Lifespan changes: From wild type to sod-2;sod-4 / From sod-2;sod-4 to multiple mutants

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Genetic mutants with sod-2, sod-4 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    Among the sod-2 double deletion mutants, all of the worms maintained the extended lifespan seen in sod-2 single deletion mutants indicating that in no case is the upregulation of another sod gene entirely responsible for the long life observed in sod-2 mutant worms 

  • Lifespan comparisons

    Double mutant sod-2(ok1030);sod-4(gk101) has a lifespan of 26.8 days, while single mutant sod-2(ok1030) has a lifespan of 27.2 days, single mutant sod-4(gk101) has a lifespan of 19.1 days and wild type has a lifespan of 17.7 days.

  • Type of interaction
    See methods


  • Citation
    View abstract

    Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 PubMed 19197346 Click here to select all mutants from this PubMed ID in the graph

Search genes: sod-2 sod-4
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Mn] 1, mitochondrial

Locus: CELE_F10D11.1

Wormbase description: sod-2 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-2 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-2 in E. coli protects against methyl viologen-induced oxidative stress.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]

Locus: CELE_F55H2.1

Wormbase description: sod-4 encodes an extracellular Cu2+/Zn2+ superoxide dismutase (SOD) that is one of five C. elegans SOD enzymes; genetic analyses indicates that sod-4 is required for redox regulation of a number of processes including axon pathfinding in the PVQ interneurons, insulin/IGF-1 signaling, and vulval development; large-scale expression studies indicate that sod-4 is expressed in the nervous system, intestine, and rectal gland cells; sod-4 transcripts are significantly upregulated in dauers.

Orthologs of sod-2;sod-4 in SynergyAge
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Species Gene
Orthologs of sod-2 in SynergyAge
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Species Gene
Drosophila melanogaster Sod2
Orthologs of sod-4 in SynergyAge
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Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: