Cyp27b1;Fgf23

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Genetic mutants with Cyp27b1, Fgf23 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Diet
standard diet
Lifespan (days)
650.0
Lifespan comparisons
Double mutant Cyp27b1(KO);Fgf-23(KO) has a lifespan of 650.0 days, while single mutant Fgf-23(KO) has a lifespan of 42.0 days and wild type has a lifespan of 650.0 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Razzaque MS et al., 2006, Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J. 20(6):720-2 16436465 Click here to select all mutants from this PubMed ID in the graph
Abstract
Fibroblast growth factor 23 null mice (Fgf-23-/-) have a short lifespan and show numerous biochemical and morphological features consistent with premature aging-like phenotypes, including kyphosis, severe muscle wasting, hypogonadism, osteopenia, emphysema, uncoordinated movement, T cell dysregulation, and atrophy of the intestinal villi, skin, thymus, and spleen. Furthermore, increased vitamin D activities in homozygous mutants are associated with severe atherosclerosis and widespread soft tissue calcifications; ablation of vitamin D activity from Fgf-23-/- mice, by genetically deleting the 1alpha(OH)ase gene, eliminates atherosclerosis and ectopic calcifications and significantly rescues premature aging-like features of Fgf-23-/- mice, resulting in prolonged survival of Fgf-23-/-/1alpha(OH)ase-/- double mutants. Our results indicate a novel role of Fgf-23 in developing premature aging-like features through regulating vitamin D homeostasis. Finally, our data support a new model of interactions among Fgf-23, vitamin D, and klotho, a gene described as being associated with premature aging process.

Search genes: Cyp27b1 Fgf23

Entrez ID
Symbol
GenAge
MGI ID

13115
Cyp27b1
View on GenAge (Cyp27b1)
MGI:1098274

cytochrome P450, family 27, subfamily b, polypeptide 1

Entrez ID
Symbol
GenAge
MGI ID

64654
Fgf23
View on GenAge (Fgf23)
MGI:1891427

fibroblast growth factor 23

Orthologs of Cyp27b1;Fgf23 in SynergyAge

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Orthologs of Cyp27b1 in SynergyAge

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Orthologs of Fgf23 in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.