akt-1;daf-16

Lifespan changes: From wild type to akt-1;daf-16

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Genetic mutants with akt-1, daf-16 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    OP50

  • Lifespan (days)

    15.3

  • Lifespan change (compared to wild type)

    -39.04%

  • Lifespan comparisons

    Double mutant akt-1(mg306);daf-16(mu86) has a lifespan of 15.3 days, while single mutant akt-1(mg306) has a lifespan of 30.0 days and wild type has a lifespan of 25.1 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Chen AT et al., 2013, Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell. 12(5):932-40 PubMed 23786484 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Diet

    OP50

  • Lifespan (days)

    13.5

  • Lifespan change (compared to wild type)

    -34.78%

  • Lifespan comparisons

    Double mutant akt-1(mg306);daf-16(mu86) has a lifespan of 13.5 days, while single mutant akt-1(mg306) has a lifespan of 32.2 days and wild type has a lifespan of 20.7 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Chen AT et al., 2013, Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell. 12(5):932-40 PubMed 23786484 Click here to select all mutants from this PubMed ID in the graph

Search genes: akt-1 daf-16
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase akt-1


Locus: CELE_C12D8.10


Wormbase description: akt-1 encodes an ortholog of the serine/threonine kinase Akt/PKB; akt-1 genetically interacts with the insulin signaling pathway and functions to regulate such processes as dauer larval development and salt chemotaxis learning; AKT-1 binds calmodulin in vitro in a calcium-dependent manner; an AKT-1::GFP fusion protein is widely expressed beginning in late stage embryos and continuing through adulthood; expression is seen in head, tail, and dorsal and ventral cord neurons, with additional expression seen in other cells including those of the pharynx, hypodermis, intestine, and spermatheca; two alleles of akt-1 (sa573 and sa700) have a Daf-c mutant phenotype at 27 degrees C (Hid phenotype).


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Forkhead box protein O;hypothetical protein


Locus: CELE_R13H8.1


Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.


Orthologs of akt-1;daf-16 in SynergyAge
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Orthologs of akt-1 in SynergyAge
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Orthologs of daf-16 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group