akt-2;eak-7

Lifespan changes: From wild type to akt-2;eak-7

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Genetic mutants with akt-2, eak-7 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Diet

    OP50

  • Lifespan (days)

    25.7

  • Lifespan change (compared to wild type)

    74.83%

  • Phenotype

    Eak-7 null mutation enhances the lifespan extension observed in akt-2 null mutants.

  • Lifespan comparisons

    Double mutant akt-2(ok393);eak-7(tm3188) has a lifespan of 25.7 days, while single mutant akt-2(ok393) has a lifespan of 21.8 days, single mutant eak-7(tm3188) has a lifespan of 18.0 days and wild type has a lifespan of 14.7 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Alam H et al., 2010, EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Cell Metab. 12(1):30-41 PubMed 20620993 Click here to select all mutants from this PubMed ID in the graph

  • Diet

    OP50

  • Lifespan (days)

    24.3

  • Lifespan change (compared to wild type)

    62.00%

  • Phenotype

    Eak-7 null mutation enhances the lifespan extension observed in akt-2 null mutants.

  • Lifespan comparisons

    Double mutant akt-2(ok393);eak-7(tm3188) has a lifespan of 24.3 days, while single mutant akt-2(ok393) has a lifespan of 19.1 days, single mutant eak-7(tm3188) has a lifespan of 17.8 days and wild type has a lifespan of 15.0 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Alam H et al., 2010, EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Cell Metab. 12(1):30-41 PubMed 20620993 Click here to select all mutants from this PubMed ID in the graph

Search genes: akt-2 eak-7
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase akt-2


Locus: CELE_F28H6.1


Wormbase description: akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Enhancer of AKt-1 null


Locus: CELE_K08E7.1


Wormbase description: eak-7 encodes a conserved protein that contains a TLDc (TBC and LysM domain-containing) domain and an N-myristoylation motif; EAK-7 negatively regulates dauer formation and longevity by controlling the nuclear activity of the DAF-16/FoxO transcription factor; an EAK-7::GFP is widely expressed and localizes to the plasma membrane.


Orthologs of akt-2;eak-7 in SynergyAge
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Orthologs of akt-2 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of eak-7 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group