Lifespan changes: From wild type to p18;Trp53

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Genetic mutants with p18, Trp53 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Phenotype

    Double homozygous p18/p53 mutant lives much less than the single homozygous mutant p18, with a slight recovery in lifespan compared to the p53 single homozygous mutant

  • Lifespan comparisons

    Double mutant p18(KO);p53(KO) has a lifespan of 163.0 days, while single mutant p53(KO) has a lifespan of 145.0 days and single mutant p18(KO) has a lifespan of 352.0 days.

  • Citation
    View abstract

    Damo LA et al., 2005, Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways. Mol Carcinog. 42(2):109-20 PubMed 15584024 Click here to select all mutants from this PubMed ID in the graph

Search genes: p18 Trp53
  • Symbol
  • GenAge

No gene information for p18

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

transformation related protein 53

Orthologs of p18;Trp53 in SynergyAge
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Species Gene
Orthologs of p18 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Trp53 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group