Lifespan changes: From wild type to Atm;Rad54B
168.0
The Rad54B(-/-) Atm (-/-) double mutant is shorter lived than both single mutants.
Double mutant Atm(KO);Rad54B(KO) has a lifespan of 168.0 days, while single mutant Atm(KO) has a lifespan of 252.0 days.
Kirshner M et al., 2009, Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair. DNA Repair (Amst). 8(2):253-61 19061978 Click here to select all mutants from this PubMed ID in the graph
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group