Lifespan changes: From wild type to gcy-35;npr-1;tax-4
21
live OP50
15.65
6.54%
Triple mutant gcy-35(ok769);npr-1(ad609);tax-4(ks28) has a lifespan of 15.65 days, while double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 20.24 days and wild type has a lifespan of 14.69 days.
Contains dependence
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 
28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
13.26
-7.34%
Triple mutant gcy-35(ok769);npr-1(ad609);tax-4(ks28) has a lifespan of 13.26 days, while double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 23.61 days and wild type has a lifespan of 14.31 days.
Contains dependence
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
13.88
-6.78%
Triple mutant gcy-35(ok769);npr-1(ad609);tax-4(ks28) has a lifespan of 13.88 days, while double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 22.54 days and wild type has a lifespan of 14.89 days.
Contains dependence
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
15.0
4.24%
Triple mutant gcy-35(ok769);npr-1(ad609);tax-4(ks28) has a lifespan of 15.0 days, while double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 20.06 days and wild type has a lifespan of 14.39 days.
Contains dependence
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
Guanylyl CYclase;Soluble guanylate cyclase gcy-35
Locus: CELE_T04D3.4
Wormbase description: gcy-35 encodes a soluble guanylyl cyclase; GCY-35 activity is required for regulation of aggregation, aerotaxis, aerokinesis, gustatory plasticity, and innate immunity; GCY-35 activity is also required in the URX sensory neurons to sense increases in O2 levels and effect corresponding behavioral changes; gcy-35::gfp reporter fusions are expressed in a number of neurons, including the AQR, PQR, and URX sensory neurons, the SDQL/R and BDU interneurons, the AVM and PVM mechanosensory neurons, the cholinergic ALN and PLN neurons, the excretory cell, and in pharyngeal and body wall muscles; gcy-35 expression in the URX neuron is positively regulated by the AHR-1 transcription complex; the heme-binding domain of GCY-35 binds molecular oxygen as well as NO and CO.
NeuroPeptide Receptor family
Locus: CELE_C39E6.6
Wormbase description: npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; in regulating social behavior, NPR-1 functions as a receptor for the FLP-18 and FLP-21 peptide ligands; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid.
Cyclic nucleotide-gated cation channel
Locus: CELE_ZC84.2
Wormbase description: tax-4 encodes a a cyclic nucleotide-gated channel subunit orthologous to the human gene ROD PHOTORECEPTOR CGMP-GATED CHANNEL (CNGA1; OMIM:123825); tax-4 is required for chemosensation and thermosensation; a TAX-4::GFP fusion protein is expressed in sensory neurons where it localizes to the cilia.
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
