glp-1;tcer-1;tcer-1

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Genetic mutants with glp-1, tcer-1, tcer-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
32.4
Lifespan change (compared to wild type)
74.19%
Phenotype
Two independent lines expressing the TCER-1::GFP fusion protein completely rescued the lifespan of tcer-1; glp-1 mutants
Lifespan comparisons
Triple mutant glp-1(e2141ts);tcer-1(OE);tcer-1(tm1452) has a lifespan of 32.4 days, while double mutant glp-1(e2141ts);tcer-1(tm1452) has a lifespan of 23.4 days.
Type of interaction
See methods
Partially known monotony. Positive epistasis
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
30.9
Lifespan change (compared to wild type)
66.13%
Phenotype
Two independent lines expressing the TCER-1::GFP fusion protein completely rescued the lifespan of tcer-1; glp-1 mutants
Lifespan comparisons
Triple mutant glp-1(e2141ts);tcer-1(OE);tcer-1(tm1452) has a lifespan of 30.9 days, while double mutant glp-1(e2141ts);tcer-1(tm1452) has a lifespan of 23.4 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
27.9
Lifespan change (compared to wild type)
50.81%
Lifespan comparisons
Triple mutant glp-1(e2141ts);tcer-1(OE);tcer-1(tm1452) has a lifespan of 27.9 days, while double mutant glp-1(e2141ts);tcer-1(tm1452) has a lifespan of 21.8 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
25.8
Lifespan change (compared to wild type)
39.46%
Lifespan comparisons
Triple mutant glp-1(e2141ts);tcer-1(OE);tcer-1(tm1452) has a lifespan of 25.8 days, while double mutant glp-1(e2141ts);tcer-1(tm1452) has a lifespan of 21.8 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
28.8
Lifespan change (compared to wild type)
55.68%
Lifespan comparisons
Triple mutant glp-1(e2141ts);tcer-1(OE);tcer-1(tm1452) has a lifespan of 28.8 days, while double mutant glp-1(e2141ts);tcer-1(tm1452) has a lifespan of 21.8 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Search genes: glp-1 tcer-1 tcer-1 glp-1;tcer-1;tcer-1

Entrez ID
Symbol
GenAge
Wormbase ID

176286
glp-1
View on GenAge (glp-1)
WBGene00001609

Protein glp-1

Locus: CELE_F02A9.6

Wormbase description: glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains

Entrez ID
Symbol
GenAge
Wormbase ID

174150
tcer-1
View on GenAge (tcer-1)
WBGene00022855

TransCription Elongation Regulator homolog

Locus: CELE_ZK1127.9

Wormbase description: none available

Entrez ID
Symbol
GenAge
Wormbase ID

174150
tcer-1
View on GenAge (tcer-1)
WBGene00022855

TransCription Elongation Regulator homolog

Locus: CELE_ZK1127.9

Wormbase description: none available

Orthologs of glp-1;tcer-1;tcer-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of glp-1 in SynergyAge

Show in SynergyAge
Species	Gene

Orthologs of tcer-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Tcerg1