Lifespan changes: From wild type to Terc;Trp53

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Genetic mutants with Terc, Trp53 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Lifespan comparisons

    Double mutant Terc(KO);Trp53(KO) has a lifespan of 148.0 days, while single mutant Terc(KO) has a lifespan of 423.0 days.

  • Citation
    View abstract

    Choudhury AR et al., 2007, Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet. 39(1):99-105 PubMed 17143283 Click here to select all mutants from this PubMed ID in the graph

Search genes: Terc Trp53
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

telomerase RNA component

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

transformation related protein 53

Orthologs of Terc;Trp53 in SynergyAge
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Species Gene
Orthologs of Terc in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trp53 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group