Lifespan changes: From wild type to Apc;Trp53 / From Apc;Trp53 to multiple mutants

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Genetic mutants with Apc, Trp53 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Lifespan comparisons

    Double mutant Apc(KO);tp53(KO) has a lifespan of 144.0 days, while single mutant Apc(KO) has a lifespan of 255.0 days.

  • Citation
    View abstract

    Stoddart A et al., 2014, Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc. Blood. 123(2):228-38 PubMed 24264229 Click here to select all mutants from this PubMed ID in the graph

Search genes: Apc Trp53
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

adenomatosis polyposis coli

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

transformation related protein 53

Orthologs of Apc;Trp53 in SynergyAge
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Species Gene
Orthologs of Apc in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trp53 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group