cyp-35A2;fat-5

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Genetic mutants with cyp-35A2, fat-5 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Lifespan (days)
15.9
Lifespan change (compared to wild type)
38.26%
Phenotype
The double mutation of fat-5 and cyp-35A2 had survival significantly extended when compared to wild-type nematodes or the short-lived fat-5(tm420) and cyp-35A2(gk317) mutants.
Lifespan comparisons
Double mutant cyp-35A2(RNAi);fat-5(tm420) has a lifespan of 15.9 days, while single mutant cyp-35A2(RNAi) has a lifespan of 10.1 days, single mutant fat-5(tm420) has a lifespan of 13.9 days and wild type has a lifespan of 11.5 days.
Type of interaction
See methods
Enhancer, opposite lifespan effects
Citation
View abstract
Imanikia S et al., 2015, The double mutation of cytochrome P450's and fatty acid desaturases affect lipid regulation and longevity in C. elegans. Biochem Biophys Rep. 2:172-178 29124160 Click here to select all mutants from this PubMed ID in the graph
Abstract
An imbalance between energy uptake and energy expenditure can lead to obesity and increase the risk of coronary heart disease, high blood pressure, stroke, type II diabetes and some cancers. Given that key elements of the energy pathway are evolutionary conserved, invertebrate research is an attractive alternative that overcomes the many legislative, financial and experimental hurdles typical of research with higher metazoan animals. Recent studies have suggested that some members of the cytochrome P450 superfamily are involved in lipid metabolism in addition to the traditional xenobiotic activity. To investigate this notion in more detail, the present study aimed to pinpoint phenotypic, genetic and genomic-level responses of

Search genes: cyp-35A2 fat-5

Entrez ID
Symbol
GenAge
Wormbase ID

182177
cyp-35A2
View on GenAge (cyp-35A2)
WBGene00015400

CYtochrome P450 family

Locus: CELE_C03G6.15

Wormbase description: cyp-35A2 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35A2 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; in addition, cyp-35A(RNAi) also results in a reduction of fat content; cyp-35A2 reporter gene fusions are strongly expressed in the intestine following treatment with xenobiotics.

Entrez ID
Symbol
GenAge
Wormbase ID

180162
fat-5
View on GenAge (fat-5)
WBGene00001397

Delta(9)-fatty-acid desaturase fat-5

Locus: CELE_W06D12.3

Wormbase description: fat-5 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial; when expressed heterologously in S. cerevisiae, FAT-5 rescues the fatty acid auxotrophy of the yeast delta-9 desaturase mutant ole1.

Orthologs of cyp-35A2;fat-5 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of cyp-35A2 in SynergyAge

Show in SynergyAge
Species	Gene

Orthologs of fat-5 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Desat1
Drosophila melanogaster	CG8630
Drosophila melanogaster	Desat2
Drosophila melanogaster	Fad2
Mus musculus	Scd2
Mus musculus	Scd1
Mus musculus	Scd4
Mus musculus	Scd3

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.