Rbm38;Trp53

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Genetic mutants with Rbm38, Trp53 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Lifespan (days)
490.0
Lifespan change (compared to wild type)
-42.15%
Phenotype
Loss of Rbm38 significantly reduces the tumor penetrance in p53-heterozygous mice (p53+/- and Rbm38-/-; p53+/-)
Lifespan comparisons
Double mutant Rbm38(KO);p53(KO) has a lifespan of 490.0 days, while single mutant p53(KO) has a lifespan of 448.0 days, single mutant Rbm38(KO) has a lifespan of 749.0 days and wild type has a lifespan of 847.0 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Zhang J et al., 2014, Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A. 111(52):18637-42 25512531 Click here to select all mutants from this PubMed ID in the graph
Abstract
RNA-binding motif protein 38 (Rbm38), also called RNPC1 [RNA-binding region (RNP1, RRM) containing 1], is a target of the p53 family and modulates p53 expression via mRNA translation. To investigate the biological function of Rbm38 in vivo, we generated an Rbm38-null mouse model. We showed that mice deficient in Rbm38 exhibit signs of accelerated aging and are prone to hematopoietic defects and spontaneous tumors. To determine the biological significance of the p53-Rbm38 loop, we showed that Rbm38 deficiency enhances accumulation of p53 induced by ionizing radiation (IR) and sensitizes mice to IR-induced lethality in a p53-dependent manner. Most importantly, Rbm38 deficiency markedly decreases the tumor penetrance in mice heterozygous for p53 via enhanced p53 expression. Interestingly, we found that Rbm38 deficiency shortens the life span of, and promotes lymphomagenesis in, mice deficient in p53. These results provide genetic evidence that Rbm38 is necessary for normal hematopoiesis and for suppressing accelerated aging and tumorigenesis. Thus, the p53-Rbm38 axis might be explored for extending longevity and for tumor suppression.

Lifespan (days)
133.0
Lifespan change (compared to wild type)
-84.30%
Phenotype
Loss of Rbm38 Shortens the Life Span of, and Facilitates Lymphomagenesis in, p53-Null Mice (homozygousRBM38-/-; p53-/- mice).
Lifespan comparisons
Double mutant Rbm38(KO);p53(KO) has a lifespan of 133.0 days, while single mutant p53(KO) has a lifespan of 175.0 days, single mutant Rbm38(KO) has a lifespan of 749.0 days and wild type has a lifespan of 847.0 days.
Type of interaction
See methods
Almost additive (negative)
Citation
View abstract
Zhang J et al., 2014, Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A. 111(52):18637-42 25512531 Click here to select all mutants from this PubMed ID in the graph
Abstract
RNA-binding motif protein 38 (Rbm38), also called RNPC1 [RNA-binding region (RNP1, RRM) containing 1], is a target of the p53 family and modulates p53 expression via mRNA translation. To investigate the biological function of Rbm38 in vivo, we generated an Rbm38-null mouse model. We showed that mice deficient in Rbm38 exhibit signs of accelerated aging and are prone to hematopoietic defects and spontaneous tumors. To determine the biological significance of the p53-Rbm38 loop, we showed that Rbm38 deficiency enhances accumulation of p53 induced by ionizing radiation (IR) and sensitizes mice to IR-induced lethality in a p53-dependent manner. Most importantly, Rbm38 deficiency markedly decreases the tumor penetrance in mice heterozygous for p53 via enhanced p53 expression. Interestingly, we found that Rbm38 deficiency shortens the life span of, and promotes lymphomagenesis in, mice deficient in p53. These results provide genetic evidence that Rbm38 is necessary for normal hematopoiesis and for suppressing accelerated aging and tumorigenesis. Thus, the p53-Rbm38 axis might be explored for extending longevity and for tumor suppression.

Search genes: Rbm38 Trp53

Entrez ID
Symbol
GenAge
MGI ID

56190
Rbm38
View on GenAge (Rbm38)
MGI:1889294

RNA binding motif protein 38

Entrez ID
Symbol
GenAge
MGI ID

22059
Trp53
View on GenAge (Trp53)
MGI:98834

transformation related protein 53

Orthologs of Rbm38;Trp53 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of Rbm38 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Caenorhabditis elegans	sup-12

Orthologs of Trp53 in SynergyAge

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Species	Gene