gpa-1;gpa-11

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with gpa-1, gpa-11 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
21.5
Lifespan change (compared to wild type)
28.74%
Phenotype
The life span of gpa-11; gpa-1 animals did not significantly differ from that of gpa-1 single mutants. These results show that life span extension in gpa-1 animals does not depend on gpa-11, but rather that gpa-11 mediates an additional signal that suppresses life span extension in gpa-1 mutants
Lifespan comparisons
Double mutant gpa-1(pk15);gpa-11(pk349) has a lifespan of 21.5 days, while single mutant gpa-1(pk15) has a lifespan of 20.4 days and wild type has a lifespan of 16.7 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Lans H, Jansen G, 2007, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 303(2):474-82 17187771 Click here to select all mutants from this PubMed ID in the graph
Abstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
16.9
Lifespan change (compared to wild type)
1.20%
Phenotype
The life span of gpa-1; gpa-11XS animals was similar to that of gpa-11XS animals, but shorter than that of gpa-1 mutants. These results show that life span extension in gpa-1 animals does not depend on gpa-11, but rather that gpa-11 mediates an additional signal that suppresses life span extension in gpa-1 mutants
Lifespan comparisons
Double mutant gpa-1(pk15);gpa-11(pkIs539) has a lifespan of 16.9 days, while single mutant gpa-11(pkIs539) has a lifespan of 17.5 days, single mutant gpa-1(pk15) has a lifespan of 20.4 days and wild type has a lifespan of 16.7 days.
Type of interaction
See methods
Antagonistic (positive)
Citation
View abstract
Lans H, Jansen G, 2007, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 303(2):474-82 17187771 Click here to select all mutants from this PubMed ID in the graph
Abstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.

Search genes: gpa-1 gpa-11

Entrez ID
Symbol
GenAge
Wormbase ID

179546
gpa-1
View on GenAge (gpa-1)
WBGene00001663

G Protein, Alpha subunit;Guanine nucleotide-binding protein alpha-1 subunit

Locus: CELE_T19C4.6

Wormbase description: gpa-1 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is involved in chemotaxis to water-soluble odorants; it is expressed in sensory neurons and in the spicule and phasmid neurons of the male tail.

Entrez ID
Symbol
GenAge
Wormbase ID

173759
gpa-11
View on GenAge (gpa-11)
WBGene00001673

Guanine nucleotide-binding protein alpha-11 subunit

Locus: CELE_C16A11.1

Wormbase description: gpa-11 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADL and ASH amphid neurons.

Orthologs of gpa-1;gpa-11 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of gpa-1 in SynergyAge

Show in SynergyAge
Species	Gene

Orthologs of gpa-11 in SynergyAge

Show in SynergyAge
Species	Gene