
        "id1": 4655,
        "id2": 4692,
        "phenotype_comparison": ""
    },
    {
        "id1": 4717,
        "id2": 4719,
        "phenotype_comparison": ""
    },
    {
        "id1": 4742,
        "id2": 4743,
        "phenotype_comparison": ""
    },
    {
        "id1": 4771,
        "id2": 4772,
        "phenotype_comparison": "hcf-1(pk924) mutant worms displayed a mean lifespan >20% longer than that of wild type and the hcf-1(pk924) long-lived phenotype was fully suppressed by daf-16(mgDf47) mutation."
    },
    {
        "id1": 4789,
        "id2": 4792,
        "phenotype_comparison": ""
    },
    {
        "id1": 4805,
        "id2": 4806,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 3000,
        "id2": 3001,
        "phenotype_comparison": ""
    },
    {
        "id1": 1501,
        "id2": 1503,
        "phenotype_comparison": ""
    },
    {
        "id1": 1191,
        "id2": 1195,
        "phenotype_comparison": ""
    },
    {
        "id1": 1204,
        "id2": 1209,
        "phenotype_comparison": ""
    },
    {
        "id1": 1207,
        "id2": 1209,
        "phenotype_comparison": ""
    },
    {
        "id1": 1218,
        "id2": 1223,
        "phenotype_comparison": ""
    },
    {
        "id1": 1221,
        "id2": 1223,
        "phenotype_comparison": ""
    },
    {
        "id1": 1206,
        "id2": 1210,
        "phenotype_comparison": ""
    },
    {
        "id1": 1220,
        "id2": 1224,
        "phenotype_comparison": ""
    },
    {
        "id1": 1222,
        "id2": 1224,
        "phenotype_comparison": ""
    },
    {
        "id1": 4813,
        "id2": 4821,
        "phenotype_comparison": ""
    },
    {
        "id1": 4831,
        "id2": 4832,
        "phenotype_comparison": "Knocking down of ftt-2 alone did not substantially reduce hcf-1(pk924) lifespan."
    },
    {
        "id1": 4850,
        "id2": 4851,
        "phenotype_comparison": ""
    },
    {
        "id1": 2110,
        "id2": 2135,
        "phenotype_comparison": ""
    },
    {
        "id1": 2219,
        "id2": 2221,
        "phenotype_comparison": ""
    },
    {
        "id1": 2223,
        "id2": 2225,
        "phenotype_comparison": ""
    },
    {
        "id1": 4864,
        "id2": 4867,
        "phenotype_comparison": ""
    },
    {
        "id1": 1781,
        "id2": 1779,
        "phenotype_comparison": ""
    },
    {
        "id1": 1785,
        "id2": 1789,
        "phenotype_comparison": ""
    },
    {
        "id1": 1787,
        "id2": 1789,
        "phenotype_comparison": ""
    },
    {
        "id1": 1793,
        "id2": 1797,
        "phenotype_comparison": ""
    },
    {
        "id1": 1795,
        "id2": 1797,
        "phenotype_comparison": ""
    },
    {
        "id1": 4888,
        "id2": 4889,
        "phenotype_comparison": ""
    },
    {
        "id1": 4910,
        "id2": 4912,
        "phenotype_comparison": ""
    },
    {
        "id1": 4930,
        "id2": 4938,
        "phenotype_comparison": ""
    },
    {
        "id1": 4954,
        "id2": 4956,
        "phenotype_comparison": ""
    },
    {
        "id1": 4970,
        "id2": 4975,
        "phenotype_comparison": ""
    },
    {
        "id1": 5003,
        "id2": 5005,
        "phenotype_comparison": ""
    },
    {
        "id1": 4913,
        "id2": 5026,
        "phenotype_comparison": ""
    },
    {
        "id1": 5046,
        "id2": 5047,
        "phenotype_comparison": ""
    },
    {
        "id1": 5063,
        "id2": 5065,
        "phenotype_comparison": ""
    },
    {
        "id1": 5078,
        "id2": 5079,
        "phenotype_comparison": ""
    },
    {
        "id1": 5096,
        "id2": 5097,
        "phenotype_comparison": ""
    },
    {
        "id1": 5130,
        "id2": 5131,
        "phenotype_comparison": ""
    },
    {
        "id1": 4317,
        "id2": 4318,
        "phenotype_comparison": "Life-span extension of daf-2(e1370) animals was reduced by bec-1 RNAi treatment. Although bec-1 RNAi had a slight inhibitory effect on the survival of wild-type animals (24 days for bec-1 RNAi-treated animals versus 28 days for untreated animals), the effect of bec-1 RNAi on shortening survival of the daf-2(e1370) mutants was significantly greater than its effects on shortening survival of wild-type animals."
    },
    {
        "id1": 4339,
        "id2": 4340,
        "phenotype_comparison": "Suppression of age-1(hx546) longevity by hsf-1(RNAi) was observed at 25\u00b0C."
    },
    {
        "id1": 4377,
        "id2": 4378,
        "phenotype_comparison": ""
    },
    {
        "id1": 2480,
        "id2": 2487,
        "phenotype_comparison": ""
    },
    {
        "id1": 2554,
        "id2": 2559,
        "phenotype_comparison": ""
    },
    {
        "id1": 2556,
        "id2": 2560,
        "phenotype_comparison": ""
    },
    {
        "id1": 2558,
        "id2": 2561,
        "phenotype_comparison": ""
    },
    {
        "id1": 2577,
        "id2": 2584,
        "phenotype_comparison": ""
    },
    {
        "id1": 2580,
        "id2": 2585,
        "phenotype_comparison": ""
    },
    {
        "id1": 2583,
        "id2": 2586,
        "phenotype_comparison": ""
    },
    {
        "id1": 2588,
        "id2": 2593,
        "phenotype_comparison": ""
    },
    {
        "id1": 2590,
        "id2": 2594,
        "phenotype_comparison": ""
    },
    {
        "id1": 2588,
        "id2": 2595,
        "phenotype_comparison": ""
    },
    {
        "id1": 2478,
        "id2": 2486,
        "phenotype_comparison": ""
    },
    {
        "id1": 4395,
        "id2": 4413,
        "phenotype_comparison": ""
    },
    {
        "id1": 4268,
        "id2": 4270,
        "phenotype_comparison": ""
    },
    {
        "id1": 4433,
        "id2": 4440,
        "phenotype_comparison": ""
    },
    {
        "id1": 4459,
        "id2": 4468,
        "phenotype_comparison": ""
    },
    {
        "id1": 4494,
        "id2": 4495,
        "phenotype_comparison": ""
    },
    {
        "id1": 4515,
        "id2": 4521,
        "phenotype_comparison": ""
    },
    {
        "id1": 4542,
        "id2": 4547,
        "phenotype_comparison": ""
    },
    {
        "id1": 4581,
        "id2": 4582,
        "phenotype_comparison": ""
    },
    {
        "id1": 4610,
        "id2": 4614,
        "phenotype_comparison": ""
    },
    {
        "id1": 4631,
        "id2": 4635,
        "phenotype_comparison": ""
    },
    {
        "id1": 21,
        "id2": 26,
        "phenotype_comparison": ""
    },
    {
        "id1": 28,
        "id2": 39,
        "phenotype_comparison": ""
    },
    {
        "id1": 32,
        "id2": 40,
        "phenotype_comparison": ""
    },
    {
        "id1": 3391,
        "id2": 3393,
        "phenotype_comparison": ""
    },
    {
        "id1": 55,
        "id2": 54,
        "phenotype_comparison": ""
    },
    {
        "id1": 64,
        "id2": 67,
        "phenotype_comparison": ""
    },
    {
        "id1": 82,
        "id2": 86,
        "phenotype_comparison": ""
    },
    {
        "id1": 84,
        "id2": 86,
        "phenotype_comparison": ""
    },
    {
        "id1": 89,
        "id2": 91,
        "phenotype_comparison": ""
    },
    {
        "id1": 112,
        "id2": 115,
        "phenotype_comparison": ""
    },
    {
        "id1": 4649,
        "id2": 4650,
        "phenotype_comparison": "The combination of akt-1(mg144) gain-of-function mutant alleles with the long-lived oga-1(ok1207) allele failed to suppress the lifespan extension associated with the oga-1 mutant. akt-1(mg144) gain-of-function mutant lifespans are shorter than that of wild type."
    },
    {
        "id1": 4671,
        "id2": 4672,
        "phenotype_comparison": ""
    },
    {
        "id1": 4673,
        "id2": 4693,
        "phenotype_comparison": ""
    },
    {
        "id1": 4718,
        "id2": 4719,
        "phenotype_comparison": "age-1(hx546) completely suppressed the shortened life span of shc-1(ok198) as the double mutants had a mean life span similar to that of the long-lived age-1 mutants. This indicates that age-1 is epistatic to shc-1 and positions age-1 downstream from shc-1."
    },
    {
        "id1": 186,
        "id2": 182,
        "phenotype_comparison": ""
    },
    {
        "id1": 178,
        "id2": 185,
        "phenotype_comparison": ""
    },
    {
        "id1": 186,
        "id2": 176,
        "phenotype_comparison": ""
    },
    {
        "id1": 183,
        "id2": 177,
        "phenotype_comparison": ""
    },
    {
        "id1": 175,
        "id2": 179,
        "phenotype_comparison": ""
    },
    {
        "id1": 4742,
        "id2": 4744,
        "phenotype_comparison": ""
    },
    {
        "id1": 4773,
        "id2": 4774,
        "phenotype_comparison": ""
    },
    {
        "id1": 4790,
        "id2": 4792,
        "phenotype_comparison": "sir-2.1(ok434) mutants exhibited lifespan similar to that of wild-type worms and always substantially shorter than that of hcf-1(pk924)."
    },
    {
        "id1": 4804,
        "id2": 4807,
        "phenotype_comparison": ""
    },
    {
        "id1": 597,
        "id2": 638,
        "phenotype_comparison": ""
    },
    {
        "id1": 4820,
        "id2": 4821,
        "phenotype_comparison": "The hcf-1(pk924);sir-2.1(O/E) worms exhibited a lifespan very similar to, or in some cases shorter than, that of hcf-1(pk924) mutants. However, in none of the hcf-1(pk924);sir-2.1(O/E) isolates generated did we observe a lifespan longer than that of hcf-1(pk924) mutants."
    },
    {
        "id1": 4829,
        "id2": 4833,
        "phenotype_comparison": ""
    },
    {
        "id1": 763,
        "id2": 837,
        "phenotype_comparison": ""
    },
    {
        "id1": 4846,
        "id2": 4851,
        "phenotype_comparison": ""
    },
    {
        "id1": 4865,
        "id2": 4867,
        "phenotype_comparison": "A null mutation of ftt-2(n4426) was only able to slightly decrease the lifespan of hcf-1 mutants."
    },
    {
        "id1": 4886,
        "id2": 4889,
        "phenotype_comparison": "RNAi against raga-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 1605,
        "id2": 1607,
        "phenotype_comparison": ""
    },
    {
        "id1": 1605,
        "id2": 1609,
        "phenotype_comparison": ""
    },
    {
        "id1": 1605,
        "id2": 1611,
        "phenotype_comparison": ""
    },
    {
        "id1": 1600,
        "id2": 1602,
        "phenotype_comparison": ""
    },
    {
        "id1": 1589,
        "id2": 1602,
        "phenotype_comparison": ""
    },
    {
        "id1": 4911,
        "id2": 4912,
        "phenotype_comparison": "Knockdown of the translation initiation factors eif-1 increased lifespan in the temperature-sensitive (ts) germline-defective mutant glp-1(bn18) , under conditions where germ cell proliferation was blocked and lifespan was extended."
    },
    {
        "id1": 4937,
        "id2": 4938,
        "phenotype_comparison": "Knockdown of TORC1 pathway gene (ragc-1) failed to increase lifespan in a skn-1 mutant."
    },
    {
        "id1": 2964,
        "id2": 2968,
        "phenotype_comparison": ""
    },
    {
        "id1": 2956,
        "id2": 2968,
        "phenotype_comparison": ""
    },
    {
        "id1": 2105,
        "id2": 2085,
        "phenotype_comparison": ""
    },
    {
        "id1": 2102,
        "id2": 2095,
        "phenotype_comparison": ""
    },
    {
        "id1": 2102,
        "id2": 2091,
        "phenotype_comparison": ""
    },
    {
        "id1": 2105,
        "id2": 2092,
        "phenotype_comparison": ""
    },
    {
        "id1": 1392,
        "id2": 1397,
        "phenotype_comparison": ""
    },
    {
        "id1": 1392,
        "id2": 1398,
        "phenotype_comparison": ""
    },
    {
        "id1": 1360,
        "id2": 1380,
        "phenotype_comparison": ""
    },
    {
        "id1": 4937,
        "id2": 4956,
        "phenotype_comparison": "RNAi against ragc-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 4948,
        "id2": 4975,
        "phenotype_comparison": "RNAi against rheb-1 gene did not increase lifespan in daf-16 mutants, in contrast to the daf-16 independent longevity associated with TOR kinase inhibition."
    },
    {
        "id1": 5004,
        "id2": 5006,
        "phenotype_comparison": ""
    },
    {
        "id1": 5021,
        "id2": 5027,
        "phenotype_comparison": ""
    },
    {
        "id1": 2350,
        "id2": 2358,
        "phenotype_comparison": ""
    },
    {
        "id1": 3090,
        "id2": 3093,
        "phenotype_comparison": ""
    },
    {
        "id1": 3097,
        "id2": 3105,
        "phenotype_comparison": ""
    },
    {
        "id1": 3099,
        "id2": 3106,
        "phenotype_comparison": ""
    },
    {
        "id1": 3088,
        "id2": 3092,
        "phenotype_comparison": ""
    },
    {
        "id1": 3097,
        "id2": 3102,
        "phenotype_comparison": ""
    },
    {
        "id1": 3099,
        "id2": 3103,
        "phenotype_comparison": ""
    },
    {
        "id1": 3115,
        "id2": 3123,
        "phenotype_comparison": ""
    },
    {
        "id1": 3115,
        "id2": 3120,
        "phenotype_comparison": ""
    },
    {
        "id1": 3117,
        "id2": 3121,
        "phenotype_comparison": ""
    },
    {
        "id1": 3117,
        "id2": 3124,
        "phenotype_comparison": ""
    },
    {
        "id1": 3165,
        "id2": 3168,
        "phenotype_comparison": ""
    },
    {
        "id1": 5042,
        "id2": 5047,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (mml-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi."
    },
    {
        "id1": 5057,
        "id2": 5065,
        "phenotype_comparison": "The kinase involved in energy metabolism that we tested (aak-2) affected longevity induced by RNAi-mediated Mit mutants analyzed other than isp-1 RNAi."
    },
    {
        "id1": 1618,
        "id2": 1647,
        "phenotype_comparison": ""
    },
    {
        "id1": 1622,
        "id2": 1649,
        "phenotype_comparison": ""
    },
    {
        "id1": 1618,
        "id2": 1651,
        "phenotype_comparison": ""
    },
    {
        "id1": 5055,
        "id2": 5079,
        "phenotype_comparison": ""
    },
    {
        "id1": 5096,
        "id2": 5098,
        "phenotype_comparison": ""
    },
    {
        "id1": 5131,
        "id2": 5132,
        "phenotype_comparison": ""
    },
    {
        "id1": 1499,
        "id2": 1502,
        "phenotype_comparison": ""
    },
    {
        "id1": 2218,
        "id2": 2220,
        "phenotype_comparison": ""
    },
    {
        "id1": 2222,
        "id2": 2224,
        "phenotype_comparison": ""
    },
    {
        "id1": 1459,
        "id2": 1461,
        "phenotype_comparison": ""
    },
    {
        "id1": 1457,
        "id2": 1461,
        "phenotype_comparison": ""
    },
    {
        "id1": 1780,
        "id2": 1777,
        "phenotype_comparison": ""
    },
    {
        "id1": 1784,
        "id2": 1788,
        "phenotype_comparison": ""
    },
    {
        "id1": 1786,
        "id2": 1788,
        "phenotype_comparison": ""
    },
    {
        "id1": 1792,
        "id2": 1796,
        "phenotype_comparison": ""
    },
    {
        "id1": 1794,
        "id2": 1796,
        "phenotype_comparison": ""
    },
    {
        "id1": 5154,
        "id2": 5155,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was suppressed by daf-16(mu86) mutation."
    },
    {
        "id1": 5177,
        "id2": 5178,
        "phenotype_comparison": ""
    },
    {
        "id1": 5221,
        "id2": 5153,
        "phenotype_comparison": "The long lifespan of rsks-1(tm1714) mutants was suppressed by hsf-1 RNAi treatment only during adulthood (adult-only RNAi) without FUdR."
    },
    {
        "id1": 5239,
        "id2": 5240,
        "phenotype_comparison": "Reducing PQM-1 activity by mutation, shortens the lifespan of daf-2(?) animals substantially, by up to 45%."
    },
    {
        "id1": 5265,
        "id2": 5266,
        "phenotype_comparison": ""
    },
    {
        "id1": 5294,
        "id2": 5296,
        "phenotype_comparison": ""
    },
    {
        "id1": 5318,
        "id2": 5320,
        "phenotype_comparison": ""
    },
    {
        "id1": 5343,
        "id2": 5344,
        "phenotype_comparison": ""
    },
    {
        "id1": 4226,
        "id2": 4231,
        "phenotype_comparison": ""
    },
    {
        "id1": 4226,
        "id2": 4233,
        "phenotype_comparison": ""
    },
    {
        "id1": 4226,
        "id2": 4235,
        "phenotype_comparison": ""
    },
    {
        "id1": 4226,
        "id2": 4237,
        "phenotype_comparison": ""
    },
    {
        "id1": 4226,
        "id2": 4239,
        "phenotype_comparison": ""
    },
    {
        "id1": 4267,
        "id2": 4269,
        "phenotype_comparison": ""
    },
    {
        "id1": 6595,
        "id2": 6596,
        "phenotype_comparison": "A double mutant combination of the hypomorphic p38Kb?25 allele and p38Kadel (p38K-DKO) had a severely reduced lifespan. Single mutants of p38Ka (p38Kadel) or p38Kb (p38K?45) also had significantly reduced lifespan."
    },
    {
        "id1": 6593,
        "id2": 6598,
        "phenotype_comparison": ""
    },
    {
        "id1": 6597,
        "id2": 6599,
        "phenotype_comparison": ""
    },
    {
        "id1": 6598,
        "id2": 6599,
        "phenotype_comparison": "Both p38K?45 and MnSODn283 alleles heterozygous over a wild type allele had normal lifespans. However, a transheterozygous combination of these two alleles had a significantly reduced lifespan."
    },
    {
        "id1": 6600,
        "id2": 6601,
        "phenotype_comparison": ""
    },
    {
        "id1": 6600,
        "id2": 6602,
        "phenotype_comparison": ""
    },
    {
        "id1": 6601,
        "id2": 6603,
        "phenotype_comparison": ""
    },
    {
        "id1": 6602,
        "id2": 6603,
        "phenotype_comparison": "E(z) 60 /+ mutants live 21% longer than Control whereas E(z) 60 trx B11 /+ + double mutants live 5% longer than Control. trx B11 /+ mutants themselves show no difference in median life span compared to Control."
    },
    {
        "id1": 6600,
        "id2": 6604,
        "phenotype_comparison": ""
    },
    {
        "id1": 6600,
        "id2": 6605,
        "phenotype_comparison": ""
    },
    {
        "id1": 6604,
        "id2": 6606,
        "phenotype_comparison": ""
    },
    {
        "id1": 6605,
        "id2": 6606,
        "phenotype_comparison": "E(z) 60 /+ mutants live 4.5% longer than E(z) 60 trx Z11 /+ double mutants. trx Z11 /+ mutants show no difference in median life span compared to Control."
    },
    {
        "id1": 6607,
        "id2": 6608,
        "phenotype_comparison": ""
    },
    {
        "id1": 6608,
        "id2": 6609,
        "phenotype_comparison": ""
    },
    {
        "id1": 6610,
        "id2": 6611,
        "phenotype_comparison": ""
    },
    {
        "id1": 6610,
        "id2": 6612,
        "phenotype_comparison": ""
    },
    {
        "id1": 6611,
        "id2": 6613,
        "phenotype_comparison": ""
    },
    {
        "id1": 6612,
        "id2": 6613,
        "phenotype_comparison": "chico extends Drosophila longevity by acting through FOXO."
    },
    {
        "id1": 6614,
        "id2": 6615,
        "phenotype_comparison": ""
    },
    {
        "id1": 6614,
        "id2": 6612,
        "phenotype_comparison": ""
    },
    {
        "id1": 6615,
        "id2": 6616,
        "phenotype_comparison": ""
    },
    {
        "id1": 6612,
        "id2": 6616,
        "phenotype_comparison": "chico extends Drosophila longevity by acting through FOXO."
    },
    {
        "id1": 6617,
        "id2": 6618,
        "phenotype_comparison": ""
    },
    {
        "id1": 6617,
        "id2": 6619,
        "phenotype_comparison": ""
    },
    {
        "id1": 6618,
        "id2": 6620,
        "phenotype_comparison": ""
    },
    {
        "id1": 6619,
        "id2": 6620,
        "phenotype_comparison": "Mutations in ced-13 and ced-4 but not egl-1 partially suppressed all these phenotypes of both isp-1 and nuo-6"
    },
    {
        "id1": 6621,
        "id2": 6622,
        "phenotype_comparison": ""
    },
    {
        "id1": 6621,
        "id2": 6623,
        "phenotype_comparison": ""
    },
    {
        "id1": 6622,
        "id2": 6624,
        "phenotype_comparison": ""
    },
    {
        "id1": 6623,
        "id2": 6624,
        "phenotype_comparison": "The ced-4 gene mutation suppressed the down-regulation of 62% of the genes in the case of nuo-6 but only 18% in the case of isp-1."
    },
    {
        "id1": 6625,
        "id2": 6626,
        "phenotype_comparison": ""
    },
    {
        "id1": 6625,
        "id2": 6627,
        "phenotype_comparison": ""
    },
    {
        "id1": 6626,
        "id2": 6628,
        "phenotype_comparison": ""
    },
    {
        "id1": 6627,
        "id2": 6628,
        "phenotype_comparison": "The ced-4 gene mutation suppressed the down-regulation of 62% of the genes in the case of nuo-6 but only 18% in the case of isp-1."
    },
    {
        "id1": 6629,
        "id2": 6630,
        "phenotype_comparison": ""
    },
    {
        "id1": 6629,
        "id2": 6631,
        "phenotype_comparison": ""
    },
    {
        "id1": 6630,
        "id2": 6632,
        "phenotype_comparison": ""
    },
    {
        "id1": 6631,
        "id2": 6632,
        "phenotype_comparison": "The longevity response is independent of apoptosis per se"
    },
    {
        "id1": 6633,
        "id2": 6634,
        "phenotype_comparison": ""
    },
    {
        "id1": 6633,
        "id2": 6635,
        "phenotype_comparison": ""
    },
    {
        "id1": 6634,
        "id2": 6636,
        "phenotype_comparison": ""
    },
    {
        "id1": 6635,
        "id2": 6636,
        "phenotype_comparison": "The longevity response is independent of apoptosis per se"
    },
    {
        "id1": 6625,
        "id2": 6637,
        "phenotype_comparison": ""
    },
    {
        "id1": 6627,
        "id2": 6638,
        "phenotype_comparison": ""
    },
    {
        "id1": 6637,
        "id2": 6638,
        "phenotype_comparison": "The longevity response is independent of apoptosis per se"
    },
    {
        "id1": 6639,
        "id2": 6640,
        "phenotype_comparison": ""
    },
    {
        "id1": 6639,
        "id2": 6641,
        "phenotype_comparison": ""
    },
    {
        "id1": 6640,
        "id2": 6642,
        "phenotype_comparison": ""
    },
    {
        "id1": 6641,
        "id2": 6642,
        "phenotype_comparison": "There were no reduction in ATP levels after heat stress in egl-1;isp-1 double mutants compared to nuo-6."
    },
    {
        "id1": 6643,
        "id2": 6644,
        "phenotype_comparison": ""
    },
    {
        "id1": 6643,
        "id2": 6645,
        "phenotype_comparison": ""
    },
    {
        "id1": 6644,
        "id2": 6646,
        "phenotype_comparison": ""
    },
    {
        "id1": 6645,
        "id2": 6646,
        "phenotype_comparison": "There were no reduction in ATP levels after heat stress in egl-1;isp-1 double mutants compared to nuo-6."
    },
    {
        "id1": 6647,
        "id2": 6648,
        "phenotype_comparison": ""
    },
    {
        "id1": 6647,
        "id2": 6649,
        "phenotype_comparison": ""
    },
    {
        "id1": 6648,
        "id2": 6650,
        "phenotype_comparison": ""
    },
    {
        "id1": 6649,
        "id2": 6650,
        "phenotype_comparison": "There were no reduction in ATP levels after heat stress in egl-1;isp-1 double mutants compared to nuo-6."
    },
    {
        "id1": 6651,
        "id2": 6652,
        "phenotype_comparison": ""
    },
    {
        "id1": 6651,
        "id2": 6653,
        "phenotype_comparison": ""
    },
    {
        "id1": 6652,
        "id2": 6654,
        "phenotype_comparison": ""
    },
    {
        "id1": 6653,
        "id2": 6654,
        "phenotype_comparison": "Loss of the intrinsic pathway suppresses the hypo-metabolic and gene expression phenotypes of isp-1 and nuo-6 mutants"
    },
    {
        "id1": 6643,
        "id2": 6655,
        "phenotype_comparison": ""
    },
    {
        "id1": 6644,
        "id2": 6656,
        "phenotype_comparison": ""
    },
    {
        "id1": 6655,
        "id2": 6656,
        "phenotype_comparison": "Loss of the intrinsic pathway suppresses the hypo-metabolic and gene expression phenotypes of isp-1 and nuo-6 mutants"
    },
    {
        "id1": 6647,
        "id2": 6657,
        "phenotype_comparison": ""
    },
    {
        "id1": 6648,
        "id2": 6658,
        "phenotype_comparison": ""
    },
    {
        "id1": 6657,
        "id2": 6658,
        "phenotype_comparison": "Loss of the intrinsic pathway suppresses the hypo-metabolic and gene expression phenotypes of isp-1 and nuo-6 mutants"
    },
    {
        "id1": 6659,
        "id2": 6660,
        "phenotype_comparison": ""
    },
    {
        "id1": 6659,
        "id2": 6661,
        "phenotype_comparison": ""
    },
    {
        "id1": 6660,
        "id2": 6662,
        "phenotype_comparison": ""
    },
    {
        "id1": 6661,
        "id2": 6662,
        "phenotype_comparison": "CED-13 acts upstream of mtROS for all phenotypes"
    },
    {
        "id1": 6663,
        "id2": 6664,
        "phenotype_comparison": ""
    },
    {
        "id1": 6663,
        "id2": 6665,
        "phenotype_comparison": ""
    },
    {
        "id1": 6664,
        "id2": 6666,
        "phenotype_comparison": ""
    },
    {
        "id1": 6665,
        "id2": 6666,
        "phenotype_comparison": "CED-13 acts upstream of mtROS for all phenotypes"
    },
    {
        "id1": 6667,
        "id2": 6668,
        "phenotype_comparison": ""
    },
    {
        "id1": 6667,
        "id2": 6669,
        "phenotype_comparison": ""
    },
    {
        "id1": 6668,
        "id2": 6670,
        "phenotype_comparison": ""
    },
    {
        "id1": 6669,
        "id2": 6670,
        "phenotype_comparison": "CED-13 acts upstream of mtROS for all phenotypes"
    },
    {
        "id1": 6671,
        "id2": 6672,
        "phenotype_comparison": ""
    },
    {
        "id1": 6671,
        "id2": 6673,
        "phenotype_comparison": ""
    },
    {
        "id1": 6672,
        "id2": 6674,
        "phenotype_comparison": ""
    },
    {
        "id1": 6673,
        "id2": 6674,
        "phenotype_comparison": "Constitutive activation of the CED pathway leads to heat-stress hyper-sensitivity"
    },
    {
        "id1": 6675,
        "id2": 6676,
        "phenotype_comparison": ""
    },
    {
        "id1": 6675,
        "id2": 6677,
        "phenotype_comparison": ""
    },
    {
        "id1": 6676,
        "id2": 6678,
        "phenotype_comparison": ""
    },
    {
        "id1": 6677,
        "id2": 6678,
        "phenotype_comparison": "Constitutive activation of the CED pathway leads to heat-stress hyper-sensitivity"
    },
    {
        "id1": 6679,
        "id2": 6680,
        "phenotype_comparison": ""
    },
    {
        "id1": 6679,
        "id2": 6681,
        "phenotype_comparison": ""
    },
    {
        "id1": 6680,
        "id2": 6682,
        "phenotype_comparison": ""
    },
    {
        "id1": 6681,
        "id2": 6682,
        "phenotype_comparison": "Constitutive activation of the CED pathway leads to heat-stress hyper-sensitivity"
    },
    {
        "id1": 6683,
        "id2": 6652,
        "phenotype_comparison": ""
    },
    {
        "id1": 6684,
        "id2": 6685,
        "phenotype_comparison": ""
    },
    {
        "id1": 6686,
        "id2": 6644,
        "phenotype_comparison": ""
    },
    {
        "id1": 6628,
        "id2": 6687,
        "phenotype_comparison": ""
    },
    {
        "id1": 6688,
        "id2": 6648,
        "phenotype_comparison": ""
    },
    {
        "id1": 6689,
        "id2": 6690,
        "phenotype_comparison": ""
    },
    {
        "id1": 6683,
        "id2": 6672,
        "phenotype_comparison": ""
    },
    {
        "id1": 6684,
        "id2": 6691,
        "phenotype_comparison": ""
    },
    {
        "id1": 6686,
        "id2": 6676,
        "phenotype_comparison": ""
    },
    {
        "id1": 6628,
        "id2": 6692,
        "phenotype_comparison": ""
    },
    {
        "id1": 6688,
        "id2": 6680,
        "phenotype_comparison": ""
    },
    {
        "id1": 6689,
        "id2": 6693,
        "phenotype_comparison": ""
    },
    {
        "id1": 6694,
        "id2": 6640,
        "phenotype_comparison": ""
    },
    {
        "id1": 6695,
        "id2": 6696,
        "phenotype_comparison": ""
    },
    {
        "id1": 6697,
        "id2": 6644,
        "phenotype_comparison": ""
    },
    {
        "id1": 6698,
        "id2": 6699,
        "phenotype_comparison": ""
    },
    {
        "id1": 6700,
        "id2": 6648,
        "phenotype_comparison": ""
    },
    {
        "id1": 6701,
        "id2": 6702,
        "phenotype_comparison": ""
    },
    {
        "id1": 6703,
        "id2": 6660,
        "phenotype_comparison": ""
    },
    {
        "id1": 6704,
        "id2": 6705,
        "phenotype_comparison": ""
    },
    {
        "id1": 6706,
        "id2": 6664,
        "phenotype_comparison": ""
    },
    {
        "id1": 6707,
        "id2": 6708,
        "phenotype_comparison": ""
    },
    {
        "id1": 6643,
        "id2": 6668,
        "phenotype_comparison": ""
    },
    {
        "id1": 6709,
        "id2": 6710,
        "phenotype_comparison": ""
    },
    {
        "id1": 1458,
        "id2": 6711,
        "phenotype_comparison": ""
    },
    {
        "id1": 6713,
        "id2": 6714,
        "phenotype_comparison": ""
    },
    {
        "id1": 1465,
        "id2": 6715,
        "phenotype_comparison": ""
    },
    {
        "id1": 1466,
        "id2": 6716,
        "phenotype_comparison": ""
    },
    {
        "id1": 6715,
        "id2": 6716,
        "phenotype_comparison": "Despite cancer resistance, the median lifespan of the G3/G4 Terc-/- Atm-/- mice was significantly shorter than that of G3/G4 Terc-/- Atm+/+ controls"
    },
    {
        "id1": 1475,
        "id2": 6717,
        "phenotype_comparison": ""
    },
    {
        "id1": 6718,
        "id2": 6719,
        "phenotype_comparison": ""
    },
    {
        "id1": 6719,
        "id2": 6720,
        "phenotype_comparison": ""
    },
    {
        "id1": 6719,
        "id2": 6721,
        "phenotype_comparison": ""
    },
    {
        "id1": 6719,
        "id2": 6722,
        "phenotype_comparison": ""
    },
    {
        "id1": 6718,
        "id2": 6723,
        "phenotype_comparison": ""
    },
    {
        "id1": 6723,
        "id2": 6724,
        "phenotype_comparison": ""
    },
    {
        "id1": 6719,
        "id2": 6725,
        "phenotype_comparison": ""
    },
    {
        "id1": 6723,
        "id2": 6726,
        "phenotype_comparison": ""
    },
    {
        "id1": 6727,
        "id2": 6728,
        "phenotype_comparison": ""
    },
    {
        "id1": 6727,
        "id2": 6729,
        "phenotype_comparison": ""
    },
    {
        "id1": 6728,
        "id2": 6730,
        "phenotype_comparison": ""
    },
    {
        "id1": 6729,
        "id2": 6730,
        "phenotype_comparison": "The ftt-2 gene modulates life span in daf-16 loss-of-function genetic background."
    },
    {
        "id1": 6727,
        "id2": 6731,
        "phenotype_comparison": ""
    },
    {
        "id1": 6728,
        "id2": 6732,
        "phenotype_comparison": ""
    },
    {
        "id1": 6731,
        "id2": 6732,
        "phenotype_comparison": "The ftt-1 gene doesn't modulate life span in daf-16 loss-of-function genetic background."
    },
    {
        "id1": 6727,
        "id2": 6733,
        "phenotype_comparison": ""
    },
    {
        "id1": 6733,
        "id2": 6734,
        "phenotype_comparison": ""
    },
    {
        "id1": 6729,
        "id2": 6734,
        "phenotype_comparison": "The strongest life span reduction was observed upon ftt-2 RNAi treatment on both daf-2 class mutants"
    },
    {
        "id1": 6733,
        "id2": 6735,
        "phenotype_comparison": ""
    },
    {
        "id1": 6731,
        "id2": 6735,
        "phenotype_comparison": "The ftt-1 RNAi treatments induced a significant life span reduction when applied to both daf-2 class mutants"
    },
    {
        "id1": 6727,
        "id2": 6736,
        "phenotype_comparison": ""
    },
    {
        "id1": 6736,
        "id2": 6737,
        "phenotype_comparison": ""
    },
    {
        "id1": 6729,
        "id2": 6737,
        "phenotype_comparison": "The strongest life span reduction was observed upon ftt-2 RNAi treatment on both daf-2 class mutants"
    },
    {
        "id1": 6736,
        "id2": 6738,
        "phenotype_comparison": ""
    },
    {
        "id1": 6731,
        "id2": 6738,
        "phenotype_comparison": "The ftt-1 RNAi treatments induced a significant life span reduction when applied to both daf-2 class mutants"
    },
    {
        "id1": 6727,
        "id2": 6739,
        "phenotype_comparison": ""
    },
    {
        "id1": 6739,
        "id2": 6740,
        "phenotype_comparison": ""
    },
    {
        "id1": 6729,
        "id2": 6740,
        "phenotype_comparison": "The ftt-2 RNAi induced a significant life span modulation in comparison with control. This result is relevant to a negative modulation of pdk-1 activity by ftt-2 that can be highlighted here by a life span shortening effect upon RNAi."
    },
    {
        "id1": 6739,
        "id2": 6741,
        "phenotype_comparison": ""
    },
    {
        "id1": 6731,
        "id2": 6741,
        "phenotype_comparison": "The ftt-1 RNAi didn't induce a significant life span modulation in comparison with control. This result is relevant to a negative modulation of pdk-1 activity by ftt-2 that can be highlighted here by a life span shortening effect upon RNAi."
    },
    {
        "id1": 6727,
        "id2": 6742,
        "phenotype_comparison": ""
    },
    {
        "id1": 6742,
        "id2": 6743,
        "phenotype_comparison": ""
    },
    {
        "id1": 6729,
        "id2": 6743,
        "phenotype_comparison": "The ftt-2 RNAi induced a significant life span modulation in comparison with control. This result is relevant to a negative modulation of pdk-1 activity by ftt-2 that can be highlighted here by a life span shortening effect upon RNAi."
    },
    {
        "id1": 6742,
        "id2": 6744,
        "phenotype_comparison": ""
    },
    {
        "id1": 6731,
        "id2": 6744,
        "phenotype_comparison": "The ftt-1 RNAi didn't induce a significant life span modulation in comparison with control. This result is relevant to a negative modulation of pdk-1 activity by ftt-2 that can be highlighted here by a life span shortening effect upon RNAi."
    },
    {
        "id1": 6745,
        "id2": 6746,
        "phenotype_comparison": ""
    },
    {
        "id1": 6745,
        "id2": 6747,
        "phenotype_comparison": ""
    },
    {
        "id1": 6746,
        "id2": 6748,
        "phenotype_comparison": ""
    },
    {
        "id1": 6747,
        "id2": 6748,
        "phenotype_comparison": "The ftt-1 gene doesn't modulate life span in daf-16 loss-of-function genetic background."
    },
    {
        "id1": 6745,
        "id2": 6749,
        "phenotype_comparison": ""
    },
    {
        "id1": 6746,
        "id2": 6750,
        "phenotype_comparison": ""
    },
    {
        "id1": 6749,
        "id2": 6750,
        "phenotype_comparison": "The ftt-2 gene modulates life span in daf-16 loss-of-function genetic background."
    },
    {
        "id1": 6745,
        "id2": 6751,
        "phenotype_comparison": ""
    },
    {
        "id1": 6751,
        "id2": 6752,
        "phenotype_comparison": ""
    },
    {
        "id1": 6747,
        "id2": 6752,
        "phenotype_comparison": "The ftt-1 RNAi treatments induced a significant life span reduction when applied to both daf-2 class mutants"
    },
    {
        "id1": 6751,
        "id2": 6753,
        "phenotype_comparison": ""
    },
    {
        "id1": 6749,
        "id2": 6753,
        "phenotype_comparison": "The ftt-2 RNAi treatments induced a significant life span reduction when applied to both daf-2 class mutants"
    },
    {
        "id1": 6745,
        "id2": 6754,
        "phenotype_comparison": ""
    },
    {
        "id1": 6754,
        "id2": 6755,
        "phenotype_comparison": ""
    },
    {
        "id1": 6747,
        "id2": 6755,
        "phenotype_comparison": "The ftt-1 RNAi treatments induced a significant life span reduction when applied to both daf-2 class mutants"
    },
    {
        "id1": 6754,
        "id2": 6756,
        "phenotype_comparison": ""
    },
    {
        "id1": 6749,
        "id2": 6756,
        "phenotype_comparison": "The strongest life span reduction was observed upon ftt-2 RNAi treatment on both daf-2 class mutants"
    },
    {
        "id1": 6757,
        "id2": 6758,
        "phenotype_comparison": ""
    },
    {
        "id1": 6757,
        "id2": 6759,
        "phenotype_comparison": ""
    },
    {
        "id1": 6758,
        "id2": 6760,
        "phenotype_comparison": ""
    },
    {
        "id1": 6759,
        "id2": 6760,
        "phenotype_comparison": "cep-1 mutation partially suppresses isp-1 mutant longevity as the cep-1;isp-1 double mutant lifespan is shorter than that of the isp-1 single mutant."
    },
    {
        "id1": 6761,
        "id2": 6762,
        "phenotype_comparison": ""
    },
    {
        "id1": 6761,
        "id2": 6763,
        "phenotype_comparison": ""
    },
    {
        "id1": 6762,
        "id2": 6764,
        "phenotype_comparison": ""
    },
    {
        "id1": 6763,
        "id2": 6764,
        "phenotype_comparison": "cep-1 mutation partially suppresses isp-1 mutant longevity as the cep-1;isp-1 double mutant lifespan is shorter than that of the isp-1 single mutant."
    },
    {
        "id1": 6765,
        "id2": 6766,
        "phenotype_comparison": ""
    },
    {
        "id1": 6765,
        "id2": 6767,
        "phenotype_comparison": ""
    },
    {
        "id1": 6766,
        "id2": 6768,
        "phenotype_comparison": ""
    },
    {
        "id1": 6767,
        "id2": 6768,
        "phenotype_comparison": "cep-1 mutation does not suppress clk-1 mutant longevity as the lifespans of two cep-1;clk-1 double mutant isolates (L4, L6) are similar to that of the clk-1 single mutant. Mutation in cep-1;clk-1L4"
    },
    {
        "id1": 6766,
        "id2": 6769,
        "phenotype_comparison": ""
    },
    {
        "id1": 6767,
        "id2": 6769,
        "phenotype_comparison": "cep-1 mutation does not suppress clk-1 mutant longevity as the lifespans of two cep-1;clk-1 double mutant isolates (L4, L6) are similar to that of the clk-1 single mutant. Mutation in cep-1;clk-1L6"
    },
    {
        "id1": 6770,
        "id2": 6771,
        "phenotype_comparison": ""
    },
    {
        "id1": 6770,
        "id2": 6772,
        "phenotype_comparison": ""
    },
    {
        "id1": 6771,
        "id2": 6773,
        "phenotype_comparison": ""
    },
    {
        "id1": 6772,
        "id2": 6773,
        "phenotype_comparison": "cep-1 mutation does not suppress clk-1 mutant longevity as the lifespans of two cep-1;clk-1 double mutant isolates (L4, L6) are similar to that of the clk-1 single mutant. Mutation in cep-1;clk-1LN4"
    },
    {
        "id1": 6771,
        "id2": 6774,
        "phenotype_comparison": ""
    },
    {
        "id1": 6772,
        "id2": 6774,
        "phenotype_comparison": "cep-1 mutation does not suppress clk-1 mutant longevity as the lifespans of two cep-1;clk-1 double mutant isolates (L4, L6) are similar to that of the clk-1 single mutant. Mutation in cep-1;clk-1LN6"
    },
    {
        "id1": 6757,
        "id2": 6775,
        "phenotype_comparison": ""
    },
    {
        "id1": 6758,
        "id2": 6776,
        "phenotype_comparison": ""
    },
    {
        "id1": 6775,
        "id2": 6776,
        "phenotype_comparison": "cep-1 mutation restores the mev-1 mutant lifespan as the lifespans of two cep-1;mev-1 isolates (L1, L32) are similar to that of wt. Mutation in cep-1;mev-1L1"
    },
    {
        "id1": 6758,
        "id2": 6777,
        "phenotype_comparison": ""
    },
    {
        "id1": 6775,
        "id2": 6777,
        "phenotype_comparison": "cep-1 mutation restores the mev-1 mutant lifespan as the lifespans of two cep-1;mev-1 isolates (L1, L32) are similar to that of wt. Mutation in cep-1;mev-1L2"
    },
    {
        "id1": 6758,
        "id2": 6778,
        "phenotype_comparison": ""
    },
    {
        "id1": 6775,
        "id2": 6778,
        "phenotype_comparison": "cep-1 mutation restores the mev-1 mutant lifespan as the lifespans of two cep-1;mev-1 isolates (L1, L32) are similar to that of wt. Mutation in cep-1;mev-1L32"
    },
    {
        "id1": 6758,
        "id2": 6779,
        "phenotype_comparison": ""
    },
    {
        "id1": 6775,
        "id2": 6779,
        "phenotype_comparison": "cep-1 mutation restores the mev-1 mutant lifespan as the lifespans of two cep-1;mev-1 isolates (L1, L32) are similar to that of wt. Mutation in cep-1;mev-1L9"
    },
    {
        "id1": 6780,
        "id2": 6762,
        "phenotype_comparison": ""
    },
    {
        "id1": 6780,
        "id2": 6781,
        "phenotype_comparison": ""
    },
    {
        "id1": 6762,
        "id2": 6782,
        "phenotype_comparison": ""
    },
    {
        "id1": 6781,
        "id2": 6782,
        "phenotype_comparison": "cep-1 mutation restores the mev-1 mutant lifespan as the lifespans of two cep-1;mev-1 isolates (L1, L32) are similar to that of wt. Mutation in cep-1,mev-1L1"
    },
    {
        "id1": 6762,
        "id2": 6783,
        "phenotype_comparison": ""
    },
    {
        "id1": 6781,
        "id2": 6783,
        "phenotype_comparison": "cep-1 mutation restores the mev-1 mutant lifespan as the lifespans of two cep-1;mev-1 isolates (L1, L32) are similar to that of wt. Mutation in cep-1;mev-1L2"
    },
    {
        "id1": 6762,
        "id2": 6784,
        "phenotype_comparison": ""
    },
    {
        "id1": 6781,
        "id2": 6784,
        "phenotype_comparison": "cep-1 mutation restores the mev-1 mutant lifespan as the lifespans of two cep-1;mev-1 isolates (L1, L32) are similar to that of wt. Mutation in cep-1;mev-1L32"
    },
    {
        "id1": 6785,
        "id2": 6786,
        "phenotype_comparison": ""
    },
    {
        "id1": 6785,
        "id2": 6787,
        "phenotype_comparison": ""
    },
    {
        "id1": 6786,
        "id2": 6788,
        "phenotype_comparison": ""
    },
    {
        "id1": 6787,
        "id2": 6788,
        "phenotype_comparison": "cep-1 mutation restores the mev-1 mutant lifespan as the lifespans of two cep-1;mev-1 isolates (L1, L32) are similar to that of wt. Mutation in cep-1;mev-1L9"
    },
    {
        "id1": 6789,
        "id2": 6790,
        "phenotype_comparison": ""
    },
    {
        "id1": 6789,
        "id2": 6791,
        "phenotype_comparison": ""
    },
    {
        "id1": 6790,
        "id2": 6792,
        "phenotype_comparison": ""
    },
    {
        "id1": 6791,
        "id2": 6792,
        "phenotype_comparison": "cep-1 mutation partially restores gas-1 mutant lifespan as two isolates of cep-1;gas-1 (L22, L34) live longer than the gas-1 single mutant. Mutation in gas-1;cep-1L22"
    },
    {
        "id1": 6790,
        "id2": 6793,
        "phenotype_comparison": ""
    },
    {
        "id1": 6791,
        "id2": 6793,
        "phenotype_comparison": "cep-1 mutation partially restores gas-1 mutant lifespan as two isolates of cep-1;gas-1 (L22, L34) live longer than the gas-1 single mutant. Mutation in gas-1;cep-1L34"
    },
    {
        "id1": 6794,
        "id2": 6795,
        "phenotype_comparison": ""
    },
    {
        "id1": 6794,
        "id2": 6796,
        "phenotype_comparison": ""
    },
    {
        "id1": 6795,
        "id2": 6797,
        "phenotype_comparison": ""
    },
    {
        "id1": 6796,
        "id2": 6797,
        "phenotype_comparison": "The cep-1 mutation partially restores gas-1 mutant lifespan as two isolates of cep-1;gas-1 (L22, L34) live longer than the gas-1 single mutant. Mutation in cep-1;gas-1L22"
    },
    {
        "id1": 6795,
        "id2": 6798,
        "phenotype_comparison": ""
    },
    {
        "id1": 6796,
        "id2": 6798,
        "phenotype_comparison": "cep-1 mutation partially restores gas-1 mutant lifespan as two isolates of cep-1;gas-1 (L22, L34) live longer than the gas-1 single mutant. Mutation in cep-1;gas-1L34"
    },
    {
        "id1": 6799,
        "id2": 6800,
        "phenotype_comparison": ""
    },
    {
        "id1": 6801,
        "id2": 6802,
        "phenotype_comparison": "CEP-1-regulated ferritin induction partially mediates the extended lifespan of isp-1 mutants. Mutation in cep-1_ftn-1&2RNAi"
    },
    {
        "id1": 6799,
        "id2": 6803,
        "phenotype_comparison": ""
    },
    {
        "id1": 6801,
        "id2": 6804,
        "phenotype_comparison": "CEP-1-regulated ferritin induction partially mediates the extended lifespan of isp-1 mutants. Mutation in isp-1 ftn-1&2RNAi"
    },
    {
        "id1": 6799,
        "id2": 6807,
        "phenotype_comparison": ""
    },
    {
        "id1": 6801,
        "id2": 6808,
        "phenotype_comparison": "CEP-1-regulated ferritin induction partially mediates the extended lifespan of isp-1 mutants. Mutation in mev-1 ftn-1&2RNAi"
    },
    {
        "id1": 6800,
        "id2": 6809,
        "phenotype_comparison": ""
    },
    {
        "id1": 6807,
        "id2": 6809,
        "phenotype_comparison": "The cep-1;mev-1 double mutants display significantly lower brood sizes than their respective single mutant controls. cep-1;mev-1 control"
    },
    {
        "id1": 6811,
        "id2": 6812,
        "phenotype_comparison": ""
    },
    {
        "id1": 6813,
        "id2": 6814,
        "phenotype_comparison": "Double RNAi-mediated knockdown of ftn-1 and ftn-2 significantly suppressed the extended lifespan of isp-1 mutants, although not to the same degree as cep-1 inactivation."
    },
    {
        "id1": 6811,
        "id2": 6815,
        "phenotype_comparison": ""
    },
    {
        "id1": 6813,
        "id2": 6816,
        "phenotype_comparison": "Both cep-1 and ftn-1/2 are important for the longevity of isp-1 mutants. isp-1_ftn-1&2RNAi"
    },
    {
        "id1": 6811,
        "id2": 6819,
        "phenotype_comparison": ""
    },
    {
        "id1": 6813,
        "id2": 6820,
        "phenotype_comparison": "The ftn-1/2 are not regulated by CEP-1 in the short-lived mev-1 mutant, the mev-1 mutant lifespan was not affected by ftn-1/2 RNAi"
    },
    {
        "id1": 6811,
        "id2": 6821,
        "phenotype_comparison": ""
    },
    {
        "id1": 6821,
        "id2": 6822,
        "phenotype_comparison": ""
    },
    {
        "id1": 6819,
        "id2": 6822,
        "phenotype_comparison": "The cep-1;mev-1 double mutants display significantly lower brood sizes than their respective single mutant controls. cep-1;mev-1 control."
    },
    {
        "id1": 6825,
        "id2": 6826,
        "phenotype_comparison": ""
    },
    {
        "id1": 6827,
        "id2": 6828,
        "phenotype_comparison": "Depleting ftn-1/2 did not rescue the shortened lifespan of the gas-1 mutant"
    },
    {
        "id1": 6825,
        "id2": 6829,
        "phenotype_comparison": ""
    },
    {
        "id1": 6827,
        "id2": 6830,
        "phenotype_comparison": "The ftn-1/2 are not regulated by CEP-1 in the short-lived mev-1 mutant, the mev-1 mutant lifespan was not affected by ftn-1/2 RNAi"
    },
    {
        "id1": 6825,
        "id2": 6831,
        "phenotype_comparison": ""
    },
    {
        "id1": 6827,
        "id2": 6832,
        "phenotype_comparison": "RNAi-mediated depletion of ftn-1/2 substantially suppressed the extended lifespan of the nuo-6 mutant."
    },
    {
        "id1": 6825,
        "id2": 6833,
        "phenotype_comparison": ""
    },
    {
        "id1": 6827,
        "id2": 6834,
        "phenotype_comparison": "Both cep-1 and ftn-1/2 are important for the longevity of isp-1 mutants."
    },
    {
        "id1": 6835,
        "id2": 6836,
        "phenotype_comparison": ""
    },
    {
        "id1": 6836,
        "id2": 6837,
        "phenotype_comparison": "The cep-1;mev-1 double mutants display significantly lower brood sizes than their respective single mutant controls."
    },
    {
        "id1": 6835,
        "id2": 6838,
        "phenotype_comparison": ""
    },
    {
        "id1": 6838,
        "id2": 6839,
        "phenotype_comparison": "The cep-1 mutation partially restores gas-1 mutant lifespan as two isolates of cep-1;gas-1 (L22, L34) live longer than the gas-1 single mutant."
    },
    {
        "id1": 6835,
        "id2": 6840,
        "phenotype_comparison": ""
    },
    {
        "id1": 6840,
        "id2": 6841,
        "phenotype_comparison": "The cep-1;clk-1 double mutant lived as long as the clk-1 single mutant"
    },
    {
        "id1": 6835,
        "id2": 6842,
        "phenotype_comparison": ""
    },
    {
        "id1": 6842,
        "id2": 6843,
        "phenotype_comparison": ""
    },
    {
        "id1": 6844,
        "id2": 6846,
        "phenotype_comparison": ""
    },
    {
        "id1": 6845,
        "id2": 6846,
        "phenotype_comparison": "wuEx123 is a sod-1 over expression."
    },
    {
        "id1": 6844,
        "id2": 6848,
        "phenotype_comparison": ""
    },
    {
        "id1": 6847,
        "id2": 6848,
        "phenotype_comparison": "Overexpression of sod-1 (wuEx152 strain)"
    },
    {
        "id1": 6849,
        "id2": 6851,
        "phenotype_comparison": ""
    },
    {
        "id1": 6850,
        "id2": 6851,
        "phenotype_comparison": "The sod-1 OE longevity is fully dependent on daf-16."
    },
    {
        "id1": 6852,
        "id2": 6854,
        "phenotype_comparison": ""
    },
    {
        "id1": 6853,
        "id2": 6854,
        "phenotype_comparison": "The sod-1 OE longevity is fully dependent on daf-16."
    },
    {
        "id1": 6855,
        "id2": 6856,
        "phenotype_comparison": ""
    },
    {
        "id1": 6847,
        "id2": 6856,
        "phenotype_comparison": "sod-1 OE longevity is partially dependent on hsf-1."
    },
    {
        "id1": 6857,
        "id2": 6858,
        "phenotype_comparison": ""
    },
    {
        "id1": 6859,
        "id2": 6860,
        "phenotype_comparison": ""
    },
    {
        "id1": 6847,
        "id2": 6860,
        "phenotype_comparison": "sod-1 OE robustly increased the life span of aak-2 mutants."
    },
    {
        "id1": 6861,
        "id2": 6862,
        "phenotype_comparison": ""
    },
    {
        "id1": 6863,
        "id2": 6865,
        "phenotype_comparison": ""
    },
    {
        "id1": 6863,
        "id2": 6867,
        "phenotype_comparison": ""
    },
    {
        "id1": 6868,
        "id2": 6869,
        "phenotype_comparison": ""
    },
    {
        "id1": 6868,
        "id2": 6870,
        "phenotype_comparison": ""
    },
    {
        "id1": 6869,
        "id2": 6871,
        "phenotype_comparison": ""
    },
    {
        "id1": 6870,
        "id2": 6871,
        "phenotype_comparison": "Overexpression of mitochondrial Mn-SOD (SOD-2) increases life span in a daf-16-dependent manner"
    },
    {
        "id1": 6872,
        "id2": 6874,
        "phenotype_comparison": ""
    },
    {
        "id1": 6875,
        "id2": 6877,
        "phenotype_comparison": ""
    },
    {
        "id1": 6878,
        "id2": 6879,
        "phenotype_comparison": ""
    },
    {
        "id1": 6878,
        "id2": 6880,
        "phenotype_comparison": ""
    },
    {
        "id1": 6879,
        "id2": 6881,
        "phenotype_comparison": ""
    },
    {
        "id1": 6880,
        "id2": 6881,
        "phenotype_comparison": "RNAi of ire-1 markedly reduced hsp-4::gfp expression in both the presence and the absence of sod-1 OE."
    },
    {
        "id1": 6878,
        "id2": 6882,
        "phenotype_comparison": ""
    },
    {
        "id1": 6879,
        "id2": 6883,
        "phenotype_comparison": ""
    },
    {
        "id1": 6882,
        "id2": 6883,
        "phenotype_comparison": "RNAi of ire-1 and xbp-1 markedly reduced hsp-4::gfp expression in both the presence and the absence of sod-1 OE."
    },
    {
        "id1": 6884,
        "id2": 6885,
        "phenotype_comparison": ""
    },
    {
        "id1": 6884,
        "id2": 6886,
        "phenotype_comparison": ""
    },
    {
        "id1": 6885,
        "id2": 6887,
        "phenotype_comparison": ""
    },
    {
        "id1": 6886,
        "id2": 6887,
        "phenotype_comparison": "RNAi of ire-1 markedly reduced hsp-4::gfp expression in both the presence and the absence of sod-1 OE."
    },
    {
        "id1": 6884,
        "id2": 6888,
        "phenotype_comparison": ""
    },
    {
        "id1": 6885,
        "id2": 6889,
        "phenotype_comparison": ""
    },
    {
        "id1": 6888,
        "id2": 6889,
        "phenotype_comparison": "RNAi of ire-1 and xbp-1 markedly reduced hsp-4::gfp expression in both the presence and the absence of sod-1 OE."
    },
    {
        "id1": 6961,
        "id2": 6966,
        "phenotype_comparison": "daf-2;drp-1 mutants exhibited a >75% increase in mean lifespan and an extension by up to 30 days in maximum lifespan when compared to their single mutant counterparts."
    },
    {
        "id1": 6967,
        "id2": 6969,
        "phenotype_comparison": ""
    },
    {
        "id1": 6968,
        "id2": 6970,
        "phenotype_comparison": ""
    },
    {
        "id1": 6967,
        "id2": 6971,
        "phenotype_comparison": ""
    },
    {
        "id1": 6971,
        "id2": 6972,
        "phenotype_comparison": ""
    },
    {
        "id1": 6969,
        "id2": 6972,
        "phenotype_comparison": "Inactivating drp-1 specifically and robustly synergizes with reduced IIS to prolong longevity."
    },
    {
        "id1": 6973,
        "id2": 6974,
        "phenotype_comparison": ""
    },
    {
        "id1": 6973,
        "id2": 6975,
        "phenotype_comparison": ""
    },
    {
        "id1": 6974,
        "id2": 6976,
        "phenotype_comparison": ""
    },
    {
        "id1": 6975,
        "id2": 6976,
        "phenotype_comparison": "daf-16(m26); clk-1(e2519) double mutants still live significantly longer than the wild type."
    },
    {
        "id1": 6977,
        "id2": 6978,
        "phenotype_comparison": ""
    },
    {
        "id1": 6977,
        "id2": 6979,
        "phenotype_comparison": ""
    },
    {
        "id1": 6978,
        "id2": 6980,
        "phenotype_comparison": ""
    },
    {
        "id1": 6979,
        "id2": 6980,
        "phenotype_comparison": "All other eat mutations that lengthen mean life span also clearly lengthen maximum life span."
    },
    {
        "id1": 6981,
        "id2": 6979,
        "phenotype_comparison": ""
    },
    {
        "id1": 6981,
        "id2": 6982,
        "phenotype_comparison": ""
    },
    {
        "id1": 6979,
        "id2": 6983,
        "phenotype_comparison": ""
    },
    {
        "id1": 6982,
        "id2": 6983,
        "phenotype_comparison": "eat-2(ad465); daf-2(e1370) worms live significantly longer than either eat-2(ad465) or daf-2(e1370)."
    },
    {
        "id1": 6977,
        "id2": 6984,
        "phenotype_comparison": ""
    },
    {
        "id1": 6979,
        "id2": 6985,
        "phenotype_comparison": ""
    },
    {
        "id1": 6984,
        "id2": 6985,
        "phenotype_comparison": "eat-2(ad465); clk-1(e2519) lives only marginally longer than clk-1(e2519)."
    },
    {
        "id1": 6981,
        "id2": 6986,
        "phenotype_comparison": ""
    },
    {
        "id1": 6986,
        "id2": 6987,
        "phenotype_comparison": ""
    },
    {
        "id1": 6979,
        "id2": 6987,
        "phenotype_comparison": "eat-2; clk-1 Double Mutants Live No Longer Than eat-2 Mutants."
    },
    {
        "id1": 6988,
        "id2": 6989,
        "phenotype_comparison": ""
    },
    {
        "id1": 6988,
        "id2": 6990,
        "phenotype_comparison": ""
    },
    {
        "id1": 6989,
        "id2": 6991,
        "phenotype_comparison": ""
    },
    {
        "id1": 6990,
        "id2": 6991,
        "phenotype_comparison": "Lifespans of two independent ocr-2 mutants on plates containing FUDR, a drug that inhibits progeny production. Loss of ocr-2 substantially extends adult lifespan"
    },
    {
        "id1": 6992,
        "id2": 6993,
        "phenotype_comparison": ""
    },
    {
        "id1": 6992,
        "id2": 6994,
        "phenotype_comparison": ""
    },
    {
        "id1": 6993,
        "id2": 6995,
        "phenotype_comparison": ""
    },
    {
        "id1": 6994,
        "id2": 6995,
        "phenotype_comparison": "Lifespans of two independent ocr-2 mutants on plates containing FUDR, a drug that inhibits progeny production. Loss of ocr-2 substantially extends adult lifespan"
    },
    {
        "id1": 6996,
        "id2": 6997,
        "phenotype_comparison": ""
    },
    {
        "id1": 6996,
        "id2": 6998,
        "phenotype_comparison": ""
    },
    {
        "id1": 6997,
        "id2": 6999,
        "phenotype_comparison": ""
    },
    {
        "id1": 6998,
        "id2": 6999,
        "phenotype_comparison": "The extended survival of osm-6 mutants was fully dependent on daf-16"
    },
    {
        "id1": 7000,
        "id2": 7001,
        "phenotype_comparison": ""
    },
    {
        "id1": 7000,
        "id2": 7002,
        "phenotype_comparison": ""
    },
    {
        "id1": 7001,
        "id2": 7003,
        "phenotype_comparison": ""
    },
    {
        "id1": 7002,
        "id2": 7003,
        "phenotype_comparison": "Loss of DAF-16/FOXO transcription factor, on L1 starvation survival."
    },
    {
        "id1": 7000,
        "id2": 7004,
        "phenotype_comparison": ""
    },
    {
        "id1": 7001,
        "id2": 7005,
        "phenotype_comparison": ""
    },
    {
        "id1": 7004,
        "id2": 7005,
        "phenotype_comparison": "Loss of DAF-16/FOXO transcription factor, on L1 starvation survival."
    },
    {
        "id1": 7006,
        "id2": 7007,
        "phenotype_comparison": ""
    },
    {
        "id1": 7006,
        "id2": 7008,
        "phenotype_comparison": ""
    },
    {
        "id1": 7007,
        "id2": 7009,
        "phenotype_comparison": ""
    },
    {
        "id1": 7008,
        "id2": 7009,
        "phenotype_comparison": "Pronounced cilia defects were required to cause enhanced L1 starvation survival, since che-2(e1033), che-3(e1124), and bbs-1(k1111); osm-12(n1606); bbs-8(nx77) triple mutants."
    },
    {
        "id1": 6890,
        "id2": 6891,
        "phenotype_comparison": ""
    },
    {
        "id1": 6890,
        "id2": 6892,
        "phenotype_comparison": ""
    },
    {
        "id1": 6891,
        "id2": 6893,
        "phenotype_comparison": ""
    },
    {
        "id1": 6892,
        "id2": 6893,
        "phenotype_comparison": "Cbp-1 RNAi blocks life extension by DR produced by three protocols. cbp-1 RNAi does not affect egg laying in N2 worms."
    },
    {
        "id1": 6890,
        "id2": 6894,
        "phenotype_comparison": ""
    },
    {
        "id1": 6894,
        "id2": 6895,
        "phenotype_comparison": ""
    },
    {
        "id1": 6892,
        "id2": 6895,
        "phenotype_comparison": "Cbp-1 RNAi blocks life extension by DR produced by three protocols. cbp-1 RNAi does not affect egg laying in N2 worms."
    },
    {
        "id1": 6890,
        "id2": 6896,
        "phenotype_comparison": ""
    },
    {
        "id1": 6896,
        "id2": 6897,
        "phenotype_comparison": ""
    },
    {
        "id1": 6892,
        "id2": 6897,
        "phenotype_comparison": "Cbp-1 RNAi blocks life extension by DR produced by three protocols. cbp-1 RNAi does not affect egg laying in N2 worms."
    },
    {
        "id1": 6890,
        "id2": 6898,
        "phenotype_comparison": ""
    },
    {
        "id1": 6898,
        "id2": 6899,
        "phenotype_comparison": ""
    },
    {
        "id1": 6892,
        "id2": 6899,
        "phenotype_comparison": "Cbp-1 RNAi blocks life extension by DR produced by three protocols. cbp-1 RNAi does not affect egg laying in N2 worms."
    },
    {
        "id1": 6890,
        "id2": 6900,
        "phenotype_comparison": ""
    },
    {
        "id1": 6900,
        "id2": 6901,
        "phenotype_comparison": ""
    },
    {
        "id1": 6892,
        "id2": 6901,
        "phenotype_comparison": "daf-2 mutant or wild-type worms under standard conditions were fed bacteria expressing control L4440 or cbp-1 dsRNA (cbp-1 RNAi only partly blocks lifespan extension by the daf-2 mutation; p<0.05). Cbp-1 RNAi blocks life extension by DR produced by three protocols."
    },
    {
        "id1": 6902,
        "id2": 6903,
        "phenotype_comparison": ""
    },
    {
        "id1": 6902,
        "id2": 6904,
        "phenotype_comparison": ""
    },
    {
        "id1": 6903,
        "id2": 6905,
        "phenotype_comparison": ""
    },
    {
        "id1": 6904,
        "id2": 6905,
        "phenotype_comparison": "Cbp-1 RNAi blocks life extension by DR produced by three protocols. cbp-1 RNAi does not affect egg laying in N2 worms. Overexpression of cbp-1 does not extend lifespan in N2 worms at 25\u00b0C."
    },
    {
        "id1": 6902,
        "id2": 6906,
        "phenotype_comparison": ""
    },
    {
        "id1": 6903,
        "id2": 6907,
        "phenotype_comparison": ""
    },
    {
        "id1": 6906,
        "id2": 6907,
        "phenotype_comparison": "daf-2 mutant or wild-type worms under standard conditions were fed bacteria expressing control L4440 or cbp-1 dsRNA (cbp-1 RNAi only partly blocks lifespan extension by the daf-2 mutation; p<0.05). Cbp-1 RNAi blocks life extension by DR produced by three protocols. daf-16 RNAi also completely blocked lifespan extension by the daf-2 mutation as previously reported."
    },
    {
        "id1": 6903,
        "id2": 6908,
        "phenotype_comparison": ""
    },
    {
        "id1": 6903,
        "id2": 6909,
        "phenotype_comparison": ""
    },
    {
        "id1": 6902,
        "id2": 6910,
        "phenotype_comparison": ""
    },
    {
        "id1": 6910,
        "id2": 6911,
        "phenotype_comparison": ""
    },
    {
        "id1": 6904,
        "id2": 6911,
        "phenotype_comparison": "Cbp-1 RNAi blocks life extension by DR produced by three protocols. Overexpression of cbp-1 does not extend lifespan in N2 worms at 25\u00b0C."
    },
    {
        "id1": 6910,
        "id2": 6912,
        "phenotype_comparison": ""
    },
    {
        "id1": 6906,
        "id2": 6912,
        "phenotype_comparison": "daf-16, and hsf-1 RNAi, the effect of cbp-1 RNAi to increase mortality in standard conditions is completely age-dependent, occurring only after midlife, and entails a doubling of the age-dependent acceleration of mortality rate without influencing initial mortality rate, inconsistent with age-independent general sickness."
    },
    {
        "id1": 6910,
        "id2": 6913,
        "phenotype_comparison": ""
    },
    {
        "id1": 6910,
        "id2": 6914,
        "phenotype_comparison": ""
    },
    {
        "id1": 6910,
        "id2": 6915,
        "phenotype_comparison": ""
    },
    {
        "id1": 6916,
        "id2": 6917,
        "phenotype_comparison": ""
    },
    {
        "id1": 6918,
        "id2": 6919,
        "phenotype_comparison": ""
    },
    {
        "id1": 6918,
        "id2": 6920,
        "phenotype_comparison": ""
    },
    {
        "id1": 6919,
        "id2": 6921,
        "phenotype_comparison": ""
    },
    {
        "id1": 6920,
        "id2": 6921,
        "phenotype_comparison": "Cbp-1 RNAi blocks life extension by DR produced by three protocols."
    },
    {
        "id1": 6922,
        "id2": 6891,
        "phenotype_comparison": ""
    },
    {
        "id1": 6922,
        "id2": 6920,
        "phenotype_comparison": ""
    },
    {
        "id1": 6891,
        "id2": 6924,
        "phenotype_comparison": ""
    },
    {
        "id1": 6920,
        "id2": 6924,
        "phenotype_comparison": "Cbp-1 RNAi blocks life extension by DR produced by three protocols."
    },
    {
        "id1": 6891,
        "id2": 6925,
        "phenotype_comparison": ""
    },
    {
        "id1": 6926,
        "id2": 6927,
        "phenotype_comparison": ""
    },
    {
        "id1": 6926,
        "id2": 6928,
        "phenotype_comparison": ""
    },
    {
        "id1": 6927,
        "id2": 6929,
        "phenotype_comparison": ""
    },
    {
        "id1": 6928,
        "id2": 6929,
        "phenotype_comparison": "Neither eak-3(mg344) nor eak-3;akt-1 double mutants lived longer than wild-type animals. eak-3;akt-1 animals had slightly shorter lifespans than akt-1(mg306) single mutants."
    },
    {
        "id1": 6930,
        "id2": 6931,
        "phenotype_comparison": ""
    },
    {
        "id1": 6930,
        "id2": 6932,
        "phenotype_comparison": ""
    },
    {
        "id1": 6931,
        "id2": 6933,
        "phenotype_comparison": ""
    },
    {
        "id1": 6932,
        "id2": 6933,
        "phenotype_comparison": "eak-3 mutation did not affect the lifespan of daf-16/FoxO mutants, suggesting that the lifespan extending effects of eak-3 mutation in a daf-2(e1370) background are mediated by DAF-16/FoxO."
    },
    {
        "id1": 6934,
        "id2": 6935,
        "phenotype_comparison": ""
    },
    {
        "id1": 6935,
        "id2": 6936,
        "phenotype_comparison": "eak-3 daf-2 double mutants exhibited extended longevity compared to daf-2 single mutants."
    },
    {
        "id1": 6934,
        "id2": 6937,
        "phenotype_comparison": ""
    },
    {
        "id1": 6934,
        "id2": 6938,
        "phenotype_comparison": ""
    },
    {
        "id1": 6937,
        "id2": 6939,
        "phenotype_comparison": ""
    },
    {
        "id1": 6938,
        "id2": 6939,
        "phenotype_comparison": "eak-3;akt-1 animals had slightly shorter lifespans than akt-1(mg306) single mutants. Neither eak-3(mg344) nor eak-3;akt-1 double mutants lived longer than wild-type animals. eak;akt-1 double mutants had lifespans comparable to eak-3 single."
    },
    {
        "id1": 6934,
        "id2": 6940,
        "phenotype_comparison": ""
    },
    {
        "id1": 6940,
        "id2": 6941,
        "phenotype_comparison": ""
    },
    {
        "id1": 6938,
        "id2": 6941,
        "phenotype_comparison": "Double mutants had lifespans comparable to WT."
    },
    {
        "id1": 6934,
        "id2": 6942,
        "phenotype_comparison": ""
    },
    {
        "id1": 6938,
        "id2": 6943,
        "phenotype_comparison": ""
    },
    {
        "id1": 6942,
        "id2": 6943,
        "phenotype_comparison": "Double mutants had lifespans comparable to WT."
    },
    {
        "id1": 6934,
        "id2": 6944,
        "phenotype_comparison": ""
    },
    {
        "id1": 6938,
        "id2": 6945,
        "phenotype_comparison": ""
    },
    {
        "id1": 6944,
        "id2": 6945,
        "phenotype_comparison": "Double mutants had lifespans comparable to WT."
    },
    {
        "id1": 6934,
        "id2": 6946,
        "phenotype_comparison": ""
    },
    {
        "id1": 6946,
        "id2": 6947,
        "phenotype_comparison": ""
    },
    {
        "id1": 6938,
        "id2": 6947,
        "phenotype_comparison": "eak;akt-1 double mutants had lifespans comparable to eak-3 single"
    },
    {
        "id1": 6948,
        "id2": 6949,
        "phenotype_comparison": ""
    },
    {
        "id1": 6948,
        "id2": 6950,
        "phenotype_comparison": ""
    },
    {
        "id1": 6949,
        "id2": 6951,
        "phenotype_comparison": ""
    },
    {
        "id1": 6950,
        "id2": 6951,
        "phenotype_comparison": "The extended longevity and the sensitivity to heat stress of the age1;drp-1 mutant compared to the age-1 mutant can be rescued by introduction of a transgene overexpressing drp-1. drp-1 RNAi affects mitochondrial morphology in muscle cells of the body wall. Both age-1 and daf-2 mutants treated with drp-1 RNAi showed substantial further increase in mean lifespan (>65% compared to age-1 and daf-2 single mutant on control RNAi)."
    },
    {
        "id1": 6948,
        "id2": 6952,
        "phenotype_comparison": ""
    },
    {
        "id1": 6952,
        "id2": 6953,
        "phenotype_comparison": ""
    },
    {
        "id1": 6950,
        "id2": 6953,
        "phenotype_comparison": "drp-1 RNAi affects mitochondrial morphology in muscle cells of the body wall. Both age-1 and daf-2 mutants treated with drp-1 RNAi showed substantial further increase in mean lifespan (>65% compared to age-1 and daf-2 single mutant on control RNAi)."
    },
    {
        "id1": 6948,
        "id2": 6954,
        "phenotype_comparison": ""
    },
    {
        "id1": 6954,
        "id2": 6955,
        "phenotype_comparison": "daf-16 RNAi completely abolished the synergistic effect of drp-1 and daf-2/age-1 mutations."
    },
    {
        "id1": 6954,
        "id2": 6956,
        "phenotype_comparison": "daf-16 RNAi completely abolished the synergistic effect of drp-1 and daf-2/age-1 mutations."
    },
    {
        "id1": 6954,
        "id2": 6958,
        "phenotype_comparison": "daf-16 RNAi completely abolished the synergistic effect of drp-1 and daf-2/age-1 mutations."
    },
    {
        "id1": 6960,
        "id2": 6961,
        "phenotype_comparison": ""
    },
    {
        "id1": 6960,
        "id2": 6962,
        "phenotype_comparison": ""
    },
    {
        "id1": 6961,
        "id2": 6963,
        "phenotype_comparison": ""
    },
    {
        "id1": 6962,
        "id2": 6963,
        "phenotype_comparison": "age-1;drp-1 and daf-2;drp-1 mutants exhibited a >75% increase in mean lifespan and an extension by up to 30 days in maximum lifespan when compared to their single mutant counterparts."
    },
    {
        "id1": 6962,
        "id2": 6964,
        "phenotype_comparison": ""
    },
    {
        "id1": 6961,
        "id2": 6964,
        "phenotype_comparison": "age-1;drp-1 and daf-2;drp-1 mutants exhibited a >75% increase in mean lifespan and an extension by up to 30 days in maximum lifespan when compared to their single mutant counterparts."
    },
    {
        "id1": 6960,
        "id2": 6965,
        "phenotype_comparison": ""
    },
    {
        "id1": 6965,
        "id2": 6966,
        "phenotype_comparison": ""
    }
]