Lifespan changes: From wild type to sod-5 / From sod-5 to multiple mutants
20
16.4
-7.34%
Single mutant sod-5(tm1246) has a lifespan of 16.4 days, while wild type has a lifespan of 17.7 days.
Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 19197346 Click here to select all mutants from this PubMed ID in the graph
Superoxide dismutase [Cu-Zn]
Locus: CELE_ZK430.3
Wormbase description: sod-5 encodes one of five superoxide (SOD) isozymes in C. elegans; along with SOD-1, SOD-5 is predicted to be one of two cytoplasmic Cu/Zn SODs in C. elegans; sod-5 expression is increased in sod-1 mutant animals and likewise, sod-1 expression is increased in sod-5 mutants, suggesting a possible mechanism of functional compensation between these two genes; the sod-5 promoter contains one copy of a DAF-16 binding element, consistent with observations that sod-5 mRNA levels increase in insulin/IGF-1 signaling pathway mutants.
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group