Lifespan changes: From wild type to gcy-33;npr-1 / From gcy-33;npr-1 to multiple mutants
21
live OP50
12.73
-7.49%
The deletion of gcy-33 did not affect N2 worms’ lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609).
Double mutant gcy-33(ok232);npr-1(ad609) has a lifespan of 12.73 days, while single mutant gcy-33(ok232) has a lifespan of 16.1 days, single mutant npr-1(ad609) has a lifespan of 15.54 days and wild type has a lifespan of 13.76 days.
Antagonistic (negative)
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 
28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
14.47
8.63%
The deletion of gcy-33 did not affect N2 worms’ lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609).
Double mutant gcy-33(ok232);npr-1(ad609) has a lifespan of 14.47 days, while single mutant gcy-33(ok232) has a lifespan of 15.4 days, single mutant npr-1(ad609) has a lifespan of 13.72 days and wild type has a lifespan of 13.32 days.
Dependent
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
13.89
10.50%
The deletion of gcy-33 did not affect N2 worms’ lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609).
Double mutant gcy-33(ok232);npr-1(ad609) has a lifespan of 13.89 days, while single mutant gcy-33(ok232) has a lifespan of 16.1 days, single mutant npr-1(ad609) has a lifespan of 15.2 days and wild type has a lifespan of 12.57 days.
Antagonistic (positive)
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
13.12
-19.71%
The deletion of gcy-33 did not affect N2 worms’ lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609).
Double mutant gcy-33(ok232);npr-1(ad609) has a lifespan of 13.12 days, while single mutant gcy-33(ok232) has a lifespan of 14.5 days, single mutant npr-1(ad609) has a lifespan of 16.94 days and wild type has a lifespan of 16.34 days.
Enhancer, opposite lifespan effects
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
10.4
-32.29%
The deletion of gcy-33 did not affect N2 worms’ lifespan. In contrast, gcy-33 deletion significantly shortened the lifespan of npr-1(ad609).
Double mutant gcy-33(ok232);npr-1(ad609) has a lifespan of 10.4 days, while single mutant gcy-33(ok232) has a lifespan of 14.9 days, single mutant npr-1(ad609) has a lifespan of 16.97 days and wild type has a lifespan of 15.36 days.
Opposite lifespan effects of single mutants
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
Guanylyl CYclase;Soluble guanylate cyclase gcy-33
Locus: CELE_F57F5.2
Wormbase description: gcy-33 encodes a soluble guanylate cyclase beta subunit; GCY-33 activity is required in the ciliated BAG head sensory neurons to sense decreases in O2 levels and effect corresponding behavioral changes; a gcy-33::GFP reporter is expressed in the BAG neurons; biochemical characterization of chimeric molecules containing the GCY-33 N-terminal H-NOX domain fused to the rat beta1 guanylate cyclase indicate that the GCY-33 H-NOX domain can form complexes with NO, CO, and O2 and that binding can positively regulate catalytic activity of the molecule.
NeuroPeptide Receptor family
Locus: CELE_C39E6.6
Wormbase description: npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; in regulating social behavior, NPR-1 functions as a receptor for the FLP-18 and FLP-21 peptide ligands; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid.
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
