Atm;Sirt6

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Genetic mutants with Atm, Sirt6 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Lifespan (days)
139.0
Lifespan comparisons
Double mutant Atm(KO);Sirt6(OE) has a lifespan of 139.0 days, while single mutant Atm(KO) has a lifespan of 110.0 days.
Citation
View abstract
Qian M et al., 2018, Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. Elife. 7. pii: e34836 29717979 Click here to select all mutants from this PubMed ID in the graph
Abstract
DNA damage accumulates with age (Lombard et al., 2005). However, whether and how robust DNA repair machinery promotes longevity is elusive. Here, we demonstrate that ATM-centered DNA damage response (DDR) progressively declines with senescence and age, while low dose of chloroquine (CQ) activates ATM, promotes DNA damage clearance, rescues age-related metabolic shift, and prolongs replicative lifespan. Molecularly, ATM phosphorylates SIRT6 deacetylase and thus prevents MDM2-mediated ubiquitination and proteasomal degradation. Extra copies of

Lifespan (days)
137.0
Lifespan comparisons
Double mutant Atm(KO);Sirt6(OE) has a lifespan of 137.0 days, while single mutant Atm(KO) has a lifespan of 118.0 days.
Citation
View abstract
Qian M et al., 2018, Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. Elife. 7. pii: e34836 29717979 Click here to select all mutants from this PubMed ID in the graph
Abstract
DNA damage accumulates with age (Lombard et al., 2005). However, whether and how robust DNA repair machinery promotes longevity is elusive. Here, we demonstrate that ATM-centered DNA damage response (DDR) progressively declines with senescence and age, while low dose of chloroquine (CQ) activates ATM, promotes DNA damage clearance, rescues age-related metabolic shift, and prolongs replicative lifespan. Molecularly, ATM phosphorylates SIRT6 deacetylase and thus prevents MDM2-mediated ubiquitination and proteasomal degradation. Extra copies of

Search genes: Atm Sirt6

Entrez ID
Symbol
GenAge
MGI ID

11920
Atm
View on GenAge (Atm)
MGI:107202

ataxia telangiectasia mutated

Entrez ID
Symbol
GenAge
MGI ID

50721
Sirt6
View on GenAge (Sirt6)
MGI:1354161

sirtuin 6

Orthologs of Atm;Sirt6 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Sirt6;tefu

Orthologs of Atm in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	tefu

Orthologs of Sirt6 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Caenorhabditis elegans	sir-2.4
Drosophila melanogaster	Sirt6

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.