Lifespan changes: From wild type to Apc;Egr1 / From Apc;Egr1 to multiple mutants
179.0
Double mutant Apc(KO);Egr1(KO) has a lifespan of 179.0 days, while single mutant Apc(KO) has a lifespan of 255.0 days.
Stoddart A et al., 2014, Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc. Blood. 123(2):228-38 24264229 Click here to select all mutants from this PubMed ID in the graph
178.0
Stoddart A et al., 2014, Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc. Blood. 123(2):228-38 24264229 Click here to select all mutants from this PubMed ID in the graph
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group