Lifespan changes: From wild type to Cyp27b1;Fgf23

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Genetic mutants with Cyp27b1, Fgf23 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Diet

    standard diet

  • Lifespan (days)


  • Lifespan comparisons

    Double mutant Cyp27b1(KO);Fgf-23(KO) has a lifespan of 650.0 days, while single mutant Fgf-23(KO) has a lifespan of 42.0 days and wild type has a lifespan of 650.0 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Razzaque MS et al., 2006, Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J. 20(6):720-2 PubMed 16436465 Click here to select all mutants from this PubMed ID in the graph

Search genes: Cyp27b1 Fgf23
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

cytochrome P450, family 27, subfamily b, polypeptide 1

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

fibroblast growth factor 23

Orthologs of Cyp27b1;Fgf23 in SynergyAge
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Species Gene
Orthologs of Cyp27b1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Fgf23 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: