cyc-1;smk-1

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Genetic mutants with cyc-1, smk-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
25.6
Lifespan change (compared to wild type)
46.29%
Phenotype
We found that smk-1 RNAi only slightly suppressed the extended life span of animals with compromised complex III activity, i.e., the cyc-1 RNAi-treated animals and isp-1(qm150) mutant animals
Lifespan comparisons
Double mutant cyc-1(RNAi);smk-1(RNAi) has a lifespan of 25.6 days, while single mutant cyc-1(RNAi) has a lifespan of 32.9 days and wild type has a lifespan of 17.5 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Wolff S et al., 2006, SMK-1, an essential regulator of DAF-16-mediated longevity. Cell. 124(5):1039-53 16530049 Click here to select all mutants from this PubMed ID in the graph
Abstract
Insulin/IGF-1 signaling (IIS) regulates aging in worms, flies, and mice through a well-characterized, highly conserved core set of components. IIS also regulates early developmental decisions, the reproductive status of the animal, innate immunity, and stress-resistance functions. In C. elegans, the sole insulin/IGF-1 receptor, DAF-2, negatively regulates the FOXO transcription factor, DAF-16. We report here on a new component of the IIS longevity pathway, SMK-1, which specifically influences DAF-16-dependent regulation of the aging process in C. elegans by regulating the transcriptional specificity of DAF-16 activity. Localization analysis of DAF-16 places SMK-1 downstream of DAF-16's phosphorylation-dependent relocation to the nucleus. Physiological and transcription analyses indicate that smk-1 is required for the innate immune, UV, and oxidative stress but not the thermal stress functions of DAF-16. SMK-1 therefore plays a role in longevity by modulating DAF-16 transcriptional specificity without affecting other processes regulated by IIS.

Search genes: cyc-1 smk-1

Entrez ID
Symbol
GenAge
Wormbase ID

172582
cyc-1
View on GenAge (cyc-1)
WBGene00000869

CYtochrome C

Locus: CELE_C54G4.8

Wormbase description: cyc-1 encodes a component of complex III ( cytochrome c reductase) required for normal ATP production; reduction of ATP production by cyc-1(RNAi) decreases growth rate and body size, slows behavior, and increases lifespan; cyc-1 encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial

Entrez ID
Symbol
GenAge
Wormbase ID

179243
smk-1
View on GenAge (smk-1)
WBGene00018285

SMEK (Dictyostelium Suppressor of MEK null) homolog

Locus: CELE_F41E6.4

Wormbase description: smk-1 encodes a novel, evolutionarily conserved protein that is orthologous to the mammalian and Dictyostelium discoideum SMEK (suppressor of MEK null) proteins; smk-1 activity is essential for several aspects of DAF-16-mediated longevity namely, the defense response to pathogenic bacteria and increased resistance to oxidative and UV-induced damage; in regulating DAF-16 activity, SMK-1 appears to act by affecting the transcription of DAF-16 target genes, such as sod-3, ctl-1, and lys-8; SMK-1 is present in the nucleus of intestinal cells, many head and tail neurons, and some hypodermal cells throughout development.

Orthologs of cyc-1;smk-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c1L;flfl
Drosophila melanogaster	Cyt-c1;flfl
Mus musculus	4932429P05Rik;Cyc1
Mus musculus	4930415L06Rik;Cyc1
Mus musculus	Cyc1;Ppp4r3a
Mus musculus	Cyc1;Ppp4r3b
Mus musculus	Cyc1;4932429P05Rik
Mus musculus	Cyc1;4930415L06Rik
Mus musculus	Cyc1;Ppp4r3a
Mus musculus	Cyc1;Ppp4r3b

Orthologs of cyc-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c1L
Drosophila melanogaster	Cyt-c1
Mus musculus	Cyc1

Orthologs of smk-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	flfl
Mus musculus	4932429P05Rik
Mus musculus	4930415L06Rik
Mus musculus	Ppp4r3a
Mus musculus	Ppp4r3b

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.