Lifespan changes: From wild type to aap-1;asm-3

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Genetic mutants with aap-1, asm-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Phenotype

    While partial loss-of-function aap-1(m889) mutants exhibited longer lifespan phenotype than wild-type animals, silencing of asm-3 in the aap-1(m889) mutants further extended the mean lifespan by 21%. These genetic results indicate that loss of asm-3 cooperates with an aap-1 loss-of-function mutation to extend animal lifespan, suggesting that asm-3 potentiates aap-1 signaling.

  • Lifespan comparisons

    Double mutant aap-1(m889);asm-3(RNAi) has a lifespan of 51.33 days, while single mutant aap-1(m889) has a lifespan of 42.41 days.

  • Citation
    View abstract

    Kim Y, Sun H, 2012;7(9):e45890., ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target. PLoS One. 7(9):e45890 PubMed 23049887 Click here to select all mutants from this PubMed ID in the graph

Search genes: aap-1 asm-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

phosphoinositide kinase AdAPter subunit

Locus: CELE_Y110A7A.10

Wormbase description: aap-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p50/p55 adaptor/regulatory subunit; AAP-1 negatively regulates lifespan and dauer development, and likely functions as the sole adaptor subunit for the AGE-1/p110 PI3K catalytic subunit to which it binds in vitro; although AAP-1 potentiates insulin-like signaling, it is not absolutely required for insulin-like signaling under most conditions.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase

Locus: CELE_W03G1.7

Wormbase description: none available

Orthologs of aap-1;asm-3 in SynergyAge
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Species Gene
Orthologs of aap-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of asm-3 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group