kri-1;tcer-1

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Genetic mutants with kri-1, tcer-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
16.0
Lifespan change (compared to wild type)
-3.03%
Phenotype
kri-1(ok1251) abolished the lifespan extension evoked by tcer-1overexpression
Lifespan comparisons
Double mutant kri-1(ok1251);tcer-1(OE) has a lifespan of 16.0 days, while single mutant tcer-1(OE) has a lifespan of 20.5 days and wild type has a lifespan of 16.5 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
17.1
Lifespan change (compared to wild type)
3.64%
Phenotype
kri-1(ok1251) abolished the lifespan extension evoked by tcer-1overexpression
Lifespan comparisons
Double mutant kri-1(ok1251);tcer-1(OE) has a lifespan of 17.1 days, while single mutant tcer-1(OE) has a lifespan of 20.5 days and wild type has a lifespan of 16.5 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
16.8
Lifespan change (compared to wild type)
-20.38%
Phenotype
kri-1(ok1251) abolished the lifespan extension evoked by tcer-1overexpression
Lifespan comparisons
Double mutant kri-1(ok1251);tcer-1(OE) has a lifespan of 16.8 days, while single mutant tcer-1(OE) has a lifespan of 22.4 days and wild type has a lifespan of 21.1 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
15.9
Lifespan change (compared to wild type)
-24.64%
Phenotype
kri-1(ok1251) abolished the lifespan extension evoked by tcer-1overexpression
Lifespan comparisons
Double mutant kri-1(ok1251);tcer-1(OE) has a lifespan of 15.9 days, while single mutant tcer-1(OE) has a lifespan of 22.4 days and wild type has a lifespan of 21.1 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Search genes: kri-1 tcer-1

Entrez ID
Symbol
GenAge
Wormbase ID

191275
kri-1
View on GenAge (kri-1)
WBGene00013955

human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog

Locus: CELE_ZK265.1

Wormbase description: kri-1 encodes an ankyrin repeat and FERM domain-containing protein orthologous to human KRIT1 (Krev interaction trapped/cerebral cavernous malformation 1, OMIM:604214); kri-1 was identified in RNAi screens for genes required for DAF-16-dependent lifespan extension in germline-depleted animals; subsequent analysis of kri-1 mutations suggests that KRI-1 is required for proper localization of DAF-16 in the intestine in response to germline loss; a rescuing KRI-1::GFP construct is expressed in larval and adult stages in pharyngeal and intestinal cells; the KRI-1::GFP is generally diffuse, but also localizes to apical and apicolateral cell surfaces as well as to intestinal nuclei in some animals.

Entrez ID
Symbol
GenAge
Wormbase ID

174150
tcer-1
View on GenAge (tcer-1)
WBGene00022855

TransCription Elongation Regulator homolog

Locus: CELE_ZK1127.9

Wormbase description: none available

Orthologs of kri-1;tcer-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Krit1;Tcerg1
Mus musculus	Tcerg1;Krit1

Orthologs of kri-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Krit1

Orthologs of tcer-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Tcerg1