Lifespan changes: From wild type to sod-1;sod-4 / From sod-1;sod-4 to multiple mutants
Examining the lifespan of sod-1 double deletion mutants revealed that deletion of sod-4 did not shorten the lifespan of sod-1 mutant worms
Double mutant sod-1(tm783);sod-4(gk101) has a lifespan of 17.5 days, while single mutant sod-1(tm783) has a lifespan of 17.3 days, single mutant sod-4(gk101) has a lifespan of 19.1 days and wild type has a lifespan of 17.7 days.
Opposite lifespan effects of single mutants
Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 19197346 Click here to select all mutants from this PubMed ID in the graph
Superoxide dismutase [Cu-Zn]
Wormbase description: sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).
Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]
Wormbase description: sod-4 encodes an extracellular Cu2+/Zn2+ superoxide dismutase (SOD) that is one of five C. elegans SOD enzymes; genetic analyses indicates that sod-4 is required for redox regulation of a number of processes including axon pathfinding in the PVQ interneurons, insulin/IGF-1 signaling, and vulval development; large-scale expression studies indicate that sod-4 is expressed in the nervous system, intestine, and rectal gland cells; sod-4 transcripts are significantly upregulated in dauers.
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