Lifespan changes: From wild type to Hgf;Sod1

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Genetic mutants with Hgf, Sod1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Lifespan comparisons

    Double mutant Hgf(OE);Sod1(G93A) has a lifespan of 295.0 days, while single mutant Sod1(G93A) has a lifespan of 250.0 days.

  • Citation
    View abstract

    Sun W et al., 2002, Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS. J Neurosci. 22(15):6537-48 PubMed 12151533 Click here to select all mutants from this PubMed ID in the graph

Search genes: Hgf Sod1
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

hepatocyte growth factor

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

superoxide dismutase 1, soluble

Orthologs of Hgf;Sod1 in SynergyAge
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Species Gene
Orthologs of Hgf in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Sod1 in SynergyAge
Show in SynergyAge
Species Gene
Caenorhabditis elegans sod-1
Caenorhabditis elegans sod-5
Drosophila melanogaster Sod1

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group