daf-3;daf-7

Lifespan changes: From wild type to daf-3;daf-7

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Genetic mutants with daf-3, daf-7 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    12.7

  • Lifespan change (compared to wild type)

    -31.72%

  • Phenotype

    The long lifespan of daf-7 mutants was suppressed by daf-3 mutations

  • Lifespan comparisons

    Double mutant daf-3(mgDf90);daf-7(RNAi) has a lifespan of 12.7 days, while single mutant daf-7(RNAi) has a lifespan of 20.3 days, single mutant daf-3(mgDf90) has a lifespan of 13.1 days and wild type has a lifespan of 18.6 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Shaw WM et al., 2007, The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 17(19):1635-45 PubMed 17900898 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    14.7

  • Lifespan change (compared to wild type)

    -40.73%

  • Phenotype

    The long lifespan of daf-7 mutants was suppressed by daf-3 mutations

  • Lifespan comparisons

    Double mutant daf-3(mgDf90);daf-7(RNAi) has a lifespan of 14.7 days, while single mutant daf-7(RNAi) has a lifespan of 20.4 days, single mutant daf-3(mgDf90) has a lifespan of 16.6 days and wild type has a lifespan of 24.8 days.

  • Type of interaction
    See methods

    Almost additive (negative)

  • Citation
    View abstract

    Shaw WM et al., 2007, The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 17(19):1635-45 PubMed 17900898 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    14.9

  • Lifespan change (compared to wild type)

    -21.58%

  • Phenotype

    The long lifespan of daf-7 mutants was suppressed by daf-3 mutations

  • Lifespan comparisons

    Double mutant daf-3(mgDf90);daf-7(RNAi) has a lifespan of 14.9 days, while single mutant daf-7(RNAi) has a lifespan of 21 days, single mutant daf-3(mgDf90) has a lifespan of 15.5 days and wild type has a lifespan of 19 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Shaw WM et al., 2007, The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 17(19):1635-45 PubMed 17900898 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    16.7

  • Lifespan change (compared to wild type)

    0.60%

  • Phenotype

    The long lifespan of daf-7 mutants was suppressed by daf-3 mutations

  • Lifespan comparisons

    Double mutant daf-3(mgDf90);daf-7(RNAi) has a lifespan of 16.7 days, while single mutant daf-7(RNAi) has a lifespan of 20.3 days, single mutant daf-3(mgDf90) has a lifespan of 14.4 days and wild type has a lifespan of 16.6 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Shaw WM et al., 2007, The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 17(19):1635-45 PubMed 17900898 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    14.9

  • Lifespan change (compared to wild type)

    -9.15%

  • Phenotype

    The long lifespan of daf-7 mutants was suppressed by daf-3 mutations

  • Lifespan comparisons

    Double mutant daf-3(mgDf90);daf-7(e1372) has a lifespan of 14.9 days, while single mutant daf-7(e1372) has a lifespan of 17.5 days, single mutant daf-3(mgDf90) has a lifespan of 15.2 days and wild type has a lifespan of 16.4 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Shaw WM et al., 2007, The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 17(19):1635-45 PubMed 17900898 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    15.5

  • Lifespan change (compared to wild type)

    0.65%

  • Phenotype

    The long lifespan of daf-7 mutants was suppressed by daf-3 mutations

  • Lifespan comparisons

    Double mutant daf-3(mgDf90);daf-7(e1372) has a lifespan of 15.5 days, while single mutant daf-7(e1372) has a lifespan of 16.1 days, single mutant daf-3(mgDf90) has a lifespan of 12.9 days and wild type has a lifespan of 15.4 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Shaw WM et al., 2007, The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 17(19):1635-45 PubMed 17900898 Click here to select all mutants from this PubMed ID in the graph

Search genes: daf-3 daf-7
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Dwarfin sma;hypothetical protein

Locus: CELE_F25E2.5

Wormbase description: daf-3 encodes a co-SMAD protein that is most closely related to Drosophila Medea and the vertebrate Smad4 proteins; DAF-3 functions as a transcriptional regulator that is required for formation of the alternative dauer larval stage as well as for regulation of pharyngeal gene expression during non-dauer development; DAF-3 activity is antagonized by signaling through the DAF-7/TGF-beta pathway which promotes reproductive growth; in yeast two-hybrid studies, DAF-3 interacts with SMA-3, another Smad protein that does not appear to have a role in dauer formation; in vitro, DAF-3 binds the organ-specific C subelement in the promoter of the pharyngeal muscle-specific myosin myo-2 and in vivo, suppresses the enhancer activity of this element during larval development; a DAF-3::GFP fusion protein is expressed in many tissues that undergo remodeling during dauer development, including the gut, nervous system and pharynx; DAF-3 localizes predominantly to the cytoplasm, but is also found in the nucleus in association with mitotic chromosomes.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Dauer larva development regulatory growth factor daf-7

Locus: CELE_B0412.2

Wormbase description: daf-7 encodes a member of the transforming growth factor beta superfamily; in C. elegans, DAF-7 functions as part of a signaling pathway that interprets environmental conditions to regulate energy-balance pathways that affect dauer larval formation, fat metabolism, egg laying, pathogen avoidance behavior, and feeding behavior; daf-7 reporter gene fusions are expressed in the ASI, ADE, and OLQ neurons, and daf-7 expression is induced in both ASI and ASJ chemosensory neurons in response to the pathogenic bacterial strain Pseudomonas aeruginosa PA14.

Orthologs of daf-3;daf-7 in SynergyAge
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Orthologs of daf-3 in SynergyAge
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Orthologs of daf-7 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group