daf-18;daf-23

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Genetic mutants with daf-18, daf-23 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
28.7
Phenotype
Extension of life span by daf- 23( m333) is not suppressed by daf-18.
Lifespan comparisons
Double mutant daf-18(e1375);daf-23(m333) has a lifespan of 28.7 days, while single mutant daf-23(m333) has a lifespan of 32.7 days.
Citation
View abstract
Larsen PL et al., 1995, Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics. 139(4):1567-83 7789761 Click here to select all mutants from this PubMed ID in the graph
Abstract
The nematode Caenorhabditis elegans responds to conditions of overcrowding and limited food by arresting development as a dauer larva. Genetic analysis of mutations that alter dauer larva formation (daf mutations) is presented along with an updated genetic pathway for dauer vs. nondauer development. Mutations in the daf-2 and daf-23 genes double adult life span, whereas mutations in four other dauer-constitutive genes positioned in a separate branch of this pathway (daf-1, daf-4, daf-7 and daf-8) do not. The increased life spans are suppressed completely by a daf-16 mutation and partially in a daf-2; daf-18 double mutant. A genetic pathway for determination of adult life span is presented based on the same strains and growth conditions used to characterize Daf phenotypes. Both dauer larva formation and adult life span are affected in daf-2; daf-12 double mutants in an allele-specific manner. Mutations in daf-12 do not extend adult life span, but certain combinations of daf-2 and daf-12 mutant alleles nearly quadruple it. This synergistic effect, which does not equivalently extend the fertile period, is the largest genetic extension of life span yet observed in a metazoan.

Search genes: daf-18 daf-23

Entrez ID
Symbol
GenAge
Wormbase ID

176869
daf-18
View on GenAge (daf-18)
WBGene00000913

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18

Locus: CELE_T07A9.6

Wormbase description: daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16.

Symbol
GenAge

daf-23
View on GenAge (daf-23)

No gene information for daf-23

Orthologs of daf-18;daf-23 in SynergyAge

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Orthologs of daf-18 in SynergyAge

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Orthologs of daf-23 in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.