sod-1;sod-4

Lifespan changes: From wild type to sod-1;sod-4 / From sod-1;sod-4 to multiple mutants

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Genetic mutants with sod-1, sod-4 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    17.5

  • Lifespan change (compared to wild type)

    -1.13%

  • Phenotype

    Examining the lifespan of sod-1 double deletion mutants revealed that deletion of sod-4 did not shorten the lifespan of sod-1 mutant worms

  • Lifespan comparisons

    Double mutant sod-1(tm783);sod-4(gk101) has a lifespan of 17.5 days, while single mutant sod-1(tm783) has a lifespan of 17.3 days, single mutant sod-4(gk101) has a lifespan of 19.1 days and wild type has a lifespan of 17.7 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 PubMed 19197346 Click here to select all mutants from this PubMed ID in the graph

Search genes: sod-1 sod-4
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Cu-Zn]


Locus: CELE_C15F1.7


Wormbase description: sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]


Locus: CELE_F55H2.1


Wormbase description: sod-4 encodes an extracellular Cu2+/Zn2+ superoxide dismutase (SOD) that is one of five C. elegans SOD enzymes; genetic analyses indicates that sod-4 is required for redox regulation of a number of processes including axon pathfinding in the PVQ interneurons, insulin/IGF-1 signaling, and vulval development; large-scale expression studies indicate that sod-4 is expressed in the nervous system, intestine, and rectal gland cells; sod-4 transcripts are significantly upregulated in dauers.


Orthologs of sod-1;sod-4 in SynergyAge
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Species Gene
Orthologs of sod-1 in SynergyAge
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Species Gene
Drosophila melanogaster Sod1
Mus musculus Sod1
Orthologs of sod-4 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group