akt-2;utx-1

Lifespan changes: From wild type to akt-2;utx-1

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Genetic mutants with akt-2, utx-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    HT115

  • Lifespan (days)

    18.23

  • Lifespan change (compared to wild type)

    11.64%

  • Phenotype

    The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway

  • Lifespan comparisons

    Double mutant akt-2(ok393);utx-1(RNAi) has a lifespan of 18.23 days, while single mutant utx-1(RNAi) has a lifespan of 19.06 days, single mutant akt-2(ok393) has a lifespan of 18.0 days and wild type has a lifespan of 16.33 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Jin C et al., 2011, Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab. 14(2):161-72 PubMed 21803287 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    HT115

  • Lifespan (days)

    21.77

  • Lifespan change (compared to wild type)

    34.72%

  • Phenotype

    The life span extension by utx-1 RNAi was also abolished in three other mutants akt-1(ok525), akt-2(ok393), sgk-1(ok538), which are defective in the IIS pathway

  • Lifespan comparisons

    Double mutant akt-2(ok393);utx-1(RNAi) has a lifespan of 21.77 days, while single mutant utx-1(RNAi) has a lifespan of 19.18 days, single mutant akt-2(ok393) has a lifespan of 24.63 days and wild type has a lifespan of 16.16 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Jin C et al., 2011, Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab. 14(2):161-72 PubMed 21803287 Click here to select all mutants from this PubMed ID in the graph

Search genes: akt-2 utx-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase akt-2


Locus: CELE_F28H6.1


Wormbase description: akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

human UTX (Ubiquitously transcribed TPR on X) homolog


Locus: CELE_D2021.1


Wormbase description: utx-1 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase, required for embryonic viability and vulval development, and for high brood sizes, locomotion, and growth sizes; UTX-1 contains a JmjC domain, is orthologous to human UTX and UTY, and is paralogous to human JMJD3; by orthology, UTX-1 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes.


Orthologs of akt-2;utx-1 in SynergyAge
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Orthologs of akt-2 in SynergyAge
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Orthologs of utx-1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group