Lifespan changes: From wild type to sod-1;sod-2;sod-4
20
23.3
31.64%
Both sod-2;sod-3;sod-5 and sod-1;sod-2;sod-4 mutant worms live significantly longer than wild-type
Triple mutant sod-1(tm783);sod-2(ok1030);sod-4(gk101) has a lifespan of 23.3 days, while double mutant sod-2(ok1030);sod-4(gk101) has a lifespan of 26.8 days, single mutant sod-1(tm783) has a lifespan of 17.3 days and wild type has a lifespan of 17.7 days.
Contains dependence
Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 19197346 Click here to select all mutants from this PubMed ID in the graph
Superoxide dismutase [Cu-Zn]
Locus: CELE_C15F1.7
Wormbase description: sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).
Superoxide dismutase [Mn] 1, mitochondrial
Locus: CELE_F10D11.1
Wormbase description: sod-2 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-2 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-2 in E. coli protects against methyl viologen-induced oxidative stress.
Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]
Locus: CELE_F55H2.1
Wormbase description: sod-4 encodes an extracellular Cu2+/Zn2+ superoxide dismutase (SOD) that is one of five C. elegans SOD enzymes; genetic analyses indicates that sod-4 is required for redox regulation of a number of processes including axon pathfinding in the PVQ interneurons, insulin/IGF-1 signaling, and vulval development; large-scale expression studies indicate that sod-4 is expressed in the nervous system, intestine, and rectal gland cells; sod-4 transcripts are significantly upregulated in dauers.
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Drosophila melanogaster | Sod2 |
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group