Lifespan changes: From wild type to Bub3;Rae1

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Genetic mutants with Bub3, Rae1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    The median overall survival of Bub3+/- and Rae1+/- mice was slightly reduced in comparison with wild-type animals (24 vs. 25 mo, respectively), but these differences were not significant. In contrast, the median survival of Bub3+/-/Rae1+/- mice was significantly reduced to 22 mo, which translates into a 12% decrease in lifespan. The reduced lifespan of Bub3+/-/Rae1+/- mice may be the result of the sum of the lifespan reductions in Bub3+/- and Rae1+/- mice.

  • Lifespan comparisons

    Double mutant Bub3(KO);Rae1(KO) has a lifespan of 660.0 days, while single mutant Rae1(KO) has a lifespan of 720.0 days, single mutant Bub3(KO) has a lifespan of 720.0 days and wild type has a lifespan of 750.0 days.

  • Type of interaction
    See methods

    Synergistic (negative)

  • Citation
    View abstract

    Baker DJ et al., 2006, Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol. 172(4):529-40 PubMed 16476774 Click here to select all mutants from this PubMed ID in the graph

Search genes: Bub3 Rae1
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

BUB3 mitotic checkpoint protein

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

ribonucleic acid export 1

Orthologs of Bub3;Rae1 in SynergyAge
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Species Gene
Orthologs of Bub3 in SynergyAge
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Species Gene
Orthologs of Rae1 in SynergyAge
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Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group