Lifespan changes: From wild type to Prkdc;Terc

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Genetic mutants with Prkdc, Terc alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    Late generation mTerc-/- mice with telomere dysfunction have shorter median lifespans relative to those with intact telomeres independent of DNA-PKcs status. When combined with DNA-PKcs deficiency, the telomere deficient mice experience a further dramatic reduction in median lifespan.

  • Lifespan comparisons

    Double mutant Prkdc(KO);Terc(KO) has a lifespan of 199.0 days, while single mutant Prkdc(KO) has a lifespan of 364.0 days, single mutant Terc(KO) has a lifespan of 320.0 days and wild type has a lifespan of 496.0 days.

  • Type of interaction
    See methods

    Almost additive (negative)

  • Citation
    View abstract

    Wong KK et al., 2007, Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres. Oncogene. 26(20):2815-21 PubMed 17072335 Click here to select all mutants from this PubMed ID in the graph

Search genes: Prkdc Terc
  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

protein kinase, DNA activated, catalytic polypeptide

  • Entrez ID
  • Symbol
  • GenAge
  • MGI ID

telomerase RNA component

Orthologs of Prkdc;Terc in SynergyAge
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Species Gene
Orthologs of Prkdc in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Terc in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: