Lifespan changes: From wild type to Mclk1;Trp53

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Genetic mutants with Mclk1, Trp53 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Phenotype

    The average and maximum lifespan of the double mutants was increased in comparison to Trp53 +/- animals, suggestive of a slower initiation or growth of tumors.

  • Lifespan comparisons

    Double mutant Mclk1(KO);Trp53(tm1Brd) has a lifespan of 430.0 days, while single mutant Trp53(tm1Brd) has a lifespan of 400.0 days.

  • Citation
    View abstract

    Wang D et al., 2012;7(11):e49606., An enhanced immune response of Mclk1⁺/⁻ mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging. PLoS One. 7(11):e49606 PubMed 23166727 Click here to select all mutants from this PubMed ID in the graph

Search genes: Mclk1 Trp53
  • Symbol
  • GenAge

No gene information for Mclk1

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

transformation related protein 53

Orthologs of Mclk1;Trp53 in SynergyAge
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Species Gene
Orthologs of Mclk1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trp53 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: