Lifespan changes: From wild type to Apc;Ku80
23
Standard lab chow (Harlan Teklad, Madison WI) and water were supplied ad libitum
294.0
-66.40%
The double mutant obtained by crossing heterozygous APC(MIN) and Ku80 homozygous -/- mutants has decreased lifespan compared to WT and single mutants
Double mutant Apc(MIN);Ku80(KO) has a lifespan of 294.0 days, while single mutant Ku80(KO) has a lifespan of 504.0 days, single mutant Apc(MIN) has a lifespan of 280.0 days and wild type has a lifespan of 875.0 days.
Dependent
Holcomb VB et al., 2008, Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res. 68(22):9497-502 19010925 Click here to select all mutants from this PubMed ID in the graph
23
Standard lab chow (Harlan Teklad, Madison WI) and water were supplied ad libitum
231.0
-73.60%
The double mutant obtained by crossing heterozygous APC(MIN) and Ku80 heterozygous +/- mutants has decreased lifespan compared to WT and single mutants
Double mutant Apc(MIN);Ku80(KO) has a lifespan of 231.0 days, while single mutant Ku80(KO) has a lifespan of 791.0 days, single mutant Apc(MIN) has a lifespan of 280.0 days and wild type has a lifespan of 875.0 days.
Almost additive (negative)
Holcomb VB et al., 2008, Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res. 68(22):9497-502 19010925 Click here to select all mutants from this PubMed ID in the graph
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Species | Gene |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group