Lifespan changes: From wild type to daf-16;npr-1 / From daf-16;npr-1 to multiple mutants
21
live OP50
16.03
15.74%
daf-16;npr-1(ad609) mutants lived significantly longer than daf-16 mutants, indicating that the beneficial effect of NPR-1(215V) inhibition is not mediated by daf-16 signaling.
Double mutant daf-16(mu86);npr-1(ad609) has a lifespan of 16.03 days, while single mutant daf-16(mu86) has a lifespan of 12.2 days, single mutant npr-1(ad609) has a lifespan of 15.18 days and wild type has a lifespan of 13.85 days.
Opposite lifespan effects of single mutants
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 
28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
13.86
2.59%
daf-16;npr-1(ad609) mutants lived significantly longer than daf-16 mutants, indicating that the beneficial effect of NPR-1(215V) inhibition is not mediated by daf-16 signaling.
Double mutant daf-16(mu86);npr-1(ad609) has a lifespan of 13.86 days, while single mutant daf-16(mu86) has a lifespan of 10.06 days, single mutant npr-1(ad609) has a lifespan of 16.48 days and wild type has a lifespan of 13.51 days.
Opposite lifespan effects of single mutants
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
21
live OP50
14.0
5.58%
daf-16;npr-1(ad609) mutants lived significantly longer than daf-16 mutants, indicating that the beneficial effect of NPR-1(215V) inhibition is not mediated by daf-16 signaling.
Double mutant daf-16(mu86);npr-1(ad609) has a lifespan of 14.0 days, while single mutant daf-16(mu86) has a lifespan of 10.18 days, single mutant npr-1(ad609) has a lifespan of 15.0 days and wild type has a lifespan of 13.26 days.
Opposite lifespan effects of single mutants
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425
Click here to select all mutants from this PubMed ID in the graph
Forkhead box protein O;hypothetical protein
Locus: CELE_R13H8.1
Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.
NeuroPeptide Receptor family
Locus: CELE_C39E6.6
Wormbase description: npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; in regulating social behavior, NPR-1 functions as a receptor for the FLP-18 and FLP-21 peptide ligands; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid.
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
