ahr-1;mekk-3

Lifespan changes: From wild type to ahr-1;mekk-3

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Genetic mutants with ahr-1, mekk-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    20.96

  • Lifespan change (compared to wild type)

    19.91%

  • Phenotype

    mekk-3 RNAi failed to extend lifespan in ahr-1(ia3) to the same extent as in WT worms.

  • Lifespan comparisons

    Double mutant ahr-1(ia3);mekk-3(RNAi) has a lifespan of 20.96 days, while single mutant mekk-3(RNAi) has a lifespan of 27.98 days, single mutant ahr-1(ia3) has a lifespan of 18.43 days and wild type has a lifespan of 17.48 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Chamoli M et al., 2014, A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans. Aging Cell. 13(4):641-55 PubMed 24655420 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    15.33

  • Lifespan change (compared to wild type)

    -12.35%

  • Phenotype

    mekk-3 RNAi failed to extend lifespan in ahr-1(ia3) to the same extent as in WT worms.

  • Lifespan comparisons

    Double mutant ahr-1(ia3);mekk-3(RNAi) has a lifespan of 15.33 days, while single mutant mekk-3(RNAi) has a lifespan of 30.29 days, single mutant ahr-1(ia3) has a lifespan of 17.1 days and wild type has a lifespan of 17.49 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Chamoli M et al., 2014, A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans. Aging Cell. 13(4):641-55 PubMed 24655420 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    14.92

  • Lifespan change (compared to wild type)

    -14.65%

  • Phenotype

    mekk-3 RNAi failed to extend lifespan in ahr-1(ju145) to the same extent as in WT worms.

  • Lifespan comparisons

    Double mutant ahr-1(ju145);mekk-3(RNAi) has a lifespan of 14.92 days, while single mutant mekk-3(RNAi) has a lifespan of 27.98 days, single mutant ahr-1(ju145) has a lifespan of 16.16 days and wild type has a lifespan of 17.48 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Chamoli M et al., 2014, A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans. Aging Cell. 13(4):641-55 PubMed 24655420 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    19.24

  • Lifespan change (compared to wild type)

    10.01%

  • Phenotype

    mekk-3 RNAi failed to extend lifespan in ahr-1(ju145) to the same extent as in WT worms.

  • Lifespan comparisons

    Double mutant ahr-1(ju145);mekk-3(RNAi) has a lifespan of 19.24 days, while single mutant mekk-3(RNAi) has a lifespan of 30.29 days, single mutant ahr-1(ju145) has a lifespan of 18.14 days and wild type has a lifespan of 17.49 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Chamoli M et al., 2014, A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans. Aging Cell. 13(4):641-55 PubMed 24655420 Click here to select all mutants from this PubMed ID in the graph

Search genes: ahr-1 mekk-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Aryl hydrocarbon receptor protein 1


Locus: CELE_C41G7.5


Wormbase description: ahr-1 encodes an aryl hydrocarbon receptor (ligand-activated basic helix-loop-helix transcription factor) ortholog that biochemically resembles its vertebrate relatives (OMIM:600253) which mediate the carcinogenic and teratogenic effects of environmental toxins; AHR-1 activity is required for specification of RMEL and RMER GABAergic neuron cell fate and negative regulation of spontaneous movement; AHR-1 binds HSP90 tightly, and forms a dimer with AHA-1 that binds DNA fragments containing the mammalian xenobiotic response element; AHR-1 is expressed in neurons.


  • Symbol
  • GenAge

No gene information for mekk-3


Orthologs of ahr-1;mekk-3 in SynergyAge
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Orthologs of ahr-1 in SynergyAge
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Species Gene
Orthologs of mekk-3 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group