Kv1.3;Mc4r

ad libitum

669.167

-21.43%

Kv1.3 gene-targeted deletion improves longevity and fecundity. The decreased fecundity typically reported for MC4R-null mice was partially rectified in Kv/MC4R-null animals in comparison to the greater than 80% pregnancy rates of either WT or Kv-null mice. The mean lifespan of the Kv-null mice significantly increased by 22% over that of WT mice whereby lifespan of the MC4R-null mice, oppositely, was significantly reduced by 36% in comparison to that of WT mice. Gene-targeted deletion of Kv1.3 in MC4R-null mice returned the lifespan of these mice to approximately WT levels.

Double mutant Kv1.3(KO);MC4R(KO) has a lifespan of 669.167 days, while single mutant MC4R(KO) has a lifespan of 547.501 days, single mutant Kv1.3(KO) has a lifespan of 973.3 days and wild type has a lifespan of 851.668 days.

Opposite lifespan effects of single mutants

Tucker K et al., 2008, Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice. Int J Obes (Lond). 32(8):1222-32 18542083 Click here to select all mutants from this PubMed ID in the graph