lin-14;lin-4

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Genetic mutants with lin-14, lin-4 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
16.6
Lifespan change (compared to wild type)
13.70%
Lifespan comparisons
Double mutant lin-14(RNAi);lin-4(e912) has a lifespan of 16.6 days, while single mutant lin-4(e912) has a lifespan of 6.9 days, single mutant lin-14(RNAi) has a lifespan of 18.7 days and wild type has a lifespan of 14.6 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Boehm M, Slack F, 2005, A developmental timing microRNA and its target regulate life span in C. elegans. Science. 310(5756):1954-7 16373574 Click here to select all mutants from this PubMed ID in the graph
Abstract
The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Lifespan extension conferred by a reduction in lin-14 was dependent on the DAF-16 and HSF-1 transcription factors, suggesting that the lin-4-lin-14 pair affects life span through the insulin/insulin-like growth factor-1 pathway. This work reveals a role for microRNAs and developmental timing genes in life-span regulation.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
25
Lifespan (days)
9.0
Lifespan change (compared to wild type)
-5.26%
Lifespan comparisons
Double mutant lin-14(n179);lin-4(e912) has a lifespan of 9 days, while single mutant lin-14(n179) has a lifespan of 12.5 days and wild type has a lifespan of 9.5 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Boehm M, Slack F, 2005, A developmental timing microRNA and its target regulate life span in C. elegans. Science. 310(5756):1954-7 16373574 Click here to select all mutants from this PubMed ID in the graph
Abstract
The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Lifespan extension conferred by a reduction in lin-14 was dependent on the DAF-16 and HSF-1 transcription factors, suggesting that the lin-4-lin-14 pair affects life span through the insulin/insulin-like growth factor-1 pathway. This work reveals a role for microRNAs and developmental timing genes in life-span regulation.

Search genes: lin-14 lin-4

Entrez ID
Symbol
GenAge
Wormbase ID

181337
lin-14
View on GenAge (lin-14)
WBGene00003003

Protein lin-14

Locus: CELE_T25C12.1

Wormbase description: lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR.

Symbol
GenAge

lin-4
View on GenAge (lin-4)

No gene information for lin-4

Orthologs of lin-14;lin-4 in SynergyAge

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Orthologs of lin-14 in SynergyAge

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Orthologs of lin-4 in SynergyAge

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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.