gcy-35;npr-1

Lifespan changes: From wild type to gcy-35;npr-1 / From gcy-35;npr-1 to multiple mutants

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Genetic mutants with gcy-35, npr-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    21.21

  • Lifespan change (compared to wild type)

    54.48%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(215F) has a lifespan of 21.21 days, while single mutant npr-1(215F) has a lifespan of 18.49 days and wild type has a lifespan of 13.73 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    19.55

  • Lifespan change (compared to wild type)

    45.46%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(215F) has a lifespan of 19.55 days, while single mutant npr-1(215F) has a lifespan of 17.95 days and wild type has a lifespan of 13.44 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    18.03

  • Lifespan change (compared to wild type)

    24.95%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(215F) has a lifespan of 18.03 days, while single mutant npr-1(215F) has a lifespan of 14.7 days and wild type has a lifespan of 14.43 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    17.95

  • Lifespan change (compared to wild type)

    33.56%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(215F) has a lifespan of 17.95 days, while single mutant npr-1(215F) has a lifespan of 15.15 days and wild type has a lifespan of 13.44 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    17.86

  • Lifespan change (compared to wild type)

    30.08%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(215F) has a lifespan of 17.86 days, while single mutant npr-1(215F) has a lifespan of 15.21 days and wild type has a lifespan of 13.73 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    20.24

  • Lifespan change (compared to wild type)

    37.78%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 20.24 days, while single mutant npr-1(ad609) has a lifespan of 16.2 days and wild type has a lifespan of 14.69 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    23.61

  • Lifespan change (compared to wild type)

    64.99%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 23.61 days, while single mutant npr-1(ad609) has a lifespan of 16.32 days and wild type has a lifespan of 14.31 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    22.54

  • Lifespan change (compared to wild type)

    51.38%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 22.54 days, while single mutant npr-1(ad609) has a lifespan of 17.74 days and wild type has a lifespan of 14.89 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    20.06

  • Lifespan change (compared to wild type)

    39.40%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 20.06 days, while single mutant npr-1(ad609) has a lifespan of 16.11 days and wild type has a lifespan of 14.39 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    19.26

  • Lifespan change (compared to wild type)

    39.97%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 19.26 days, while single mutant gcy-35(ok769) has a lifespan of 14.2 days, single mutant npr-1(ad609) has a lifespan of 18.77 days and wild type has a lifespan of 15.43 days.

  • Type of interaction
    See methods

    Almost additive (positive)

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    18.43

  • Lifespan change (compared to wild type)

    38.36%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 18.43 days, while single mutant gcy-35(ok769) has a lifespan of 15.8 days, single mutant npr-1(ad609) has a lifespan of 16.97 days and wild type has a lifespan of 15.36 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    22.46

  • Lifespan change (compared to wild type)

    78.68%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 22.46 days, while single mutant gcy-35(ok769) has a lifespan of 13.5 days, single mutant npr-1(ad609) has a lifespan of 16.94 days and wild type has a lifespan of 16.34 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    live OP50

  • Lifespan (days)

    15.79

  • Lifespan change (compared to wild type)

    52.41%

  • Phenotype

    Growing the worms on live OP50 at 25°C shortened the lifespan of all strains. The lifespans of gcy-35, and npr-1(ad609) mutants grown in this environment were similar to N2 controls.

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 15.79 days, while single mutant gcy-35(ok769) has a lifespan of 10.57 days, single mutant npr-1(ad609) has a lifespan of 12.32 days and wild type has a lifespan of 10.36 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    live OP50

  • Lifespan (days)

    14.0

  • Lifespan change (compared to wild type)

    21.32%

  • Phenotype

    Growing the worms on live OP50 at 25°C shortened the lifespan of all strains. The lifespans of gcy-35, and npr-1(ad609) mutants grown in this environment were similar to N2 controls.

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 14.0 days, while single mutant gcy-35(ok769) has a lifespan of 10.85 days, single mutant npr-1(ad609) has a lifespan of 12.17 days and wild type has a lifespan of 11.54 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    live OP50

  • Lifespan (days)

    15.38

  • Lifespan change (compared to wild type)

    24.23%

  • Phenotype

    Growing the worms on live OP50 at 25°C shortened the lifespan of all strains. The lifespans of gcy-35, and npr-1(ad609) mutants grown in this environment were similar to N2 controls.

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 15.38 days, while single mutant gcy-35(ok769) has a lifespan of 12.5 days, single mutant npr-1(ad609) has a lifespan of 12.78 days and wild type has a lifespan of 12.38 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    UV killed OP50

  • Lifespan (days)

    14.69

  • Lifespan change (compared to wild type)

    8.57%

  • Phenotype

    gcy-35 mutants had shorter lifespans than N2 controls on dead OP50 at 25°C. When gcy-35;npr-1(ad609) worms were grown at 25°C on dead OP50, their lifespan was similar to N2 animals.

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 14.69 days, while single mutant gcy-35(ok769) has a lifespan of 12.97 days, single mutant npr-1(ad609) has a lifespan of 17.69 days and wild type has a lifespan of 13.53 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    25

  • Diet

    UV killed OP50

  • Lifespan (days)

    14.95

  • Lifespan change (compared to wild type)

    5.65%

  • Phenotype

    gcy-35 mutants had shorter lifespans than N2 controls on dead OP50 at 25°C. When gcy-35;npr-1(ad609) worms were grown at 25°C on dead OP50, their lifespan was similar to N2 animals.

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 14.95 days, while single mutant gcy-35(ok769) has a lifespan of 13.08 days, single mutant npr-1(ad609) has a lifespan of 13.35 days and wild type has a lifespan of 14.15 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    15

  • Diet

    live OP50

  • Lifespan (days)

    20.53

  • Lifespan change (compared to wild type)

    4.00%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 20.53 days, while single mutant npr-1(ad609) has a lifespan of 19.76 days and wild type has a lifespan of 19.74 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    15

  • Diet

    live OP50

  • Lifespan (days)

    22.45

  • Lifespan change (compared to wild type)

    9.57%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 22.45 days, while single mutant npr-1(ad609) has a lifespan of 21.4 days and wild type has a lifespan of 20.49 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    15

  • Diet

    live OP50

  • Lifespan (days)

    21.67

  • Lifespan change (compared to wild type)

    -0.60%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 21.67 days, while single mutant npr-1(ad609) has a lifespan of 22.43 days and wild type has a lifespan of 21.8 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    15

  • Diet

    UV killed OP50

  • Lifespan (days)

    20.73

  • Lifespan change (compared to wild type)

    18.25%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 20.73 days, while single mutant npr-1(ad609) has a lifespan of 20.69 days and wild type has a lifespan of 17.53 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    15

  • Diet

    UV killed OP50

  • Lifespan (days)

    20.52

  • Lifespan change (compared to wild type)

    12.81%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 20.52 days, while single mutant npr-1(ad609) has a lifespan of 24.97 days and wild type has a lifespan of 18.19 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    15

  • Diet

    UV killed OP50

  • Lifespan (days)

    17.6

  • Lifespan change (compared to wild type)

    -15.10%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 17.6 days, while single mutant npr-1(ad609) has a lifespan of 20.74 days and wild type has a lifespan of 20.73 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    18.69

  • Lifespan change (compared to wild type)

    34.95%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 18.69 days, while single mutant npr-1(ad609) has a lifespan of 15.18 days and wild type has a lifespan of 13.85 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    18.65

  • Lifespan change (compared to wild type)

    38.05%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 18.65 days, while single mutant npr-1(ad609) has a lifespan of 16.48 days and wild type has a lifespan of 13.51 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    18.81

  • Lifespan change (compared to wild type)

    41.86%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 18.81 days, while single mutant npr-1(ad609) has a lifespan of 15.0 days and wild type has a lifespan of 13.26 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    22.13

  • Lifespan change (compared to wild type)

    50.65%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 22.13 days, while single mutant npr-1(ad609) has a lifespan of 16.03 days and wild type has a lifespan of 14.69 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    23.08

  • Lifespan change (compared to wild type)

    62.42%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 23.08 days, while single mutant npr-1(ad609) has a lifespan of 18.78 days and wild type has a lifespan of 15.41 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    21.97

  • Lifespan change (compared to wild type)

    62.98%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 21.97 days, while single mutant npr-1(ad609) has a lifespan of 14.07 days and wild type has a lifespan of 14.03 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    20.59

  • Lifespan change (compared to wild type)

    33.61%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 20.59 days, while single mutant npr-1(ad609) has a lifespan of 16.23 days and wild type has a lifespan of 13.67 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    21

  • Diet

    live OP50

  • Lifespan (days)

    22.1

  • Lifespan change (compared to wild type)

    57.52%

  • Lifespan comparisons

    Double mutant gcy-35(ok769);npr-1(ad609) has a lifespan of 22.1 days, while single mutant npr-1(ad609) has a lifespan of 14.12 days and wild type has a lifespan of 13.48 days.

  • Type of interaction
    See methods

    Partially known monotony. Positive epistasis

  • Citation
    View abstract

    Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 PubMed 28054425 Click here to select all mutants from this PubMed ID in the graph

Search genes: gcy-35 npr-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Guanylyl CYclase;Soluble guanylate cyclase gcy-35

Locus: CELE_T04D3.4

Wormbase description: gcy-35 encodes a soluble guanylyl cyclase; GCY-35 activity is required for regulation of aggregation, aerotaxis, aerokinesis, gustatory plasticity, and innate immunity; GCY-35 activity is also required in the URX sensory neurons to sense increases in O2 levels and effect corresponding behavioral changes; gcy-35::gfp reporter fusions are expressed in a number of neurons, including the AQR, PQR, and URX sensory neurons, the SDQL/R and BDU interneurons, the AVM and PVM mechanosensory neurons, the cholinergic ALN and PLN neurons, the excretory cell, and in pharyngeal and body wall muscles; gcy-35 expression in the URX neuron is positively regulated by the AHR-1 transcription complex; the heme-binding domain of GCY-35 binds molecular oxygen as well as NO and CO.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

NeuroPeptide Receptor family

Locus: CELE_C39E6.6

Wormbase description: npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; in regulating social behavior, NPR-1 functions as a receptor for the FLP-18 and FLP-21 peptide ligands; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid.

Orthologs of gcy-35;npr-1 in SynergyAge
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Species Gene
Orthologs of gcy-35 in SynergyAge
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Species Gene
Orthologs of npr-1 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group