rrf-3;skr-12

Lifespan changes: From wild type to rrf-3;skr-12

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Genetic mutants with rrf-3, skr-12 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    OP50

  • Lifespan (days)

    18.9

  • Lifespan comparisons

    Double mutant rrf-3(pk1426);skr-12(RNAi) has a lifespan of 18.9 days, while single mutant rrf-3(pk1426) has a lifespan of 18.5 days.

  • Citation
    View abstract

    Ewald CY et al., 2015, Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 519(7541):97-101 PubMed 25517099 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    OP50

  • Lifespan (days)

    20.6

  • Lifespan comparisons

    Double mutant rrf-3(pk1426);skr-12(RNAi) has a lifespan of 20.6 days, while single mutant rrf-3(pk1426) has a lifespan of 20.5 days.

  • Citation
    View abstract

    Ewald CY et al., 2015, Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 519(7541):97-101 PubMed 25517099 Click here to select all mutants from this PubMed ID in the graph

Search genes: rrf-3 skr-12
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

RNA-dependent RNA polymerase Family


Locus: CELE_F10B5.7


Wormbase description: rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

SKp1 Related (ubiquitin ligase complex component)


Locus: CELE_C52D10.6


Wormbase description: skr-12 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-12 has no known function in vivo, since skr-12(RNAi) animals are at least superficially normal.


Orthologs of rrf-3;skr-12 in SynergyAge
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Orthologs of rrf-3 in SynergyAge
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Species Gene
Orthologs of skr-12 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group