Lifespan changes: From wild type to sod-3;sod-5 / From sod-3;sod-5 to multiple mutants

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Genetic mutants with sod-3, sod-5 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

     sod-3;sod-5 mutant worms had a similar lifespan to wild-type worms

  • Lifespan comparisons

    Double mutant sod-3(tm760);sod-5(tm1246) has a lifespan of 20 days, while single mutant sod-3(tm760) has a lifespan of 17.1 days, single mutant sod-5(tm1246) has a lifespan of 16.4 days and wild type has a lifespan of 17.7 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 PubMed 19197346 Click here to select all mutants from this PubMed ID in the graph

Search genes: sod-3 sod-5
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Mn] 2, mitochondrial

Locus: CELE_C08A9.1

Wormbase description: sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16 and chromatin immunoprecipitation (ChIP) studies demonstrate that DAF-16 can directly bind the sod-3 promoter; heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Cu-Zn]

Locus: CELE_ZK430.3

Wormbase description: sod-5 encodes one of five superoxide (SOD) isozymes in C. elegans; along with SOD-1, SOD-5 is predicted to be one of two cytoplasmic Cu/Zn SODs in C. elegans; sod-5 expression is increased in sod-1 mutant animals and likewise, sod-1 expression is increased in sod-5 mutants, suggesting a possible mechanism of functional compensation between these two genes; the sod-5 promoter contains one copy of a DAF-16 binding element, consistent with observations that sod-5 mRNA levels increase in insulin/IGF-1 signaling pathway mutants.

Orthologs of sod-3;sod-5 in SynergyAge
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Species Gene
Orthologs of sod-3 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster Sod2
Orthologs of sod-5 in SynergyAge
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Species Gene
Drosophila melanogaster Sod1
Mus musculus Sod1

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: