eat-2;elt-3

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Genetic mutants with eat-2, elt-3 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
HT115
Lifespan (days)
11.8
Lifespan change (compared to wild type)
-4.07%
Phenotype
elt-3(RNAi) suppresses the longevity phenotype of eat-2(ad1116) mutants, which have a defect in pharyngeal pumping that results in dietary restriction.
Lifespan comparisons
Double mutant eat-2(ade465);elt-3(RNAi) has a lifespan of 11.8 days, while single mutant elt-3(RNAi) has a lifespan of 12.1 days, single mutant eat-2(ade465) has a lifespan of 14.3 days and wild type has a lifespan of 12.3 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Budovskaya YV et al., 2008, An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell. 134(2):291-303 18662544 Click here to select all mutants from this PubMed ID in the graph
Abstract
To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a corresponding decrease in expression in old worms. elt-3 regulates a large number of downstream genes that change expression in old age, including ugt-9, col-144, and sod-3. elt-5(RNAi) and elt-6(RNAi) worms have extended longevity, indicating that elt-3, elt-5, and elt-6 play an important functional role in the aging process. These results identify a transcriptional circuit that guides the rapid aging process in C. elegans and indicate that this circuit is driven by drift of developmental pathways rather than accumulation of damage.

Search genes: eat-2 elt-3

Entrez ID
Symbol
GenAge
Wormbase ID

175072
eat-2
View on GenAge (eat-2)
WBGene00001133

Neuronal acetylcholine receptor subunit eat-2

Locus: CELE_Y48B6A.4

Wormbase description: eat-2 encodes a ligand-gated ion channel subunit most closely related to the non-alpha-subunits of nicotinic acetylcholine receptors (nAChR); EAT-2 functions postsynaptically in pharyngeal muscle to regulate the rate of pharyngeal pumping; eat-2 is also required for normal life span and defecation; a functional EAT-2::GFP fusion protein localizes to two small dots near the junction of pharyngeal muscles pm4 and pm5, which is the site of the posterior-most MC motor neuron processes and the MC synapse; eat-2 genetically interacts with eat-18, which encodes a predicted novel transmembrane protein expressed in pharyngeal muscle and required for proper function of pharyngeal nicotonic receptors.

Entrez ID
Symbol
GenAge
Wormbase ID

181503
elt-3
View on GenAge (elt-3)
WBGene00001251

Erythroid-Like Transcription factor family

Locus: CELE_K02B9.4

Wormbase description: elt-3 gene encodes a GATA transcription factor; during embryogenesis, ELT-3 appears to act downstream of ELT-1, also a GATA transcription factor, in a redundant pathway controlling hypodermal cell differentiation; ELT-3 is also required for positive regulation of transcription of nlp-29, which encodes an antimicrobial peptide, in response to fungal infection and gpdh-1 in response to salt stress; in addition, ELT-3 may also play a role in regulating adult lifespan; ELT-3 is expressed in all of the major hypodermal cells except the lateral seam cells and localizes to the nucleus; elt-3 expression in the hypodermis is positively regulated by ELT-1 and negatively regulated by ELT-5 and ELT-6.

Orthologs of eat-2;elt-3 in SynergyAge

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Orthologs of eat-2 in SynergyAge

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Orthologs of elt-3 in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.