Sirt6;Trp53

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with Sirt6, Trp53 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Lifespan (days)
344.0
Lifespan change (compared to wild type)
-67.61%
Phenotype
Heterozygosity of Trp53 rescues in part the extremely reduced longevity of Sirt6-deficient (Sirt6-/-) female mice.
Lifespan comparisons
Double mutant Sirt6(KO);p53(KO) has a lifespan of 344.0 days, while single mutant Sirt6(KO) has a lifespan of 24.0 days, single mutant p53(KO) has a lifespan of 473.0 days and wild type has a lifespan of 1062.0 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Ghosh S et al., 2018, Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice. Elife. 7. pii: e32127 29474172 Click here to select all mutants from this PubMed ID in the graph
Abstract
Mammalian sirtuin 6 (Sirt6) is a conserved NAD

Lifespan (days)
237.0
Lifespan change (compared to wild type)
-76.32%
Phenotype
Heterozygosity of Trp53 rescues in part the extremely reduced longevity of Sirt6-deficient (Sirt6-/-) male mice.
Lifespan comparisons
Double mutant Sirt6(KO);p53(KO) has a lifespan of 237.0 days, while single mutant Sirt6(KO) has a lifespan of 24.0 days, single mutant p53(KO) has a lifespan of 473.0 days and wild type has a lifespan of 1001.0 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Ghosh S et al., 2018, Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice. Elife. 7. pii: e32127 29474172 Click here to select all mutants from this PubMed ID in the graph
Abstract
Mammalian sirtuin 6 (Sirt6) is a conserved NAD

Search genes: Sirt6 Trp53

Entrez ID
Symbol
GenAge
MGI ID

50721
Sirt6
View on GenAge (Sirt6)
MGI:1354161

sirtuin 6

Entrez ID
Symbol
GenAge
MGI ID

22059
Trp53
View on GenAge (Trp53)
MGI:98834

transformation related protein 53

Orthologs of Sirt6;Trp53 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of Sirt6 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Caenorhabditis elegans	sir-2.4
Drosophila melanogaster	Sirt6

Orthologs of Trp53 in SynergyAge

Show in SynergyAge
Species	Gene

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.