gpa-11;odr-3

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Genetic mutants with gpa-11, odr-3 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
14.8
Lifespan change (compared to wild type)
-11.38%
Phenotype
gpa-11; odr-3 mutants had a life span shorter than odr-3 mutants but similar to gpa-11 mutants, suggesting that the extended life span of odr-3 mutants requires the function of gpa-11. We favor the idea that odr-3 inhibits longevity by signaling via gpa-11.
Lifespan comparisons
Double mutant gpa-11(pk349);odr-3(n1605) has a lifespan of 14.8 days, while single mutant odr-3(n1605) has a lifespan of 17.1 days, single mutant gpa-11(pk349) has a lifespan of 16.8 days and wild type has a lifespan of 16.7 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Lans H, Jansen G, 2007, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 303(2):474-82 17187771 Click here to select all mutants from this PubMed ID in the graph
Abstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.

Temperature °C
25
Lifespan (days)
17.2
Lifespan change (compared to wild type)
-1.71%
Phenotype
gpa-11; odr-3 mutants had a life span shorter than odr-3 mutants but similar to gpa-11 mutants, suggesting that the extended life span of odr-3 mutants requires the function of gpa-11. We favor the idea that odr-3 inhibits longevity by signaling via gpa-11.
Lifespan comparisons
Double mutant gpa-11(pk349);odr-3(n1605) has a lifespan of 17.2 days, while single mutant odr-3(n1605) has a lifespan of 19.7 days, single mutant gpa-11(pk349) has a lifespan of 17 days and wild type has a lifespan of 17.5 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lans H, Jansen G, 2007, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 303(2):474-82 17187771 Click here to select all mutants from this PubMed ID in the graph
Abstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
24.3
Lifespan change (compared to wild type)
45.51%
Phenotype
Loss-of-function of odr-3 and extra copies of gpa-11 synergistically extended life span, suggesting that, in wild type animals, gpa-11 promotes longevity and odr-3 inhibits longevity.
Lifespan comparisons
Double mutant gpa-11(pkIs540);odr-3(n1605) has a lifespan of 24.3 days, while single mutant odr-3(n1605) has a lifespan of 17.1 days and wild type has a lifespan of 16.7 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Lans H, Jansen G, 2007, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 303(2):474-82 17187771 Click here to select all mutants from this PubMed ID in the graph
Abstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.

Temperature °C
25
Lifespan (days)
25.4
Lifespan change (compared to wild type)
45.14%
Phenotype
Loss-of-function of odr-3 and extra copies of gpa-11 synergistically extended life span, suggesting that, in wild type animals, gpa-11 promotes longevity and odr-3 inhibits longevity.
Lifespan comparisons
Double mutant gpa-11(pkIs540);odr-3(n1605) has a lifespan of 25.4 days, while single mutant odr-3(n1605) has a lifespan of 19.7 days, single mutant gpa-11(pkIs540) has a lifespan of 22.8 days and wild type has a lifespan of 17.5 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Lans H, Jansen G, 2007, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 303(2):474-82 17187771 Click here to select all mutants from this PubMed ID in the graph
Abstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
25.8
Lifespan change (compared to wild type)
54.49%
Phenotype
Loss-of-function of odr-3 and extra copies of gpa-11 synergistically extended life span, suggesting that, in wild type animals, gpa-11 promotes longevity and odr-3 inhibits longevity.
Lifespan comparisons
Double mutant gpa-11(pkls539);odr-3(n1605) has a lifespan of 25.8 days, while single mutant odr-3(n1605) has a lifespan of 17.1 days, single mutant gpa-11(pkIs539) has a lifespan of 17.5 days and wild type has a lifespan of 16.7 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Lans H, Jansen G, 2007, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 303(2):474-82 17187771 Click here to select all mutants from this PubMed ID in the graph
Abstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.

Temperature °C
25
Lifespan (days)
34.7
Lifespan change (compared to wild type)
98.29%
Phenotype
Loss-of-function of odr-3 and extra copies of gpa-11 synergistically extended life span, suggesting that, in wild type animals, gpa-11 promotes longevity and odr-3 inhibits longevity.
Lifespan comparisons
Double mutant gpa-11(pkls539);odr-3(n1605) has a lifespan of 34.7 days, while single mutant odr-3(n1605) has a lifespan of 19.7 days, single mutant gpa-11(pkls539) has a lifespan of 21.1 days and wild type has a lifespan of 17.5 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Lans H, Jansen G, 2007, Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol. 303(2):474-82 17187771 Click here to select all mutants from this PubMed ID in the graph
Abstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.

Search genes: gpa-11 odr-3

Entrez ID
Symbol
GenAge
Wormbase ID

173759
gpa-11
View on GenAge (gpa-11)
WBGene00001673

Guanine nucleotide-binding protein alpha-11 subunit

Locus: CELE_C16A11.1

Wormbase description: gpa-11 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ADL and ASH amphid neurons.

Entrez ID
Symbol
GenAge
Wormbase ID

179806
odr-3
View on GenAge (odr-3)
WBGene00003850

Guanine nucleotide-binding protein alpha-17 subunit

Locus: CELE_C34D1.3

Wormbase description: odr-3 encodes a G protein alpha subunit; odr-3 activity is required for normal chemotaxis, odorant avoidance, and nociceptive function as well as cilium morphogenesis in chemosensory neurons; an ODR-3::GFP is expressed in five pairs of sensory neurons AWA, AWB, AWC, ASH, and ADF; the AWC neurons consistently express GFP most strongly, while the AWB neurons express at lower levels and the AWA, ASH, and ADF neurons express only weakly; in AWC neurons, ODR-3::GFP localizes to cilia which have a characteristic wing-shaped morphology.

Orthologs of gpa-11;odr-3 in SynergyAge

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Orthologs of gpa-11 in SynergyAge

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Orthologs of odr-3 in SynergyAge

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