Rbm38;Trp53

Lifespan changes: From wild type to Rbm38;Trp53

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with Rbm38, Trp53 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)

    490.0

  • Lifespan change (compared to wild type)

    -42.15%

  • Phenotype

    Loss of Rbm38 significantly reduces the tumor penetrance in p53-heterozygous mice (p53+/- and Rbm38-/-; p53+/-)

  • Lifespan comparisons

    Double mutant Rbm38(KO);p53(KO) has a lifespan of 490.0 days, while single mutant p53(KO) has a lifespan of 448.0 days, single mutant Rbm38(KO) has a lifespan of 749.0 days and wild type has a lifespan of 847.0 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Zhang J et al., 2014, Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A. 111(52):18637-42 PubMed 25512531 Click here to select all mutants from this PubMed ID in the graph

  • Lifespan (days)

    133.0

  • Lifespan change (compared to wild type)

    -84.30%

  • Phenotype

    Loss of Rbm38 Shortens the Life Span of, and Facilitates Lymphomagenesis in, p53-Null Mice (homozygousRBM38-/-; p53-/- mice).

  • Lifespan comparisons

    Double mutant Rbm38(KO);p53(KO) has a lifespan of 133.0 days, while single mutant p53(KO) has a lifespan of 175.0 days, single mutant Rbm38(KO) has a lifespan of 749.0 days and wild type has a lifespan of 847.0 days.

  • Type of interaction
    See methods

    Almost additive (negative)

  • Citation
    View abstract

    Zhang J et al., 2014, Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A. 111(52):18637-42 PubMed 25512531 Click here to select all mutants from this PubMed ID in the graph

Search genes: Rbm38 Trp53
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

RNA binding motif protein 38


  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

transformation related protein 53


Orthologs of Rbm38;Trp53 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Rbm38 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trp53 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group