Lifespan changes: From wild type to Rbm38;Trp53
490.0
-42.15%
Loss of Rbm38 significantly reduces the tumor penetrance in p53-heterozygous mice (p53+/- and Rbm38-/-; p53+/-)
Double mutant Rbm38(KO);p53(KO) has a lifespan of 490.0 days, while single mutant p53(KO) has a lifespan of 448.0 days, single mutant Rbm38(KO) has a lifespan of 749.0 days and wild type has a lifespan of 847.0 days.
Dependent
Zhang J et al., 2014, Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A. 111(52):18637-42 25512531 Click here to select all mutants from this PubMed ID in the graph
133.0
-84.30%
Loss of Rbm38 Shortens the Life Span of, and Facilitates Lymphomagenesis in, p53-Null Mice (homozygousRBM38-/-; p53-/- mice).
Double mutant Rbm38(KO);p53(KO) has a lifespan of 133.0 days, while single mutant p53(KO) has a lifespan of 175.0 days, single mutant Rbm38(KO) has a lifespan of 749.0 days and wild type has a lifespan of 847.0 days.
Almost additive (negative)
Zhang J et al., 2014, Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A. 111(52):18637-42 25512531 Click here to select all mutants from this PubMed ID in the graph
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Species | Gene |
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Species | Gene |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group