asm-3;daf-18;rrf-3

Lifespan changes: From wild type to asm-3;daf-18;rrf-3

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with asm-3, daf-18, rrf-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    10.1

  • Phenotype

    The lifespan extension phenotypes produced by inactivation of asm-3 gene was suppressed by a null mutation of daf-18, daf-18(nr2037)

  • Lifespan comparisons

    Triple mutant asm-3(RNAi);daf-18(nr2037);rrf-3(pk1426) has a lifespan of 10.1 days, while double mutant daf-18(nr2037);rrf-3(pk1426) has a lifespan of 9.9 days.

  • Citation
    View abstract

    Kim Y, Sun H, 2012;7(9):e45890., ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target. PLoS One. 7(9):e45890 PubMed 23049887 Click here to select all mutants from this PubMed ID in the graph

Search genes: asm-3 daf-18 rrf-3 asm-3;daf-18;rrf-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase


Locus: CELE_W03G1.7


Wormbase description: none available


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18


Locus: CELE_T07A9.6


Wormbase description: daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

RNA-dependent RNA polymerase Family


Locus: CELE_F10B5.7


Wormbase description: rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene.


Orthologs of asm-3;daf-18;rrf-3 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of asm-3 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of daf-18 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of rrf-3 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group