Lifespan changes: From wild type to Atm;Rad54

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Genetic mutants with Atm, Rad54 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Phenotype

    The Rad54(-/-) Atm (-/-) double mutant is shorter lived than both single mutants.

  • Lifespan comparisons

    Double mutant Atm(KO);Rad54(KO) has a lifespan of 140.0 days, while single mutant Atm(KO) has a lifespan of 210.0 days and single mutant Rad54(KO) has a lifespan of 630.0 days.

  • Citation
    View abstract

    Kirshner M et al., 2009, Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair. DNA Repair (Amst). 8(2):253-61 PubMed 19061978 Click here to select all mutants from this PubMed ID in the graph

Search genes: Atm Rad54
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

ataxia telangiectasia mutated

  • Symbol
  • GenAge

No gene information for Rad54

Orthologs of Atm;Rad54 in SynergyAge
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Species Gene
Orthologs of Atm in SynergyAge
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Species Gene
Orthologs of Rad54 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: