Lifespan changes: From wild type to sod-1;sod-3 / From sod-1;sod-3 to multiple mutants
Examining the lifespan of sod-1 double deletion mutants revealed that deletion of sod-3 did not shorten the lifespan of sod-1 mutant worms
Double mutant sod-1(tm783);sod-3(tm760) has a lifespan of 21 days, while single mutant sod-1(tm783) has a lifespan of 17.3 days, single mutant sod-3(tm760) has a lifespan of 17.1 days and wild type has a lifespan of 17.7 days.
Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 19197346 Click here to select all mutants from this PubMed ID in the graph
Superoxide dismutase [Cu-Zn]
Wormbase description: sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).
Superoxide dismutase [Mn] 2, mitochondrial
Wormbase description: sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16 and chromatin immunoprecipitation (ChIP) studies demonstrate that DAF-16 can directly bind the sod-3 promoter; heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress.
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