Lifespan changes: From wild type to cyc-1;nhr-80
20
HT115
32.0
64.10%
cyc-1 RNAi, which reduces mitochondrial function, extend longevity to a comparable extent in nhr-80(tm1011) mutants and in wild type animals, suggesting that these pathways are not affected by NHR-80.
Double mutant cyc-1(RNAi);nhr-80(tm1011) has a lifespan of 32.0 days, while single mutant nhr-80(tm1011) has a lifespan of 15.5 days, single mutant cyc-1(RNAi) has a lifespan of 30.0 days and wild type has a lifespan of 19.5 days.
Enhancer, opposite lifespan effects
Goudeau J et al., 2011, Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. PLoS Biol. 9(3):e1000599 
21423649
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20
HT115
19.5
18.18%
cyc-1 RNAi, which reduces mitochondrial function, extend longevity to a comparable extent in nhr-80(tm1011) mutants and in wild type animals, suggesting that these pathways are not affected by NHR-80.
Double mutant cyc-1(RNAi);nhr-80(tm1011) has a lifespan of 19.5 days, while single mutant nhr-80(tm1011) has a lifespan of 15.0 days, single mutant cyc-1(RNAi) has a lifespan of 20.0 days and wild type has a lifespan of 16.5 days.
Opposite lifespan effects of single mutants
Goudeau J et al., 2011, Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. PLoS Biol. 9(3):e1000599 21423649
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CYtochrome C
Locus: CELE_C54G4.8
Wormbase description: cyc-1 encodes a component of complex III ( cytochrome c reductase) required for normal ATP production; reduction of ATP production by cyc-1(RNAi) decreases growth rate and body size, slows behavior, and increases lifespan; cyc-1 encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial
Nuclear Hormone Receptor family
Locus: CELE_H10E21.3
Wormbase description: nhr-80 encodes a nuclear hormone receptor, expressed in the intestine, that regulates expression of the delta-9 desaturases FAT-5/-6/-7, and thus regulates fatty acid metabolism; NHR-80 is fully required for any expression of FAT-7, full expression of FAT-5/-6, viability in the absence of FAT-6, and transcriptional hyperactivation of fat-7 in the absence of FAT-6, and for a fully normal adult lifespan; nhr-80 is expressed robustly in the intestine during larval and adult stages of development, with some expression also seen in head muscles; nhr-80 is specific to nematodes, being a divergent ortholog of HNF4 with many paralogs in C. elegans; nhr-80(tm1011) mutants, like nhr-49 mutants, have an increased ration of saturated 18:0 fatty acids to monounsaturated 18:1 ones (4.6 instead of 2.2); nhr-80(tm1011) mutants are viable and fertile and have no increase in fat storage, but double fat-6(tm331);nhr-80(tm1011) mutants, (or fat-6(tm331) mutants subjected to nhr-80(RNAi), are synthetically lethal unless cultured on media supplemented with desaturated fatty acids.
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
